CO2021000046A2 - Sight-binding antibodies to acidic pH - Google Patents
Sight-binding antibodies to acidic pHInfo
- Publication number
- CO2021000046A2 CO2021000046A2 CONC2021/0000046A CO2021000046A CO2021000046A2 CO 2021000046 A2 CO2021000046 A2 CO 2021000046A2 CO 2021000046 A CO2021000046 A CO 2021000046A CO 2021000046 A2 CO2021000046 A2 CO 2021000046A2
- Authority
- CO
- Colombia
- Prior art keywords
- acidic
- sight
- binding antibodies
- antibodies
- vista
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente solicitud se relaciona con anticuerpos que se unen específicamente al supresor de activación de linfocitos T que contiene inmunoglobulina con dominio V (VISTA) a pH ácido y su uso en el tratamiento del cáncer. En algunas modalidades, los anticuerpos se unen específicamente a VISTA humano a pH ácido, pero no se unen significativamente a VISTA humano a pH neutro o fisiológico.The present application relates to antibodies that specifically bind to the T-lymphocyte activation suppressor containing V domain immunoglobulin (VISTA) at acidic pH and their use in the treatment of cancer. In some embodiments, the antibodies specifically bind to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862696622P | 2018-07-11 | 2018-07-11 | |
US201862733450P | 2018-09-19 | 2018-09-19 | |
US201962826330P | 2019-03-29 | 2019-03-29 | |
PCT/US2019/041154 WO2020014327A2 (en) | 2018-07-11 | 2019-07-10 | Antibodies binding to vista at acidic ph |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2021000046A2 true CO2021000046A2 (en) | 2021-04-19 |
Family
ID=67470712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2021/0000046A CO2021000046A2 (en) | 2018-07-11 | 2021-01-06 | Sight-binding antibodies to acidic pH |
Country Status (16)
Country | Link |
---|---|
US (1) | US20220073617A1 (en) |
EP (1) | EP3820902A2 (en) |
JP (1) | JP2022513421A (en) |
KR (1) | KR20210031722A (en) |
CN (1) | CN112638948A (en) |
AU (1) | AU2019301120A1 (en) |
BR (1) | BR112021000303A2 (en) |
CA (1) | CA3104536A1 (en) |
CL (5) | CL2021000012A1 (en) |
CO (1) | CO2021000046A2 (en) |
IL (1) | IL279944A (en) |
MX (1) | MX2021000213A (en) |
PE (1) | PE20210687A1 (en) |
SG (1) | SG11202100102VA (en) |
TW (1) | TW202028235A (en) |
WO (1) | WO2020014327A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018132476A1 (en) | 2017-01-11 | 2018-07-19 | Bristol-Myers Squibb Company | Psgl-1 antagonists and uses thereof |
CN110740749A (en) | 2017-03-14 | 2020-01-31 | 戊瑞治疗有限公司 | Antibodies that bind to VISTA at acidic pH |
CN111971304A (en) * | 2018-03-21 | 2020-11-20 | 戊瑞治疗有限公司 | Antibodies binding to VISTA at acidic pH |
AU2019301120A1 (en) * | 2018-07-11 | 2021-02-25 | Bristol-Myers Squibb Company | Antibodies binding to VISTA at acidic pH |
BR112022004831A2 (en) * | 2019-09-19 | 2022-06-07 | Bristol Myers Squibb Co | Antibodies that bind to seen at acidic pH |
US20230272082A1 (en) * | 2021-11-09 | 2023-08-31 | Sensei Biotherapeutics, Inc. | Anti-vista antibodies and uses thereof |
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CN116920085A (en) * | 2016-02-12 | 2023-10-24 | 詹森药业有限公司 | anti-VISTA (B7H 5) antibodies |
WO2018008555A1 (en) | 2016-07-07 | 2018-01-11 | 日本ゼオン株式会社 | Binder composition for nonaqueous secondary battery electrodes, slurry composition for nonaqueous secondary battery electrodes, electrode for nonaqueous secondary batteries, and nonaqueous secondary battery |
WO2018132476A1 (en) | 2017-01-11 | 2018-07-19 | Bristol-Myers Squibb Company | Psgl-1 antagonists and uses thereof |
CN110740749A (en) * | 2017-03-14 | 2020-01-31 | 戊瑞治疗有限公司 | Antibodies that bind to VISTA at acidic pH |
CN111971304A (en) * | 2018-03-21 | 2020-11-20 | 戊瑞治疗有限公司 | Antibodies binding to VISTA at acidic pH |
US20190300610A1 (en) * | 2018-03-29 | 2019-10-03 | Hummingbird Bioscience Pte. Ltd. | Vista antigen-binding molecules |
AU2019301120A1 (en) * | 2018-07-11 | 2021-02-25 | Bristol-Myers Squibb Company | Antibodies binding to VISTA at acidic pH |
BR112022004831A2 (en) * | 2019-09-19 | 2022-06-07 | Bristol Myers Squibb Co | Antibodies that bind to seen at acidic pH |
-
2019
- 2019-07-10 AU AU2019301120A patent/AU2019301120A1/en active Pending
- 2019-07-10 US US17/258,866 patent/US20220073617A1/en active Pending
- 2019-07-10 PE PE2021000018A patent/PE20210687A1/en unknown
- 2019-07-10 CA CA3104536A patent/CA3104536A1/en active Pending
- 2019-07-10 SG SG11202100102VA patent/SG11202100102VA/en unknown
- 2019-07-10 TW TW108124306A patent/TW202028235A/en unknown
- 2019-07-10 CN CN201980057653.4A patent/CN112638948A/en active Pending
- 2019-07-10 JP JP2021500886A patent/JP2022513421A/en active Pending
- 2019-07-10 KR KR1020217003857A patent/KR20210031722A/en unknown
- 2019-07-10 EP EP19745902.7A patent/EP3820902A2/en active Pending
- 2019-07-10 BR BR112021000303-7A patent/BR112021000303A2/en unknown
- 2019-07-10 MX MX2021000213A patent/MX2021000213A/en unknown
- 2019-07-10 WO PCT/US2019/041154 patent/WO2020014327A2/en active Application Filing
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2021
- 2021-01-04 IL IL279944A patent/IL279944A/en unknown
- 2021-01-05 CL CL2021000012A patent/CL2021000012A1/en unknown
- 2021-01-06 CO CONC2021/0000046A patent/CO2021000046A2/en unknown
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2022
- 2022-10-25 CL CL2022002945A patent/CL2022002945A1/en unknown
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- 2022-10-25 CL CL2022002944A patent/CL2022002944A1/en unknown
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2023
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TW202028235A (en) | 2020-08-01 |
MX2021000213A (en) | 2021-03-25 |
CL2022002946A1 (en) | 2023-04-21 |
EP3820902A2 (en) | 2021-05-19 |
WO2020014327A3 (en) | 2020-02-27 |
CL2022002945A1 (en) | 2023-04-21 |
CN112638948A (en) | 2021-04-09 |
CA3104536A1 (en) | 2020-01-16 |
CL2022002944A1 (en) | 2023-04-21 |
WO2020014327A2 (en) | 2020-01-16 |
CL2023002543A1 (en) | 2024-01-19 |
SG11202100102VA (en) | 2021-02-25 |
AU2019301120A1 (en) | 2021-02-25 |
BR112021000303A2 (en) | 2021-04-13 |
JP2022513421A (en) | 2022-02-08 |
KR20210031722A (en) | 2021-03-22 |
US20220073617A1 (en) | 2022-03-10 |
CL2021000012A1 (en) | 2021-05-24 |
PE20210687A1 (en) | 2021-04-08 |
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