CO2019013649A2 - Oral Solid Pharmaceutical Compositions of Dabigatran Etexilate - Google Patents
Oral Solid Pharmaceutical Compositions of Dabigatran EtexilateInfo
- Publication number
- CO2019013649A2 CO2019013649A2 CONC2019/0013649A CO2019013649A CO2019013649A2 CO 2019013649 A2 CO2019013649 A2 CO 2019013649A2 CO 2019013649 A CO2019013649 A CO 2019013649A CO 2019013649 A2 CO2019013649 A2 CO 2019013649A2
- Authority
- CO
- Colombia
- Prior art keywords
- pharmaceutical compositions
- solid pharmaceutical
- oral solid
- dabigatran etexilate
- etexilate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a composiciones farmacéuticas sólidas orales que comprenden dabigatrán etexilato en forma de la base libre o en forma de sales, polimorfos, solvatos, hidratos o ésteres farmacéuticamente aceptables del mismo.The present invention relates to oral solid pharmaceutical compositions comprising dabigatran etexilate in the form of the free base or in the form of pharmaceutically acceptable salts, polymorphs, solvates, hydrates or esters thereof.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2017/06848A TR201706848A2 (en) | 2017-05-10 | 2017-05-10 | SOLID ORAL PHARMACEUTICAL COMPOSITIONS CONTAINING DABIGATRAN ETEXCLATE |
TR2018/06309A TR201806309A2 (en) | 2017-05-10 | 2018-05-04 | Solid oral pharmaceutical compositions of dabigatran etexilate |
PCT/TR2018/050221 WO2019004980A2 (en) | 2017-05-10 | 2018-05-10 | Solid oral pharmaceutical compositions of dabigatran etexilate |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2019013649A2 true CO2019013649A2 (en) | 2020-05-15 |
Family
ID=64559741
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2019/0013649A CO2019013649A2 (en) | 2017-05-10 | 2019-12-03 | Oral Solid Pharmaceutical Compositions of Dabigatran Etexilate |
Country Status (8)
Country | Link |
---|---|
EP (2) | EP3621599A2 (en) |
AU (1) | AU2018293361B2 (en) |
BR (1) | BR112019023781A2 (en) |
CO (1) | CO2019013649A2 (en) |
EA (1) | EA201992644A1 (en) |
NZ (1) | NZ759901A (en) |
TR (2) | TR201706848A2 (en) |
WO (1) | WO2019004979A2 (en) |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE121699A1 (en) | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | BICYCLE HETERO CYCLES DISSTITUTED AS INHIBITORS OF THROMBIN |
DE10337697A1 (en) | 2003-08-16 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tablet containing 3 - [(2 - {[4- (hexyloxycarbonylamino-iminomethyl) -phenyl-amino] -methyl} -1-methyl-1H-benzimidazole-5-carbonyl) -pyridin-2-yl-amino] - propionic acid ethyl ester or its salts |
US20130177652A1 (en) | 2010-07-01 | 2013-07-11 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Pharmaceutical oral dosage forms comprising dabigatran etexilate and its pharmaceutically acceptable salts |
EP3858337A3 (en) * | 2012-02-21 | 2021-09-29 | Towa Pharmaceutical Europe, S.L. | Oral pharmaceutical compositions of dabigatran etexilate |
EP2740471B1 (en) | 2012-12-07 | 2015-05-27 | Hexal AG | Oral pharmaceutical composition comprising dabigatran etexilate |
CN104784147B (en) * | 2014-01-20 | 2018-01-23 | 成都苑东生物制药股份有限公司 | A kind of dabigatran etexilate methanesulfonate pharmaceutical capsules composition and preparation method thereof |
IN2014MU01042A (en) | 2014-03-26 | 2015-10-02 | Cadila Healthcare Ltd | |
EP2929884A1 (en) * | 2014-04-11 | 2015-10-14 | Sanovel Ilac Sanayi ve Ticaret A.S. | Pharmaceutical combinations of dabigatran and h2-receptor antagonists |
CN104095830A (en) * | 2014-05-22 | 2014-10-15 | 万特制药(海南)有限公司 | Preparation method for mesylate dabigatran capsule |
CN105560206A (en) * | 2014-10-13 | 2016-05-11 | 重庆圣华曦药业股份有限公司 | Preparation of Pradaxa capsule |
IN2015CH01145A (en) * | 2015-03-09 | 2016-09-16 | ||
WO2016142821A2 (en) * | 2015-03-09 | 2016-09-15 | Alphamed Formulations Pvt. Ltd | Compositions containing a thrombin inhibitor |
-
2017
- 2017-05-10 TR TR2017/06848A patent/TR201706848A2/en unknown
-
2018
- 2018-05-04 TR TR2018/06309A patent/TR201806309A2/en unknown
- 2018-05-10 EA EA201992644A patent/EA201992644A1/en unknown
- 2018-05-10 EP EP18811674.3A patent/EP3621599A2/en not_active Withdrawn
- 2018-05-10 NZ NZ759901A patent/NZ759901A/en not_active IP Right Cessation
- 2018-05-10 AU AU2018293361A patent/AU2018293361B2/en not_active Ceased
- 2018-05-10 WO PCT/TR2018/050220 patent/WO2019004979A2/en unknown
- 2018-05-10 BR BR112019023781-0A patent/BR112019023781A2/en not_active Application Discontinuation
- 2018-05-10 EP EP18811675.0A patent/EP3634388A2/en not_active Withdrawn
-
2019
- 2019-12-03 CO CONC2019/0013649A patent/CO2019013649A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
EA201992644A1 (en) | 2020-04-07 |
WO2019004979A2 (en) | 2019-01-03 |
TR201806309A2 (en) | 2018-11-21 |
AU2018293361A1 (en) | 2020-01-02 |
EP3634388A2 (en) | 2020-04-15 |
BR112019023781A2 (en) | 2020-06-02 |
NZ759901A (en) | 2021-12-24 |
WO2019004979A3 (en) | 2019-04-11 |
AU2018293361B2 (en) | 2021-09-16 |
TR201706848A2 (en) | 2018-11-21 |
EP3621599A2 (en) | 2020-03-18 |
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