CO2019002123A2 - Plantas y métodos para aumentar y disminuir la síntesis de cannabinoides - Google Patents

Plantas y métodos para aumentar y disminuir la síntesis de cannabinoides

Info

Publication number
CO2019002123A2
CO2019002123A2 CONC2019/0002123A CO2019002123A CO2019002123A2 CO 2019002123 A2 CO2019002123 A2 CO 2019002123A2 CO 2019002123 A CO2019002123 A CO 2019002123A CO 2019002123 A2 CO2019002123 A2 CO 2019002123A2
Authority
CO
Colombia
Prior art keywords
plants
cannabinoids
methods
synthesis
decrease
Prior art date
Application number
CONC2019/0002123A
Other languages
English (en)
Inventor
Robert F Roscow
Original Assignee
Canopy Growth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Canopy Growth Corp filed Critical Canopy Growth Corp
Publication of CO2019002123A2 publication Critical patent/CO2019002123A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nutrition Science (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Esta divulgación se refiere a nuevas plantas y métodos para aumentar y disminuir la síntesis de cannabinoides. Las plantas descritas en este documento comprenden proporciones y concentraciones no naturales de cannabinoides en plantas del género cannabis. Los métodos descritos en el presente documento comprenden la manipulación de la ruta biosintética de los cannabinoides para producir plantas del género cannabis con proporciones y concentraciones de cannabinoides no naturales.
CONC2019/0002123A 2016-08-18 2019-03-06 Plantas y métodos para aumentar y disminuir la síntesis de cannabinoides CO2019002123A2 (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201662376521P 2016-08-18 2016-08-18
US201662385102P 2016-09-08 2016-09-08
US201662416084P 2016-11-01 2016-11-01
US201662416098P 2016-11-01 2016-11-01
US201662429039P 2016-12-01 2016-12-01
US201662429046P 2016-12-01 2016-12-01
US201662429049P 2016-12-01 2016-12-01
PCT/US2017/047587 WO2018035450A1 (en) 2016-08-18 2017-08-18 Plants and methods for increasing and decreasing synthesis of cannabinoids

Publications (1)

Publication Number Publication Date
CO2019002123A2 true CO2019002123A2 (es) 2019-05-31

Family

ID=61197425

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0002123A CO2019002123A2 (es) 2016-08-18 2019-03-06 Plantas y métodos para aumentar y disminuir la síntesis de cannabinoides

Country Status (12)

Country Link
US (1) US11466283B2 (es)
EP (1) EP3500090A4 (es)
CN (1) CN109890202A (es)
AU (1) AU2017313843A1 (es)
BR (1) BR112019003024A8 (es)
CA (1) CA3033875A1 (es)
CL (1) CL2019000434A1 (es)
CO (1) CO2019002123A2 (es)
MX (1) MX2019001968A (es)
PE (1) PE20190654A1 (es)
WO (1) WO2018035450A1 (es)
ZA (1) ZA201900986B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
WO2019152736A1 (en) 2018-01-31 2019-08-08 Canopy Holdings, LLC Hemp powder
CN113264914A (zh) * 2018-02-20 2021-08-17 麦姆德制药(佛罗里达)公司 用于治疗物质成瘾和其它障碍的遗传修饰的大麻植物和修饰的大麻素化合物
CA3105433C (en) * 2018-08-17 2023-07-11 Canbreed Ltd. Cannabis plant cells with reduced delta-9-tetrahydrocannabinol (thc) content
CA3119729A1 (en) 2018-10-10 2020-04-16 Treehouse Biotech, Inc. Synthesis of cannabigerol
CN113227353A (zh) * 2018-11-14 2021-08-06 马努斯生物合成股份有限公司 用于产生大麻素的微生物细胞及方法
WO2020176547A1 (en) 2019-02-25 2020-09-03 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
GB2597189B (en) * 2019-04-11 2024-06-05 Meng Lim Kah Process for producing a genetically modified seed
CA3139112A1 (en) * 2019-05-09 2020-11-12 New West Genetics Inc. Methods for production of low cost terpenoids, including cannabinoids, and varieties adapted for large-scale planting and density optimization including cannabinoid preservation
AU2020284184A1 (en) * 2019-05-29 2021-12-23 BetterSeeds Ltd. Cannabis plants with improved yield
WO2021007663A1 (en) * 2019-07-12 2021-01-21 Canopy Growth Corporation Cannabinoid derivatives
EP4004212A1 (en) * 2019-07-30 2022-06-01 The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Institute) Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby
CN112441952B (zh) * 2019-08-28 2021-08-06 析木津生物医药(广州)有限公司 一种大麻二酚-3-磺酸及其制备方法和应用、大麻二酚衍生物
WO2021046154A1 (en) * 2019-09-06 2021-03-11 James Berman Genetic modification of plants
EP4038095A4 (en) * 2019-10-01 2023-11-01 Empyrean Neuroscience, Inc. GENETICALLY MODIFIED PLANTS AND PROCESSES FOR THEIR PRODUCTION
EP4038094A4 (en) * 2019-10-01 2023-11-01 Empyrean Neuroscience, Inc. GENETICALLY MODIFIED PLANTS AND METHODS OF PREPARATION THEREOF
EP4037676A4 (en) * 2019-10-02 2023-02-22 Canopy Growth Corporation CANNABINOID DERIVATIVES
CN114555797A (zh) * 2019-10-11 2022-05-27 新加坡国立大学 使用新型芳香异戊二烯基转移酶生物合成大麻素前体
AU2020378910A1 (en) * 2019-11-04 2022-06-16 Agriculture Victoria Services Pty Ltd A method to produce targeted gene editing constructs
WO2021240508A1 (en) * 2020-05-27 2021-12-02 Canbreed Ltd Cannabis plants with improved agronomic traits
BR112023000188A2 (pt) * 2020-07-13 2023-01-31 Betterseeds Ltd Cannabis com teor de canabinoide alterado
CA3150867A1 (en) * 2020-07-16 2022-01-20 Canopy Growth Corporation Cannabis plant with increased cannabigerolic acid
WO2022081681A1 (en) * 2020-10-13 2022-04-21 Canopy Growth Corporation Cannabis plant with increased cannabichromenic acid
WO2023195781A1 (ko) * 2022-04-05 2023-10-12 주식회사 진코어 유전자 교정 단백질을 포함하는 대마 유전자 교정용 조성물 및 이를 이용한 대마 유전자 교정 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2770774C (en) * 2009-08-12 2020-07-14 National Research Council Of Canada Aromatic prenyltransferase from cannabis
WO2011127589A1 (en) * 2010-04-15 2011-10-20 National Research Council Of Canada Genes and proteins for aromatic polyketide synthesis
US20160177404A1 (en) 2011-08-18 2016-06-23 Courtagen Life Sciences Inc. Cannabis genomes and uses thereof
US20140245494A1 (en) 2013-02-25 2014-08-28 Ytzchak Cohen Cannabis plant named erez
US10441617B2 (en) 2013-03-15 2019-10-15 Biotech Institute, Llc Breeding, production, processing and use of medical cannabis
EP3186376B1 (en) * 2014-08-27 2019-03-20 Caribou Biosciences, Inc. Methods for increasing cas9-mediated engineering efficiency
WO2016189384A1 (en) * 2015-05-28 2016-12-01 Tweed Inc. Cannabis plants having modified expression of thca synthase

Also Published As

Publication number Publication date
MX2019001968A (es) 2019-10-02
BR112019003024A8 (pt) 2019-09-10
AU2017313843A1 (en) 2019-03-07
ZA201900986B (en) 2019-12-18
CA3033875A1 (en) 2018-02-22
EP3500090A1 (en) 2019-06-26
PE20190654A1 (es) 2019-05-08
WO2018035450A1 (en) 2018-02-22
EP3500090A4 (en) 2020-01-08
CN109890202A (zh) 2019-06-14
BR112019003024A2 (pt) 2019-05-14
US20200181631A1 (en) 2020-06-11
US11466283B2 (en) 2022-10-11
CL2019000434A1 (es) 2019-05-24

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