CO2018014230A2 - Antagonistas del receptor de angiotensina-1 - Google Patents

Antagonistas del receptor de angiotensina-1

Info

Publication number
CO2018014230A2
CO2018014230A2 CONC2018/0014230A CO2018014230A CO2018014230A2 CO 2018014230 A2 CO2018014230 A2 CO 2018014230A2 CO 2018014230 A CO2018014230 A CO 2018014230A CO 2018014230 A2 CO2018014230 A2 CO 2018014230A2
Authority
CO
Colombia
Prior art keywords
angiotensin
receptor antagonists
pregnancy
formula
compounds
Prior art date
Application number
CONC2018/0014230A
Other languages
English (en)
Inventor
Jacek Stalewski
Edward Earl Cable
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of CO2018014230A2 publication Critical patent/CO2018014230A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En un aspecto, esta descripción presenta compuestos de la fórmula (1) o una sal farmacéuticamente aceptable de los mismos: AAI-Arg-Val-AA4-AA5-His-Pro-AA8-OH (1), en la que AA1, AA4, AA5 y AA8 se definen en la especificación. Los compuestos de la fórmula (1) se pueden utilizar para tratar la hipertensión (por ejemplo, hipertensión inducida por el embarazo), preclamsia o una enfermedad renal inducida por el embarazo.
CONC2018/0014230A 2016-08-23 2018-12-26 Antagonistas del receptor de angiotensina-1 CO2018014230A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16185403 2016-08-23
PCT/EP2017/063455 WO2017207760A1 (en) 2016-06-02 2017-06-02 Angiotensin-1-receptor antagonists

Publications (1)

Publication Number Publication Date
CO2018014230A2 true CO2018014230A2 (es) 2019-02-08

Family

ID=56801410

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0014230A CO2018014230A2 (es) 2016-08-23 2018-12-26 Antagonistas del receptor de angiotensina-1

Country Status (12)

Country Link
US (2) US10344054B2 (es)
KR (1) KR102520808B1 (es)
CN (1) CN109311942A (es)
AU (1) AU2017275748B2 (es)
CA (1) CA3025853A1 (es)
CO (1) CO2018014230A2 (es)
EA (1) EA201892381A1 (es)
MA (1) MA45099B1 (es)
PT (1) PT3464324T (es)
SG (1) SG11201810167SA (es)
TW (1) TWI776812B (es)
WO (1) WO2017207760A1 (es)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1102848C (zh) * 1997-04-08 2003-03-12 何占山 一种治疗高血压病的化学药物组合物
US7326706B2 (en) * 2003-08-15 2008-02-05 Bristol-Myers Squibb Company Pyrazine modulators of cannabinoid receptors
US7553836B2 (en) * 2006-02-06 2009-06-30 Bristol-Myers Squibb Company Melanin concentrating hormone receptor-1 antagonists
TWI448284B (zh) * 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
CN101765590B (zh) * 2007-05-24 2015-11-25 埃尔德鲁格股份有限公司 1，(3)，5-取代的咪唑、它们在治疗高血压中的用途以及它们的制备方法
ES2558629T3 (es) * 2008-12-29 2016-02-05 Trevena, Inc. Efectores de beta-arrestina y composiciones y métodos de uso de los mismos
EP2442824A2 (en) * 2009-06-19 2012-04-25 MedImmune, LLC Protease variants
SG11201501145SA (en) * 2012-08-13 2015-04-29 Otago Innovation Ltd NT-proCNP AS A BIOMARKER OF VASCULAR DISORDERS AND PREGNANCY COMPLICATION

Also Published As

Publication number Publication date
US10344054B2 (en) 2019-07-09
KR102520808B1 (ko) 2023-04-12
PT3464324T (pt) 2021-06-30
WO2017207760A1 (en) 2017-12-07
US20170349629A1 (en) 2017-12-07
SG11201810167SA (en) 2018-12-28
CN109311942A (zh) 2019-02-05
AU2017275748B2 (en) 2021-04-01
MA45099B1 (fr) 2021-07-29
TWI776812B (zh) 2022-09-11
CA3025853A1 (en) 2017-12-07
EA201892381A1 (ru) 2019-06-28
KR20190015307A (ko) 2019-02-13
US20200102348A1 (en) 2020-04-02
TW201819399A (zh) 2018-06-01
AU2017275748A1 (en) 2018-12-06

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