CN87105799A - B超胃肠造影剂的制造工艺 - Google Patents
B超胃肠造影剂的制造工艺 Download PDFInfo
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Abstract
由B超胃肠造影剂制造工艺制得的造影剂，填补了B超对胃肠道病变检查的空白。
本工艺过程是：将挑选合格的海螵蛸，经洗刷、浸漂、干燥、除硬膜、粉碎、过筛、消毒、制得的海螵蛸细粉80％与20％研细的100目白芨细粉混合均匀分装交囊，即制得所需要的造影剂。经过四年对一千多病例的临床实验，超声符合率可达96.2～98.6％。
Description
本工艺制得的造影剂命名为ST-1胃肠造影剂，即B超胃肠造影剂。
本工艺还适用于某种治疗伤口溃烂及止血药物的制备。
现检索出在《中西医结合杂志》第四期第三卷248～250页上刊登的题目为“中医理论的X线诊断学研究”一文经与本发明仔细对照，发现该文与本发明不属同一类别，也就是说，国内外还设有与本发明相近似的研究。由于胃内粘液、声阻抗等因素的干扰，又设有找到适用的B超胃肠造影剂的制造工艺，所以B超尚不能检查胃肠道的病变。
为了解决上述问题，本发明提供了一种造影剂的制造工艺，所制得的造影剂填补了B超对胃肠道病变检查的空白。
本工艺及实施例如下：
挑选→洗刷→浸漂→干燥→除硬膜→粗碎→细碎→干燥→过筛→消毒→装胶囊，
1、挑选：从海螵蛸中精选出长9Cm以上、宽5Cm以上、厚1.5Cm以上，色白，完整者。
2、洗刷：用清水软刷将挑选出的海螵蛸洗刷干净。
3、浸漂：将洗刷净的海螵蛸用清水浸漂在池中2～3日，上用重物压住勿令浮起，每日换水1～2次，漂至无咸味及腥臭气为度。
4、干燥：将浸漂好的海螵蛸用日光晒干或用低温干燥法干燥（不超过50℃），或用真空干燥法干燥使海螵蛸内部水气蒸发。
5、除硬膜：将干燥好的海螵蛸两个表面的硬脆角质、半透明的皮膜用手工或机械方法除去。
6、粗碎：将除去硬膜的海螵蛸粉碎为粗粉。
7、细碎：将海螵蛸粗粉再加工为细粉。
8、干燥：为了方便过筛，细碎后的海螵蛸细粉，再干燥一次，为低温干燥（不超过50℃）使细粉充分干燥。
9、过筛：将干燥后的细粉过100目筛。
10、消毒：将过筛后的细粉置硫化罐内经SO2气体消毒，再摊放置紫外线灯下照射15分钟。海螵蛸细粉的化学成分为：碳酸钙在80%以上，胶质、有机质在10%以上。
11、装胶囊：将80%的海螵蛸细粉与起胶质作用的20%的100目白芨细粉，混合均匀，分装胶囊。即制得B超胃肠造影剂。
其造影原理如下：造影剂中的碳酸钙中和胃酸后产生CO2气泡，饮水500～1000毫升后呈“雪花状”浮游现象，由于造影剂中的胶质物质对溃疡、癌肿粘膜表面上能逐渐积聚、融合成索块或光团图象，形成明显的界面，由于造影剂能使胃腔充盈造成胃壁粘膜在声阻抗方面的差异，从而显示胃形态、位置、胃腔大小，胃壁厚度，排空时间及胃病变所在情况;能显示胃肠功能紊乱;显示小肠、盲肠、结肠各部位的病变。
用本工艺试制成的B超胃肠造影剂，从1983年至1987年6月止，共做了1323例病例，对胃炎、胃窦炎、慢性线表性胃炎、胃下垂、胃癌及胃肠道肿瘤进行诊断，并与X线、胃镜、病理活检、手术对照，超声符合率可达96.2～98.6%。
附：贵阳市科学技术情报研究所检索出的一篇文献及对检索结果的分析报告。
Claims (6)
1、B超胃肠造影剂的制造工艺，由挑选，洗刷，干燥，粉碎，制剂构成，其特征在于，洗刷后，要经过浸漂，干燥后经过除硬膜，粉碎后经过过筛，消毒等工艺过程。
2、按权利要求1所说的制造工艺，其特征在于，挑选过程是精选出长9Cm以上，宽5Cm以上，厚1.5Cm以上，色白，完整的海螵蛸。
3、按权利要求1所说的制造工艺，其特征在于，将洗刷净的海螵蛸用清水浸漂在池中2～3日，上用重物压住勿令浮起，每日换水1～2次，漂至无咸味及腥臭气为度。
4、按权利要求1所说的制造工艺，其特征在于，除硬膜是用手工或机械方法除去海螵蛸的硬脆角质、半透明的皮膜。
5、按权利要求1所说的制造工艺，其特征在于，过筛是将海螵蛸粉过100目筛，得到细粉。
6、按权利要求1所说的制造工艺，其特征在于，消毒是将过筛后的细粉置硫化罐内经SO2气体消毒，再摊放置紫外线灯下照射15分钟。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 87105799 CN1013830B (zh) | 1987-08-26 | 1987-08-26 | B超胃肠造影剂的制造工艺 |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 87105799 CN1013830B (zh) | 1987-08-26 | 1987-08-26 | B超胃肠造影剂的制造工艺 |
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| Publication Number | Publication Date |
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| CN87105799A true CN87105799A (zh) | 1988-04-06 |
| CN1013830B CN1013830B (zh) | 1991-09-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 87105799 Expired CN1013830B (zh) | 1987-08-26 | 1987-08-26 | B超胃肠造影剂的制造工艺 |
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| CN (1) | CN1013830B (zh) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5558854A (en) * | 1991-09-17 | 1996-09-24 | Sonus Pharmaceuticals | Ultrasound contrast media comprising perfluoropentane and perfluorohexane gas |
| US5558094A (en) * | 1991-09-17 | 1996-09-24 | Sonus Pharmaceuticals, Inc. | Methods for using persistent gases as ultrasound contrast media |
| US5573751A (en) * | 1991-09-17 | 1996-11-12 | Sonus Pharmaceuticals, Inc. | Persistent gaseous bubbles as ultrasound contrast media |
| US5595723A (en) * | 1993-01-25 | 1997-01-21 | Sonus Pharmaceuticals | Method for preparing storage stable colloids |
| US5707607A (en) * | 1993-01-25 | 1998-01-13 | Sonus Pharmaceuticals, Inc. | Phase shift colloids as ultrasound contrast agents |
| US5837221A (en) * | 1996-07-29 | 1998-11-17 | Acusphere, Inc. | Polymer-lipid microencapsulated gases for use as imaging agents |
| CN1051006C (zh) * | 1994-08-31 | 2000-04-05 | 宋振才 | 一种胆囊胆道造影剂 |
| US6245319B1 (en) | 1993-01-25 | 2001-06-12 | Sonus Pharmaceuticals, Inc. | Colloidal dispersions of perfluoropentane |
| US6723303B1 (en) | 1991-09-17 | 2004-04-20 | Amersham Health, As | Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane |
| US8586005B2 (en) | 2004-06-04 | 2013-11-19 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
| CN110251694A (zh) * | 2019-07-15 | 2019-09-20 | 陕西中医药大学 | 一种胃肠超声造影剂及其制备方法 |
-
1987
- 1987-08-26 CN CN 87105799 patent/CN1013830B/zh not_active Expired
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6620404B1 (en) | 1991-09-17 | 2003-09-16 | Amersham Health A/S | Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media |
| US5558094A (en) * | 1991-09-17 | 1996-09-24 | Sonus Pharmaceuticals, Inc. | Methods for using persistent gases as ultrasound contrast media |
| US5573751A (en) * | 1991-09-17 | 1996-11-12 | Sonus Pharmaceuticals, Inc. | Persistent gaseous bubbles as ultrasound contrast media |
| US6723303B1 (en) | 1991-09-17 | 2004-04-20 | Amersham Health, As | Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane |
| US5558854A (en) * | 1991-09-17 | 1996-09-24 | Sonus Pharmaceuticals | Ultrasound contrast media comprising perfluoropentane and perfluorohexane gas |
| US5707607A (en) * | 1993-01-25 | 1998-01-13 | Sonus Pharmaceuticals, Inc. | Phase shift colloids as ultrasound contrast agents |
| US5876696A (en) * | 1993-01-25 | 1999-03-02 | Sonus Pharmaceuticals, Inc. | Composition comprising a fluorine containing surfactant and perfluoropentane for ultrasound |
| US6245319B1 (en) | 1993-01-25 | 2001-06-12 | Sonus Pharmaceuticals, Inc. | Colloidal dispersions of perfluoropentane |
| US6569404B1 (en) | 1993-01-25 | 2003-05-27 | Amersham Health A/S | Phase shift colloids as ultrasound contrast agents |
| US5707606A (en) * | 1993-01-25 | 1998-01-13 | Sonus Pharmaceuticals, Inc. | Phase shift colloids as ultrasound contrast agents |
| US5595723A (en) * | 1993-01-25 | 1997-01-21 | Sonus Pharmaceuticals | Method for preparing storage stable colloids |
| CN1051006C (zh) * | 1994-08-31 | 2000-04-05 | 宋振才 | 一种胆囊胆道造影剂 |
| US5837221A (en) * | 1996-07-29 | 1998-11-17 | Acusphere, Inc. | Polymer-lipid microencapsulated gases for use as imaging agents |
| US8586005B2 (en) | 2004-06-04 | 2013-11-19 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
| CN110251694A (zh) * | 2019-07-15 | 2019-09-20 | 陕西中医药大学 | 一种胃肠超声造影剂及其制备方法 |
| CN110251694B (zh) * | 2019-07-15 | 2022-08-12 | 陕西中医药大学 | 一种胃肠超声造影剂及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1013830B (zh) | 1991-09-11 |
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