CN2894654Y - Rumen administering release controller - Google Patents
Rumen administering release controller Download PDFInfo
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- CN2894654Y CN2894654Y CN 200620050435 CN200620050435U CN2894654Y CN 2894654 Y CN2894654 Y CN 2894654Y CN 200620050435 CN200620050435 CN 200620050435 CN 200620050435 U CN200620050435 U CN 200620050435U CN 2894654 Y CN2894654 Y CN 2894654Y
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Abstract
The utility model relates to a controlled-release drug delivery device for rumen of animals comprising a tube (2), a grain (5), a medicine-separated matrix (6), a spring (3), and a screw cap (1). The tubular tube is provided with a drug release hole (8) in a base (7), with inside diameter of 12-18 mm, length of 100-120mm, tube wall with thickness of 1.5mm, and 250mm long spring diameter of 0.8mm. The medicine-separated matrix is made of dissoluble substances, and the controlled-release device containing medication expelling parasites regularly is put into rumen of animals can release the medication regularly in bodies of animals to maintain a long-term effect of medicine and expel parasites.
Description
Technical field
This utility model relates to a kind of veterinary drug doser, is applicable to the administration apparatus of driving away the ruminant endoparasite.
Background technology
Parasitic disease is to threaten the pastoral area to produce common disease, and the sickness rate height infects fast mutually.At present the Flubendazole who uses is a kind of new broad spectrum antihelmintic, has been widely used in driving away the first nematicide of hair, esophageal orifice nematicide, back strongylid of pig and goat etc. clinically; Praziquantel not only has the effect of well killing to Erichsen schistosomicide, Schistosoma mansoni, Schistosoma japonicum, and other trematodiasiss and cestode also there is good killing action, but these medicines are by the mode of single administration, because of the drug effect dispose procedure very fast, the intravital parasite of animal repelling in can only the short time, and want the intravital parasite of long-term animal repelling, then need long-term multiple dosing, both increase labour force and cost, be difficult to reach effect preferably again.
Summary of the invention
The purpose of this utility model is to provide a kind of utensil that carries regular expeling sheep endoparasite medicine, and after the animal cud was gone in input, medicine discharged in animal body termly, and the long term maintenance that reaches active drug discharges with regular, to drive away parasitic purpose.
This utility model is by cylindrical shell, powder column, form every medicine substrate, spring, nut etc.Cylindrical shell, cover are made with polypropylene tube, and material is not had specific requirement, and dottle pin can be made with plastics, cylindrical shell is a tubulose, and there is small delivery aperture at the pipe end, and small delivery aperture quantity and small delivery aperture diameter can be determined according to the release dosage and the speed of medicine, be generally 2, can have 1～4, the general 3mm of small delivery aperture diameter, cylinder internal diameter is 12～18mm, pipe range is 100～120mm, and thickness of pipe wall 1.5mm, spring diameter are 0.8mm, long 250mm is used in the slow dissolved material of gastric every medicine substrate and makes.Can once put into several different powder columns as required in the cylindrical shell, or use every medicine substrate separately, the difference by every resolving time of medicine substrate discharges different medicines, reaches dosing time, and is permanently effective.
Powder column is made up of anthelmintic and proper proportion substrate, has certain rigidity, shape, and size is supporting with cylindrical shell.Anthelmintic is praziquantel, Flubendazole, and substrate is selected polyethylene glycol 6000 for use, one or more in stearic acid, tween-80, the liquid paraffin.When making patent medicine, substrate and praziquantel were pressed 1: 7, good with the Flubendazole in 1: 9 ratio scale, put into the 100ml beaker respectively, place 70 ℃ of water baths molten altogether, pour cooling forming in the mould after stirring into, the size of mould matches with the internal diameter of cylindrical shell, be cut into the long segment of 10mm, standby.Then use polyethylene glycol 6000 every medicine substrate, stearic acid, tween 80, liquid paraffin are made.
Successively with base, every medicine substrate, powder column, dottle pin, spring are put into cylindrical shell, cover the cover fastening, promptly become the regular administration controlled release of cud device.When giving animals administer, can coat fluid lubricant at drum surface, it is pharyngeal that animal is obeyed in throwing, allows it swallow naturally.
This utility model advantage: easy to use, medicine discharges termly, and keeps the regular hour, and anthelminthic effect is good, reaches the effect that purifies grazing.
Description of drawings
Fig. 1 is a sketch map of the present utility model.
1, nut 2, cylindrical shell 3, spring 4, dottle pin
5, powder column 6, every medicine substrate 7, base 8, small delivery aperture
The specific embodiment
Make cylindrical shell 2, make a tubular barrel 2 that bottom seat envelope is equipped with, the available threaded cap seal of an end is equipped with polypropylene tube, dottle pin 4 made of plastic, its size matches with cylindrical shell 2.Make powder column 5, to press 1: 7 every medicine substrate 6 and praziquantel, good with the Flubendazole in 1: 9 ratio scale, put into two 100ml beakers respectively, place 70 ℃ of water baths molten altogether, pour cooling forming in the mould after stirring respectively into, the size of mould matches with the internal diameter of controlled release device cylindrical shell 2, be cut into the long segment of 10mm, standby.Every the making of medicine substrate 6, with the mixed heating of polyethylene glycol 6000, stearic acid and liquid paraffin, pour mould into by 4: 4: 2, make every medicine substrate 6.Can slowly dissolve at gastric every medicine substrate 6, size adapts with cylindrical shell 2, and thickness can be determined according to the time of different medicines and dispenser.Finished product is made, and opens the small delivery aperture 8 of 2 diameter 3mm on fixed cylinder 2 bases 7, the base 7, will put well every medicine substrate 6, powder column 5 successively, puts into dottle pin 4, spring 3 at last, covers the cover fastening, promptly becomes the regular administration controlled release of cud device.Use, when giving animals administer, can coat fluid lubricant on cylindrical shell 2 surfaces, it is pharyngeal that animal is obeyed in throwing, allows it swallow naturally.
Clinical effectiveness after this utility model is implemented:
Experimental animal: female Liuyang black goat, body weight 17～31kg, machine are divided into 3 groups, and 30 every group, the I group is for throwing clothes Flubendazole one praziquantel controlled release pill group; The II group is for the stomach tube single administration and throw in empty ball (not containing medicine) group; The III group is for throwing in empty ball matched group.3 groups of goats of duration of test are free range husbandry together.
Medication administration method: I group is for throwing clothes Flubendazole one praziquantel controlled release pill group, and coating liquid paraffin on controlled release device cylindrical shell delivers to that goat is pharyngeal to allow it swallow voluntarily.II group goat is thrown behind the empty ball of clothes according to a conventional method promptly by the body weight administration, Flubendazole 50mg/kg, praziquantel 40mg/kg mixing and water adding 150ml, and add 5～6 tweens-80 and make suspension, throw clothes with stomach tube.III group is not containing coating liquid paraffin on the controlled release device cylindrical shell of tablet for throwing in empty ball matched group, delivers to that goat is pharyngeal to allow it swallow voluntarily.
Clinical observation: the test goat has parasite in the body after testing before test, fervescence is arranged, and appetite reduces, abdominal distention, constipation, or the symptom of dysentery; Or mucosa is pale, becomes thin, and is disorderly thick or spiritual depressed by hair, anemia.After throwing in medicine, I, II group goat takes a turn for the better gradually, and body temperature drops to normally gradually behind the 15d, and feces is normal, and is glossy by hair, and appetite increases.Behind 45～75d, the symptom before trying appears again in the goat of II group.During off-test, the body condition of I group goat is organized significantly better than II.III group goat constantly aggravates in the duration of test symptom, shows as progressive emaciation, and anemia is serious further, under the goat eyelid that has, the jaw, dysplasia edema appears, in the breast hypogastrium.At duration of test, I and II group test goat there is no toxicity.
Egg count: adopt excrement from test goat rectum, 3 groups of all 1d and dispensing back the 5th, 15,30,45,60,75,90,105 and 120d samplings before dispensing of goat, each excrement sample calculates nematicide and trematodiasis worm's ovum number in every 1g feces with the saturated brine floating method and the sedimentation method respectively.The results are shown in Table 1 and table 2, I group goat dispensing back 5d nematicide worm's ovum slip is 94.5%, and trematodiasis worm's ovum slip is 86.9%; It still is 100% that the 15th～90d nematicide and trematodiasis worm's ovum slip are 100%, the 120d trematodiasis worm's ovum slip.II group goat dispensing back 5d nematicide worm's ovum slip is 96.5%, and trematodiasis worm's ovum slip is 90.3%; 15d nematicide worm's ovum slip is 98.4%, and the worm's ovum number progressively gos up behind the 30d; 15d trematodiasis worm's ovum slip is that 91.4%, the 45d trematodiasis worm's ovum slip is 95.7%, and the worm's ovum number progressively gos up behind the 60d.III group goat worm's ovum number only before test 5d reduction is arranged slightly, rise gradually subsequently.
Body weight: 1d and dispensing back the 30th, 60,90 and 120d carry out empty stomach to every goat and weigh before dispensing, calculate respectively organize the goat average weight and with dispensing before do longitudinal comparison, I group and II, III organize and do lateral comparison.The results are shown in Table 3, during off-test, the 1st, the average weight gain of II and III group goat is respectively 11.4,7.7 and 5.9kg.The average weight gain of I group is organized high 5.5kg than the high 3.7kg of average weight gain of II group than III.
Respectively organize the situation that nematicide worm's ovum number changes in the goat feces before and after table 1 anthelmintic
| Group | Project | Before the dispensing | After the dispensing | ||||||||
| 5d | 15d | 30d | 45d | 60d | 75d | 90d | 105d | 120d | |||
| The I group | The worm's ovum number (individual/G) | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 36 | 69 | |
| Worm's ovum slip (%) | 362 | 94.5 | 100 | 100 | 100 | 100 | 100 | 100 | 90.1 | 80.9 | |
| The II group | The worm's ovum number (individual/G) | 11 | 5 | 8 | 43 | 64 | 115 | 102 | 177 | 282 | |
| Worm's ovum slip (%) | 313 | 96.5 | 98.4 | 97.4 | 86.3 | 79.6 | 63.3 | 67.4 | 43.5 | 15.3 | |
| The III group | The worm's ovum number (individual/G) | 275 | 298 | 251 | 327 | 370 | 352 | 363 | 307 | 376 | |
| Worm's ovum slip (%) | 391 | 29.4 | 23.8 | 33.2 | 16.4 | 5.4 | 10.8 | 7.2 | |||
Respectively organize the situation that trematodiasis worm's ovum number changes in the goat feces before and after table 2 anthelmintic
| Group | Project | Before the dispensing | After the dispensing | ||||||||
| 5d | 15d | 30d | 45d | 60d | 75d | 90d | 105d | 120d | |||
| The I group | The worm's ovum number (individual/G) | 84 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Worm's ovum slip (%) | 85.9 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | ||
| The II group | The worm's ovum number (individual/G) | 93 | 9 | 8 | 5 | 4 | 23 | 19 | 36 | 72 | 85 |
| Worm's ovum slip (%) | 90.3 | 91.4 | 94.6 | 95.7 | 78.5 | 79.6 | 61.3 | 22.6 | 8.6 | ||
| The III group | The worm's ovum number (individual/G) | 66 | 53 | 61 | 69 | 88 | 85 | 96 | 83 | 97 | 91 |
| Worm's ovum slip (%) | 19.7 | 7.5 | |||||||||
Goat body weight change situation before and after table 3 test
| Group | Average weight (Kg) before the test | Dispensing back different time average weight (Kg) | Test back average weight (Kg) | |||
| 30d | 60d | 90d | 120d | |||
| The I group | 23.8 | 28.1 | 31.6 | 33.8 | 35.2 | 11.4 |
| The II group | 27.7 | 30.9 | 32.8 | 33.6 | 35.4 | 7.7 |
| The III group | 25.5 | 28.8 | 29.7 | 30.7 | 31.4 | 5.9 |
Claims (3)
1. cud administration controlled release device is characterized in that: by cylindrical shell (2), powder column (5), form every medicine substrate (6), spring (3), nut (1), dottle pin (4), cylindrical shell (2) is a tubulose, and small delivery aperture (8) is arranged on the base (7).
2. cud administration controlled release device according to claim 1 is characterized in that: 1～4 small delivery aperture (8) is arranged on the base (7), can discharge the anthelmintic drug of effective dose in the cylindrical shell (2) in cud.
3. cud administration controlled release device according to claim 1 is characterized in that: cylindrical shell (2) internal diameter is 12～18mm, and pipe range is 100～150mm, thickness of pipe wall 1.5mm, and spring (3) diameter is 0.8mm, long 250mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620050435 CN2894654Y (en) | 2006-03-28 | 2006-03-28 | Rumen administering release controller |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620050435 CN2894654Y (en) | 2006-03-28 | 2006-03-28 | Rumen administering release controller |
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| Publication Number | Publication Date |
|---|---|
| CN2894654Y true CN2894654Y (en) | 2007-05-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200620050435 Expired - Fee Related CN2894654Y (en) | 2006-03-28 | 2006-03-28 | Rumen administering release controller |
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| CN (1) | CN2894654Y (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104963655A (en) * | 2015-06-16 | 2015-10-07 | 中国石油天然气股份有限公司 | Subsection releasing downhole tool with thermodynamics partition boards |
| CN114402931A (en) * | 2022-01-20 | 2022-04-29 | 云南省林业和草原科学院 | Cultivation method of polygonatum kingianum under forest |
| CN114431093A (en) * | 2022-02-07 | 2022-05-06 | 云南省林业和草原科学院 | High-ridge cultivation method for konjak |
-
2006
- 2006-03-28 CN CN 200620050435 patent/CN2894654Y/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104963655A (en) * | 2015-06-16 | 2015-10-07 | 中国石油天然气股份有限公司 | Subsection releasing downhole tool with thermodynamics partition boards |
| CN104963655B (en) * | 2015-06-16 | 2017-07-07 | 中国石油天然气股份有限公司 | A kind of releasing by parts downhole tool with thermodynamics dividing plate |
| CN114402931A (en) * | 2022-01-20 | 2022-04-29 | 云南省林业和草原科学院 | Cultivation method of polygonatum kingianum under forest |
| CN114431093A (en) * | 2022-02-07 | 2022-05-06 | 云南省林业和草原科学院 | High-ridge cultivation method for konjak |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |