CN2863046Y - Nuclear track-etched membrane composite wound dressing - Google Patents
Nuclear track-etched membrane composite wound dressing Download PDFInfo
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- CN2863046Y CN2863046Y CN 200620000921 CN200620000921U CN2863046Y CN 2863046 Y CN2863046 Y CN 2863046Y CN 200620000921 CN200620000921 CN 200620000921 CN 200620000921 U CN200620000921 U CN 200620000921U CN 2863046 Y CN2863046 Y CN 2863046Y
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- nuclear pore
- layer
- nucleopore
- pore film
- dressing
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Abstract
The utility model provides a compound wound dressing with nuclear pore film, mainly comprising a nuclear pore film layer (1), a hydrogels layer (2) that covers the nuclear pore film layer and wound surface's contacting side. Wherein, the nuclear pore film layer is composed of monolayer nuclear pore film or formed by the compounding of multilayer nuclear pore film. Each layer of nuclear pore film is arranged from large to small and from up to down in order according to the pore diameter. Between the films is connected with contact adhesive. The pore diameter of the nuclear pore film is ranged from 10 to 50 micron and the penetrating rate is ranged from 0.05% to 50%. The surface of the nuclear pore film is provided with gridding and non-micropore lines, wherein, the gridding line breadth is 0.5 to 2 mm and the line distance is 5 to 20mm. The thickness of the nuclear pore film layer is 10 to 50 micron and the thickness of the hydrogels layer is 0.1 to 10 mm. The other side of the nuclear pore film layer can be coated with one reinforcing layer. This reinforcing layer adopts the transparent lacunaris semi-penetrating polymer material or non-woven fabric material and its pore diameter is larger than that of the nuclear pore film layer that is matched with it. The utility model's compound wound dressing with nuclear pore film not only brightens and obstructs germs, but also provides slight wet healing environment for the wound surface and directly gives medicine to the wound surface.
Description
Technical field
This utility model relates to and a kind ofly is used to burn, the compounded dressing for wound of scald and traumatic wounds protecting wound surface and treatment, particularly relates to a kind of compounded dressing for wound that surface distributed has the nucleopore rete of micrometer level porous structure that comprises.
Background technology
Be used at present burn, scald and the compounded dressing for wound of traumatic wounds protecting wound surface and treatment mainly contains following several:
(1). on back lining materials such as polrvinyl chloride, polyethylene, polypropylene, non-woven fabrics polyurethane, apply medical pressure-sensitive adhesive, the film that makes is sticked on the wound surface.
(2). three layers of compound wound dressing, use ventilative continuous film as the protection backing layer usually; Non-woven fabrics, foamed materials or fabric etc. are as the occlusion backing layer; With the adhesion layer of skin adhesion totally three layers be composited.
(3). the compound wound dressing of aquogel type.This class dressing is composited by several parts such as continuous ventilated membrane, non-woven fabrics or fabric skeleton, hydrogel, adhesive usually.
More than existingly variously be used to burn, the compound dressing of protecting wound surface such as scald, wound and treatment can satisfy isolate bacteria substantially, absorb peritoneal effluent, breathe freely, provide function such as moistening healing environment; but in order to satisfy the function that intercepts antibacterial; it is base material that these compound dressing adopt fluid-tight continuous ventilated membrane substantially; because the moisture-vapor transmission of this class ventilated membrane is far below the air penetrability of human body skin; the higher relatively characteristics of the transudate of wound site itself so just produce hydrops easily and bring out infection under dressing in addition.In order to address this problem, compound one deck absorbed layer is wanted in existing all kinds of dressing mostly, but also there is the absorption saturation problem in this absorbed layer to wound fluid.Simultaneously, existing all kinds of dressing all exist can not be under special circumstances directly to the defective of wound surface administration, therefore, when needs are changed dressings to wound surface or dressing absorbs when saturated, generally just need the timely debridement of medical worker to reach more change dressings, increase medical worker's burden so on the one hand, brought unfavorable factor (such as increasing infected chance etc.) also for simultaneously patient's wound healing.
Nucleopore membranes has another name called nuclear track etching-film (Nuclear Track-Etched Membrane), is a kind of novel microporous filter membrane that grows up the external seventies.Nucleopore membranes has aperture relatively big, the chemical stability of homogeneous, intensity, thermally-stabilised characteristics such as good, is the desirable filter membrane of a kind of secondary filter and sieve particle.Therefore can utilize this excellent characteristic of nucleopore membranes with its composite bed as compounded dressing for wound.
Summary of the invention
The purpose of this utility model be to provide a kind of can satisfy transparent, intercept antibacterial, can reach the moisture-vapor transmission approaching again with human body skin, functions such as little moistening healing environment are provided for wound surface, simultaneously, can also realize direct a kind of nuclear pore membrane composite wound dressing to the wound surface administration.
The nuclear pore membrane composite wound dressing that this utility model provides mainly comprises the nucleopore rete, be covered in the hydrogel layer of nucleopore rete and wound surface contact side, wherein the nucleopore rete is made up of the monolayer nucleopore membranes or is compounded to form by the multilamellar nucleopore membranes, each layer nucleopore membranes is arranged above and below successively by the aperture is descending, and be bonding with pressure sensitive adhesive between film and the film.
The nuclear pore membrane composite wound dressing nucleopore membranes that this utility model provides further comprises: the pore diameter range of nucleopore membranes is the 1-10 micron, and penetrating rate scope is 0.05%-50%; There are the lines of latticed pore-free on the nucleopore membranes surface, and wherein the grid lines width is 0.5-2mm, and line-spacing is 5-20mm; The thickness of nucleopore rete is at the 10-50 micron, and the thickness of hydrogel layer is at 0.1-10mm.
The nuclear pore membrane composite wound dressing that this utility model provides further comprises: the opposite side at the nucleopore rete covers one deck enhancement layer, this enhancement layer is selected semi-transparent polymeric material of transparent porous or nonwoven cloth material for use, and the aperture greater than with the aperture of the nucleopore rete of its coupling.
Can to adopt any one polymeric film such as polrvinyl chloride, polyethylene, polypropylene, polyurethane film, PET of thickness 10-50 micron be base material to the nucleopore membranes layer in the nuclear pore membrane composite wound dressing that this utility model provides, the copper mould that itself and surface are had a geometrical pattern is transferred device with identical speed together and transmits irradiation window through a high energy heavy particle accelerator, and what give off from the irradiation window is that energy is up to the charged particle beam more than the 100MeV.By adjusting the transfer rate and the particle beam intensity of film, just can control the energetic particle beam density of beating on film, thereby the pore density that control finally forms on film, weigh (being the shared area ratio of micropore on the unit are) with penetrating rate, its scope is 0.05%---50%, preferable range is 0.3-30%, thereby can make the air penetrability of film and human body skin approaching, to keep the little moistening healing environment of wound surface.Film behind the irradiation adopts the chemical reagent etching method through after the suitable processing, can obtain suitable micropore size by the control etching period and promptly obtain nucleopore rete in this utility model wound dressing.Wherein the pore diameter range of nucleopore membranes can be 1 to 10 micron, and preferred aperture is the 3-7 micron, so both can well intercept antibacterial, does not influence the infiltration with medicinal liquid of appearing of wound exudate again.As select 25 microns PET thin film of thickness for use, when particle beam irradiation density is 10
6Individual/centimetre
2, etched aperture is 7 microns, the penetrating rate of the nucleopore membranes of making is about 35%.On the other hand, in order to make the nucleopore membranes layer material keep certain tearing strength, mould can be designed to fenestral fabric, the lines that can on membrane material, keep latticed pore-free like this after the radiation, general grid lines width is 0.5-2mm, line-spacing is 5-20mm, and this grid lines also can be used as medical personnel and observes the more use of scale wound of closing.
When adopting the multilamellar nucleopore membranes in the nuclear pore membrane composite medical dressing that this utility model provides, serve as maximum, can descend more than 3 layers of result of use with 3 layers.
Hydrogel layer in this utility model is selected existing material for use, becomes the aqueous solution after fixing to make as the monomer or the polymer formulation of one or more Jia Jibingxisuanβ-Qiang Yizhis, acrylate, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol oxide, Polyethylene Glycol etc.The purpose of compound water congealing glue-line is for wound surface provides trickleer protection, eliminates Ranvier's membrane and the possible slight adhesion of wound surface, and the medicine of slow release also can be provided to wound surface simultaneously.Because the nucleopore rete of this utility model indication wound dressing has had functions such as transparent, permeable gas, obstruct antibacterial, thereby when selecting hydrogel as composite bed, aspects such as its intensity, antibacterial obstruct are just no longer included strict demand, therefore, the thickness of hydrogel just can be optional in the 0.1-10mm scope, preferably at 0.1-1mm.
In the compounded dressing for wound that this utility model provides, can on the nucleopore rete, directly form hydrogel layer, also can between two-layer, use binding material compound by the crosslinking with radiation method; In addition, as selectable ingredient, can also sneak into other slow release treatment ingredient in the hydrogel layer, such as silver sulfadiazine, antibiotic etc.
In the compounded dressing for wound that this utility model provides, a side that contacts with wound surface at hydrogel can also cover release paper or the stripping film that one deck scribbles silicone, during use it is taken off to get final product.
The main effect of compound enhancement layer is other characteristics that can not influence the nucleopore rete for the intensity that increases wound dressing simultaneously again in this utility model, therefore can select the transparent porous polymer material similar for use to nucleopore membranes, the aperture of this porous film material if greater than with the aperture of the nucleopore membranes of its coupling, generally do not do specific (special) requirements.The porous adhesive tape that can select for use 3M company to provide, also can be directly with the bigger film similar in aperture to nucleopore membranes, as: polrvinyl chloride, polyethylene, polypropylene, polyurethane film, PET etc., can also select nonwoven cloth material for use, can directly be bonded together with pressure sensitive adhesive between each tunic.
Nucleopore membranes, hydrogel, the release paper that scribbles silicone or stripping film, enhancement layer material can be made square, rectangle, circle or elliptical shape respectively in this utility model, their size does not have particular provisions, as long as bigger, generally have more about 1--2cm than the wound surface length of side than wound surface.
The film material that last formed wound dressing is the sheet type in this utility model is through cutting, can using after the sterilization, packing.
In sum; the compounded dressing for wound that this utility model provides have good mechanical strength, transparency and intercept with approaching permeable gas of human body skin and fabulous antibacterial, the protecting wound surface performance; can provide well little moistening healing environment for wound surface on the one hand; the recovery from illness of acceleration wound surface; alleviate patient's misery; also reduced medical personnel's working strength on the other hand, can be widely used in burning, the protecting wound surface and the treatment of scald and traumatic wounds wound surface.This wound dressing process radiation sterilization in addition, but long term store.
Description of drawings
Fig. 1 is the generalized section of embodiment 1 Wound dressing in this utility model.
Fig. 2 is the schematic top plan view of embodiment 1 Wound dressing in this utility model.
Fig. 3 is the generalized section of embodiment 2 in this utility model.
Fig. 4 is the generalized section of embodiment 3 in this utility model.
The specific embodiment
Below in conjunction with accompanying drawing this utility model is described in detail, but protection domain of the present utility model is not limited in following examples.
Embodiment 1:
Referring to accompanying drawing 1, select 25 microns of thickness for use, 7 microns in aperture, the PET nucleopore rete (1) of penetrating rate 40%, be furnished with the lines of latticed pore-free on it, the grid lines width is 1mm, line-spacing is 10mm (can referring to accompanying drawing 2), it is cut into the 200mm*125mm size, place the mold box of 200mm*125mm*1mm, pouring one layer thickness about 1mm above, proportioning is polyvinyl alcohol (PVA): polyvinylpyrrolidone (PVP): the mixed solution of water=10: 4: 86, seal and fill nitrogen after the cobalt source x ray irradiation x of 50kGy dosage, form one deck hydrogel composite bed (2) at the nucleopore membranes laminar surface, this hydrogel composite bed and nucleopore rete can reasonablely combine, and with wound surface good attaching are arranged also, but can not form adhesion, can keep other good characteristic of nucleopore rete simultaneously again.Adopt the method for consubstantiality contrast, scope of medication 1% area is observed clinical efficacy, safety and the untoward reaction of this dressing treatment II degree burn wound, and makes comparisons with oil gauze.Through 18 routine clinical verifications, the result shows: shallow II degree burn wound 6 days healing rates, these dressing groups of healing time are 62.8% ± 33.9% and 8.7 ± 2.3 day, oil gauze group average out to 38.1% ± 30.1% and 11.7 ± 2.1 days.14 days healing rates of deep ii degree burn wound surface, this dressing group average out to 77.0% ± 12.5% of healing time and 16.6 ± 2.4 days, the oil gauze group is 59.5% ± 12.5% and 20.2 ± 2.3 day.The P value all＜0.05.Shallow II degree 1 day, 3 days, 7 days VAS of burn wound this dressing group average out to 3.4 ± 2.1,1.8 ± 1.1,0.7 ± 0.9 of marking, oil gauze group average out to 5.2 ± 2.6,2.8 ± 2.1,0.8 ± 0.3, and this dressing group average out to 2.8 ± 2.6,1.9 ± 1.8,0.7 ± 0.8 of deep ii degree burn wound surface, oil gauze group average out to 4.1 ± 2.8,2.8 ± 2.5,1.0 ± 1.0.Hinder back 15 minutes these dressing group skin temperature measurements and show that skin temperature is lower than contrast oil gauze group, it is not obvious to hinder back 30 minutes two groups of difference, and hinder 1,3 day this dressing group pain scores in back and be better than the oil gauze group, P value＜0.01, the 7th day two groups of difference are not obvious after hindering.Menses routine urinalysis, hepatic and renal function inspection do not see that medication causes abnormal change, do not see whole body and local anaphylaxis, also do not see other untoward reaction.This dressing is the dressing of a kind of burn wound safely and effectively.
Embodiment 2:
Referring to accompanying drawing 3, select 25 microns of thickness for use, 7 microns in aperture, the PET nucleopore membranes of penetrating rate 20% is first tunic, 25 microns of thickness, 10 microns in aperture, the PET nucleopore membranes of penetrating rate 30% is second tunic, and it is cut into the 100mm*100mm size, bond with pressure sensitive adhesive two-layer then, compound its penetrating rate of back test is about 10%, and intensity increases, and other performance is constant.Be placed in the mold box of 100mm*100mm*1mm, water the about 0.5mm of a layer thickness above, proportioning is polyvinyl alcohol (PVA): carrageenan: the mixed solution of water=6: 7: 87, seal and fill nitrogen after the cobalt source x ray irradiation x of 40kGy dosage forms one deck hydrogel composite bed (2) on nucleopore rete (1) surface.
Embodiment 3:
Referring to accompanying drawing 4, select 25 microns of thickness for use, 7 microns in aperture, the PET nucleopore rete (1) of penetrating rate 20%, it is cut into the 100mm*100mm size, and the transparent porous adhesive tape of using 3M company is as enhancement layer (3), and the nucleopore rete is pasted together therewith then, and around it, coat pressure sensitive adhesive, pack back irradiation sterilization is preserved.Adopt after this method, under the constant situation of other performance, composite membrane is greatly improved than monofilm intensity.Be placed in the mold box of 100mm*100mm*1mm, water the about 0.2mm of a layer thickness above, proportioning is polyvinyl alcohol (PVA): polyethylene glycol oxide (PEO): the mixed solution of water=8: 4: 88, seal and fill nitrogen after the cobalt source x ray irradiation x of 60kGy dosage forms one deck hydrogel composite bed (2) at the nucleopore membranes laminar surface.
Claims (5)
1. nuclear pore membrane composite wound dressing, it is characterized in that: this dressing mainly comprises nucleopore rete (1), be covered in the hydrogel layer (2) of nucleopore rete (1) and wound surface contact side, wherein the nucleopore rete is made up of the monolayer nucleopore membranes or is compounded to form by the multilamellar nucleopore membranes, each layer nucleopore membranes is arranged above and below successively by the aperture is descending, and be bonding with pressure sensitive adhesive between film and the film.
2. nuclear pore membrane composite wound dressing as claimed in claim 1 is characterized in that: the pore diameter range of nucleopore membranes is the 1-10 micron, and penetrating rate scope is 0.05%-50%.
3. nuclear pore membrane composite wound dressing as claimed in claim 2 is characterized in that: there are the lines of latticed pore-free on the nucleopore membranes surface, and wherein the grid lines width is 0.5-2mm, and line-spacing is 5-20mm.
4. as claim 2 or 3 described nuclear pore membrane composite wound dressings, it is characterized in that: the thickness of nucleopore rete is at the 10-50 micron, and the thickness of hydrogel layer is at 0.1-10mm.
5. nuclear pore membrane composite wound dressing as claimed in claim 4, it is characterized in that: the opposite side at the nucleopore rete covers one deck enhancement layer (3), this enhancement layer is selected semi-transparent polymeric material of transparent porous or nonwoven cloth material for use, and the aperture greater than with the aperture of the nucleopore rete of its coupling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620000921 CN2863046Y (en) | 2006-01-13 | 2006-01-13 | Nuclear track-etched membrane composite wound dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620000921 CN2863046Y (en) | 2006-01-13 | 2006-01-13 | Nuclear track-etched membrane composite wound dressing |
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| CN2863046Y true CN2863046Y (en) | 2007-01-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200620000921 Expired - Lifetime CN2863046Y (en) | 2006-01-13 | 2006-01-13 | Nuclear track-etched membrane composite wound dressing |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103611184A (en) * | 2013-11-27 | 2014-03-05 | 长春吉原生物科技有限公司 | Hydrogel of composite semipermeable membrane and preparation method thereof |
| CN108904135A (en) * | 2018-09-15 | 2018-11-30 | 深圳市浓华生物电子科技有限公司 | A kind of moisture film is cured the wound patch |
| CN110022825A (en) * | 2016-12-21 | 2019-07-16 | 宝洁公司 | Absorbing structure |
| CN115887733A (en) * | 2022-11-28 | 2023-04-04 | 天津中医药大学 | 3D printing silver-loaded antibacterial traditional Chinese medicine dressing and preparation method thereof |
| CN116495838A (en) * | 2023-06-27 | 2023-07-28 | 西北农林科技大学深圳研究院 | Nuclear pore membrane structure for sewage purification |
-
2006
- 2006-01-13 CN CN 200620000921 patent/CN2863046Y/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103611184A (en) * | 2013-11-27 | 2014-03-05 | 长春吉原生物科技有限公司 | Hydrogel of composite semipermeable membrane and preparation method thereof |
| CN110022825A (en) * | 2016-12-21 | 2019-07-16 | 宝洁公司 | Absorbing structure |
| US11369524B2 (en) | 2016-12-21 | 2022-06-28 | The Procter & Gamble Company | Absorbent structure |
| CN110022825B (en) * | 2016-12-21 | 2024-02-27 | 宝洁公司 | Absorbent structure |
| CN108904135A (en) * | 2018-09-15 | 2018-11-30 | 深圳市浓华生物电子科技有限公司 | A kind of moisture film is cured the wound patch |
| CN115887733A (en) * | 2022-11-28 | 2023-04-04 | 天津中医药大学 | 3D printing silver-loaded antibacterial traditional Chinese medicine dressing and preparation method thereof |
| CN115887733B (en) * | 2022-11-28 | 2024-02-27 | 天津中医药大学 | 3D printing silver-loaded antibacterial traditional Chinese medicine dressing and preparation method thereof |
| CN116495838A (en) * | 2023-06-27 | 2023-07-28 | 西北农林科技大学深圳研究院 | Nuclear pore membrane structure for sewage purification |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20070131 |
|
| EXPY | Termination of patent right or utility model | ||
| DD01 | Delivery of document by public notice |
Addressee: Xu Li Document name: Notification of Expiration of Patent Right Duration |