CN2835993Y - Spectrophotometer for full-automatic biochemical analyzer - Google Patents

Spectrophotometer for full-automatic biochemical analyzer Download PDF

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Publication number
CN2835993Y
CN2835993Y CN 200520093838 CN200520093838U CN2835993Y CN 2835993 Y CN2835993 Y CN 2835993Y CN 200520093838 CN200520093838 CN 200520093838 CN 200520093838 U CN200520093838 U CN 200520093838U CN 2835993 Y CN2835993 Y CN 2835993Y
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CN
China
Prior art keywords
signal
chip microcomputer
output
spectrophotometer
clinical chemistry
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Expired - Fee Related
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CN 200520093838
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Chinese (zh)
Inventor
吴海波
康长武
杨竹力
欧勇军
王长津
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanchang Biotech A & C Biotechnical Industry Incorporated Company
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Neusoft Medical Systems Co Ltd
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Priority to CN 200520093838 priority Critical patent/CN2835993Y/en
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Abstract

The utility model discloses a spectrophotometer for a full-automatic biochemical analyser, which belongs to the technical field of medical appliances. The utility model is provided with a light source, a sample cup, a monochromator, a photodetection circuit and a current detection circuit, wherein detection signals are output from the photodetection circuit and the current detection circuit; multiple selectors are connected with output ends of the photodetection circuit and the current detection circuit, and output signals of the multiple selectors are transmitted to a monolithic computer via a signal amplifier and an A/D converter; the monolithic computer is connected with a main control system or an upper computer of the full-automatic biochemical analyser via a communication interface. The utility model has the advantages that measurement precision can be increased, and simultaneously, debugging work and maintenance work are convenient.

Description

A kind of spectrophotometer that is used for automatic clinical chemistry analyzer
Technical field
The utility model relates to technical field of medical instruments, specifically a kind of spectrophotometer that is used for automatic clinical chemistry analyzer.
Background technology
Automatic clinical chemistry analyzer is as the fine measuring instrument of typical light, mechanical, electrical combination, many, the technical sophistication of the branches of learning and subjects that relate to, spectrophotometer wherein is one of core component of this instrument, the task that spectrophotometer will be finished is that the polychromatic light that light source is sent is divided into needed monochromatic light, handles after the monochromatic light signal that utilizes photodetector will have sample information becomes electric signal.At present most automatic clinical chemistry analyzers all are with spectrophotometric method chemical substance to be measured, and have some instruments also to use other assay method, as dual wavelength or three-wavelength method, fluorescence polarization method, turbidimetry etc.The utility model adopts spectrophotometric method, and it is theoretical foundation with the Beer law.
At present the spectrophotometric structure used of automatic clinical chemistry analyzer as shown in Figure 1, it constitutes light source, monochromator, sample cup, photodetector and current detecting.The spectrophotometric analog electrical signal that is output as, select through delivering to subsequent conditioning circuit after the cable transmission, amplify and the A/D conversion process, send to host computer then and carry out computing, finally obtain the absorbance of measured object, this process is called the processing procedure of analog electrical signal, there is certain defective in this processing procedure, promptly the analog electrical signal that obtains through photodetector and current detecting very a little less than, its antijamming capability is very poor, and this signal also will just can be sent to through the transmission of longer distance and selects usually, the processing of amplification and A/D conversion, such processing procedure will be brought interference to the analog electrical signal in the transmission course, this interference directly has influence on the precision of measurement result, even in the transmission course of signal, adopt the electromagnetic screen sleeve pipe to reduce interference, still can not eliminate fully but disturb, so analog electrical signal small fluctuation in transmission course, through follow-up selection, will become a bigger error after amplification and the conversion process, even what the circuit of back and computation process were made in this case accurately reliably can not change the error that above-mentioned processing procedure produces again, and to the influence that precision produced of measurement result.Also there is defective in the spectrophotometer that existing in addition automatic clinical chemistry analyzer is used in debugging and maintenance process, because spectrophotometer can not carry out independence debugging and maintenance, need the support of other software and hardware, it is very complicated and difficult to make that so the debugging of equipment and maintenance process become.
The utility model content
The purpose of this utility model is to provide a kind of improved spectrophotometer that is used for automatic clinical chemistry analyzer, both can eliminate the interference that the long Distance Transmission of simulating signal is introduced, and also can make things convenient for spectrophotometric debugging and maintenance job simultaneously.
For achieving the above object, the technical solution adopted in the utility model is:
The utlity model has light source, sample cup, monochromator and photodetection circuit and current detection circuit, its detection signal is by photodetection circuit and current detection circuit output, output terminal at photodetection circuit and current detection circuit is connected to MUX, the output signal of this MUX is delivered to single-chip microcomputer through signal amplifier, A/D converter, and this single-chip microcomputer links to each other with automatic clinical chemistry analyzer master control system or host computer by communication interface.
The signal input part of described MUX is connected to the simulating signal from photodetection circuit and current detection circuit output, its signal output part links to each other with the signal input tube pin of signal amplifier, the output signal of signal amplifier becomes digital signal by output pin and is connected to memory expansion and address decoder after the A/D converter conversion, reading/the conversion and control end of A/D converter, data latches Enable Pin and data bus link to each other with the respective pin of memory expansion and address decoder respectively, the outer ROM gating signal end of the sheet of this memory expansion and address decoder, address latch signal end and reading, write the respective pin that end is connected to single-chip microcomputer respectively, this single-chip microcomputer carries out communication by RS-485 bus and Biochemical Analyzer master control system and is connected.
Reset terminal at single-chip microcomputer also is connected to a power supply monitor, and the RESET input of this power supply monitor, reset output terminal and hand-reset end are connected to the respective pin of memory expansion and address decoder respectively; Described MUX is at least 16 and selects one MUX; Described host computer is a computing machine, and single-chip microcomputer carries out communication by RS-232 serial ports and computing machine and is connected; Described single-chip microcomputer can be digital signal processor or field programmable gate array.
The utlity model has following advantage and beneficial effect:
1. improved the precision of measurement result.The utility model adds MUX, signal amplifier and A/D converter by the output terminal at photodetection circuit and current detection circuit, and A/D converter is controlled by single-chip microcomputer, be responsible for simultaneously carrying out communication with external unit, result after being about to change sends to the automatic clinical chemistry analyzer master control system or host computer carries out computing, a kind of improved spectrophotometer structure like this can be eliminated the interference that analog signal transmission is brought, and makes measurement result more accurately reliable;
2. debugging and maintenance job have been made things convenient for.The utility model directly links to each other with computing machine by the RS-232 serial communication port that aims at the debugging design, under the condition that does not need the support of automatic clinical chemistry analyzer complete machine, can finish spectrophotometric debugging, simplified debugging work, shortened debug time, also provided convenience for follow-up maintenance job.
Description of drawings
Fig. 1 is a spectrophotometric structured flowchart in the prior art;
Fig. 2 is the spectrophotometric structured flowchart of the utility model;
Fig. 3 is circuit theory diagrams of the present utility model;
Fig. 4 is the electric hookup of the utility model single chip part;
Fig. 5 is the electric hookup of the utility model power supply monitor part;
Fig. 6 is the electric hookup of the utility model MUX part;
Fig. 7 is the electric hookup of the utility model signal amplifier part;
Fig. 8 is the electric hookup of the utility model A/D converter part.
Embodiment
As shown in Figure 2, consider the shortcoming of prior art, the utility model improves on portion's structure within it, be about to select amplification and A/D conversion portion to add wherein, by a single-chip microcomputer A/D converter M6 is controlled, be responsible for simultaneously and external communication, result after being about to change issues the automatic clinical chemistry analyzer master control system or host computer carries out computing, so both can eliminate the interference that the long Distance Transmission of simulating signal is introduced, also can make things convenient for spectrophotometric debugging and maintenance job simultaneously.
The utility model is improved to digital signal output with the spectrophotometer of simulating signal output, makes testing result more accurately and reliably, convenient simultaneously debugging and maintenance.Concrete implementation method has increased signal processing as shown in Figure 2 on the basis of original circuit, this part is by selecting amplification, A/D conversion and a slice single-chip microcomputer to constitute, and the Single-chip Controlling signal processing can be finished and external communication simultaneously.
The schematic diagram of this system is shown in Fig. 3~8, here single-chip microcomputer M2 selects 80C251 for use, external memorizer expansion and address decoder M5, specifically comprise a slice W27C512 extender storer, a slice 71024 growth data storeies and a slice address decoder GAL, the output of address decoder GAL is as the chip enable signal of each latch and storer; Single-chip microcomputer M2 can carry out communication by RS-485 bus and RS-232 serial ports and outside; The multi-channel analog electric signal (present embodiment is 12 tunnel) that obtains from photodetection circuit and current detection circuit at first enters MUX M8, present embodiment selects for use 16 to select one multi-way switch MUX16 that 12 tunnel simulating signals of input are selected output, promptly 12 tunnel simulating signals are connected to signal input part S1~S12 of multi-way switch MUX16, output terminal 1Q~4Q and the 6Q of its address wire A0~A3 and Enable Pin ground connection location latch U5, provide after latching through latch (present embodiment adopt 74LS547) by single-chip microcomputer M2 by address bus BUS, which signal selection will handle, and the clock signal of latch is taken from the output terminal of address decoder GAL;
Signal amplifier M7 selects OP07 for use in the present embodiment, adopt three grades of structure for amplifying, the first order is voltage follower U13, the second level is that the adjustable proportional amplifier of enlargement factor is amplifier U12, the third level is the fixing proportional amplifier U11 of multiple, by first~the 3rd potentiometer P1~P3 each amplifier is returned to zero respectively; The output terminal of MUX M8 is connected to the negative input end (2 pin) of the voltage follower U13 of signal amplifier M7 inside, the output terminal of voltage follower U13 is received the anti-phase ratio amplifying circuit of the Gain Adjustable that is made of amplifier U12, the output of amplifier U12 is delivered to A/D converting unit U10 (present embodiment is selected ADC976 for use) again behind the proportional amplifier U11 through fixing multiple and is carried out A/D and change, the result of A/D conversion delivers to first, the second latch U8, U9 (present embodiment is all selected 74HC245 for use) latchs, wait for that single-chip microcomputer M2 reads, behind the single-chip microcomputer M2 read data with data storage in the expanded data storer, finally send to Biochemical Analyzer master control system or host computer, so far finish the process that photodetection circuit and the detected analog electrical signal of current detection circuit is changed into digital signal by RS-485 bus or RS-232.
Present embodiment is selected the power supply monitor of MAX791 chip formation singlechip microprocessor for use, the running status of monitoring single-chip microcomputer, and this power supply monitor can be realized the hand-reset of single-chip microcomputer by hand-reset end MR simultaneously.
Single-chip microcomputer M2 is by sending, receive pin TXD1, the external a slice RS-232 interface of RXD1 and computer realization serial communication in the present embodiment.
Single-chip microcomputer M2 in the utility model can select other model for use, also can select novel microprocessor for use, as DSP (digital signal processor) or FPGA (field programmable gate array) etc.
The utility model adds MUX, signal amplifier and A/D converter at the output terminal of photodetection circuit and current detection circuit, and A/D converter is controlled by single-chip microcomputer, be responsible for simultaneously carrying out communication with external unit, result after being about to change sends to the automatic clinical chemistry analyzer master control system or host computer carries out computing, can eliminate the interference that analog signal transmission is brought by so a kind of improved spectrophotometer structure, make measurement result more accurately reliable; Can directly link to each other with computing machine by the RS-232 serial communication port that aims at the debugging design in addition, under the condition that does not need the complete machine support, can finish spectrophotometric debugging, simplified debugging work, shortened debug time, also provided convenience for follow-up maintenance job.

Claims (6)

1. spectrophotometer that is used for automatic clinical chemistry analyzer, has light source, sample cup, monochromator and photodetection circuit and current detection circuit, its detection signal is by photodetection circuit and current detection circuit output, it is characterized in that: the output terminal at photodetection circuit and current detection circuit is connected to MUX (M8), the output signal of this MUX (M8) is through signal amplifier (M7), A/D converter (M6) is delivered to single-chip microcomputer (M2), and this single-chip microcomputer (M2) links to each other with automatic clinical chemistry analyzer master control system (M1) or host computer by communication interface.
2. by the described spectrophotometer that is used for automatic clinical chemistry analyzer of claim 1, it is characterized in that: the signal input part of described MUX (M8) is connected to the simulating signal from photodetection circuit and current detection circuit output, its signal output part (Signa 11-OUT) links to each other with the signal input tube pin (Signa 11-IN) of signal amplifier (M7), the output signal of signal amplifier (M7) becomes digital signal by output pin (Signa 12-OUT) and is connected to memory expansion and address decoder (M5) after A/D converter (M6) conversion, reading/conversion and control end (U10-R/C) of A/D converter (M6), data latches Enable Pin (U9-E, U8-E) and data bus (BUS) link to each other with the respective pin of memory expansion respectively with address decoder (M5), the outer ROM gating signal end (PSEN) of the sheet of this memory expansion and address decoder (M5), address latch signal end (ALE) and reading, write end (RD, WR) be connected to the respective pin of single-chip microcomputer (M2) respectively, this single-chip microcomputer (M2) carries out communication by RS-485 bus and Biochemical Analyzer master control system and is connected.
3. by the described spectrophotometer that is used for automatic clinical chemistry analyzer of claim 2, it is characterized in that: the reset terminal (RST) at single-chip microcomputer (M2) also is connected to a power supply monitor (M3), and the RESET input (CE-IN) of this power supply monitor (M3), reset output terminal (CE-OUT) and hand-reset end (MR) are connected to the respective pin of memory expansion and address decoder (M5) respectively.
4. by the described spectrophotometer that is used for automatic clinical chemistry analyzer of claim 2, it is characterized in that: described MUX (M8) is at least 16 and selects one MUX.
5. by the described spectrophotometer that is used for automatic clinical chemistry analyzer of claim 1, it is characterized in that: described host computer is a computing machine, and single-chip microcomputer (M2) carries out communication by RS-232 serial ports and computing machine and is connected.
6. by any one described spectrophotometer that is used for automatic clinical chemistry analyzer in the claim 1,2 or 3, it is characterized in that: described single-chip microcomputer (M2) can be digital signal processor or field programmable gate array.
CN 200520093838 2005-11-25 2005-11-25 Spectrophotometer for full-automatic biochemical analyzer Expired - Fee Related CN2835993Y (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104458599A (en) * 2014-12-18 2015-03-25 武真真 Intelligent biochemical analyzer
CN110220848A (en) * 2019-06-19 2019-09-10 珠海森龙生物科技有限公司 A kind of Biochemical Analyzer photodetector system and Biochemical Analyzer Photoelectric Detection box

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104458599A (en) * 2014-12-18 2015-03-25 武真真 Intelligent biochemical analyzer
CN110220848A (en) * 2019-06-19 2019-09-10 珠海森龙生物科技有限公司 A kind of Biochemical Analyzer photodetector system and Biochemical Analyzer Photoelectric Detection box

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C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: NANCHANG BIOTE A + C BIOTECHNICAL INDUSTRY INCORPO

Free format text: FORMER OWNER: DONGRUAN MEDICAL SYSTEMS CO., LTD., SHENYANG

Effective date: 20110928

C41 Transfer of patent application or patent right or utility model
COR Change of bibliographic data

Free format text: CORRECT: ADDRESS; FROM: 110179 SHENYANG, LIAONING PROVINCE TO: 330012 NANCHANG, JIANGXI PROVINCE

TR01 Transfer of patent right

Effective date of registration: 20110928

Address after: 330012 Nanchang Dongsheng Industrial Zone, Jiangxi, East Road, No. 699

Patentee after: Nanchang Biotech A & C Biotechnical Industry Incorporated Company

Address before: Hunnan rookie street Shenyang city Liaoning province 110179 No. 2

Patentee before: Dongruan Medical Systems Co., Ltd., Shenyang

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20061108

Termination date: 20131125