CN2785598Y - Structural improvement of imbeded particle - Google Patents
Structural improvement of imbeded particle Download PDFInfo
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- CN2785598Y CN2785598Y CN 200420094496 CN200420094496U CN2785598Y CN 2785598 Y CN2785598 Y CN 2785598Y CN 200420094496 CN200420094496 CN 200420094496 CN 200420094496 U CN200420094496 U CN 200420094496U CN 2785598 Y CN2785598 Y CN 2785598Y
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Abstract
The utility model relates to a medical appliance, particularly to a structural improvement on imbedded particles. The imbedded particle comprises a coating (1) and an adsorbing body (2), and the coating made of biology polyester degrading materials contains the adsorbing body, and the adsorbing body made of biology polyester degrading materials has a multiporous structure and absorbs active materials. The imbedded particle can be made into a signal particle or a particle chain comprising a plurality of particles of which the heads and the tail parts are connected. The utility model has a peculiar structure, and the particles form a chain shape is favorable for adjusting the radiological dose as required. The biological high molecular materials can be absorbed and has time-controlled biodegradability and moldability, so the utility model is good for being produced into a required shape and has definite mechanical strength; the utility model can effectively prevent an embedded body from shifting and moving in the body, and has wide clinical application foreground.
Description
One, technical field
This utility model relates to a kind of medical appliance, particularly a kind of improvement of implanting particle structure.
Two, background technology
Radiotherapy is one of main treatment means of malignant tumor, but traditional external exposure is restricted its application because radiation is wild greatly, normal structure is low to the lonizing radiation dosis tolerata.Internal radiation is a kind of emerging treating malignant tumor means between tissue, it mainly is the three-dimensional location of appliance computer planning system (TPS) design, the modern times image-guided down by Wicresoft's mode with radioactive particle by tumor size, form implantation tumour in or be subjected in the tissue of tumor-infiltrated infringement, send lasting, short-range lonizing radiation by mini-radioactive resource, make tumor tissues suffer farthest to kill and wound, and normal structure is not damaged or microlesion is only arranged, and finally reaches therapeutic purposes.Characteristics such as wound is little, target dose is evenly distributed because the particle implanted treatment has, and the normal surrounding tissue damage is little, thereby this Therapeutic Method is paid attention to gradually clinical.But be to use the Package casing of titanium alloy as particle at present, displacement and migration easily take place in its, cause tumor by local radiological dose deficiency after the migration, also easily cause blood vessel embolism, and can not biodegradation, need shortcoming such as second operation, influenced its use.
The radioactive particle method for implantation is compared with external exposure has quite significantly advantage: (1) has the design of 3-D treatment plan, three-dimensional configuration that can the accurate reconstruction tumor, accurately particle position, quantity and input path are implanted in design, have satisfied that target dose is specialized, the optimal design requirement of individuation; (2) dosage of tumor acceptance obviously increases, and radiation injury is little, and most of energy all can be absorbed by tumor tissues, and complication is low; (3) persistence irradiation, biological effect obviously improves, and the dna double chain interruption is destroyed fully, and higher radiobiological effect is arranged; (4) easy and simple to handle, cost of equipment is low; (5) short-half-life, radioactive source low-yield, low-activity are embedded in the special container, and operation technique does not contact particle, make protection safer.Particle is implanted the treatment that has been used to multiple malignant tumor at present, comprises cerebroma, nasopharyngeal carcinoma, cancer of pancreas, rectal cancer, pulmonary carcinoma and carcinoma of prostate etc., and obtains preferable clinical effectiveness.
Three, summary of the invention
The purpose of this utility model is to overcome the deficiencies in the prior art part, the implantation particle that provide that a kind of local radiological dose is easy to adjust, biological degradability and the compatibility are good, can not be shifted and move, is difficult for causing blood vessel embolism.
The purpose of this utility model is achieved in that implanting particle comprises by shell (1) and adsorbate (2), wherein contained adsorbate by shell with what biological polyester degradation material was made, the adsorbate made from biological polyester degradation material is a loose structure, be adsorbed with radioactive substance on it, make single particle; In addition, can also be with the end to end formation particle chain of a plurality of particles.
This utility model structure uniqueness, difficult avoiding moved or is shifted, and bioabsorbable polymer material can be absorbed, and the biodegradation time controlled (from several thoughtful 1 year), the bioabsorbable polymer material degradation time is consistent die-away time with the radioactive substance on the adsorbate; This utility model also has plasticity, still can keep its shape in the certain hour after implanting; Particle forms chain and helps adjusting as required radiological dose, has broad clinical application prospect.
Four, description of drawings
Fig. 1 is a structure chart of the present utility model.
The figure number explanation:
1---by shell; 2---adsorbate.
Five, the specific embodiment
Implant particle and comprise by shell (1) and adsorbate (2), it is characterized in that being contained adsorbate with what biological polyester degradation material was made by shell, the adsorbate made from biological polyester degradation material is a loose structure, is adsorbed with radioactive substance on it, for example
103Pb, NaI
125Thereby, make single particle; Also can be with the end to end formation particle chain of a plurality of particles, number of particles can increase and decrease as required, thereby reaches the purpose of control, adjustment radiological dose.
Implanting particle is 4.5mm by the length of shell, and diameter is 0.8mm; The length of adsorbate is 3.0mm, and diameter is 0.1-0.5mm.Made with the biological polyester degradation material of atresia by shell.
Biological polyester degradation material is poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGA), polylactide (PLA) or poly-second lactone (PCL) etc.
This utility model structure uniqueness, adopt bioabsorbable polymer material to encapsulate radioactive particle as shell, except having the better tissues compatibility with human body, avoided implant displacement and migration in vivo effectively, also can degradation in vivo become innocuous substance and excrete even displacement and migration take place, need not second operation and take out implant; Bioabsorbable polymer material can be absorbed, and the biodegradation time controlled (from several thoughtful 1 year), the bioabsorbable polymer material degradation time is consistent die-away time with the radioactive substance on the adsorbate; This utility model also has plasticity, is convenient to be processed into required shape, and certain mechanical strength is arranged, and still can keep its shape in the certain hour after implanting; Particle forms chain and helps adjusting as required radiological dose, has broad clinical application prospect.Can replace the original metal shell packing of particle, be widely used in the high and poky tumor of differentiation degree; The tumor that needs reservation critical function sex organization or operation will involve vitals; The protopathy example that can't perform the operation; External exposure poor effect or underdosage, additional as the local dose of external exposure.The disease kind of suitable particle implanted treatment is very extensive, comprises cerebral glioma, metastatic encephaloma, meningioma; Nasopharyngeal carcinoma, orbital internal tumor (melanoma of choroid), retinoblastoma, oropharynx cancer, carcinoma of tongue, carcinoma of floor of mouth, cheek mucosa cancer, cervical metastatic cancer; Pulmonary carcinoma, mesothelioma of pleura, breast carcinoma; Cancer of pancreas, cancer of biliary duct, hepatocarcinoma; Carcinoma of prostate, gynecological tumor; Soft tissue and bone tumor.
Claims (5)
1, implanting morphology of particles improves, implanting particle comprises by shell (1) and adsorbate (2), it is characterized in that being contained adsorbate with what biological polyester degradation material was made by shell, the adsorbate made from biological polyester degradation material is a loose structure, is adsorbed with radioactive substance on it.
2, improve according to the described implantation morphology of particles of claim 1, it is characterized in that the end to end formation particle chain of a plurality of particles.
3, improve according to claim 1 or 2 described implantation morphology of particles, it is characterized in that by the length of shell be 4.5mm, diameter is 0.8mm; The length of adsorbate is 3.0mm, and diameter is 0.1-0.5mm.
4, improve according to the described implantation morphology of particles of claim 1, it is characterized in that being made with the biological polyester degradation material of atresia by shell.
5, improve according to claim 1 or 2 described implantation morphology of particles, it is characterized in that biological polyester degradation material is poly-Acetic acid, hydroxy-, bimol. cyclic ester, polylactide or poly-second lactone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200420094496 CN2785598Y (en) | 2004-10-29 | 2004-10-29 | Structural improvement of imbeded particle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200420094496 CN2785598Y (en) | 2004-10-29 | 2004-10-29 | Structural improvement of imbeded particle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2785598Y true CN2785598Y (en) | 2006-06-07 |
Family
ID=36774172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200420094496 Expired - Fee Related CN2785598Y (en) | 2004-10-29 | 2004-10-29 | Structural improvement of imbeded particle |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2785598Y (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111840586A (en) * | 2020-07-22 | 2020-10-30 | 原子高科股份有限公司 | Biodegradable radioactive particles, particle composition and preparation method |
-
2004
- 2004-10-29 CN CN 200420094496 patent/CN2785598Y/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111840586A (en) * | 2020-07-22 | 2020-10-30 | 原子高科股份有限公司 | Biodegradable radioactive particles, particle composition and preparation method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060607 Termination date: 20101029 |