Background technology
External the heating of general microwave is that microwave radiometer is aimed at patient body lesions position prolonged exposure, and the heat effect by microwave raises the temperature of irradiated site, reaches the purpose of treatment disease.Because microwave radiation can make the polar molecule in the competent cell bump with friction generates heat in the motion of microwave electromagnetic field high speed when penetrating tissue.Microwave hyperthermia device in the past utilizes this principle that the organism local temperature is raise exactly, and utilizes the difference that pathological tissues and normal structure heat tolerate in the organism and treat disease.As diseases such as the mankind's certain micro-organisms, parasites, because pathogen is to thermo-responsive, when diseased region was heated, microorganism or parasite can be dead because of thermic.The BSD400 heat therapy machine of producing as U.S. BSD company uses the microwave of 915MHZ frequency, and peak power is 400W, has adhered radiation head, and radiant power decays rapidly, the serious and only 3-4cm of the degree of depth that heats of patient's body surface burned; The UHR-2000 type heat therapy machine that Hunan company produces uses the 915MHZ microwave frequency, and peak power reaches 1.2KW, heat at a distance, skin burn reduces, and the degree of depth of heating increases to some extent, but only local oncotherapy there is certain effect, low or invalid to systemic disease efficient.
In order to solve a whole-body hyperthermia difficult problem, the TEMET1000 type whole-body thermotherapeutic machine that U.S. company produces, the design blood of human body is drawn from the femoral vein of a side, in the extracorporeal circulation process, use the microwave principle heating blood, from the input of opposite side femoral vein, make body temperature maintain 41-43 degree centigrade again, but this equipment price costliness, the Therapeutic Method complexity, side effect and complication are many, should not promote.The infrared space of the ETSPACE storehouse that domestic Shenzhen company produces, utilize that infrared ray is external heats, also can make the whole body fervescence, but infrared ray is to human body penetration power extreme difference, heat transfer process is general to body surface organization's damage, and adding needs general anesthesia, and the induction time of heating reaches 2-4 hour, probably cause patient skin to be scalded, the tolerance of patients with advanced cancer also is a problem.
The utility model content
The technical problems to be solved in the utility model is, defective at the prior art existence, a kind of microwave whole body heating apparatus is proposed, this device can be to the full metastomium even heating of human body, heat by large tracts of land, deep, by blood circulation heat is sent to whole body and play the whole-body hyperthermia effect, two big major side effects and complication that the body surface that occurs during minimizing is treated is as much as possible simultaneously burnt and patient collapses.
Technical solution of the present utility model is, a kind of microwave whole body heating apparatus, referring to accompanying drawing 1, comprise control electronic computer 9 and display 10, control circuit 1, microwave source 2, two microwave radiometers 3, two microwave pulse manipulators 4, two microwave beam bunchers 5, three-dimensional motion bed 6, human body vital sign monitoring device 8, the signal output part that can accurately gather the human body vital sign monitoring device 8 of body temperature is connected with the corresponding signal output port of described electronic computer 9, another road is connected to control circuit 1 to the I/O interface one tunnel of this electronic computer 9 with the drive circuit of described three-dimensional motion bed 6 is continuous, the output port of described control circuit 1 connects the control circuit of microwave source 2, two microwave radiometers 3 are its input with microwave source 2 all, the input of two microwave pulse manipulators 4 its corresponding microwave radiometer 3 delivery outlets respectively links to each other, its outfan is connected with its corresponding microwave beam buncher 5 respectively, described two microwave radiometers 3 be installed in one make it from the 7 body surface 5-48cm of patient on the three-dimensional motion bed apart from adjustable mechanism on.The corresponding patient 7 in both sides can carry out the microwave irradiation place simultaneously about these two microwave radiometers 3 were installed in the three-dimensional motion bed respectively, below output cable wherein is than the long 16.4CM of top output cable both half wavelength, according to the microwave phase theory, reach the positive synergistic effect.
Operation principle of the present utility model comprises: (1) microwave pulse ripple modulation technique, and make the continuous microwave radiation become the intermittence microwave radiation, increase microwave the living organism tissue is put depth of penetration heating, and reduce the body surface thermal dose, to prevent the skin heat damage; (2) microwave beam forming technigue utilizes the conduction refraction principle of microwave in different medium, makes the microwave energy of unit are increase by 20 times; (3) human body adds temperature technique up and down simultaneously, according to the microwave phase theory, carries out microwave irradiation simultaneously at the human body upper and lower surface, and the below output cable reaches the positive synergistic effect than the long 16.4CM of top output cable both half wavelength, and the efficient of heating is obviously increased; (4) even mobile berth makes last patient's trunk short time high strength even heating, and body surface organization's damage probability obviously reduces, and would not influence heating effect because heat retention is imitated in the body.
Because human malignancies, acquired immune deficiency syndrome (AIDS), schistosomicide etc. are systemic disease, having only could more effective treatment with the mode of whole-body hyperthermia.Therefore, this utility model can pass through the microwave exposure organism, makes its whole body fervescence to effectively treating temperature, is 39-41.5 ℃ as malignant tumor Ya Gaowen whole-body hyperthermia, and the standard whole-body hyperthermia is 41.6-43 ℃.
Microwave source 2 of the present utility model adopts general magnetron, and output is that 0-5KW is adjustable, reference frequency output 600MHZ-1500MHZ, and that this heating system adopts is 915MHZ or 433MHZ.
Microwave radiometer 3 adopts general microwave radiometer, and bore is 164-656mm, and microwave source is installed in its input port, and delivery outlet links to each other with microwave pulse manipulator 4, from heating organism surface 5-48cm.
Microwave pulse manipulator 4 adopts general pulse-modulator, and the microwave continuous ripple is become discontinuity wave.In carrier frequency is under the situation of 915MHZ or 433MHZ, impose the 50-600HZ frequency of modulated wave, with the sine wave modulation of former 915MHZ or 433MHZ is impulse wave, make the microwave after the modulation have microwave safe and the strong advantage of rf wave penetration power concurrently, and it is not enough to have overcome the depth of microwave penetration, and rf wave causes soft tissue hot injury's weakness easily.
Microwave beam buncher 5 is the organic material politef of special single face convex lens shape, and its diameter is 100-500mm, and the hyperboloid summit is 40-200mm to the distance of arc base plane.
Vital sign monitoring device 8 is mainly the thermocouple temperature measuring apparatus that 8-16 leads film, gather esophagus (representing the thoracic cavity temperature), internal ear (representing the intracranial temperature), rectum (representative temperature in peritoneal cavity) and body surface many places skin temperature, go out partes corporis humani position body temperature by computer human body body temperature Model Calculation, its error<0.1 ℃.Be furnished with blood pressure, blood oxygen, pulse, respiratory frequency measuring device simultaneously, can in time reflect the changes of vital signs situation.
Computer 9 is an ordinary PC, its I/O interface links to each other with microwave source control circuit and three-dimensional motion bed, can show vital sign and provide control signal to arrive microwave source and three-dimensional motion bed that the output and the three-dimensional motion bed bed body position in adjusting and controlled microwave source are with the control human body temperature.
Adopt the phantom result of the test such as the following table of this utility model whole body heating system: experiment condition is microwave frequency 915MHZ, output 0-1500W, warm-up time: 5 minutes; The irradiator mould surface distance 25cm that exsomatizes.
Phantom experimental result (Δ t0-5min degree of intensification) is as following table:
Depth of penetration heating (cm) | Temperature (t0-5min ℃) | t-Max,% | Regional cm * cm heats |
0 | 2.84 | 100% | >20×20 |
1 | 2.63 | 93% | >20×20 |
2 | 2.38 | 83% | 20×20 |
3 | 2.06 | 70% | 19×19 |
4 |
1.92 |
63% |
17.5×17.5 |
5 |
1.81 |
57% |
15×15 |
6 |
1.77 |
55% |
13.5×13.5 |
7 |
1.66 |
49% |
11.2×11.2 |
8 |
1.54 |
42% |
11.2×11.2 |
9 |
1.68 |
49% |
13.5×13.5 |
10 |
1.82 |
57% |
15×15 |
11 |
1.98 |
66% |
17.5×17.5 |
12 |
2.23 |
77% |
19×19 |
13 |
2.44 |
84% |
20×20 |
14 |
2.60 |
92% |
>20×20 |
15 |
2.82 |
100% |
>20×20 |
Zoopery: a 70Kg live hog, heated part live hog breast abdominal part.Thermometric position: umbilicus and xiphoid-process line mid point rectus abdominis m. edge.
Experiment condition: microwave rate 915MHZ, output 800W, irradiator from the pig epidermis apart from 25cm, warm-up time 10 minutes.
Experimental result such as following table:
Depth of penetration heating (cm) | Temperature (℃) | Depth of penetration heating (cm) | Temperature (℃) |
0 | 43.5 | 0 | 43.6 |
1 | 43.4 | 1 | 43.4 |
2 | 43.2 | 2 | 43.3 |
3 | 42.9 | 3 | 43.1 |
4 |
42.7 |
4 |
42.8 |
5 |
42.6 |
5 |
42.7 |
6 |
42.5 |
6 |
42.7 |
7 |
42.6 |
7 |
42.5 |
8 |
42.4 |
8 |
42.4 |
9 |
42.4 |
9 |
42.4 |
10 |
42.3 |
10 |
42.4 |
Above-mentioned experimental result proof is in the 0-20cm depth bounds, and temperature difference is very little, and the different parts temperature is close, proves absolutely that its efficiency of heating surface is obvious, and heat distribution is even, can reach and control effectively treatment temperature.
When using body utility model whole body microwave hyperthermia device that patient is treated, patient only feels that the body internal heat generation do not have other incompatible reaction, increases along with fervescence has sweat gland secretion, in time replenish body fluid to patient.This therapy equipment has safe and effective, wide accommodation, and characteristics such as Operation and Maintenance is easy.
In the medical application of the present utility model, first-selected human malignancies.Especially middle and terminal cancer has patient 20-40% evident in efficacy.The three-dimensional motion bed is made whole-body hyperthermia during by orbiting motion, is positioned certain point, can do local thermotherapy during directly according to tumor locus.Human other infectious disease such as acquired immune deficiency syndrome (AIDS), viral influenza, schistosomicide etc. also there is certain curative effect.Benign diseases such as nonspecific inflammation such as rheumatoid, rheumatism, nonspecific colonitis, pelvic inflammatory disease, prostate hyperplasia also had better therapeutic effect.
As from the foregoing, this utility model is a kind of microwave whole body heating apparatus.By being heated in uniform large-area deep, trunk position, by blood circulation heat to be sent to whole body again and play the whole-body hyperthermia effect, three-dimensional bed fixed point is aimed at microwave radiometer, can carry out tumor by local thermotherapy and other benign disease thermotherapy.The efficient of heating height has no side effect.