CN2732185Y - Body surface non-trauma biological tissue detection device - Google Patents
Body surface non-trauma biological tissue detection device Download PDFInfo
- Publication number
- CN2732185Y CN2732185Y CN 200420000872 CN200420000872U CN2732185Y CN 2732185 Y CN2732185 Y CN 2732185Y CN 200420000872 CN200420000872 CN 200420000872 CN 200420000872 U CN200420000872 U CN 200420000872U CN 2732185 Y CN2732185 Y CN 2732185Y
- Authority
- CN
- China
- Prior art keywords
- optical fiber
- body surface
- infrared
- biological
- fourier transformation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The utility model relates to a body surface non-trauma biological tissue detection device. The body surface non-trauma biological tissue detection device comprises a Fourier spectrometer and a group of additional device. The additional device comprises an optical fiber sampling accessory, an optical fiber coupling component and an infrared detector component. With the body surface non-trauma biological tissue detection device, the user can detect the variance of living biological tissue molecular structure in the early period, and the user doesn't have any discomfort feeling in the testing. The additional device is in the left side, the right side or middle of the Fourier spectrometer. The body surface non-trauma biological tissue detection device has a simple operation and is quick and accurate, and the body surface non-trauma biological doesn't have any harm to the human body.
Description
Technical field:
This utility model relates to the isolated plant of the non-invasive detection of biological of a kind of body surface soma molecule structure change.
Background technology:
Change with iconography method detection bodies inner tissue, as detecting the method for pathological changes such as hypertrophy, tumor take place, commonly used clinically at present have X-ray, CT and a MRI etc.A common requirement of these methods is must form by existing foreign body in body, and can utilize imaging mode to detect after after reaching certain volume, promptly having " occupy-place effect ".Even and sometimes in the body existing swollen thing form, but volume is less,, generally also is difficult to detect as diameter below 1cm, often needs to take out in the body with traumatic method to detect after organizing.In this method, the process of sampling can cause patient's misery, and the testing process required time is longer.Therefore, after this detection method is used in patient usually subjective symptoms is arranged, or just implement after finding certain result with other biochemistry detection method.Such as, the pathological section check of in operation process, carrying out etc.And this moment often in the disease, late period, may miss golden hour.Because for numerous disease, early diagnosis is the key of curing.
Known every kind of material all has its characteristic infrared absorption spectra, promptly only absorbs some wavelength and does not absorb the infrared ray of other wavelength, so the infrared absorption spectrum of feature can be used for carrying out the qualitative analysis of material.In addition, because the total amount of material is directly proportional with absorption intensity, therefore can also utilize absorption spectra to carry out the quantitative analysis of material.Infrared spectrometer measurement of species at present commonly used is used to study the variation of material molecular structure to the absorbance (or transmitance) of infra-red radiation.Bio-tissue includes nucleic acid, protein, fat etc., under normal circumstances with pathological state under, the composition of these biomolecule, structure can be different.According to this principle, existing human infrared spectrum detects cancerous cell, Bao Dao document such as Benedeth the earliest, AppliedSpectroscopy, 1986,40,39.But measuring also, it need pass through complicated sample making technology, time-consuming, and be traumatic method.But therefore press for the method for a kind of Non-Invasive early diagnosis bio-tissue pathological changes of development.
Fourier transformation infrared spectrometer (being called for short FT-IR) is the infrared spectrometer of at present extensive use, is made up of light source, optical measuring system, computer data processing system, computer interface and electronics systems several main parts.Wherein optical measuring system is used for the measurement collection data, and computer is used for deal with data and control instrument operation.FT-IR can be sent to the light of all wavelengths in the detector simultaneously, and the signal that detector received is an interferogram.After gathering interferogram, computer is converted to spectrogram by the method for fast fourier transform with interferogram.That is, the difference absorption of each wavelength in the interferogram is differentiated (so-called Fourier transform is exactly with the sine in the time domain or cosine function and the mutual conversion of frequency category) one by one.(referring to Wu Jinguang chief editor " modern age Fourier transform infrared spectroscopy technology and application ", science tech publishing house, 1994).
The FT-IR that uses has polytype and model at present, if any research, analytical type, universal and various tailored versions etc., but when no matter carrying out sample determination with the instrument of which kind of type, all need to get a certain amount of testing sample, place then on the relevant adnexa of infrared spectrometer inner sample chamber and measure.Sometimes sample also needs just can be suitable for measuring through handling in advance, as biological sample is carried out homogenization processing etc.Such method not only bothers, and can not solve the problem of direct mensuration organism, also can produce the organizational structure of biological sample and destroy, and influence measurement result.Therefore be sought after Fourier transformation infrared spectrometer is improved, as have can be at the organism surface surface sample, and the special-purpose sniffer of directly measuring, make it can be directly used in organism such as human body and measure, that is, can directly measure at body surface.Therefore also require this instrument performance stable, easy to operate, be easy to move, higher signal to noise ratio and detection limit etc. are arranged.In addition, be directly used in the detection of organism, also require to be convenient to sterilize repeatedly with examinee's contact portion in the instrument, avoid cross infection.
Summary of the invention:
The purpose of this utility model is the device of a kind of detection of biological of development soma molecule structure change.
The isolated plant that this utility model provides is to have increased by a cover attachment device on common Fourier transformation infrared spectrometer.Wherein used common Fourier transformation infrared spectrometer, refer to measuring range be in infrared various types of Fourier transformation infrared spectrometers, can be by hereinafter described carry out appropriate reconstruction or the redesign small-sized Fourier transformation infrared spectrometer.
The attachment device of described isolated plant comprises optical fiber sampling adnexa, optical fiber coupling component, Infrared Detectors parts, and division is as follows.
1. optical fiber sampling adnexa: form by middle infrared optical fiber (comprising incident optical and outgoing optical fiber), optical fiber ATR probe.Incident optical and outgoing optical fiber are connected with optical fiber ATR probe.Be used to gather the organizational information of detected part.
The infrared optical fiber diameter is 1-3mm, and its length can be selected arbitrarily according to actual needs, and the material of employing can be crystalline material or their mixture such as halogenide, sulfide, and its logical optical range is: 700-4000cm
-1
Optical fiber ATR probe can comprise multiple different structure, and as taper shape or cylinder oblique section shape, diameter is 3-10mm.The material of fibre-optical probe can adopt crystalline materials such as ZnSe, Ge, ZnS, Si, halogenide, sulfide;
Can not have influence on serviceability for guaranteeing to sterilize repeatedly in the use, can adopt the design of sealing, as designing stainless protection layer at optical fiber and probe outer wall.
The principle that optical fiber sampling adnexa adopts is the attenuated total reflectance principle, during measurement optical fiber ATR probe is directly contacted patient's body surface, as positions such as mammary gland, the parotid gland, thyroid.
2. optical fiber coupling component: form by off-axis paraboloidal mirror and Precision trimming mechanism.Its effect is the hot spot that the directional light that the interferometer from infrared spectrometer comes out is converted into 1-3mm, makes the incident optical of its efficient coupled into optical fibres sampling adnexa.
Wherein off-axis paraboloidal mirror has 2;
Precision trimming mechanism is a spiral position adjuster etc., is used to adjust the position of parabolic lens, makes its vernier focusing to optical fiber.
3. Infrared Detectors parts: form by off-axis paraboloidal mirror, detector and three-dimensional adjustable shelf.
Wherein, detector can use MCT detector (tellurium-cadmium-hydrargyrum) or the pyroelectricity class detector (as TGS, DTGS, DLATGS) or the photoelectricity class detector (as InSb) of liquid nitrogen refrigerating or electric refrigeration modes, and these detectors all can obtain by the outsourcing mode.
Off-axis paraboloidal mirror can converge to directional light on the detector; The effect of three-dimensional adjustable shelf is that the infrared light that sends through optical fiber coupling component and reflecting mirror is converged on the detector, makes the energy maximum of the light that detector accepts, and satisfies the signal to noise ratio requirement of whole instrument.
Optical fiber coupling component all is fixed on the optical table between interferometer component and Infrared Detectors parts, and optical fiber sampling adnexa is fixed on the optical fiber coupling component.They and interferometer component and infrared light supply parts constitute a complete Fourier transformation infrared spectrometer light path system.
The attachment device of above-described Fourier transformation infrared spectrometer can be with processing of the optics of this area routine and machining process, as method such as grind is processed.In above-mentioned each parts of this attachment device, except that this paper mention especially, material therefor, structure and processing method belong to all that present technique field those of ordinary skill is known or general various materials, structure and method.
The Fourier transformation infrared spectrometer that has attachment device of this utility model development adopts integrated design in appearance, and this attachment device can be arranged on the left side (seeing Fig. 1, Fig. 2), the right (the seeing Fig. 3, Fig. 4) or middle (seeing Fig. 5, Fig. 6) of Fourier transformation infrared spectrometer.Determine according to actual needs and flexibly.
Although the volume of device of the present utility model can be big or small different, inner each parts also can have multiple arrangement mode, and these all do not influence the performance and the application of this utility model device.But because this device in use needs to change at any time the field of employment, therefore best mode is instrument compactness and a miniaturization as far as possible, flexible and convenient to use, and instrument internal do not use too much moving component, can guarantee better that instrument does not influence the reliability of detection in moving transfer process.
Because infrared gear is subjected to the restriction of optical material characteristic, this quasi-instrument is all had relatively high expectations to ambient humidity, practical situation at environment complicated condition in the clinical practice, can do encapsulation process to this instrument outside or light path system, promptly except in Machine Design, adopting the design of seal interference instrument, can also adopt the wet stronger window materials of ability of moisture resistance such as ZnSe, light path part integral sealings such as interferometer, light source, optical fiber coupling component, detector are got up.The modular connection that connects optical fiber is only left in the instrument outside, and the adnexa of can quickly and easily optical fiber being sampled during use detects on connecting, in the hope of reaching the optimum adaptation to environmental change.Device through sealing not only can reduce the damage to optical element and precise guide rail of dust and humid air, prolongs the life-span of instrument, can also guarantee the relatively stable of environment, reduces the influence of airborne moisture to measurement result, improves the signal to noise ratio of instrument.
The measuring principle of this instrument is: the infrared light that infrared light supply sends forms infrared interference light behind infrared interferometer, infrared interference light enters the incident optical of optical fiber sampling adnexa by optical fiber coupling component, enter optical fiber ATR probe again, optical fiber ATR probe directly contacts human body surface detected part (mammary gland for example, the parotid gland, body surface positions such as thyroid) sampling, after the sampling, the infrared interference light that has infrared information enters the outgoing optical fiber of optical fiber sampling adnexa, return optical fiber coupling component, enter into detector through reflecting mirror, detector becomes the signal of telecommunication to pass through the A/D conversion again the infrared interference conversion of signals, become digital signal, by date processing and fast fourier transform, draw the spectrogram (spectroscopic data) that has the tissue infrared information at last.If in conjunction with dedicated computer software detection information is handled, outut devices such as use portable computer can provide the result of determination whether the tissue position has pathological changes of surveying immediately.
The operating procedure that detects with device of the present utility model is:
With the pop one's head in air background of first sweep measuring environment of optical fiber ATR, then probe is placed on the skin surface of person under inspection's detected part, closely contact scans, and the resolution of instrument is 4cm
-1Or 8cm
-1, scanning times is more than 16 times.Obtain the spectrum that contrasted with background, spectral region is: 800-4000cm
-1Whole scanning needed 2 minutes can finish test approximately.
Can determine scanning times according to actual needs, scanning times is many more, and signal to noise ratio (S/N) is high more, and the result is accurate more, but spended time is also many more.Usually be advisable with 32 scanning.
Use this device and can measure the vivo biological tissue change of molecular structure, pathological changes that therefore can the earlier detection tissue comprises hamartoplasia, fibroma, malignant tumor etc.This device is particularly useful for measuring in early days the body of gland position, as the pathological changes of mammary gland, thyroid, the parotid gland.For hamartoplasia, the pathological changes of basic, normal, high degree all can be measured, and the person under inspection does not have any discomfort sensation in the test.
This device is simple to operate, and is accurate fast, and health is not had any injury.
Description of drawings:
Fig. 1 is the instrument layout figure that the left side is provided with the Fourier transformation infrared spectrometer of attachment device;
Fig. 2 is the index path that the left side is provided with the Fourier transformation infrared spectrometer of attachment device;
Fig. 3 is the instrument layout figure that the right is provided with the Fourier transformation infrared spectrometer of attachment device;
Fig. 4 is the index path that the right is provided with the Fourier transformation infrared spectrometer of attachment device;
Fig. 5 is the middle instrument layout figure that is provided with the Fourier transformation infrared spectrometer of attachment device;
Fig. 6 is a cylinder oblique section shape optical fiber ATR sonde configuration sketch map;
Fig. 7 is a cylinder oblique section shape optical fiber ATR probe outline drawing;
Fig. 8 is a tapered cylindrical optical fiber ATR sonde configuration sketch map;
Fig. 9 is a tapered cylindrical optical fiber ATR probe outline drawing.
Among the above-mentioned figure, 1-5 is the parts of the attachment device of this utility model development, wherein, the 1st, infrared optical fiber, the 2nd, optical fiber ATR probe, the 3rd, Infrared Detectors, the 4th, plane mirror, the 5th, off-axis paraboloidal mirror;
6-10 is the original parts of Fourier transformation infrared spectrometer of not being with attachment device, wherein, the 6th, fixed mirror, the 7th, index glass, the 8th, beam splitter, the 9th, condenser lens, the 10th, laser instrument, the 11st, infrared light supply.
The 12nd, optical fiber interface, the 13rd, probing shell, the 14th, crystalline material probe.
Use instrument: the special use sealing mid-infrared light spectrometer that second optical instrument factory, Beijing makes is equipped with middle infrared optical fiber and ATR probe and MCT (tellurium-cadmium-hydrargyrum) detector (cooled with liquid nitrogen).
Detection method:
1. energized is adjusted, and makes optical fiber output energy the highest, at 2450cm
-1Energy coefficient (Gain=4) is about 56.
2. at first breast portion skin to be measured is cleaned with ethanol and water, then the ATR probe is placed on the detected part skin (for mazalgia takes place, or the palp patient of swollen thing arranged, probe should be positioned on the outer surface skin of diseased region), carry out sweep measuring 32 times, according to the characteristic peak (1000cm of breast lesion
-1～1800cm
-1Wave band and 2800cm
-1～3000cm
-1Wave band) variation (with respect to the characteristic peak of normal breast) with the contrast of standard spectrum data, is judged lesion degree, as cyclomastopathy, tumor etc.Should observe at 1400-1490cm emphatically
-1In the wave-number range, whether there is obvious difference, as～1460cm
-1,～1400cm
-1Peak shape, Strength Changes can provide for information about.
Claims (9)
1. the device of the non-invasive detection of biological of a body surface soma is characterized in that comprising a Fourier transformation infrared spectrometer and a cover attachment device, and described attachment device comprises optical fiber sampling adnexa, optical fiber coupling component, Infrared Detectors parts; Described attachment device is positioned at the left side, the right or the centre of Fourier transformation infrared spectrometer.
2. the device of the non-invasive detection of biological of body surface according to claim 1 soma, it is characterized in that described optical fiber sampling adnexa by in infrared incident optical and outgoing optical fiber, optical fiber ATR probe forms, and incident optical and outgoing optical fiber are popped one's head in optical fiber ATR and are connected.
3. the device of the non-invasive detection of biological of body surface according to claim 1 soma is characterized in that described optical fiber coupling component is made up of off-axis paraboloidal mirror and Precision trimming mechanism.
4. the device of the non-invasive detection of biological of body surface according to claim 1 soma is characterized in that described Infrared Detectors parts are made up of off-axis paraboloidal mirror, detector and three-dimensional adjustable shelf.
5. according to the described device of each claim in the claim 1～4, it is characterized in that wherein optical fiber coupling component is between the interferometer component and Infrared Detectors parts of Fourier transformation infrared spectrometer, all be fixed on the optical table, optical fiber sampling adnexa is fixed on the optical fiber coupling component, and above-mentioned parts and interferometer component and the complete Fourier transformation infrared spectrometer light path system of infrared light supply parts formation.
6. device according to claim 1 and 2 is characterized in that described optical fiber and optical fiber ATR probe outer wall has stainless protection layer.
7. device according to claim 1 and 2, the shape that it is characterized in that the structure of described optical fiber ATR probe is conical.
8. device according to claim 1 and 2 is characterized in that the shape of the structure of described optical fiber ATR probe is a cylinder oblique section shape.
9. the device of the non-invasive detection of biological of body surface according to claim 1 soma is characterized in that wherein light path part integral sealing, and optical fiber sampling adnexa can be connected by the joint of instrument outside or separate with the other parts of isolated plant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200420000872 CN2732185Y (en) | 2004-01-19 | 2004-01-19 | Body surface non-trauma biological tissue detection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200420000872 CN2732185Y (en) | 2004-01-19 | 2004-01-19 | Body surface non-trauma biological tissue detection device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2732185Y true CN2732185Y (en) | 2005-10-12 |
Family
ID=35068032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200420000872 Expired - Fee Related CN2732185Y (en) | 2004-01-19 | 2004-01-19 | Body surface non-trauma biological tissue detection device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2732185Y (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105699323A (en) * | 2016-03-08 | 2016-06-22 | 中国科学院合肥物质科学研究院 | Drug detection system based on Fourier transform NIRSA (near infrared spectroscopy analysis) technology |
| CN109975209A (en) * | 2019-04-19 | 2019-07-05 | 荧飒光学科技（上海）有限公司 | Decaying for Fourier transform spectrometer, is all-trans injection device |
-
2004
- 2004-01-19 CN CN 200420000872 patent/CN2732185Y/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105699323A (en) * | 2016-03-08 | 2016-06-22 | 中国科学院合肥物质科学研究院 | Drug detection system based on Fourier transform NIRSA (near infrared spectroscopy analysis) technology |
| CN109975209A (en) * | 2019-04-19 | 2019-07-05 | 荧飒光学科技（上海）有限公司 | Decaying for Fourier transform spectrometer, is all-trans injection device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7697976B2 (en) | Non-evasive method and apparatus of detection of organism tissues | |
| CN1101934C (en) | Method and apparatus for multi-spectral analysis in noninvasive NIR spectroscopy | |
| KR100520857B1 (en) | Methods and apparatus for multi-spectrum analysis in noninvasive infrared spectroscopy | |
| EP1494577B1 (en) | Spectroscopic analysis of tissue to detect diabetes | |
| US6990364B2 (en) | Noninvasive measurement of glucose through the optical properties of tissue | |
| US20060206018A1 (en) | Method and apparatus for noninvasive targeting | |
| US20020072676A1 (en) | Apparatus and method ofor spectroscopic analysis of human or animal tissue in or body fluids | |
| JP2003508745A (en) | Analyte determination method using arrays of near infrared, adjacent visible spectrum and longer near infrared wavelengths | |
| AU2002249985A1 (en) | Noninvasive measurement of glucose through the optical properties of tissue | |
| JP2003524761A (en) | Method and apparatus for making a spectroscopic calibration model | |
| Kong et al. | A novel non-imaging optics based Raman spectroscopy device for transdermal blood analyte measurement | |
| US20010048077A1 (en) | Apparatus and method for spectroscopic analysis of human or animal tissue or body fluids | |
| US20190277755A1 (en) | Device and method for tissue diagnosis in real-time | |
| US20160341668A1 (en) | Angled confocal spectroscopy | |
| US20230190150A1 (en) | Hemoglobin concentration measuring system, transvaginal probe, attachment, and hemoglobin concentration measuring method | |
| CN2732185Y (en) | Body surface non-trauma biological tissue detection device | |
| CN111631681A (en) | Diagnosis system for detecting oral cancer based on infrared Fourier spectrum | |
| KR20090071339A (en) | Tissue density analysis method of ginseng fresh root by Near Infrared Spectroscopy | |
| CN117204795A (en) | Real-time spectrum imaging endoscope, imaging system and method | |
| CN116570223A (en) | Hyperspectral endoscopic system combined with sampler mirror | |
| Bindig et al. | Detection of malignant tissues by using infrared microscopy and fiber optic spectroscopy | |
| CZ2013789A3 (en) | Combined optical probe for non-invasive diagnostics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20051012 Termination date: 20100219 |