CN2722250Y

CN2722250Y - Optical spit blood sugar device without wound

Info

Publication number: CN2722250Y
Application number: CN 200420063305
Authority: CN
Inventors: 孙晶华; 吕惠志
Original assignee: Harbin Engineering University
Current assignee: Harbin Engineering University
Priority date: 2004-08-18
Filing date: 2004-08-18
Publication date: 2005-08-31
Anticipated expiration: 2014-08-18

Abstract

The utility model relates to an optical spit blood sugar device without wound, comprising a light source, a light path part, a photodetector, a circuit part, a one-chip computer, an input circuit, a display part and an interface circuit. The traditional analysis method of detecting blood sugar concentration and the existing electronic blood sugar detecting instrument which belong to detecting with wound require adopting blood sample, bring pain for the patient, exist the danger that virus infects the patients through the blood, and limit the detecting frequency of the blood sugar. The experiment proves that the glucose content in spit is as only 1/50-1/100 as the glucose content in blood, so the blood sugar value is detected through human's spit, and the precision must attain 0. 01mmol/L. The utility model has the advantages of that the device detects directly the sugar content in spit, and displays directly the sugar content in blood through analysis, comparison and processing of the computer. With high detecting precision and good repeatability, the optical spit blood sugar device without wound is applied to medical system and the family widely.

Description

Optics does not have the wound salivary blood sugar instrument

Technical field

The utility model relates to a kind of optics does not have the wound salivary blood sugar instrument.

Background technology

Diabetes are one of four big principal diseases of harm humans health, have become global health problem.The diabetes patient worldwide increases just year by year.The World Health Organization (WHO) estimates that the whole world had 1.43 hundred million diabetics approximately in 1998, and by 2025, along with population growth, aging and regional urbanization, this numeral will reach 300,000,000.China diabetic sum has reached 3,000 ten thousand more than, still has diabetic more than half undiscovered.

The cause of disease more complicated of diabetes, and can cause multiple complications.Because diabetic's pancreas is excreting insulin normally, makes glucose (blood sugar) concentration in the blood can not remain on normal level.Therefore must often detect blood sugar concentration,, keep the normal level of blood sugar by oral hypoglycemic medicine and an amount of insulin of injection.Thereby accurately measuring blood concentration is extremely important.Excessive and very few take medicine and insulin injection all is very disadvantageous concerning the patient.

At present, domestic and international diabetic's blood sugar test generally adopts the method for chemical detection.The each detection needs to gather patients'blood, exposed the shortcoming of following inherence:

(1) there is the danger of virus by blood infection;

(2) stand the misery of acupuncture because the wound of diabetic own just is difficult for healing, when serious in addition human body fester gradually, so this detection method is very unfavorable to treatment of diabetes;

(3) limited the detection frequency of blood sugar;

(4) although it is noninvasive that glucose in urine detects, limitation is bigger, and the crowd who is lower than kidney threshold value (10mmol/L) and is higher than normal value (7mmol/L) for those blood sugar can not in time sound a warning, and testing result is not accurate enough.

People be badly in need of a kind of painless, continuously, blood sugar detecting method easily.Therefore, the Woundless blood sugar detection method is the inexorable trend of blood sugar test technical development, and it will make the diabetes detection means produce qualitative leap, and treatment of diabetes is had important and practical meanings.

Do not see " no wound salivary blood sugar instrument " this product on the home market at present, report a kind of " no wound salivary blood sugar instrument " in the pertinent literature, it is to design according to " sugar content in the human saliva is very approaching with the sugar content in the blood ".And experimental results show that of we and Japanese expert: the sugar content in the human saliva only is 1/50～1/100 of the sugar content in the blood.Obviously the measurement that this " no wound salivary blood sugar instrument " is used for the blood sugar content is inaccurate.Normal person blood glucose value≤7mmol/L on an empty stomach wants the saliva measuring blood value by the people, and its precision will reach more than the 0.01mmol/L, and the sample amount of taking of saliva is again limited.The utility model proposes under this background.

Summary of the invention

The utility model provide a kind of AT, utilize optical means directly to measure the blood sugar test instrument of saliva.This instrument is made up of light source [1], light path part [2], photodetector [7], circuit part [8], one-chip computer [11], input circuit [12], display part [13] and interface circuit [14].Wherein light path part [2] is made of optical lens [3], optical filter [4], sample cell [5], optical lens [6], and circuit part [8] is made of amplifying circuit [9], A/D change-over circuit [10], and display part [13] are made of display circuit and LCDs.

Design concept of the present utility model is according to as follows:

After adding a certain amount of enzyme phenol reagent in the different glucose solution of equal volume concentration, the absorption spectrum of its glucose solution as shown in Figure 2.As seen from Figure 2, the wavelength of absorption peak correspondence is 505nm, the absorption peak amplitude difference of the glucose solution of variable concentrations.Therefore, by measuring the amplitude of absorption peak, can measure concentration of glucose.

The concentration of the glucose solution that records with said method and the relation curve of absorbance are as shown in Figure 3.Point out that in the document of being consulted when the concentration of glucose solution was higher, promptly when this method lower limit was above, the concentration and the absorbance of glucose solution were linear, as seen from Figure 3, really so.But when concentration was low, the concentration of glucose solution and the relation of absorbance were not appeared in the newspapers.And this is used in the utility model just.It is a kind of nonlinear relationship as can be seen from Figure 3, and this moment absorbance value very low.In order to improve measuring accuracy, we are that the monochromatic light of 505nm is as light source with wavelength, get the value of the integration (area under the curve of spectrum) of spectrum amplitude in this light source bandwidth as detectable signal, adopt Lagrangian many-valued insertion that data are handled, draw the glucose content in the saliva, provide glucose content in the blood through conversion.

Principle of work of the present utility model is as follows:

The structured flowchart of this instrument as shown in Figure 1.The light that light source [1] sends becomes directional light through optical lens [3]; Mating plate [4] becomes the monochromatic light that wavelength is 505nm after filtration; Testing sample by in the sample cell [5] focuses on the incidence window of photodetector [7] through optical lens [6]; Photodetector [7] converts light signal to electric signal; Electric signal amplifies through amplifying circuit [9]; Through A/D change-over circuit [10] analog signal conversion is become digital signal input one-chip computer [11]; Person's to be measured actual blood-sugar content is imported one-chip computer [11] as calibration value by the button on the input circuit [12], analyze, compare, converse blood glucose value by one-chip computer [11], deliver to display part [13] and directly show blood-sugar content by LCDs, also can be by interface circuit [14] output measurement data, for external Computer Storage data or printing examining report.

The utility model has the advantages that the precision height, good reproducibility, accuracy rate is greater than 90%, extensively suitable medical system and family.

Description of drawings

Fig. 1 optics does not have wound salivary blood sugar instrument structured flowchart

The abosrption spectrogram of Fig. 2 glucose solution

The concentration of Fig. 3 glucose solution and the graph of relation of absorbance

Fig. 4 optics does not have wound salivary blood sugar instrument index path

Fig. 5 optics does not have wound salivary blood sugar instrument amplification circuit diagram

Fig. 6 optics does not have wound salivary blood sugar instrument A/D change-over circuit figure

Fig. 7 optics does not have wound salivary blood sugar instrument input circuit figure

Fig. 8 optics does not have wound salivary blood sugar instrument display part circuit diagram

Fig. 9 optics does not have wound salivary blood sugar instrument interface circuit figure

Embodiment

With the value of distilled water as background, with the standard glucose aqueous solution instrument is demarcated, timing signal will be deducted the value of background.

2. get about the about 1000 μ l of the saliva of newly separating out in the hypogloeeis, the clear liquid 500 μ l in the middle of getting, the enzyme phenol reagent 3.6ml of adding geometric ratio, mixing injects 10mm light path cuvette sample cell [5].

3. to import single-chip microcomputer [11] (only survey and once be used for calibration) as actual measured value by the blood-sugar content numerical value of taking blood sample to record with chemical method.

4. light source [1] adopts 12V 50W bromine tungsten filament lamp, and wavelength is 400-760nm, places the focus place of optical lens [2]; At the preceding 10mm aperture diaphragm that adds of light source [1], the restriction luminous flux, optical lens [3] is the convex lens of 20mm for focal length, the light that comes out by optical lens [3] is directional light; Through wavelength is that 505nm self-control optical filter [4] becomes monochromatic light; By the testing sample of sample cell [5], focus on the incidence window of photodetector [7] through optical lens [6]; Optical lens [6] is the convex lens of focal length 20mm, and photodetector [7] is the CR114 side window type photomultiplier that Japanese shore pine produces, and the light of 505nm wavelength is in its peak response scope; Photodetector [7] converts light signal to electric signal; Electric signal amplifies through amplifying circuit [9]; Through A/D change-over circuit [10] analog signal conversion is become digital signal input one-chip computer [11]; Person's to be measured actual blood-sugar content is imported single-chip microcomputer as calibration value by the button on the input circuit [12], analyze, compare, converse blood glucose value by one-chip computer [11], deliver to display part [13] and directly show blood-sugar content by LCDs, also can be by interface circuit [14] output measurement data, for external Computer Storage data or printing examining report.One-chip computer [11] is compared blood-sugar content numerical value with the dense value of content of glucose in the saliva, with the program of finishing data are analyzed, compared and handle, and converses the blood-sugar content value, demonstrates blood glucose value at last on LCDs.

The utility model has the advantages that influence, the precision height that can eliminate other factors, can reach 0.005mmol/L, good reproducibility, accuracy rate is greater than 90%, extensively suitable medical system and family.

Claims

1. an optics does not have the wound salivary blood sugar instrument, the circuit part [8], one-chip computer [11], input circuit [12], display part [13], the interface circuit [14] that it is characterized in that light path part [2] that its formation comprises light source [1], is made up of optical lens [3], optical filter [4], sample cell [5] and optical lens [6], photodetector [7], be made up of amplifying circuit [9], A/D change-over circuit [10]; Wherein light source [1], optical lens [3], optical filter [4], sample cell [5], optical lens [6] carry out the light signal transmission successively between the photodetector [7]; Connect by circuit successively between photodetector [7], amplifying circuit [9], A/D change-over circuit [10] and the one-chip computer [11]; One-chip computer [11] carries out electric signal with input circuit [12], display part [13] and interface circuit [14] respectively again and is connected.