CN2714078Y - Inhalator through nose - Google Patents

Abstract

The utility model, belonging to the field of health medical apparatus and instruments, discloses an inhalator through nose which comprises a curved inhalator body (1) that can hold medicine. Both ends of the curved inhalator body (1) can be clamped in two nostrils and are provided with air holes (10) for medicine odor to pass through. The utility model is characterized in that: both ends of the inhalator body (1) is sheathed with dismountable sealing caps (2) to seal the air holes (10); the fitting surfaces of the sealing caps (2) and the inhalator body are cylinder surfaces; the inhalator body (1) is connected into an openable box (3) by the sealing caps (2); the box bottom and the box cover are hinged; the sealing caps (2) are integratedly hinged with the box bottom and the box cover; the box (3) is provided with a burglar proof mechanism (35-39). The utility model has the advantages of easy carry and use, fine appearance, simple manufacture, and fitness of one-time use.

Description

Through nasal inhaler

Technical field this utility model relates to a kind of health-care hospital apparatus, particularly a kind of administration apparatus of snuffing medicament.

Background technology snuffing agent is one of nasal cavity medicine, and used medicated pillow among the people can be described as the blank that per nasal sucks medicine.The doctor often went into nose with medicamental pulverata and got and sneeze to have one's ideas straightened out ancient times, was used for patient's emergency.First snuffing side medicine surplus having recorded ten in " Li Yue Pianwen, Rhymed Discourse for Topical Remedies " is with diseases such as treatment headache, singultus, malaria, puerperal blood faintss.Bright Li Shizhen (1518-1593 A.D.) Compendium of Material Medica has been introduced cinnabar dress capsule, wears in body and the hair worn in a bun or coil, with controlling the experience of being insomnia.

Nose administration treatment disease is increasingly extensive in clinical practice in recent years, compares with other administering mode, and nose administration has special advantage: (1) effect is rapid, and intranasal administration can be walked around blood brain barrier and directly medicine be delivered to brain.It is thin that nasal mucosa has mucosal wall, rich blood vessel, and the characteristics that intercellular substance is big are coated with microvillus on the nasal mucosa, make the drug absorption total effective area improve (the nasal membrane area has 120～150 square centimeters).After drug molecule is adsorbed in mucosa, just see through mucosa at an easy rate and enter blood, directly enter blood circulation by dlural sinus and jugular vein.Pulmonary also can provide great alveolar surface area to be used to absorb the drug in addition, compare with small intestinal, there is approximately identical surface area in pulmonary, medicine can arrive rapidly, can form higher pulse concentration, not only the small-molecule drug fast Absorption can be made, also polypeptide drug and macromolecular drug can be absorbed.(2) nose administration can avoid medicine to the gastrointestinal pessimal stimulation, avoids the metabolic degradation effect to medicine of liver, gastrointestinal tract, has also avoided the small intestinal necessary liver first-pass effect that absorbs the drug simultaneously, and degree of absorption is better, improves drug bioavailability.(3) dosage is little, and expense is low.(4) safety is good, and untoward reaction takes place few.For example many neuropeptide medicines are structurally similar to hormone, have sizable hormone side effect usually after entering blood flow, can reduce the medication amount that enters in the blood significantly by the intranasal loading and address this problem.(5) can bring into play the local therapeutic effects of medicine.At nasal cavity, trachea and pulmonary disease direct drug injection, the medicine mucomembranous surface that goes directly, concentration is high also to directly act on affected part, and therapeutical effect is stronger.(6) mode of inhalation, patient is easy to accept, and is particularly useful for the child, and can uses in diet, thereby make medication convenient.(7) nasal cavity is being abound with abundant olfactory nerves cell, so the abnormal smells from the patient of medicine meeting irritating smell cell, reaches the central nervous system and produces olfactory sensation, regulates central nervous system and neuro function, thereby plays intensive treatment.

In recent years the drug delivery system of Xing Qiing (Drug Delivery System[DDS]) development rapidly, its purport is to pursue to use minimum drug dose, is reduced to minimum side effect, the curative effect that performance is maximum, nose administration meets these requirements.Show according to the relevant market analysis, be subjected to the promotion of new technique, the pulmonary administration market that per nasal sucks will be fast-developing in the coming years.Nearly 2,300,000,000 dollars of the whole world, pulmonary administration market in 2002 by 2009, is expected to rise to 9,100,000,000 dollars.Report points out that novel pulmonary administration technology will be more easy to use and cheap, and can accomplish multiple dose medicine coordination administration.(chlorofluorocarbon, CFC) class technology will be the leading roles in market as metered dose inhaler (MDIs), powder inhaler (DPIs), liquid atomizing suction apparatus (LBIs) and InspirEase to non-chloro-fluorocarbon chemical compound.

The summary of the invention the purpose of this utility model is that proposition is a kind of easy to carry, suitable disposable through nasal inhaler, by the serial expanded technical scheme, it is carried in storage have reliable sealing performance and easy occupation mode in the process, have simultaneously and make advantage simple, with low cost.Its technical scheme comprises the sweeping inhaler body that can hold medicine, and its two ends can be fastened in two nostrils, has the ventilative hole that can supply drug smell to appear at its two-end part.Described medicine can be the snuffing medicament that is used for medical treatment, or is used for plants essential oil, the aromatic of current consumption.Described inhaler body can resilient clamp in the nasal septum both sides, also can open and be supported in nasal cavity to two-side elastic.

More specifically scheme is, described inhaler body has the cylinder shell of ventilative hole by two arranged side by side in the same way and constitutes with the joining elasticity card of two housings by two joints, described joint is made of overcoat and the interior cover that the bottom links to each other, elasticity links the bottom that is connected to two joints, be fixedly connected between the overcoat of the peristoma insertion joint of described housing and the interior cover, its concrete connected mode can be that thread connection or annular snap close connect.

Because inhaler will stretch into nasal cavity and contact with nasal membrane, so being not suitable for the repetition powder charge, it uses, only need the disposable medicine of packing into, treat during use that property of medicine volatilization finishes, promptly discardable.As disposable medical appliance, require its cost very low, structure should be tried one's best simply.Scheme is, described inhaler body is by two cylinders arranged side by side in the same way and be connected in that integrated elasticity card constitutes between two cylinders, and the axis of described cylinder is straight shape, has port on the front end face of cylinder, can be used as medicine pack into passage and ventilative hole.Two pipes are two autonomous container, can be thick slightly with respect to the curved card of elasticity, help clamping nasal septum.

When inhaler is used for medical purpose, often need other people to assist to use, the shape of inhaler should make things convenient for other people to hold.Concrete scheme is that described inhaler body is the clamp shape, has a pair of pincers handle that extends back, and can hold for finger.Described pincers be being from the formation that extends back of elasticity card body, also can be in the technique scheme rear end of cylinder body extend back form.

For pursuing the simplest structure, minimum production cost, can adopt following technical scheme, described inhaler body is made of the bending pipe of internal communication, and the body of bending is a medicament reservoir, also be the elasticity jig, the two-port of pipe can be used as medicine pack into passage and ventilative hole.Specifically can obtain very high speed of production by longer pipe through cutting off and hot bending technique molding, cost is extremely low.Because its internal run-through, make it have relatively large spatial accommodation, the drug smell that can also guarantee the inhaler two ends volatilizees simultaneously and finishes.It is fast to be specially adapted to evaporation rate, needs the big liquid preparation of dose.

Because the snuffing medicine has volatile characteristic, if adopt the method for the medicine of only just packing into before use, convenient inadequately, science are not suitable for the general public and use.Reasonable method should be by production firm medicine to be packed in the inhaler, and consumer only need open and use and gets final product.Inhaler behind this medicine that just requires to pack into is being stored, must be able to sealed when carrying.Specifically can be socketed with departing sealing cap,, when using, take down sealing cap and get final product described ventilative pore closure at the two ends of described inhaler body.After described inhaler puts sealing cap, being medicinal inhalation devices, is again the packing container of medicine.

The mode that is sealed and matched at sealing cap and inhaler two ends, multiple variation can be arranged, because the described inhaler bodily form is small and exquisite, real practical scheme should be tried one's best simply, one of its scheme is that the mating surface between described sealing cap and the inhaler body is the face of cylinder or the face of cylinder that tapering is arranged slightly, utilize the elasticity of material, open and close by direct plug.When the inhaler bodily form hour, this face that is sealed and matched is simple and practical.In particular cases described mating surface also can be elliptical cylinder-shape, abnormal shape or threaded engagement.Sealing cap can be two, is socketed in the inhaler two ends respectively; Also can make the sealing cap at inhaler two ends be connected as one the integral molded plastic molding; Even can make a plurality of inhalers by sealing cap connect into one row carry.

In order to make inhaler that better portability be arranged, described inhaler body is connected in the able to turn on or off box by its sealing cap, when using, open box, to pull out inhaler and get final product, it is very compact that integral body seems.The shape of box and structure can be provided with flexibly, and be square, oblate or special-shaped.Can be to be connected and fixed or one-body molded between sealing cap and the box, even be exactly that the sealing cap body is mixed a lid and formed.Box, is equivalent to be provided with dual-seal for inhaler if sealing is tighter at the bottom of lid and the box to providing protective effect at interior inhaler.

Consider the cost of box and inhaler, practical concrete scheme is, at the bottom of the box of described box and lid be connected by flexible hinge, at the bottom of described sealing cap and the box, lid, hinge be one-body molded.Such box and inhaler be two parts just altogether, and cost increases few, and is very easy to use.

As the packing container of commodity, on box, preferably be provided with destructive antitheft opening mechanism, to ensure the safe and sanitary of inhaler.Concrete scheme is, peristoma position at the bottom of lid or box is connected with the flap that extends laterally by the junction point that can rupture, at the bottom of box or the corresponding position of lid be connected with equally laterally the travel(l)ing rest that extends, firmly connects with the restriction lid between described flap and the travel(l)ing rest and be opened, thus the described junction point locking of releasing that take place to rupture when flap and travel(l)ing rest are together pulled to lid.Be provided with between at the bottom of lid and the box or be not provided with hinge can, when hinge not being set, the junction point of described flap should be more, pin lid from a plurality of directions.Described travel(l)ing rest is because of having a certain flexibility with box is one-body molded.The mode that firmly connects between flap and the travel(l)ing rest can link by latching device, also can be ultra-sonic welded or bonding, and requirement can not delamination.

(MDI) compares with quantitative aerosol, and disclosed in the utility model is portable mini suction apparatus through nasal inhaler, and its advantage is that the small and exquisite cost of the bodily form is low, and disposable use uses up promptly discardable; Using method is simple and convenient, need not the medical worker and instructs; The administration longer duration can uninterruptedly use in 24 hours, and life and work is had no effect; The outward appearance exquisiteness, easy to carry.

The one piece of inhaler of can only packing in the above-mentioned box is made the outward appearance of small and exquisite exquisiteness, also can pack in each box five pieces or ten pieces, and this manner of packing approaches the chewing gum that people like, is fit to very much carry.Simple and practical like this inhaler has been arranged, can play certain facilitation the exploitation of relative medicine new product.It can either be used as medical apparatus, also is suitable for current consumption.For example pack in the inhaler aromatic of refreshing clearly lung moistening as the mini air freshener that the individual uses, is used for influencing people's the mood and the mental status.Its current consumption product as similar chewing gum and so on are carried out the marketing, will have unlimited vast market prospect.If single box retail price is controlled in 1 mao, large price is no more than 1 yuan, can have very strong commercial viability.Along with the appearance of new product medicine, described inhaler can be used for that refreshment, relieving stress, hypnosis are stable, nourishing the lung to arrest cough, smoking cessation drug rehabilitation, heart tonifying first aid, alleviate long-term medications such as temporary transient medication such as cold symptoms or blood pressure lowering, blood sugar lowering.

Description of drawings

Fig. 1 is embodiment one inhaler and sealing cap view sub-anatomy thereof.

Fig. 2 is embodiment two inhalers and box view sub-anatomy thereof.

Fig. 3 is a box closed state schematic appearance shown in Figure 2.

Fig. 4 is embodiment three inhalers and box closed state sketch map, and the antetheca of lid is cut.

Fig. 5 is inhaler shown in Figure 4 and box opening sketch map, and the antetheca of lid is cut.

Fig. 6 is a box closed state schematic appearance shown in Figure 4.

Fig. 7 is embodiment four anti-theft box closed state schematic appearance.

Fig. 8 is a not closed state sketch map of embodiment four inhalers and anti-theft box.

Fig. 9 is embodiment five anti-theft box closed state schematic appearance.

Figure 10 is not closed state sketch maps of embodiment five anti-theft boxs.

The specific embodiment

Embodiment one, (referring to Fig. 1) inhaler body 1 has the cylinder shell 12 of ventilative hole 10 by two arranged side by side in the same way and constitutes with the joining elasticity card 11 of two housings by two joints, described joint is made of overcoat 14 and the interior cover 15 that the bottom links to each other, elasticity card 11 is connected in the bottom of two joints, the peristoma of described housing 12 is inserted between the overcoat 14 and interior cover 15 of joint, in barrel-type casing 12 peristoma internal diameters reach, have the annular snap close 13 that is meshed on the external diameter of cover 15, make the two be maintained fixed connection.Extend a pair of pincers 18 at the rear portion of elasticity card 11, hold with finger with convenient.

Sealing cap 2 is complementary with the two ends of inhaler body 1, be two tubular medicated caps that one arranged side by side links to each other, utilize the elasticity of material, be sealed and matched between overcoat 14 external diameters of sealing cap 2 internal diameters and inhaler adapter, its mating surface is the face of cylinder, thereby all ventilative holes of inhaler body 1 are closed.More reliable for the cooperation that makes the two, the snap close 21 of annular spread can be set at sealing cap 2 peristoma inwalls, deviate from easily to prevent inhaler body 1.

This routine described joint is set to inside and outside Portuguese bowline structure, its major advantage is directly to match with sealing cap 2, sealing effectiveness and described cylinder shell 12 are irrelevant, and sealing property is reliable, also makes tubular shell 12 more firm with connecting of elasticity card 11 simultaneously.This routine described inhaler heavy dose of granular medicament dosage form that relatively is fit to pack into.Pull out the sealing cap 2 of inhaler outside during use, utilize two tubular shells 12 of inhaler and relatively thick slightly joint overcoat 14 be clamped in the nasal septum both sides and get final product.The outside dimension of joint overcoat 14 can approach the nostril thickness, and is bigger because of the nasal cavity inner space when it stretches into nasal cavity with the increase capacity, can not influence eupnea.

Embodiment two, (referring to Fig. 2) inhaler body 1 is by two cylinders 16 arranged side by side in the same way and be connected in that integrated elasticity card 11 constitutes between two cylinders, the axis of described cylinder 16 is straight shape, has port one 7 on the front end face of cylinder 16, can be used as medicine pack into passage and ventilative hole.The peristoma of port one 7 is the fillet shape that inwardly draws in, to adapt to nasal cavity and to contain medicated core.Cylinder 16 inside can be packed fibrous material or other porous material into as medicated core, resiliency supported links at cylinder 16 inwalls or the fixed mount 19 bottom cylinder, to receive liquid preparation (because of the medicated core form is relevant with the medicament that is held, so do not draw among the figure).The advantage of this routine inhaler is that cost simple in structure is low, and its structure is well suited for the Shooting Technique one-shot forming, can be by the mode demoulding of push rod is set in mold cores.According to the needs of holding of medicament, some ventilative holes 10 also can be set on the face of cylinder of cylinder 16, be beneficial to medicine and distribute.The material of inhaler can be high density polyethylene (HDPE), polypropylene, preferably uses silica gel material.

For increasing sealing effectiveness, the sealing ring 22 of projection and the internal diameter of sealing cap 2 can be set in the external diameter rear end of inhaler cylinder 16 be sealed and matched, the mating surface between the two is the face of cylinder.(referring to Fig. 2, Fig. 3) this example has just been formed a box inhaler 1 has been contained wherein at the supporting cap 32 of sealing cap 2 oral areas, can play a protective role to inhaler.Can also the hasp 33 that be interlocked be set between sealing cap 2 and cap 32, throw off easily to prevent the two.Hasp 33 is provided with handle, opens with convenient.

Embodiment three, and (referring to Fig. 4, Fig. 5, Fig. 6) inhaler body 1 is made of the bending pipe of internal communication, and the body 1 of bending is a medicament reservoir, also is the elasticity jig, and the two-port 17 of pipe can be used as medicine pack into passage and ventilative hole.Body 1 can be by long tube through cutting off bending and molding, and its shape approximation is held on the nasal septum both sides in U-shaped during use.The porous medicated core of body 1 inner filling is used for receiving medicinal liquid (figure does not draw).

Inhaler body 1 is connected in the able to turn on or off box 3 by sealing cap 2.Box 3 connects and composes by flexible hinge 31 at the bottom of by lid and box, described sealing cap 2 with at the bottom of the box, lid and hinge 31 integrated injection moldings, have elastic lock mechanism 34 between at the bottom of lid and the box, it can not thrown off voluntarily.The outward appearance of box 3 is oblate, whole no tangible ridge, and its bodily form is big or small similar to usual coin, as individual big tablet, is convenient to very much consumer and carries and use.The leading edge of having scratched snap close 34 gently with finger tip during unlatching gets final product.According to the box of structure shown in this example, its main-vision surface shape is not confined to circle, can also be rhombus or other abnormity oval, fillet.Than higher medicine, can use the aluminum-plastic composite membrane Vacuum Package for some seal requests directly with inhaler body 1 or together with the method for box 3 according to the encapsulation tablet.

Embodiment four, and the structure and the example two of (referring to Fig. 7, Fig. 8) this routine inhaler body 1 are identical, just clamp handle, and the bodily form is smaller and more exquisite, relatively is suitable for using in daily life.

The lid of box 3 and the peristoma at the bottom of the box are flat mouthful, cooperate comparatively closely, are equivalent to be provided with second resealing for inhaler.At the bottom of the box of box 3 and lid be connected by flexible hinge 31, at the bottom of lid, the box, hinge 31 and sealing cap 2 integrated injection moldings, can guarantee lid and the elaboration that cooperates at the bottom of the box.The difference of this routine box and precedent is that box 3 has anti-pirate of the open function.Specifically be connected with the flap 36 that extends laterally at the peristoma position of lid by the junction point 35 that can rupture, the corresponding position at the bottom of box is connected with the travel(l)ing rest 38 that extends equally laterally by flexible hinge 37.The edge of described flap 36 has the snap close 39 of turnup, and the edge that can pin travel(l)ing rest 38 is opened with the restriction lid solid and reliablely.When flap 36 was pulled, by the effect of travel(l)ing rest 38, thereby the locking of fracture releasing to lid took place in described junction point 35, and lid can be raised.After flap 36 is fractureed, be retained on the travel(l)ing rest 38, can not produce unnecessary rubbish because of fracture.

Embodiment five, and (referring to Fig. 9, Figure 10) on the basis of last routine antitheft box, this example is arranged with many group sealing caps 2 in box 3, can hold many pieces of inhaler bodies 1.Described flap 36 is connected a plurality of directions of lid peristoma by more junction point 35, and anti-pirate of the open effect is more obvious.It is corresponding with flap 36 that the lid feather edge has the travel(l)ing rest 38 that connects by flexible character of flexible ribs 37, the snap close of rolling 39 firm buckles by a nearly week of flap 36 edges between the two connect, lobed pin matches with corresponding pin-and-hole on the travel(l)ing rest 38 on the flap 36, to strengthen the connecting relation of the two.The hinge 31 of antitheft box shown in the figure is arranged on the narrow limit of box, also can be arranged on the long limit of box according to hobby in concrete the enforcement.

Claims (10)

1. through nasal inhaler, it is characterized in that comprise the sweeping inhaler body (1) that can hold medicine, its two ends can be fastened in two nostrils, have the ventilative hole (10) that can supply drug smell to appear at its two-end part.

2. according to claim 1 through nasal inhaler, it is characterized in that, described inhaler body (1) has the cylinder shell (12) of ventilative hole (10) by two arranged side by side in the same way and constitutes with the joining elasticity card of two housings (11) by two joints, described joint is made of overcoat (14) and the interior cover (15) that the bottom links to each other, elasticity card (11) two ends are connected in the bottom of two joints, are fixedly connected between the overcoat (14) of the peristoma insertion joint of described housing (12) and the interior cover (15).

3. according to claim 1 through nasal inhaler, it is characterized in that, described inhaler body (1) is by two cylinders (16) arranged side by side in the same way and be connected in integrated elasticity card (11) formation between two cylinders, the axis of described cylinder (16) is straight shape, on the front end face of cylinder (16), have port (17), can be used as medicine pack into passage and ventilative hole.

4. according to claim 1,2 or 3 described, it is characterized in that described inhaler body (1) is the clamp shape, have a pair of pincers that extend back, can hold for finger (18) through nasal inhaler.

5. according to claim 1 through nasal inhaler, it is characterized in that described inhaler body (1) is made of the bending pipe of internal communication, the body of bending is a medicament reservoir, also be the elasticity jig, the two-port of pipe (17) can be used as medicine pack into passage and ventilative hole.

6. according to claim 1,2,3 or 5 described, it is characterized in that the two ends of described inhaler body (1) are socketed with departing sealing cap (2), described ventilative hole (10) is sealed through nasal inhaler.

7. according to claim 6ly it is characterized in that through nasal inhaler the mating surface between described sealing cap (2) and the inhaler body (1) is the face of cylinder.

8. according to claim 6ly it is characterized in that through nasal inhaler described inhaler body (1) is connected in the able to turn on or off box (3) by its sealing cap (2).

9. describedly according to Claim 8 it is characterized in that through nasal inhaler, at the bottom of the box of described box (3) and lid be connected by flexible hinge (31), described sealing cap (2) with at the bottom of the box, lid, hinge be one-body molded.

10. according to Claim 8 or 9 described through nasal inhaler, it is characterized in that, peristoma position at the bottom of lid or box is connected with the flap (36) that extends laterally by the junction point (35) that can rupture, at the bottom of box or the corresponding position of lid be connected with equally laterally the travel(l)ing rest (38) that extends, firmly connects with the restriction lid between described flap (36) and the travel(l)ing rest (38) and is opened, described junction point (35) when flap (36) and travel(l)ing rest (38) are together pulled thus the locking of fracture releasing to lid takes place.

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