CN2679683Y - Multiple-channel array sampler - Google Patents
Multiple-channel array sampler Download PDFInfo
- Publication number
- CN2679683Y CN2679683Y CN 200420021008 CN200420021008U CN2679683Y CN 2679683 Y CN2679683 Y CN 2679683Y CN 200420021008 CN200420021008 CN 200420021008 CN 200420021008 U CN200420021008 U CN 200420021008U CN 2679683 Y CN2679683 Y CN 2679683Y
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- array
- mixing chamber
- sampler
- capillary
- point
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Abstract
The utility model discloses a multiple-channel array sampler. Prior technique is limited to single channel sampler, and exists the defects of long analytical cycle, low efficiency, complicated operation, etc. The utility model applying the array sampler makes fractionation test obtain good effect. The multiple-channel array sampler comprises a micro-volume mixing chamber array, a sampler capillary array and a sampler plate. The micro-volume mixing chamber is a triplet mixing chamber comprising an upper port, a lower port and a horizontal port. The lower port is connected with the sample capillary. The sample plate positions below the sampler capillary and can move by a three-dimensional automatic moving platform. The utility model is applied to multi-dimensional array chromatographic fractionation system with array number corresponding to the system, and greatly enhances the efficiency of analysis of the system.
Description
Technical field
The utility model is a kind of multichannel array spot sample device, can be used for the high flux miniature array spot sample device of array chromatographic fractionation system and substance assistant laser desorpted ionized mass spectrometry.
Background technology
Substance assistant laser desorpted/MALDI-MS (MALDI-MS) is the novel mass spectrum of a kind of soft ionomerization of just growing up over past ten years.MALDI be 1988 by initiatives such as Germany scientist Karas.This technology utilizes laser radiation to be scattered in sample in the matrix, makes heat-labile big molecule be able to enter gas phase with complete ionic species.The birth of this technology is that mass spectrum has been opened up wide application prospect in fields such as life sciences, now becomes the main identification of means of in the proteome research protein being identified note day by day.At present, the spot sample device of the spot sample device of such test macro, especially chromatographic fractionation system is confined to the single channel point sample, exists efficient low, can't satisfy the needs of developing multichannel array stratographic analysis.
Summary of the invention
The purpose of this utility model is to obtain a kind of efficient height, easily robotization, effective multichannel array spot sample device.
The multichannel array spot sample device, by the long-pending mixing chamber array (1) of microbody, point sample capillary array (2) constitutes.Miniature mixing chamber array is to have to go up (8), the mixing chamber array of following (9) and (10) three ports in side, the lower port of mixing chamber array (10) links with point sample capillary array (8), array chromatographic column (11) when the upper port of mixing chamber array and test links, mixing chamber array side port (10) is connected with syringe pump (5) by carrying matrix capillary array (4), miniature mixing chamber array is corresponding one by one with array post and point sample capillary array, number of arrays can be decided as required, form to tens arrays by several, be point template (6) under the point sample capillary array, the point template sample can detect for substance assistant laser desorpted ionized mass spectrum or Other Instruments.
The long-pending mixing chamber array of microbody is made of the long-pending mixing chamber of 2-50 microbody, and corresponding point sample capillary array also is 2-50.
The point sample capillary array is fixed by the kapillary geometrical clamp.
Point template places on the three-dimensional mobile platform (7) automatically, and along with moving of platform, array sample has improved detection efficiency greatly for instrument detecting on the point template.
The utility model novel structure, manufacture craft is uncomplicated on the prior art basis, and this device is applied to multichannel array chromatogram detection efficiency height, effective, automaticity height.
Description of drawings
Fig. 1 is the structural representation of the utility model spot sample device.
Fig. 2 is the miniature mixing chamber array junctions of a utility model composition.
Fig. 3 is the sectional structure chart of the miniature mixing chamber of the utility model.
1 is the long-pending mixing chamber array of microbody among the above-mentioned figure, the 2nd, and point sample capillary array, the 3rd, kapillary geometrical clamp, the 4th, carry the matrix capillary array, the 5th, syringe pump, the 6th, point template, the 7th, three-dimensional mobile platform automatically, the 8th, miniature mixing chamber upper port, the 9th, miniature mixing chamber lower port, the 10th, the horizontal port of miniature mixing chamber, the 11st, mixing chamber body, the 12nd, mixing chamber upper cover plate, the 13rd, mixing chamber lower cover, the 14th, sealing gasket, the 15th, chromatographic column array.
Embodiment
1. the making of the long-pending mixing chamber array of microbody:
At long 5cm, wide 1cm, thickness are on the 1cm stainless steel, from reaching three directions in front up and down, get out the threeway duct that internal diameter is 0.25mm with the spacing machinery of 1.25mm, as shown in Figure 2.On a cover plate, get out 10 of the apertures that internal diameter is 0.5mm with the spacing of 1mm.Place the latex pad respectively at each opening of the channel place,, three row quartz capillaries are inserted from the inlet of three directions in threeway duct respectively, and be screwed the be placed in skin in threeway duct of three identical cover plates.The long-pending mixing chamber of each microbody has three connectors: go up connector, following connector and horizontal connector (sectional view as shown in Figure 3).Connector is connected with the array chromatographic column respectively on each, and following connector is connected with the point sample capillary array respectively, and horizontal connector is connected with the matrix discharge pump.Be carved with equally spaced conduit in the kapillary geometrical clamp, be used for fixing the point sample capillary array.
2. the making of hyperchannel spot sample device:
Array chromatographic column, point sample capillary array and conveying matrix capillary array are placed the corresponding upper and lower and horizontal port of the long-pending mixing chamber array of microbody respectively, point sample capillary array lower end is fixed with the kapillary geometrical clamp, place the point template top, point template places on the three-dimensional mobile platform, constitute the hyperchannel spot sample device, as shown in Figure 1.
3. the utility model spot sample device is applied to the multi-dimension array chromatographic fractionation system, has obtained following good result: the efficient height, separation component and matrix on-line mixing in hyperchannel, easily robotization, effective.
Claims (4)
1, a kind of multichannel array spot sample device, by the long-pending mixing chamber array (1) of microbody, point sample capillary array (2), constitute, it is characterized in that miniature mixing chamber array is to have to go up (8), the mixing chamber array of following (9) and (10) three ports in side, the lower port of mixing chamber array (10) links with point sample capillary array (8), array chromatographic column (11) when the upper port of mixing chamber array and test links, mixing chamber array side port (10) is connected with syringe pump (5) by carrying matrix capillary array (4), miniature mixing chamber array is corresponding one by one with array post and point sample capillary array, is point template (6) under the point sample capillary array.
2, multichannel array spot sample device according to claim 1 is characterized in that the long-pending mixing chamber array of microbody is made of the long-pending mixing chamber of 2-50 microbody.
3, multichannel array spot sample device according to claim 1 is characterized in that the point sample capillary array is fixing by kapillary geometrical clamp (3).
4, multichannel array spot sample device according to claim 1 is characterized in that point template places on the three-dimensional mobile platform (7) automatically.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200420021008 CN2679683Y (en) | 2004-03-18 | 2004-03-18 | Multiple-channel array sampler |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200420021008 CN2679683Y (en) | 2004-03-18 | 2004-03-18 | Multiple-channel array sampler |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2679683Y true CN2679683Y (en) | 2005-02-16 |
Family
ID=34583341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200420021008 Expired - Fee Related CN2679683Y (en) | 2004-03-18 | 2004-03-18 | Multiple-channel array sampler |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2679683Y (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105467077A (en) * | 2015-11-17 | 2016-04-06 | 重庆大学 | Spotting head for producing microarray sensor |
| CN106908563A (en) * | 2015-12-23 | 2017-06-30 | 中美华世通生物医药科技（武汉）有限公司 | Spotting system and method |
| CN109541093A (en) * | 2018-10-29 | 2019-03-29 | 山东省分析测试中心 | A kind of pretreatment of nanoliter level mass spectrum sample and sample introduction combined apparatus and its method |
-
2004
- 2004-03-18 CN CN 200420021008 patent/CN2679683Y/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105467077A (en) * | 2015-11-17 | 2016-04-06 | 重庆大学 | Spotting head for producing microarray sensor |
| CN106908563A (en) * | 2015-12-23 | 2017-06-30 | 中美华世通生物医药科技（武汉）有限公司 | Spotting system and method |
| CN106908563B (en) * | 2015-12-23 | 2024-01-05 | 中美华世通生物医药科技(武汉)股份有限公司 | Sample application system and method |
| CN109541093A (en) * | 2018-10-29 | 2019-03-29 | 山东省分析测试中心 | A kind of pretreatment of nanoliter level mass spectrum sample and sample introduction combined apparatus and its method |
| CN109541093B (en) * | 2018-10-29 | 2019-08-27 | 山东省分析测试中心 | A kind of pretreatment of nanoliter level mass spectrum sample and sample introduction combined apparatus and its method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |