CN2646709Y - Equipment for real-time observing gel electrophoresis - Google Patents
Equipment for real-time observing gel electrophoresis Download PDFInfo
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- CN2646709Y CN2646709Y CN 03273931 CN03273931U CN2646709Y CN 2646709 Y CN2646709 Y CN 2646709Y CN 03273931 CN03273931 CN 03273931 CN 03273931 U CN03273931 U CN 03273931U CN 2646709 Y CN2646709 Y CN 2646709Y
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Abstract
The utility model discloses a device to observe the gel electrophoresis in real time. The utility model consists of a box base, a black box for placing the electrophoresis groove, a non violet light source and an optical filter; the black box is positioned on the box base; the non violet light source is provided on the bottom in the box base or the back; the upper cover of the non violet light source is provided with an optical filter; the installing position corresponding with the non violet light source in the upper side of the black box forms an observing port; the observing port is fixed with an optical filter. The utility model adopts the non violet light source as the light source and does not adopt the violet light source, and the utility model is provided with a black box and does not need to be used in a black room, therefore the utility model can conveniently observe the electrophoresis phenomenon directly in real time; moreover the utility model also can be used for detecting when the electrophoresis is finished, and the utility model realize the multifunction of the machine and has universalism.
Description
Technical field
The utility model relates to a kind of equipment of real-time monitored gel electrophoresis, realizes electrophoresis is carried out the analytical equipment of real-time monitored thereby refer in particular to a kind of visible light that utilizes as light source, different sizes that can be built-in, the electrophoresis tank of specification.
Background technology
Electrophoresis is meant the phenomenon that charged particle moves to the electrode with self oppositely charged in electric field.Electrophoresis, be meant that charged test sample (for example: protein, nucleotide etc.) is in inertia supporting dielectric (coagulating, reach kapillary etc. as paper, cellulose acetate, Ago-Gel, polyacrylamide), under effect of electric field, carry out swimming to its corresponding electrode direction by speed separately, make component be separated into narrow district's band, the detection method that usefulness is suitable writes down its Zone electophoresis band collection of illustrative plates or calculates the method for its percentage composition.Has effect fast and accurately owing to use the component of electrophoresis check and analysis material, so electrophoresis is widely used in every field such as chemical industry, medical science, food, environmental protection.Electrophoretic analysis purpose according to different can adopt different electrophoresis methods and detection method, adopts agarose gel electrophoresis or polyacrylamide gel electrophoresis as nucleic acid is carried out the electrophoresis.And in order observing, to need gel is dyeed, under transilluminator, to observe then, take pictures, or directly analyze with gel imaging system.
Traditional electrophoresis tank introduction: vary in size according to gel, the model of electrophoresis tank is also different with size.The common vertical electrophoresis groove that the horizontal strip electrophoresis groove that is applicable to agarose electrophoresis is arranged and be applicable to polyacrylamide gel electrophoresis.In order to observe gel, must dye to gel amplifying nucleic acid etc., generally adopt fluorescent dye, as bromination second pyridine (EB), SYBR Green etc.According to used dyestuff and analysis purpose difference, can be respectively before electrophoresis, in the electrophoresis, behind the electrophoresis gel is dyeed.
The gel analysis equipment introduction: gel analysis equipment general using uviol lamp is mixed the only optical filter of saturating ultraviolet light again as light source, above the gel after the dyeing is placed on, can observe.General this ultra-violet analysis equipment has three kinds, and a kind of is the uv analyzer that does not have camera bellows, needs to use in the darkroom; Another kind is the uv analyzer that camera bellows is arranged, and need not the darkroom, and is easy to use.Also having a kind of is portable uviol lamp, can observe gel in electrophoresis He behind the electrophoresis.These equipment can be mixed camera, and gel is taken a picture.In addition, on these equipment, mix again, just become the gel imaging analysis system by computer-controlled digital camera or a CCD and a cover imgae processing software.The common ground of above instrument uses ultraviolet light as light source exactly, thereby has also brought their common drawback, and promptly ultraviolet ray is to the infringement of human body and sample.
Non-ultraviolet source and succeeding in developing by U.S. Clare Chemical Research company as the gel electrophoresis analysis equipment of light source with visible light, and to have released with Dark Reader be the series of products of trade name, this instrument is made of a visible light source and two optical filters, light source is a conventional fluorescent lamps, two optical filters are respectively blue and orange, blue color filter can only see through blue visible light, visible lights such as other are green, orange, red can not see through, and orange optical filter just in time can only see through visible lights such as green, orange, red on the contrary, can not see through blue light.Light source is positioned at the bottom, is blue color filter and orange optical filter then successively, is observed gel between two-layer optical filter.Light that light source sends is through blue color filter, in the blue excitation optical excitation gel of generation with the fluorescent dye of nucleic acid combination, it is green, orange, red that fluorescent dye sends etc. launches the orange optical filter of light transmission, can be observed or take a picture.And blue background light can not see through orange optical filter, can not be observed.So just can observe nucleic acid with the fluorescent dye combination.This equipment has many advantages, and is higher as sensitivity for analysis, do not use ultraviolet source, greatly reduces infringement to human body and sample etc.But Dark Reader does not have camera bellows, needs to use in the darkroom, brings inconvenience to the experimenter.This point is the major defect of this product.
The electrophoretic transmissive instrument of integrating is introduced: traditional method all is to utilize above electrophoresis apparatus of introducing and gel analysis equipment to carry out electrophoretic analysis respectively, promptly after electrophoresis is finished, again gel is placed on the analyser and observes, this method generally can only be seen final electrophoresis result, can not see the situation in the electrophoresis process in real time.So-called real-time monitored is exactly in electrophoresis sample to be observed, and real-time monitored helps detecting the collection of data, the convenient analysis, and foranalysis of nucleic acids is significant.So people are seeking the method for real-time monitored electrophoresis always.The method that adopts is to integrate electrophoresis apparatus and gel analysis equipment and constitute a whole electrophoresis scope, i.e. the electrophoretic transmissive instrument.Instrument of electrophoretic transmissive instrument has been realized electrophoresis and two kinds of functions of gel observation.The electrophoretic transmissive instrument has two kinds at present.
First kind is to carry out real-time monitored with integrating electrophoresis tank and general ultraviolet analyser, promptly below common electrophoresis tank uviol lamp is installed, and adds a ultraviolet filter.In electrophoresis process, open uviol lamp and can carry out real-time monitored.This instrument does not generally have camera bellows, needs electrophoresis, observation in the darkroom.Simultaneously, use UV-irradiation for a long time, can cause damage sample.So in order to protect sample, most of experiments can not be used this equipment, this point has limited the use of this product greatly.This shortcoming also is fatal, says in a sense, and this also is not a qualified instrument.
Second kind of visible light electrophoretic transmissive instrument of releasing by Clare Chemical Research company.With first kind of instrument class seemingly, just do not use ultraviolet source.
The detailed method of seeing above-mentioned observation electrophoresis, be not difficult to find that there is following point in it:
One, have the gel analysis equipment of camera bellows all to adopt ultraviolet source, ultraviolet ray is all very big to human body and test sample infringement, influences staff's the health and the quality of test sample; Though and DarkReader uses visible light as light source, does not have camera bellows, must in the darkroom, use operation inconvenience.
Two, the equipment of two kinds of real-time observation methods is that the electrophoretic transmissive instrument does not have camera bellows yet, must carry out in the darkroom, and it is very inconvenient to operate;
Three, the electrophoretic transmissive instrument is that an electrophoresis tank and an analyser are integrated, i.e. all corresponding one by one analyser of each electrophoresis tank, and analyser cost height, and this integration certainly will cause the waste of analyser, and is uneconomical, economical.
Four, existing real-time monitored electrophoresis equipment only is applicable to horizontal strip electrophoresis, and is not suitable for vertical electrophoresis, does not have ubiquity;
Five, existing real-time monitored electrophoresis equipment only is applicable to range estimation, also of no usely by computer-controlled digital camera or CCD electrophoresis process is carried out " observation " in real time, promptly so-called real-time electrophoresis imaging system.
The utility model content
Fundamental purpose of the present utility model is to provide a kind of equipment of real-time monitored gel electrophoresis, and it utilizes visible light as light source, does not adopt ultraviolet source, and is furnished with camera bellows, need not to use in the darkroom, can observe electrophoresis directly, in real time, and observation is convenient.
Secondary objective of the present utility model is to provide a kind of equipment of real-time monitored gel electrophoresis, it is applicable to the horizontal strip electrophoresis groove or the vertical electrophoresis groove of all size, model, size, realize the real-time monitored electrophoresis, also can after finishing, observe electrophoresis simultaneously with this instrument, realize a tractor serves several purposes, have ubiquity.
For reaching above-mentioned purpose, solution of the present utility model is:
A kind of equipment of real-time monitored gel electrophoresis, mainly form by the camera bellows of block, ccontaining electrophoresis tank, non-ultraviolet source and optical filter, camera bellows is located on the block, non-ultraviolet source is installed in block inner bottom part or back, the installation site of the corresponding non-ultraviolet source of camera bellows upside forms observation port, sets firmly a tablet filter on the observation port in addition.
The bottom of above-mentioned block or back form a light source mounting groove, and non-ultraviolet source fixedly is located in this mounting groove.
The observation port of above-mentioned camera bellows is rotary type by cooperatively interact between itself and the camera bellows rotating shaft and axle sleeve and is fixed on the camera bellows upside, so that rotation observation port, can be corresponding with the light source that is fixed on block bottom or back, thus have the effect of the observation level of being convenient to, vertical two kinds of electrophoresis tanks concurrently.
The shooting mouth is formed on the top of above-mentioned camera bellows, also sets firmly a slice long wave optical filter on the shooting mouth.
Corresponding respectively bottom or back visible light source form the bearing of being convenient to locate the level of setting or vertical electrophoresis groove in the above-mentioned block.
The electrophoresis tank outlet is arranged in the above-mentioned block.
The movable cover of above-mentioned camera bellows is put on block, so that remove camera bellows, makes things convenient for electrophoresis tank to insert.
Above-mentioned block is installed on the sliding rail, so that block by skidding off in the camera bellows or slipping into, makes things convenient for electrophoresis tank or waits to observe the taking-up of article or insert.
Above-mentioned non-ultraviolet source loam cake is established a tablet filter, so that be suitable for when optical wavelength heterogeneity that the light source of selecting for use sends or wavelength coverage broad.
Offer on the above-mentioned camera bellows and be convenient to the door that electrophoresis tank is inserted.
After adopting said structure, the utility model compared with prior art has following advantage:
One, the utility model utilizes non-ultraviolet light as light source, self has camera bellows, do not need the darkroom can directly observe electrophoresis, and, after the position of corresponding non-ultraviolet source is provided with electrophoresis tank in block, get final product the real-time monitored electrophoresis by observation port, the utlity model has the effect of observing electrophoresis conveniently, directly, in real time;
Two, the utility model is not incorporated into electrophoresis tank and gel analysis device together, again at the bottom surface or the non-ultraviolet source of trailing flank shape mounting groove of block inner bottom part, so, can be used with the horizontal strip electrophoresis groove or the vertical electrophoresis groove of various models, size with a gel analysis device, when realizing real-time monitored, needn't resemble the so-called electrophoretic transmissive instrument that preamble is introduced, an electrophoresis tank and an analyser are integrated, so, the equipment manufacturing cost of the utility model real-time monitored gel electrophoresis is low, economical, easy to use.Simultaneously, the utility model also can be observed with this instrument after electrophoresis is finished, and realizes a tractor serves several purposes, has ubiquity;
Three, the utility model adopts non-ultraviolet source (as blue light) observation, avoids adopting ultraviolet ray observation, and non-ultraviolet source is harmless to human body and test sample, has avoided influencing staff's the health and the quality of test sample;
Four, the utility model is owing to have the shooting mouth, so can be suitable for electrophoresis process being carried out " observation " in real time by computer-controlled digital camera or CCD, it is so-called real-time electrophoresis imaging system, can gather the gel images in the electrophoresis process at any time, computing machine perhaps is set control and make it gather once image set time every certain.Such benefit is unnecessaryly to keep otherly or must understand the electrophoresis situation at set intervals at electrophoresis always, and promptly after setting instrument behind the last sample, the experimenter can leave.Because computing machine is gathered once image at set intervals, can not miss the golden hour of observation.This point is extremely important for the electrophoresis such as polyacrylamide gel of need electrophoresis more than several hours.
Description of drawings
Fig. 1 is structure of the present utility model and the use synoptic diagram that is applicable to the horizontal strip electrophoresis groove;
Fig. 2 is the use synoptic diagram that the utility model is applicable to the vertical electrophoresis groove.
Specific embodiment
See also shown in Fig. 1,2, the equipment of a kind of real-time monitored gel electrophoresis that the utility model discloses mainly is made up of camera bellows 1, non-ultraviolet source 2 and the optical filter 3 and 6 of block A, ccontaining electrophoresis tank 4 or 5.
The electrophoresis tank outlet is arranged, so that electrophoresis tank 4 or 5 energized work in the block A.Block A respectively forms a light source mounting groove 12 at the bottom surface and the trailing flank of its bottom, two groups of non-ultraviolet sources 2 fixedly are located at respectively in two mounting grooves 12, when optical wavelength heterogeneity of sending when the light source of selecting for use or wavelength coverage broad, need lid to establish a tablet filter 3 on the light source 2, promptly the notch of light source mounting groove 12 lid is established a tablet filter 3.Wherein: non-ultraviolet source 2 can be fluorescent light, white flag lamp, electricity-saving lamp, light emitting diode, laser etc. light source, rather than uviol lamp.Which kind of non-ultraviolet source specifically adopts decided by demand.
The light source 2 at corresponding respectively bottom and back forms the bearing 13 and 14 of being convenient to locate the level of setting or vertical electrophoresis groove 4 or 5 in the block A, when electrophoresis tank 4 or 5 is inserted camera bellows 1, can make electrophoresis tank 4 or 5 location by bearing 13 or 14, so that observation.
The installation site of the corresponding visible light source 2 of camera bellows 1 upside forms observation port 15, sets firmly a slice long wave optical filter 6 on the observation port 15 in addition.In order to observe level, vertical two kinds of electrophoresis tanks 4 or 5 by this observation port 15, form cooperatively interact rotating shaft and axle sleeve 16 between observation port 15 and camera bellows 1 contact site, by cooperatively interacting between this rotating shaft and the axle sleeve 16, make observation port 15 be rotary type and be fixed on camera bellows 1 upside, rotate observation port 15, can be corresponding with the visible light source 2 that is fixed on block A bottom or back, thus have the effect of being convenient to observe level in the camera bellows 1, vertical two kinds of electrophoresis tanks 4 or 5 concurrently.Certainly, the utility model also can reflect the vertical electrophoresis image by a specular-reflection unit, is may observe vertical electrophoresis image so that needn't rotate observation port, does not do at this and gives unnecessary details.
Optical texture of the present utility model is such, constitute by a non-ultraviolet source 2 and two optical filters 3,6, light source 2 is non-ultraviolet sources, two optical filters 3 are different with 6, the visible light minimal wave length that long wavelength of the visible light that optical filter 3 sees through and optical filter 6 see through is approaching, promptly visible light after filtration the light that filters of mating plate 3 can not see through optical filter 6 substantially.Light source 2 is positioned at the bottom, is optical filter 3 and optical filter 6 then successively, is observed gel between two-layer optical filter 3 and 6.Light source 2 is positioned at the bottom or the back of block, the light that light source 2 sends is mating plate 3 after filtration, and the fluorescent dye of sample (as nucleic acid) combination, the emission light transmission long wave optical filter 6 that the wavelength that fluorescent dye sends is long can be observed or take a picture in the excitation gel that produces.And the bias light that filters through shortwave optical filter 3 can not see through long wave optical filter 6, can not be observed.So just can observe nucleic acid with the fluorescent dye combination.
When carrying out the real-time monitored of electrophoresis with the utility model, must at first carry out fluorescent dyeing to sample, that is to say and to select for use those can be before electrophoresis or the fluorescent dye that dyes in the electrophoresis, as: bromination second pyridine (EB), SYBR Green I etc., used materials such as selected electrophoresis tank and glue holder must be to have good visible light permeability.
Method of operating is: with suitable fluorescent dye sample is dyeed, before then electrophoresis tank 4 or 5 being placed on (as: with the horizontal strip electrophoresis groove 4 of agarose electrophoresis) on the transmission filter 3 of equipment block A bottom or being placed on the transmission filter 3 at equipment block A back (as: the vertical electrophoresis groove 5 of usefulness polyacrylamide gel electrophoresis), the light that equipment light source 2 is sent can see through gel.Go up sample then, connect electrophoresis tank 4 or 5 power supplys, open device power supply (DPS), carry out real-time monitored.
The utility model self has camera bellows 1, and need not the darkroom, thus can directly the electrophoresis tank 4 or 5 of inserting in the camera bellows 1 be observed, thus realize purpose convenient, direct, the real-time monitored electrophoresis; And the light source 2 that the utility model adopts is visible light (as a blue light), 2 pairs of human bodies of non-ultraviolet source and test sample harmless (or the infringement that causes than ultraviolet source is little), handling safety; Can be suitable in the utility model camera bellows 1 inserting level or vertical all size, the electrophoresis tank of model, have ubiquity, and avoid causing the waste of analyser according to the observation needs, economical, economical.
Handle for the ease of the numerical analysis that observation station is got, the utility model also forms shooting mouth 17 at the top of camera bellows 1, also set firmly a tablet filter 6 on the shooting mouth 17, like this, mouthful 17 pairs of electrophoresis that observe of can making a video recording are thus taken pictures, and the process of real time record electrophoresis more can be connected to the signal of this collection the computing machine microprocessing systems, in time electrophoresis is analyzed, realized the automatic analyzing and processing of electrophoresis.
In a word, the utility model compared with prior art, the main points of its invention are: camera bellows 1 of preparation on visualizer, in camera bellows 1, adopt visible light to observe, thereby reach purpose convenient, direct, the real-time monitored electrophoresis, these means of all utilizations are carried out the instrument of electrophoresis observation and analysis, all should belong to the category of this case.
Claims (10)
1, a kind of equipment of real-time monitored gel electrophoresis, it is characterized in that: mainly form by the camera bellows of block, ccontaining electrophoresis tank, non-ultraviolet source and optical filter, camera bellows is located at the block top, non-ultraviolet source is installed in block inner bottom part or back, the installation site of the corresponding non-ultraviolet source of camera bellows upside forms observation port, sets firmly a tablet filter on the observation port in addition.
2, the equipment of a kind of real-time monitored gel electrophoresis as claimed in claim 1 is characterized in that: the bottom of block or back form a light source mounting groove, and non-ultraviolet source fixedly is located in this mounting groove.
3, the equipment of a kind of real-time monitored gel electrophoresis as claimed in claim 1 is characterized in that: the observation port of camera bellows is rotary type by cooperatively interact between itself and the camera bellows rotating shaft and axle sleeve and is fixed on the camera bellows upside.
4, the equipment of a kind of real-time monitored gel electrophoresis as claimed in claim 1 is characterized in that: the shooting mouth is formed on the top of camera bellows, also sets firmly a tablet filter on the shooting mouth.
5, the equipment of a kind of real-time monitored gel electrophoresis as claimed in claim 1 is characterized in that: corresponding respectively bottom or the non-ultraviolet source in back form the bearing of being convenient to locate the level of setting or vertical electrophoresis groove in the block.
6, the equipment of a kind of real-time monitored gel electrophoresis as claimed in claim 1, it is characterized in that: block is installed on the sliding rail.
7, the equipment of a kind of real-time monitored gel electrophoresis as claimed in claim 1 is characterized in that: the electrophoresis tank outlet is arranged in the block.
8, the equipment of a kind of real-time monitored gel electrophoresis as claimed in claim 1 is characterized in that: the camera bellows movable guard is put on block.
9, the equipment of a kind of real-time monitored gel electrophoresis as claimed in claim 1 is characterized in that: offer on the camera bellows and be convenient to the door that electrophoresis tank is inserted.
10, the equipment of a kind of real-time monitored gel electrophoresis as claimed in claim 1 is characterized in that: non-ultraviolet source loam cake is established the optical filter that a slice is applicable to the non-ultraviolet source of wavelength heterogeneity or wavelength coverage broad.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03273931 CN2646709Y (en) | 2003-08-26 | 2003-08-26 | Equipment for real-time observing gel electrophoresis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03273931 CN2646709Y (en) | 2003-08-26 | 2003-08-26 | Equipment for real-time observing gel electrophoresis |
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| CN2646709Y true CN2646709Y (en) | 2004-10-06 |
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| CN 03273931 Expired - Fee Related CN2646709Y (en) | 2003-08-26 | 2003-08-26 | Equipment for real-time observing gel electrophoresis |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006111082A1 (en) * | 2005-04-18 | 2006-10-26 | Yunkang Liu | A device for real-time and continuous monitoring gel electrophoresis and method thereof |
| CN101949886A (en) * | 2010-08-27 | 2011-01-19 | 亚亚科技股份有限公司 | Real-time fluorescence electrophoresis apparatus |
| CN102690880A (en) * | 2011-03-24 | 2012-09-26 | 苏州风采信息技术有限公司 | Electrophoresis method based on agarose gel |
| CN102866194A (en) * | 2012-09-05 | 2013-01-09 | 上海市东方医院 | Multivariate electrophoresis interpretoscope |
| CN103713033A (en) * | 2013-12-31 | 2014-04-09 | 南京山诺生物科技有限公司 | Real-time, visible and image-shared nucleic acid electrophoresis device |
| CN104422584A (en) * | 2013-09-05 | 2015-03-18 | 技嘉科技股份有限公司 | Accommodating device for providing light shielding environment and light shielding test system |
| CN104849340A (en) * | 2015-05-20 | 2015-08-19 | 中国科学院生物物理研究所 | Electrophoresis experiment platform capable of observing nucleic acid in real time |
| CN107064497A (en) * | 2017-06-13 | 2017-08-18 | 福建省农业科学院畜牧兽医研究所 | A kind of portable electrophoresis and photographing device and its application method |
| CN108226109A (en) * | 2017-12-12 | 2018-06-29 | 安徽师范大学 | A kind of simple gel imaging device |
-
2003
- 2003-08-26 CN CN 03273931 patent/CN2646709Y/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006111082A1 (en) * | 2005-04-18 | 2006-10-26 | Yunkang Liu | A device for real-time and continuous monitoring gel electrophoresis and method thereof |
| CN101949886A (en) * | 2010-08-27 | 2011-01-19 | 亚亚科技股份有限公司 | Real-time fluorescence electrophoresis apparatus |
| CN102690880A (en) * | 2011-03-24 | 2012-09-26 | 苏州风采信息技术有限公司 | Electrophoresis method based on agarose gel |
| CN102866194A (en) * | 2012-09-05 | 2013-01-09 | 上海市东方医院 | Multivariate electrophoresis interpretoscope |
| CN104422584A (en) * | 2013-09-05 | 2015-03-18 | 技嘉科技股份有限公司 | Accommodating device for providing light shielding environment and light shielding test system |
| CN104422584B (en) * | 2013-09-05 | 2017-06-23 | 技嘉科技股份有限公司 | The accommodating device and shading test system of shading environment are provided |
| CN103713033A (en) * | 2013-12-31 | 2014-04-09 | 南京山诺生物科技有限公司 | Real-time, visible and image-shared nucleic acid electrophoresis device |
| CN104849340A (en) * | 2015-05-20 | 2015-08-19 | 中国科学院生物物理研究所 | Electrophoresis experiment platform capable of observing nucleic acid in real time |
| CN104849340B (en) * | 2015-05-20 | 2017-09-15 | 中国科学院生物物理研究所 | Real-time monitored nucleic acid electrophoresis experiment porch |
| CN107064497A (en) * | 2017-06-13 | 2017-08-18 | 福建省农业科学院畜牧兽医研究所 | A kind of portable electrophoresis and photographing device and its application method |
| CN108226109A (en) * | 2017-12-12 | 2018-06-29 | 安徽师范大学 | A kind of simple gel imaging device |
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| CF01 | Termination of patent right due to non-payment of annual fee |