CN2503865Y - Medicine released support - Google Patents

Medicine released support Download PDF

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Publication number
CN2503865Y
CN2503865Y CN01232493U CN01232493U CN2503865Y CN 2503865 Y CN2503865 Y CN 2503865Y CN 01232493 U CN01232493 U CN 01232493U CN 01232493 U CN01232493 U CN 01232493U CN 2503865 Y CN2503865 Y CN 2503865Y
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China
Prior art keywords
bare bracket
drug
type support
release type
drug release
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Expired - Lifetime
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CN01232493U
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Chinese (zh)
Inventor
蒲忠杰
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Lepu Medical Technology Beijing Co Ltd
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Individual
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Abstract

The utility model discloses a supporting frame for releasing effective drug. The effective drug mixed in biological absorbent high molecular material, and the mixture of the drug and the biological absorbent high molecular material are stored in slits and holes in the net ring of the supporting frame and coated on the inner and the outer surfaces of the supporting frame; after the supporting frame is implanted into the human body, the effective drug coated on the surfaces of the supporting frame and stored in the net ring of the supporting frame is gradually released out while the high molecular material is absorbed by the human body. The drug stored in the ring net of the supporting frame can make the drug total content in the supporting frame main body increased by more than 40 percent to the existing drug supporting frame, and the drug releasing time is prolonged.

Description

Drug release type support
Technical field
This utility model relates to medical apparatus, specifically a kind of drug release type support, and it is mainly used to expand the various pipelines of tissue, such as cardiovascular, cerebrovascular, esophagus, intestinal, urethra etc.
Technical background
The various pipelines of Stent treatment human body are recent two decades medical domains with the fastest developing speed.Chinese patent ZL98206577.9, ZL99200308.3, ZL99257673.3 has invented various supports.In fact also there are some problems in Stent, such as the coronary artery bracket that is implanted in coronary artery, the restenosis rate of 10-30% is arranged; Implant the support of esophagus, its cancer condition of illness might stop up esophagus by the support expansion again again.For this reason, people begin to note developing the support with curative effect of medication effect.This support, can be with the cardiovascular that stops up, esophagus, intestinal expansion, can discharge the medicine of different purposes to the local field of support contact by certain speed again, prevent to be expanded the restenosis of blood vessel, the growing up or the formation of anti-tampon etc. of esophageal carcinoma symptom of suppressing to be expanded extruding.
U.S. Pat 6,153 is invented a kind of coating stent of medicine 252 (on November 28th, 2000).In this coating stent of medicine, but active drug be mixed in the macromolecule of bio-absorbable (Biodegradable), be coated on the inside and outside wall of support the about 5 μ m of coating thickness.
Patent US5 invents a kind of drug stent 891,108 (on April 6th, 1999).This support is become by the hollow metal filament winding, and active drug is contained in the centre of metal hollow silk, in the side of silk aperture is arranged, after support is inserted, medicine along aperture to exosmosis.
Patent US6, the support of 153,252 inventions is because its technologic feasibility might be practical.But because medicine only is coated on the outer wall, coating layer thickness is subjected to factor affecting such as geometrical factor and adhesion, again can not be too thick, cause US6 like this, the drug stent of 153,252 inventions, the active drug amount is little in the coat, release time is shorter, might finish with regard to discharging by active drug in very short time, and can't satisfy therapeutic effect.On the other hand, the stent drug coating thickness can only uniform distribution in entire bracket, can't satisfy medicine discharges different doses at the support different parts requirement.
In sum, prior art has improvement, perfect necessity, increases the new varieties of efficient better medicament release type support.
Summary of the invention
The purpose of this utility model provides a kind of drug release type support, and technology is simple, and the medicine storage amount is big, and pharmaceutical release time is long.
The purpose of this utility model is achieved in that
A kind of drug release type support, the tubular body of its bare bracket for constituting by a plurality of disjunctor net rings, the material of this bare bracket is the biocompatibility metal or alloy, it is characterized in that:
A. machine-processed by the inner storage of the bare bracket of forming by aperture that distributes according to certain rules and/or slit on the anchor ring of the net ring of bare bracket;
B. in the inner storage mechanism of this bare bracket, storing active drug bioresorbable macromolecule mixture;
C. on this bare bracket surface, applying active drug bioresorbable macromolecule mixture.
Support outmost surface behind described coating hybrid medicine also is coated with the resistance permeation coating of sustained release speed.
Also be coated with on described bare bracket surface and promote active drug Bioabsorbable macromolecule mixture to apply ability, biocompatibility macromolecule adherent coating, this adherent coating are applying active drug bioresorbable macromolecule mixture outward.
The expanding support of described bare bracket for being made by biocompatibility metal and metal alloy can be balloon-expandable, also can be self-expansion type.
The aperture of the inner storage mechanism of described bare bracket is rounded, rectangle, and triangle, polygon, any in the semicircle, their size is not more than the net ring width of bare bracket.
The distribution of aperture in the described bare bracket net ring in net ring can be one to drain into many rows and distribute, and can be uniform distribution, also can be non-uniform Distribution; This aperture can be a through hole, also can be blind hole, and this blind hole can be the single face blind hole, also can be two-sided blind hole.
Slit in the described bare bracket net ring can be a row or multi-row distribution along bare bracket net ring, and it can be in the disconnection Anywhere of net ring, this slit can be the upper and lower groove that communicates, also can be for end groove is arranged, this groove can be the single face groove, also can be two-sided groove.
Described active drug can be a chemicals, bio-pharmaceutical, and gene base medicine, and it can be a kind of medicine, also can be the mixture of two or more medicines.
Described storage, the material that is coated on the bioresorbable macromolecule mixture of bare bracket have the bioresorbable macromolecular material of biocompatibility for all.
The material of described resistance permeation coating is and the biological absorptive material of all biocompatibility that its thickness is between 1 μ m-50 μ m.
The material of described adherent coating is and all biocompatible materialses that thickness is between 1 μ m-50 μ m.
Described biocompatibility metal and alloy are the biocompatible materials of all Metal Substrate, or the composite of their compositions.Can be rustless steel, NiTi memorial alloy, Ti alloy, any in the gold-plated stainless steel composite material and combination thereof.
This utility model has following actively useful effect:
Drug stent of the present utility model, advantage such as it is big to have a medicament contg, and release time is long.
Fig. 6, Fig. 7 have compared the structure of this patent and existing drug release type support.Obviously as seen, support of the present utility model significantly increases the content of dispersion of this drug release type support owing to the medicine that is stored in " storage mechanism ".Give one example at this and to describe.The width of supposing bare bracket is 125 μ m, and thickness is 125 μ m, and face coat thickness is 5 μ m, and hole diameter is 25 μ m, and aperture becomes single uniform distribution (as Fig. 8, Fig. 9), and the density of little pore size distribution is 20 μ m.The existing stent drug mixture content of the long bare bracket net of every 1mm ring is 26 * 10 5μ m 3, and this stent drug content is 38 * 10 5μ m 8, improve 45% more than.If with reference to support shown in Figure 13, its medicinal mixture content will further improve.
The rate of release of this stent drug is by the dissolving infiltration rate control of bioresorbable macromolecular material in the medicinal mixture in human body.The dissolving infiltration rate that can adjust the bioresorbable macromolecular material is in theory controlled the rate of release of medicine.This drug release type support is owing to some medicine leaves in " storage mechanism ", and the thickness of " storage mechanism " (suitable bare bracket thickness, usually between 100-200 μ m) be far longer than the thickness (being generally 5 μ m) of the coating that is coated in the bare bracket surface, human body react with it and make the dissolving of bioresorbable macromolecular material and the speed that absorbs very slow.Make drug release type support of the present utility model have support now, medicine can be kept the long period.
Description of drawings
Fig. 1 is the construction profile sketch map of the coating stent of medicine of this utility model use, is cylindrical stent embodiment;
The same Fig. 1 of Fig. 2 is truncated cone support embodiment;
The same Fig. 1 of Fig. 3 is the reducing support embodiment that two ends are big along its length, the centre is little;
The same Fig. 3 of Fig. 4 is cylindrical in the middle of along its length, and two ends are the reducing support embodiment of reducing truncated cone;
Fig. 5 is the plane outspread drawing of a kind of bare bracket embodiment of this utility model, and circular aperture is uniformly distributed on the net ring;
Fig. 6 is the cross section sectional structure sketch map of prior art drug release type support;
Fig. 7 is the cross section sectional structure sketch map of this utility model coating stent of medicine;
Fig. 8 is the plane outspread drawing of a kind of bare bracket embodiment of this utility model, and circular aperture is uniformly distributed on the net ring;
Fig. 9 is the partial enlarged drawing of a net ring among Fig. 8;
The same Fig. 8 of Figure 10 is the plane outspread drawing of another kind of bare bracket embodiment, and square aperture is uniformly distributed on the net ring;
Figure 11 is the partial enlarged drawing of a net ring among Figure 10;
Figure 12 shows the single net ring partial enlarged drawing of another bare bracket embodiment, and slit is uniformly distributed on the net ring;
Figure 13 shows the single net ring partial enlarged drawing of another bare bracket embodiment, and slit and circular hole mixed and alternate are distributed on the net ring;
The same Fig. 7 of Figure 14 is the plane outspread drawing of another bare bracket embodiment, and the circular hole uneven distribution is on the net ring;
The same Fig. 6 of Figure 15 is the structural representation that has the drug release type support embodiment of surface resistance permeation coating of the present utility model;
The same Fig. 6 of Figure 16 is the structural representation that has the drug release type support embodiment of adherent coating of the present utility model;
The same Fig. 6 of Figure 17 is the structural representation that has the drug release type support embodiment of adherent coating, medicinal mixture coating and resistance permeation coating of the present utility model;
Figure 18 is the local enlarged detail of a net ring among Figure 17.
Accompanying drawing number
1. bare bracket 101. nets encircle
2. store machine-processed 201. apertures, 202. slits
3. the medicine in the storage mechanism
4. medicinal mixture coating
5. resistance permeation coating
6. adherent coating
L. stent length B. support girth (π D)
D. support (disjunctor net ring tubular body) external diameter
D. shelf inner diameter
D1. the external diameter behind the rack outer surface coated medicament layer
D1. the internal diameter behind the support inner surface coated medicament layer
W. net ring width
L. store the pitch-row of the aperture of mechanism
T. store the width of the slit of mechanism
Specific embodiment
Please refer to Fig. 1 to Fig. 5, this utility model is a kind of drug release type support, the tubular body of its bare bracket for constituting by a plurality of disjunctor net rings, the material of this bare bracket is the biocompatibility metal or alloy, the main distinction feature of this utility model and prior art support is:
On the anchor ring of the net ring of bare bracket, see Fig. 5, Fig. 8, Fig. 9, Figure 10, Figure 11, Figure 12, Figure 13, Figure 14 by the inner storage machine-processed 2 of the bare bracket of forming by aperture 201 that distributes according to certain rules and/or slit 202.
Around this bare bracket net ring 101 and storing active drug bioresorbable macromolecule mixture 3 in the inner storage mechanism 2 of bare bracket and see Fig. 7;
On the surface of this bare bracket 1, apply active drug bioresorbable macromolecule mixture 4 and seeing Fig. 7.
In the embodiment shown in fig. 15, also be coated with the resistance permeation coating 5 of sustained release speed in the bare bracket outmost surface.
Figure 16, Figure 17, embodiment illustrated in fig. 18 in, the bare bracket outer surface also be coated with promote active drug Bioabsorbable macromolecule mixture apply ability, biocompatibility macromolecule adherent coating 6, this adherent coating is applying active drug bioresorbable macromolecule mixture 4 outward.
During enforcement, the expanding support of described bare bracket for being made by biocompatibility metal and metal alloy can be balloon-expandable, also can be self-expansion type.
During enforcement, the aperture of the inner storage mechanism of described bare bracket is rounded, rectangle, and triangle, polygon, any in the shapes such as semicircle, their size is not more than the net ring width of bare bracket.
During enforcement, the distribution of the aperture in the described bare bracket net ring in the net ring can be that a row sees that Fig. 9, Figure 11 arrange distribution at the most, can be uniform distribution, also can be that non-uniform Distribution is seen Figure 14, also can be non-uniform Distribution; This aperture 201 can be a through hole, also can be blind hole, and this blind hole can be the single face blind hole, also can be two-sided blind hole.
During enforcement, slit in the described bare bracket net ring, can distribute along bare bracket net ring one row and see Figure 12, or many row's distributions, it can be in the disconnection Anywhere of net ring, and it can be in the disconnection Anywhere of net ring, the groove that this slit 202 can upper and lowerly communicate, also can be for end groove is arranged, this groove can be the single face groove, also can be two-sided groove.
During enforcement, described active drug can be a chemicals, bio-pharmaceutical, and gene base medicine, and it can be a kind of medicine, also can be the mixture of two or more medicines.
During enforcement, described storage, be coated with the bioresorbable macromolecule that invests bare bracket, the material of mixture has the bioresorbable macromolecular material of biocompatibility for all, they can be AliphaticPolysters elastoners, Polyethe-esters, Polyalkylenes oxalates, Polyiminocarbonates, any among the Polyorthoesters.
During enforcement, the material of described resistance permeation coating is and the biological absorptive material of all biocompatibility that its thickness is between 1 μ m-50 μ m.
During enforcement, the material of described adherent coating is and all biocompatible materialses that thickness is between 1 μ m-50 μ m.
During enforcement, described biocompatibility metal and alloy are the biocompatible materials of all Metal Substrate, or the composite of their compositions.Such as rustless steel, NiTi memorial alloy, Ti alloy, gold-plated stainless steel composite material
Construction features of the present utility model and clinical practice:
Drug release type support of the present utility model is the bare bracket of being made by biocompatible materials, riddle the active drug bioresorbable macromolecule mixture in " storage mechanism " net, active drug bioresorbable macromolecule mixture three parts that are coated on the bare bracket surface constitute.
Bare bracket before applying, by various biocompatible materials, as: rustless steel, marmem, biology can be inhaled the property received macromolecular material etc. and makes, and support shape cylindrical or truncated cone and bonded reducing along its length thereof is seen Fig. 1, Fig. 2, Fig. 3, Fig. 4.Support can be balloon expandable stent, also can be the self-expansion type support.On support net ring, a lot of apertures that distribute are according to certain rules arranged, this aperture is referred to as " storage mechanism ".These apertures provide the space for the storage of medicine.Aperture can be any interior what shape, such as circle, and semicircle, rectangle, square, triangle etc., but be preferably circular.The size of circle is preferably 5 μ m-50 μ m less than bare bracket net ring width.These apertures distribute according to certain rules, such as uniform distribution, but also non-uniform Distribution.After the narrow meshed bare bracket coated medicament coating, medicine be filled in the support net around and " storage mechanism " lining.Advantages such as it is simple that drug stent of the present utility model has technology, and the medicine storage amount is big, and release time is long.
Fig. 8, Fig. 9 have illustrated a kind of typical bare bracket expanded view.In this bare bracket expanded view, the clearly visible small sircle hole that is present in the bare bracket net ring.This circular hole is uniform distribution in whole bare bracket.After this bare bracket applied through medicine, active drug and bioresorbable macromolecular material mixture were full of these circular holes, thereby make medicine be stored in these apertures.In Fig. 9, aperture only has a row in net ring, in fact also can make two rows, even arranges aperture more and be distributed on the net ring.Among Fig. 9, any change of little hole geometry does not influence the essence of this utility model support.
Figure 10, Figure 11 have provided a kind of bare bracket plane outspread drawing that is made of " storage mechanism " square aperture.
The drug release type support of the present invention design is applicable to the bare bracket of any style and pattern.Fig. 5 has provided another flat expanded view of bare bracket that has " storage mechanism ".In this support, circular aperture is uniformly distributed in the support net ring.
The bare bracket plane outspread drawing that Figure 12 has provided another kind to have " storage mechanism ".In this figure, " storage mechanism " is the slit that distributes along the net ring.These slits are some local disconnection of net ring, and the width of slit is less than the width of net ring, and best width dimensions is between the 1 μ m-50 μ m.Look slit width and net ring width, narrow fluffy many row's distributions of also can making.
With respect to the aperture among Fig. 8, Fig. 9, Figure 11 and Fig. 5, the slit of Figure 12 signal has bigger medicine storage capacity.But because slit must be at some local fracture, this has just caused at slit incision position medicine amount and has obviously reduced.In order to subdue the generation of this situation, Figure 13 has illustrated a kind of bare bracket plane outspread drawing that has aperture and slit simultaneously.The bare bracket of this slit and aperture hybridization type has the high and equally distributed characteristics of medicament contg simultaneously.
The various bare brackets with " storage mechanism " that Fig. 5, Fig. 8 to Figure 13 provide, medicine is uniformly distributed on the support.During practical application, can require the medicament contg of some part of support to be different from other positions.This utility model provides the probability that realizes this requirement, and " storage mechanism " in the distribution density of support different parts, can reach this requirement as long as just change.Figure 14 has provided a kind of bare bracket plane outspread drawing.Aperture is lower in the two ends of support distribution density, and distribution density is higher at the middle part of support.The middle part of this drug release type support has than the more release amount of medicine in end.
Drug stent of the present utility model can further apply other one deck on the medicinal mixture coating, even the layer high molecule thin film, and the main effect of this layer film is the medicinal mixture coating Chinese medicine rate of release that further slows down, and is called the resistance permeable formation at this.It could dissolve absorption behind the certain hour after support is inserted human body, with the rate of release of this medicine layer that slows down, this resistance permeable formation can be made by the water-soluble macromolecular material usually, and Figure 15 signal has the drug release type support that hinders permeable formation.
This drug release type support also can be before the coated medicament mixture, earlier with bare bracket surface-coated one deck macromolecule membrane coating.The effect of this film coating is an adhesiveness of improving the medicinal mixture coating.It is generally made by adhesiveness excellent biocompatibility macromolecular material.After this layer adherent coating evenly is coated on the bare bracket surface, can make the coating of medicinal mixture coating become easy.Claim that at this this coating is an adherent coating.The drug release type support that has adherent coating, as shown in figure 16.
This drug release type support can have coating of adhesiveness simultaneously, medicinal mixture coating and resistance permeation coating such as Figure 17, shown in Figure 180, its better effects if.
This utility model is stored in " storage mechanism " and the medicinal mixture on bare bracket surface is made up of active drug and carrier two parts.The stent applications field is different with the medication purpose, and active drug can be done corresponding conversion.
This drug release type support, the active drug in its coating can be any medicines.Mainly comprise following a few class: the preventing restenosis of blood vessel medicine; Preventing thrombosis forms medicine; The anticancer medicine of growing up; Antibiotic medicine etc.
Concrete active drug comprises (but not exclusively placing restrictions on): Sirolimus; Paclitaxel; Heparin; Aspirin; Coumadin; Urokinase; Hirudin; Streptokinase; Antiproliferaties (merhotrexate, fluorouracil, adriamycin); Antioxidants (ascorbic acid, beta carotene, vitamin E); Elastin; Collagen; Infegrins etc.Can contain a kind of active medicine in the mixture, also may contain the active medicine of two or more different therapeutical effect simultaneously.
The effect of carrier is to form thin film at rack surface, with pharmaceutical pack with which between, the rate of release of control medicine.
Carrier material must satisfy following condition:
1. it must have bioresorbable, (Biodegradable);
2. it must have thin film formation (Film-forming) ability.When the bare bracket surface-coated, can not lump.
3. the thin film that is formed by it must can bear certain power and not deform, ties and split, fall piece.
Can be applied to the novel biological absorptive material of this reality and comprise following a few class, they are: aliphatic Polysters; Polyether-esters; Polyalkylenes oxalates; Polyimino carbonates; Polyorthoesters; Polyoxoxaesters; Polyamidoesters; And above-mentioned all kinds of compositions.The most suitable Bioabsorbable macromolecular material of the present utility model is Aliphatic polysters.
Above-mentioned material is an English name, mostly is new material, does not still have Chinese pool name.

Claims (12)

1. drug release type support, the tubular body of its bare bracket for constituting by a plurality of disjunctor net rings, the material of this bare bracket is the biocompatibility metal or alloy, it is characterized in that:
A. machine-processed by the inner storage of the bare bracket of forming by aperture that distributes according to certain rules and/or slit on the anchor ring of the net ring of bare bracket;
B. in the inner storage mechanism of this bare bracket, storing active drug bioresorbable macromolecule mixture;
C. on this bare bracket surface, applying active drug bioresorbable macromolecule mixture.
2. drug release type support as claimed in claim 1 is characterized in that: the support outmost surface behind described coating hybrid medicine also is coated with the resistance permeation coating of sustained release speed.
3. drug release type support as claimed in claim 1, it is characterized in that: also be coated with on described bare bracket surface and promote active drug Bioabsorbable macromolecule mixture to apply ability, biocompatibility macromolecule adherent coating, this adherent coating are applying active drug bioresorbable macromolecule mixture outward.
4. drug release type support as claimed in claim 1 is characterized in that: the expanding support of described bare bracket for making by biocompatibility metal and metal alloy, can be balloon-expandable, and also can be self-expansion type.
5. drug release type support as claimed in claim 1 is characterized in that: the aperture of the inner storage mechanism of described bare bracket is rounded, rectangle, and triangle, polygon, any in the semicircle, their size is not more than the net ring width of bare bracket.
6. drug release type support as claimed in claim 1 is characterized in that: the distribution of the aperture in the described bare bracket net ring in net ring can be one to drain into many rows and distribute, and can be uniform distribution, also can be non-uniform Distribution; This aperture can be a through hole, also can be blind hole, and this blind hole can be the single face blind hole, also can be two-sided blind hole.
7. drug release type support as claimed in claim 1, it is characterized in that: the slit in the described bare bracket net ring, can be a row or multi-row distribution along bare bracket net ring, it can be in the disconnection Anywhere of net ring, this slit can be the upper and lower groove that communicates, also can be for end groove is arranged, this groove can be the single face groove, also can be two-sided groove.
8. drug release type support as claimed in claim 1 is characterized in that: described active drug can be a chemicals, bio-pharmaceutical, and gene base medicine, and it can be a kind of medicine, also can be the mixture of two or more medicines.
9. drug release type support as claimed in claim 1 is characterized in that: described storage, the material that is coated on the bioresorbable macromolecule mixture of bare bracket have the bioresorbable macromolecular material of biocompatibility for all.
10. drug release type support as claimed in claim 1 is characterized in that: the material of described resistance permeation coating is and the biological absorptive material of all biocompatibility that its thickness is between 1 μ m-50 μ m.
11. drug release type support as claimed in claim 1 is characterized in that: the material of described adherent coating is and all biocompatible materialses that thickness is between 1 μ m-50 μ m.
12. drug release type support as claimed in claim 1 is characterized in that: described biocompatibility metal and alloy, be the biocompatible materials of all Metal Substrate, or the composite of their compositions.Can be rustless steel, NiTi memorial alloy, Ti alloy, any in the gold-plated stainless steel composite material and combination thereof.
CN01232493U 2001-08-01 2001-08-01 Medicine released support Expired - Lifetime CN2503865Y (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102113927A (en) * 2009-12-30 2011-07-06 微创医疗器械(上海)有限公司 Self-expanded stent
CN102908171A (en) * 2011-08-02 2013-02-06 倍捷医疗科技江苏有限公司 Human body lumen therapeutic device
CN103330607A (en) * 2013-06-27 2013-10-02 河南科技大学 Self-retracting intraesophageal bracket capable of carrying radiation elements for partial radiotherapy
CN104352293A (en) * 2014-11-25 2015-02-18 北京航空航天大学 Drug eluting stent capable of reducing late thrombosis
CN106963525A (en) * 2012-01-27 2017-07-21 美敦力瓦斯科尔勒公司 Hollow medicine filling bracket and the method for forming the hollow medicine filling bracket
CN107095728A (en) * 2017-05-19 2017-08-29 东莞颠覆产品设计有限公司 Carried stent in tube chamber

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102113927A (en) * 2009-12-30 2011-07-06 微创医疗器械(上海)有限公司 Self-expanded stent
CN102908171A (en) * 2011-08-02 2013-02-06 倍捷医疗科技江苏有限公司 Human body lumen therapeutic device
CN106963525A (en) * 2012-01-27 2017-07-21 美敦力瓦斯科尔勒公司 Hollow medicine filling bracket and the method for forming the hollow medicine filling bracket
CN106963525B (en) * 2012-01-27 2019-12-20 美敦力瓦斯科尔勒公司 Hollow drug-filled stents and methods of forming the same
CN103330607A (en) * 2013-06-27 2013-10-02 河南科技大学 Self-retracting intraesophageal bracket capable of carrying radiation elements for partial radiotherapy
CN103330607B (en) * 2013-06-27 2015-07-01 河南科技大学 Self-retracting intraesophageal bracket capable of carrying radiation elements for partial radiotherapy
CN104352293A (en) * 2014-11-25 2015-02-18 北京航空航天大学 Drug eluting stent capable of reducing late thrombosis
CN107095728A (en) * 2017-05-19 2017-08-29 东莞颠覆产品设计有限公司 Carried stent in tube chamber

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ASS Succession or assignment of patent right

Owner name: BEIJING YUEPU MEDICAL APPARATUS CO. LTD.

Free format text: FORMER OWNER: PU ZHONGJIE

Effective date: 20040528

C41 Transfer of patent application or patent right or utility model
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Effective date of registration: 20040528

Address after: 102200 Beijing City, Changping District science and Technology Park of Zhongguancun science and Technology Building 3 layer Beikong Guo Libin

Patentee after: Beijing Lepu Medical Device Co., Ltd.

Address before: 723001 No. 106, Chen Jiaying family building, Hanzhoung Teachers College, Hanzhoung, Shaanxi

Patentee before: Pu Zhongjie

C56 Change in the name or address of the patentee

Owner name: LE PU (BEIJING) MEDICAL DEVICES CO.

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Address after: Beijing City, Changping District Zhongguancun Science Park Beikong science and Technology Building 3 floor, zip code: 102200

Patentee after: Lepu (Beijing) Medical Instrument Co., Ltd.

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Expiration termination date: 20110801

Granted publication date: 20020807