CN1762330A - Medicine-loading sustained-releasing nanosphere alimentary tract stent - Google Patents
Medicine-loading sustained-releasing nanosphere alimentary tract stent Download PDFInfo
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Abstract
An alimentary canal supporting stand with micro-nanometer ball carrying medicine, belonging to the medical technique field, comprising: supporting stand, back lining layer, micro-nanometer ball carrying medicine, storing layer for the micro-nanometer ball carrying medicine and protective layer, the back lining layer is covered on the surface of the supporting stand, the back lining layer clings tightly to the supporting stand, the storing layer for the micro-nanometer ball carrying medicine is on the back lining layer, the protective layer is the outset layer and is located above the storing layer, and the micro-nanometer ball carrying medicine is located in the storing layer. The invention is used to treat the good or bad narrow of the esophagus and other alimentary canal, it not only possesses mechanical expansion function but also the function of partial treatment, the storing layer for the micro-nanometer ball carrying medicine will release the medicine directly to the tumor tissue or other pathology tissue to treat the good or bad narrow of the alimentary canal, which can solve the obstruction resulted from the narrow in the long run.
Description
Technical field
What the present invention relates to is the member of a kind of medicine and technical field of medical instruments, specifically, is a kind of medicine-loading sustained-releasing nanosphere alimentary tract stent.
Background technology
Digestive tract is good, malignant stricture is common clinically disease.Wherein, digestive tract malignant stricture digestive tract cancer patient's disease occurred frequently especially.Except surgical resection, radiation and chemotherapy method, interventional therapy means commonly used mainly contain balloon expandable (mainly for benign stricture) and support is inserted.For middle and advanced stage digestive tract cancer patient, it is considerable palliative treatment means that support is inserted, and can effectively improve middle and advanced stage digestive tract cancer patient's quality of life, prolongs life span.But still there are following 2 deficiencies at least in conventional metals support and overlay film frame: 1. do not possess real local therapeutic effects, only play the effect of appeasing that mechanical support and short-term subtract disease, and powerless to the generation that prevents the restenosis due to the tumor growth; Though overlay film frame can prevent the interior growth (ingrowth) of tumor to a certain extent, but still can not prevent the vertical undue growth (overgrowth) and the repressive restenosis (oppressing stricture) of tumor.2. metal rack still need cooperate the whole body drug treatment after implanting, but the cancerous tissue blood drug level after the whole body administration is low, is difficult to reach effective treatment concentration; If want to reach therapeutic effect, just must carry out heavy dose of long term administration treatment, but most cancer therapy drug toxic and side effects is very big, organ lesion or the extremely weak middle and advanced stage digestive tract cancer patient of body constitution have appearred for majority, and be worthless.Be head it off, can reach topical treatment, reduce the purpose of toxic and side effects by medicine is carried on the support in every way.
Find by prior art documents, the Chinese patent publication number is CN2638761Y, open day be JIUYUE in 2004 8 days, patent name is: the esophagus drug stent, this patent readme is: " a kind of by carrier implant patient's esophageal tumor narrow section the esophagus drug stent, it by nitinol alloy wire graticule mesh support, coat the medical polymer film of graticule mesh support, being coated in has silicon rubber film and the trocar sheath that medicine oozes out the hole to constitute on the antitumor drug coating on the medical polymer film, the coated coating.Esophagus drug stent after the implantation, it except the performance and function that keep esophageal stents appear, its treatment with suppress the antitumor drug coating and slowly ooze out contact and reach the purpose for the treatment of esophageal tumor with esophageal tumor from oozing out the hole." its weak point is as follows: the one, the be written into amount of medicine in macromolecular material not enough (the too high mechanical performance that will influence film of drug loading); the 2nd, the rate of release of 5-fluorouracil in silicone rubber medicine film is slower; behind release-controlled film, and the release of medicine will be too slow; At last, controlled release layer with holes very easily is subjected to breakage in the support course of conveying, thereby influences release rate of drugs greatly.And be pharmaceutical carrier with the micro-nano-sphere; can improve drug loading greatly; and the dissolution rate and the permeable membrane that help to improve medicine absorb; at last on the micro-nano ball surface coated with the water solublity protecting film; can protect medicine carrying micro-nano ball layer; and the damage of protecting film itself can't influence drug release rate, because of this layer only shields, implants and can dissolve disappearance voluntarily.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, a kind of medicine-loading sustained-releasing nanosphere alimentary tract stent is provided.Make it be used for the treatment of esophagus and other gastral benign and malignant stenosis, not only has the mechanicalness dilating effect, and has a local therapeutic effects, the micro-nano ball storage layer will directly discharge medicine in tumor tissues or other pathological tissues, the digestive tract benign and malignant stenosis is treated, and what permanent solution digestive tract benign and malignant stenosis caused blocks.
The present invention is achieved by the following technical solutions; the present invention includes: support, backing layer, medicine carrying micro-nano ball, medicine carrying micro-nano ball storage layer and protective layer; backing layer wraps at rack surface; backing layer is close to support; medicine carrying micro-nano ball storage layer is located on the backing layer; protective layer is an outermost layer, and protective layer is located on the medicine carrying micro-nano ball storage layer, and the medicine carrying micro-nano ball is located in the medicine carrying micro-nano ball storage layer.
Described backing layer, its material are following any one or multiple: silicone rubber, politef, polyurethane, polrvinyl chloride, polyethylene, aluminium foil, polypropylene, polystyrene, polyethylene terephthalate, Merlon, Carmomer, carboxymethyl cellulose, hydroxypropyl cellulose, hyaluronic acid, poly-aspartic-acid, polyglutamic acid, sulphuric acid levulose acid anhydride, polystyrolsulfon acid, polyvinyl sulfuric acid ester, chondroitin sulfate, heparin bioadhesive material; Polyvinyl pyrrolidone, cross-linking polyethylene pyrrolidone, polyvinyl alcohol, ethylene vinyl acetate copolymer, Polyethylene Glycol, poloxamer, polyacrylic, starch and derivant thereof, cellulose and derivant thereof, arabic gum, gelatin, chitosan, alginate.
Described backing layer can be monolayer, also can be multilamellar.
Described backing layer can contain the pressure sensitive adhesive composition, and the pressure sensitive adhesive component content is 0-100%.
Described pressure sensitive adhesive, its material are following any one or multiple: rubber type pressure-sensitive adhesive, thermoplastic elastomer pressure-sensitive adhesive, Acrylic Pressure Sensitive Adhesive, organosilicon.
Described medicine carrying micro-nano ball, its particle diameter are 10nm-990um.Described micro-nano ball carrier material is following any one or a few: albumin, gelatin, collagen protein, ethyl cellulose, starch, crosslinked starch, polylactide, poly-Acetic acid, hydroxy-, bimol. cyclic ester, Acetic acid, hydroxy-, bimol. cyclic ester/lactide copolymer, polycaprolactone, poly-Alpha-hydroxy acids, polyamino acid, chitosan, sodium alginate.
Described medicine carrying micro-nano ball can carry one or more anti-proliferative drug and antitumor drug.
Described anti-proliferative drug comprises: paclitaxel, taxotere, rapamycin, dexamethasone, sirolimus, aryltretinoin ethylester, probucol.
Described antitumor drug comprises: alkylating agent, antimetabolite, antitumor antibiotics class, plant extract and derivatives class thereof, dioxygen piperazidine class, platinum class, antibody curing cancer drug, gene therapy medicament.
Described alkylating agent comprises: nitrogen mustards, Ethylenimine class, methanesulfonates and hexahydroxylic alcohols derivant, nitrosoureas, hydrazine class, triazenes imidazoles.
Described antimetabolite comprises: pyrimidine antagonist, purine antagonist, folic acid antagonists.
Described antitumor antibiotics class comprises: peptide antibiotics, quinones antibiotic.
Described plant extract and derivatives class thereof comprise: taxanes, vinblastine, camptothecin.
Described medicine carrying micro-nano ball storage layer, its thickness is 0.1um-3000um.
Described protective layer is water-solubility membrane or biodegradable film, perhaps for containing the Nondegradable material membrane in hole.
Described water-solubility membrane, its material are following any one or a few: polyvinyl pyrrolidone, polyvinyl alcohol, Polyethylene Glycol, poloxamer, polyacrylic acid, sodium polyacrylate, carbomer, starch, dextrin, methylcellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hypromellose, arabic gum, gelatin, chitosan, sodium alginate, hyaluronic acid, albumin, agar, poly-maltotriose, xanthan gum, guar gum.
Described biodegradable film, its material are following any one or a few: polylactide and poly-Acetic acid, hydroxy-, bimol. cyclic ester and copolymer thereof, polybutylcyanoacrylate, polycaprolactone, poly-para-dioxane ketone and copolymer, polyanhydride, poloxamer, poly phosphazene, L-tyrosine derivative macromolecule, poe, polyether ester, polyesteramide, poly(ether-urethane), poly phosphate, amino acids polymer, natural polysaccharide and modified xylanase, oxidized cellulose, Fibrinogen, fibrin, collagen protein, gelatin and Biodegradable hydrogel.
The described Nondegradable material that contains the hole is meant following any one or a few: silicone rubber, silicones, EU, PAUR, ethylene/vinyl acetate copolymer, Merlon, politef, polrvinyl chloride, polyethylene, polypropylene, polystyrene, polyethylene terephthalate.
Medicine-loading sustained-releasing nanosphere alimentary tract stent of the present invention comprises support, backing layer, medicine carrying micro-nano ball, medicine carrying micro-nano ball storage layer and protective layer.The backing layer of innermost layer is close to support, prevents that drug solution from oozing out the solid-liquid matter that does not also allow in the digestive tract and immersing from backing layer.Outermost layer is a protecting film, can protect medicine carrying micro-nano ball storage layer to avoid polluting, and in the complete implant into body of medicine-loading sustained-releasing nanosphere alimentary tract stent.The loss of protective film and the damaged release that can not influence medicine, this is that general release-controlled film, organic short infiltration layer or medicine film layer itself are inaccessible as protecting film institute.After in the medicine-loading sustained-releasing nanosphere alimentary tract stent implant into body, the micro-nano ball storage layer directly contacts and carries out the release of medicine with pathological tissues, thereby plays the effect of part, targeting, slow administration.
The present invention is pharmaceutical carrier with the micro-nano ball, can improve drug loading greatly, and helps to improve the stripping behavior and the permeable membrane absorption of medicine, and the protecting film of micro-nano ball surface coverage can be protected medicine carrying micro-nano ball layer, is convenient to support and carries.The damage of protecting film itself can't influence drug release rate, because protecting film only shields, and control drug release not.The prepared micro-nano ball of the present invention has excellent particle size and particle size distribution, higher entrapment and carrying drug ratio.The micro-nano ball appendix can carry out targeting, slowly and long-term release after on the support near position, digestive tract tumor position (and mucosa), the digestive tract that treatment innocent and malignant tumour and other pathological changes cause blocks or be narrow.
The specific embodiment
Embodiment 1
The present invention includes: support, backing layer, medicine carrying micro-nano ball, medicine carrying micro-nano ball storage layer, protective layer; backing layer wraps at rack surface; backing layer is close to support; the medicine carrying micro-nano ball is stated from the medicine carrying micro-nano ball storage layer; medicine carrying micro-nano ball storage layer is located on the backing layer, and protective layer is located on the medicine carrying micro-nano ball storage layer.
Described backing layer is a monolayer, and its material is a silicone rubber.
Described backing layer contains rubber type pressure-sensitive adhesive, and the pressure sensitive adhesive component content is 50%.
Described micro-nano ball carrier material is an albumin, and described medicine carrying micro-nano ball carries a kind of antitumor drug camptothecin, and described medicine carrying micro-nano ball is 1um.
Described medicine carrying micro-nano ball storage layer, its thickness is 100um.
Described protective layer is to be the water-solubility membrane polyvinyl pyrrolidone.
The prepared support of the present invention, be used for the treatment of narrow that the malignant biliary tumor causes, not only has the mechanicalness dilating effect, and the medicine that discharges can be directly acted near pathological tissues or its, thereby carry out slowly, long term administration narrow treatment that the malignant biliary tumor is caused in the part.
Embodiment 2
The present invention includes: support, backing layer, medicine carrying micro-nano ball, medicine carrying micro-nano ball storage layer, protective layer; backing layer wraps at rack surface; backing layer is close to support; the medicine carrying micro-nano ball is stated from the medicine carrying micro-nano ball storage layer; medicine carrying micro-nano ball storage layer is located on the backing layer, and protective layer is located on the medicine carrying micro-nano ball storage layer.
Described backing layer is two-layer, and inner layer material is polyethylene and polyacrylic blend.Skin is a pressure sensitive adhesive, and its composition is the thermoplastic elastomer pressure-sensitive adhesive, and the pressure sensitive adhesive component content is 100%.
Described micro-nano ball carrier material is a gelatin, and described medicine carrying micro-nano ball is the anti-proliferative drug paclitaxel, and described medicine carrying micro-nano ball is 1nm.
Described medicine carrying micro-nano ball storage layer, its thickness is 1um.
Described protective layer is the biodegradable film, and material is natural polysaccharide.
The prepared support of the present invention, be used for the treatment of narrow that the esophagus malignant tumor causes, not only has the mechanicalness dilating effect, and the medicine that discharges can be directly acted near pathological tissues or its, thereby carry out slowly, long term administration narrow treatment that the malignant biliary tumor is caused in the part.
Embodiment 3
The present invention includes: support, backing layer, medicine carrying micro-nano ball, medicine carrying micro-nano ball storage layer, protective layer; backing layer wraps at rack surface; backing layer is close to support; the medicine carrying micro-nano ball is stated from the medicine carrying micro-nano ball storage layer; medicine carrying micro-nano ball storage layer is located on the backing layer, and protective layer is located on the medicine carrying micro-nano ball storage layer.
Described backing layer is two-layer, and the inner layer material of being close to support is a polyurethane, and cladding material is the acrylic compounds pressure sensitive adhesive.Described backing layer acrylic compounds pressure sensitive adhesive.
Described micro-nano ball carrier material is a starch, and described medicine carrying micro-nano ball antitumor drug is a cisplatin, and described medicine carrying micro-nano ball is 50um.
Described medicine carrying micro-nano ball storage layer, its thickness is 300um.
Described protective layer be for the Nondegradable film material that contains micropore be macropore silicone rubber.
The prepared support of the present invention, be used for the treatment of narrow that the esophagus malignant tumor causes, not only has the mechanicalness dilating effect, and the medicine that discharges can be directly acted near pathological tissues or its, thereby carry out slowly, long term administration narrow treatment that the esophagus malignant tumor is caused in the part.
Embodiment 4
The present invention includes: support, backing layer, medicine carrying micro-nano ball, medicine carrying micro-nano ball storage layer, protective layer; backing layer wraps at rack surface; backing layer is close to support; the medicine carrying micro-nano ball is stated from the medicine carrying micro-nano ball storage layer; medicine carrying micro-nano ball storage layer is located on the backing layer, and protective layer is located on the medicine carrying micro-nano ball storage layer.
Described backing layer, its material are monolayer, and material is a politef.
Described pressure sensitive adhesive, on backing layer, its material is silicone based.
Described micro-nano ball carrier material is Acetic acid, hydroxy-, bimol. cyclic ester/lactide copolymer, and described medicine carrying micro-nano ball is the alkylating agent 5-fluorouracil.Described medicine carrying micro-nano ball is 10um.
Described medicine carrying micro-nano ball storage layer, its thickness is 100um.
Described protective layer be for water soluble film material be chitosan.
The prepared support of the present invention, be used for the treatment of narrow that the esophagus malignant tumor causes, not only has the mechanicalness dilating effect, and the medicine that discharges can be directly acted near pathological tissues or its, thereby carry out slowly, long term administration narrow treatment that the esophagus malignant tumor is caused in the part.
Embodiment 5
The present invention includes: support, backing layer, medicine carrying micro-nano ball, medicine carrying micro-nano ball storage layer, protective layer; backing layer wraps at rack surface; backing layer is close to support; the medicine carrying micro-nano ball is stated from the medicine carrying micro-nano ball storage layer; medicine carrying micro-nano ball storage layer is located on the backing layer, and protective layer is located on the medicine carrying micro-nano ball storage layer.
Described backing layer is a monolayer, and its material is a politef.
Described pressure sensitive adhesive, on backing layer, its material is silicone based.
Described micro-nano ball carrier material is a gelatin, and described medicine carrying micron ball carrying anti-tumor medicine is a Bleomycin A5, and described medicine carrying microballoons is 500nm.
Described medicine carrying micro-nano ball storage layer, its thickness is 300um.
Described protective layer is to be water-solubility membrane, and its material is a hypromellose.
The prepared support of the present invention, be used for the treatment of narrow that malignant duodenal tumors causes, not only has the mechanicalness dilating effect, and the medicine that discharges can be directly acted near pathological tissues or its, thereby carry out slowly, long term administration narrow treatment that malignant duodenal tumors is caused in the part.
Embodiment 6
The present invention includes: support, backing layer, medicine carrying micro-nano ball, medicine carrying micro-nano ball storage layer, protective layer; backing layer wraps at rack surface; backing layer is close to support; the medicine carrying micro-nano ball is stated from the medicine carrying micro-nano ball storage layer; medicine carrying micro-nano ball storage layer is located on the backing layer, and protective layer is located on the medicine carrying micro-nano ball storage layer.
Described backing layer is a monolayer, and its material is the silicone rubber pressure sensitive adhesive.
Described micro-nano ball glue carrier material is a polycaprolactone, and the contained antitumor drug of described medicine carrying micro-nano ball is a rapamycin, and described medicine carrying micro-nano ball is 50um.
Described medicine carrying micro-nano ball storage layer, its thickness is 500um.
Described protective layer is to be hypromellose.
The prepared support of the present invention, be used for the treatment of narrow that the esophagus malignant tumor causes, not only has the mechanicalness dilating effect, and the medicine that discharges can be directly acted near pathological tissues or its, thereby carry out slowly, long term administration narrow treatment that the esophagus malignant tumor is caused in the part.
Embodiment 7
The present invention includes: support, backing layer, medicine carrying micro-nano ball, medicine carrying micro-nano ball storage layer, protective layer; backing layer wraps at rack surface; backing layer is close to support; the medicine carrying micro-nano ball is stated from the medicine carrying micro-nano ball storage layer; medicine carrying micro-nano ball storage layer is located on the backing layer, and protective layer is located on the medicine carrying micro-nano ball storage layer.
Described backing layer is a monolayer, and its material is a Merlon.
Described backing layer contains pressure sensitive adhesive composition polyisobutylene class pressure sensitive adhesive, and the pressure sensitive adhesive component content is 10%.
Described micro-nano ball carrier material is a crosslinked starch, but described medicine carrying micro-nano ball carrying anti-tumor medicine vinblastine, and described medicine carrying micro-nano ball is 30um.
Described medicine carrying micro-nano ball storage layer, its thickness is 500um.
Described protective layer is to be biological degradability membrane material poe.
The prepared support of the present invention, be used for the treatment of narrow that malignant tumor of colon causes, not only has the mechanicalness dilating effect, and the medicine that discharges can be directly acted near pathological tissues or its, thereby carry out slowly, long term administration narrow treatment that malignant tumor of colon is caused in the part.
Embodiment 8
The present invention includes: support, backing layer, medicine carrying micro-nano ball, medicine carrying micro-nano ball storage layer, protective layer; backing layer wraps at rack surface; backing layer is close to support; the medicine carrying micro-nano ball is stated from the medicine carrying micro-nano ball storage layer; medicine carrying micro-nano ball storage layer is located on the backing layer, and protective layer is located on the medicine carrying micro-nano ball storage layer.
Described backing layer is two-layer, and the material of internal layer is a polystyrene, and outer field material is the thermoplastic elastomer pressure sensitive adhesive.
Described nanometer ball carrier material is a starch, and described medicine carrying micro-nano ball can carry one or more anti-proliferative drug dexamethasone, and described medicine-carried nanospheres is 10nm.
Described medicine carrying micro-nano ball storage layer, its thickness is 100nm.
Described protective layer is for water-solubility membrane or is the biodegradable film, perhaps for containing the Nondegradable material membrane of micropore.
Described water soluble film material is the water-soluble material methylcellulose.
The prepared support of the present invention, be used for the treatment of narrow that the malignant biliary tumor causes, not only has the mechanicalness dilating effect, and the medicine that discharges can be directly acted near pathological tissues or its, thereby carry out slowly, long term administration narrow treatment that the malignant biliary tumor is caused in the part.
Embodiment 9
The present invention includes: support, backing layer, medicine carrying micro-nano ball, medicine carrying micro-nano ball storage layer, protective layer; backing layer wraps at rack surface; backing layer is close to support; the medicine carrying micro-nano ball is stated from the medicine carrying micro-nano ball storage layer; medicine carrying micro-nano ball storage layer is located on the backing layer, and protective layer is located on the medicine carrying micro-nano ball storage layer.
Described backing layer is a monolayer, and its material is a polystyrene.
Described backing layer can contain pressure sensitive adhesive composition Acrylic Pressure Sensitive Adhesive, and the pressure sensitive adhesive component content is 10%.
Described micro-nano ball carrier material is poly-Acetic acid, hydroxy-, bimol. cyclic ester, and described medicine carrying micro-nano ball carries JM-216, and described medicine carrying micro-nano ball is 50um.
Described medicine carrying micro-nano ball storage layer, its thickness is 1000um.
Described protective layer is to be water-solubility membrane, and its material is a sodium alginate.
The prepared support of the present invention, be used for the treatment of narrow that the large intestine malignant tumor causes, not only has the mechanicalness dilating effect, and the medicine that discharges can be directly acted near pathological tissues or its, thereby carry out slowly, long term administration narrow treatment that the large intestine malignant tumor is caused in the part.
Embodiment 10
The present invention includes: support, backing layer, medicine carrying micro-nano ball, medicine carrying micro-nano ball storage layer, protective layer; backing layer wraps at rack surface; backing layer is close to support; the medicine carrying micro-nano ball is stated from the medicine carrying micro-nano ball storage layer; medicine carrying micro-nano ball storage layer is located on the backing layer, and protective layer is located on the medicine carrying micro-nano ball storage layer.
Described backing layer is a monolayer, and its material is an ethylene vinyl acetate copolymer.
Described backing layer contains silicone ingredients, and the pressure sensitive adhesive component content is 60%.
Described micro-nano ball carrier material is a collagen protein, and described anti-proliferative drug is a rapamycin, and described medicine carrying micro-nano ball is 150nm.
Described medicine carrying micro-nano ball storage layer, its thickness is 10um.
Described protective layer be for water soluble film material be chitosan.
The prepared support of the present invention, be used for the treatment of narrow that the esophagus malignant tumor causes, not only has the mechanicalness dilating effect, and the medicine that discharges can be directly acted near pathological tissues or its, thereby carry out slowly, long term administration narrow treatment that the esophagus malignant tumor is caused in the part.
Embodiment 11
The present invention includes: support, backing layer, medicine carrying micro-nano ball, medicine carrying micro-nano ball storage layer, protective layer; backing layer wraps at rack surface; backing layer is close to support; the medicine carrying micro-nano ball is stated from the medicine carrying micro-nano ball storage layer; medicine carrying micro-nano ball storage layer is located on the backing layer, and protective layer is located on the medicine carrying micro-nano ball storage layer.
Described backing layer is two-layer, and inner layer material is an aluminium foil, and skin is a rubber type pressure-sensitive adhesive.
Described micro-nano ball carrier material is poly-Alpha-hydroxy acids, and the antitumor drug that described medicine carrying micro-nano ball can carry is a paclitaxel, and described medicine carrying micro-nano ball is 300nm.
Described medicine carrying micro-nano ball storage layer, its thickness is 3000um.
Described protective layer is for containing the Nondegradable material poly tetrafluoroethylene of macropore.
The prepared support of the present invention, be used for the treatment of narrow that stomach (cardia and pylorus place) malignant tumor causes, not only has the mechanicalness dilating effect, and the medicine that discharges can be directly acted near pathological tissues or its, thereby carry out slowly, long term administration narrow treatment that stomach (cardia and pylorus place) malignant tumor is caused in the part.
Claims (10)
1. medicine-loading sustained-releasing nanosphere alimentary tract stent; comprise: support, backing layer, medicine carrying micro-nano ball, medicine carrying micro-nano ball storage layer; it is characterized in that; comprise: protective layer, backing layer wrap at rack surface, and backing layer is close to support; medicine carrying micro-nano ball storage layer is located on the backing layer; protective layer is an outermost layer, and protective layer is located on the medicine carrying micro-nano ball storage layer, and the medicine carrying micro-nano ball is located in the medicine carrying micro-nano ball storage layer.
2. medicine-loading sustained-releasing nanosphere alimentary tract stent according to claim 1, it is characterized in that, described backing layer, its material are following any one or multiple: silicone rubber, politef, polyurethane, polrvinyl chloride, polyethylene, aluminium foil, polypropylene, polystyrene, polyethylene terephthalate, Merlon, Carmomer, carboxymethyl cellulose, hydroxypropyl cellulose, hyaluronic acid, poly-aspartic-acid, polyglutamic acid, sulphuric acid levulose acid anhydride, polystyrolsulfon acid, polyvinyl sulfuric acid ester, chondroitin sulfate, heparin bioadhesive material; Polyvinyl pyrrolidone, cross-linking polyethylene pyrrolidone, polyvinyl alcohol, ethylene vinyl acetate copolymer, Polyethylene Glycol, poloxamer, polyacrylic, starch and derivant thereof, cellulose and derivant thereof, arabic gum, gelatin, chitosan, alginate.
3. medicine-loading sustained-releasing nanosphere alimentary tract stent according to claim 1 and 2, it is characterized in that, described backing layer can contain the pressure sensitive adhesive composition, the pressure sensitive adhesive component content is 0-100%, described pressure sensitive adhesive, its material are following any one or multiple: rubber type pressure-sensitive adhesive, thermoplastic elastomer pressure-sensitive adhesive, Acrylic Pressure Sensitive Adhesive, organosilicon.
4. medicine-loading sustained-releasing nanosphere alimentary tract stent according to claim 1 is characterized in that, described medicine carrying micro-nano ball, its particle diameter are 10nm-990um.
5. medicine-loading sustained-releasing nanosphere alimentary tract stent according to claim 4, it is characterized in that, described micro-nano ball carrier, its material are following any one or a few: albumin, gelatin, collagen protein, ethyl cellulose, starch, crosslinked starch, polylactide, poly-Acetic acid, hydroxy-, bimol. cyclic ester, Acetic acid, hydroxy-, bimol. cyclic ester/lactide copolymer, polycaprolactone, poly-Alpha-hydroxy acids, polyamino acid, chitosan, sodium alginate.
6. medicine-loading sustained-releasing nanosphere alimentary tract stent according to claim 1, it is characterized in that, described medicine carrying micro-nano ball can carry one or more anti-proliferative drug and antitumor drug, described anti-proliferative drug comprises: paclitaxel, taxotere, rapamycin, dexamethasone, sirolimus, aryltretinoin ethylester, probucol, described antitumor drug comprises: alkylating agent, antimetabolite, antitumor antibiotics class, plant extract and derivatives class thereof, dioxygen piperazidine class, platinum class, antibody curing cancer drug, gene therapy medicament.
7. medicine-loading sustained-releasing nanosphere alimentary tract stent according to claim 6, it is characterized in that, described alkylating agent comprises: nitrogen mustards, Ethylenimine class, methanesulfonates and hexahydroxylic alcohols derivant, nitrosoureas, hydrazine class, triazenes imidazoles, described antimetabolite comprises: pyrimidine antagonist, purine antagonist, folic acid antagonists, described antitumor antibiotics class comprises: peptide antibiotics, quinones antibiotic, described plant extract and derivatives class thereof comprise: taxanes, vinblastine, camptothecin.
8. medicine-loading sustained-releasing nanosphere alimentary tract stent according to claim 1 is characterized in that, described medicine carrying micro-nano ball storage layer, and its thickness is 0.1um-3000um.
9. medicine-loading sustained-releasing nanosphere alimentary tract stent according to claim 1 is characterized in that, described protective layer is water-solubility membrane or biodegradable film, perhaps for containing the Nondegradable material membrane in hole.
10. medicine-loading sustained-releasing nanosphere alimentary tract stent according to claim 9, it is characterized in that, described water-solubility membrane, its material are following any one or a few: polyvinyl pyrrolidone, polyvinyl alcohol, Polyethylene Glycol, poloxamer, polyacrylic acid, sodium polyacrylate, carbomer, starch, dextrin, methylcellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hypromellose, arabic gum, gelatin, chitosan, sodium alginate, hyaluronic acid, albumin, agar, poly-maltotriose, xanthan gum, guar gum; Described biodegradable film, its material are following any one or a few: polylactide, poly-Acetic acid, hydroxy-, bimol. cyclic ester, poly (lactide-co-glycolide), polybutylcyanoacrylate, polycaprolactone, poly-para-dioxane ketone and copolymer thereof, polyanhydride, poloxamer, poly phosphazene, L-tyrosine derivative macromolecule, poe, polyether ester, polyesteramide, poly(ether-urethane), poly phosphate, the amino acids polymer, natural polysaccharide and modified xylanase thereof, oxidized cellulose, Fibrinogen, fibrin, collagen protein, gelatin and Biodegradable hydrogel; The described Nondegradable material that contains the hole is meant following any one or a few: silicone rubber, silicones, EU, PAUR, ethylene/vinyl acetate copolymer, Merlon, politef, polrvinyl chloride, polyethylene, polypropylene, polystyrene, polyethylene terephthalate.
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| CN 200510030443 CN1762330A (en) | 2005-10-13 | 2005-10-13 | Medicine-loading sustained-releasing nanosphere alimentary tract stent |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698319A (en) * | 2012-03-02 | 2012-10-03 | 首都医科大学附属北京朝阳医院 | Anti-tumor biological patch |
| CN103418036A (en) * | 2013-08-13 | 2013-12-04 | 山东省医疗器械研究所 | Bonding-type digestive tract support and production method thereof |
| CN106377290A (en) * | 2016-08-19 | 2017-02-08 | 北京派尔特医疗科技股份有限公司 | Drug-loaded titanium nail and preparation method thereof |
| CN106750388A (en) * | 2017-02-23 | 2017-05-31 | 青岛农业大学 | A kind of preparation method of Arabic gum hollow nano-sphere |
| CN107469156A (en) * | 2017-09-30 | 2017-12-15 | 焦德超 | A kind of film covering type Y type biliary tract prosthesises for being locally covered with chemotherapeutics |
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| CN102698319A (en) * | 2012-03-02 | 2012-10-03 | 首都医科大学附属北京朝阳医院 | Anti-tumor biological patch |
| CN103418036A (en) * | 2013-08-13 | 2013-12-04 | 山东省医疗器械研究所 | Bonding-type digestive tract support and production method thereof |
| CN106377290B (en) * | 2016-08-19 | 2018-06-22 | 北京派尔特医疗科技股份有限公司 | A kind of medicine-carried titanium nail and load medicine titanium nail and preparation method thereof |
| CN106377290A (en) * | 2016-08-19 | 2017-02-08 | 北京派尔特医疗科技股份有限公司 | Drug-loaded titanium nail and preparation method thereof |
| US10286117B2 (en) | 2016-08-19 | 2019-05-14 | B.J. Zh. F. Panther Medical Equipment Co. Ltd. | Titanium nail capable of loading drug and drug-loaded titanium nail and preparing method of the same |
| CN106750388A (en) * | 2017-02-23 | 2017-05-31 | 青岛农业大学 | A kind of preparation method of Arabic gum hollow nano-sphere |
| CN106750388B (en) * | 2017-02-23 | 2018-12-28 | 青岛农业大学 | A kind of preparation method of Arabic gum hollow nano-sphere |
| CN107469156A (en) * | 2017-09-30 | 2017-12-15 | 焦德超 | A kind of film covering type Y type biliary tract prosthesises for being locally covered with chemotherapeutics |
| CN107469156B (en) * | 2017-09-30 | 2020-04-14 | 郑州大学第一附属医院 | Laminated Y-shaped bile duct stent partially covered with chemotherapeutic drugs |
| CN112899215A (en) * | 2017-11-30 | 2021-06-04 | 山西加乐医疗科技有限责任公司 | Cell scaffold and preparation method thereof |
| CN109966564A (en) * | 2017-12-28 | 2019-07-05 | 先健科技(深圳)有限公司 | Carry medicine ball capsule and preparation method thereof |
| CN109528693A (en) * | 2018-12-20 | 2019-03-29 | 武汉科福新药有限责任公司 | A kind of rapamycin cataplasm and preparation method thereof |
| CN109528693B (en) * | 2018-12-20 | 2022-03-01 | 武汉科福新药有限责任公司 | Rapamycin cataplasm and preparation method thereof |
| CN109568336A (en) * | 2018-12-29 | 2019-04-05 | 江苏靶标生物医药研究所有限公司 | A kind of composition and its application of platinum-like compounds and chondroitin sulfate |
| CN109568336B (en) * | 2018-12-29 | 2021-10-08 | 江苏靶标生物医药研究所有限公司 | Composition of platinum compound and chondroitin sulfate and application thereof |
| CN112603616A (en) * | 2021-01-29 | 2021-04-06 | 南京市儿童医院 | Recyclable full-coated drug-loaded esophageal stent special for children and manufacturing method thereof |
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