CN2480051Y - Large power high-voltage pulse microcapsule preparation instrument - Google Patents
Large power high-voltage pulse microcapsule preparation instrument Download PDFInfo
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- CN2480051Y CN2480051Y CN 00253538 CN00253538U CN2480051Y CN 2480051 Y CN2480051 Y CN 2480051Y CN 00253538 CN00253538 CN 00253538 CN 00253538 U CN00253538 U CN 00253538U CN 2480051 Y CN2480051 Y CN 2480051Y
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Electrotherapy Devices (AREA)
Abstract
The utility model relates to a microcapsule producer, in particular to a device for preparing micro-sphere droplet in the theory of electric circuitry. The prepared droplet can form a microcapsule by the chemical treatment, and the microcapsule can be used as an immunity isolation tool for curing nervous diseases or nutritional disorder by transplanting histiocyte, a mean of delivery for gene therapy, and a novel capsule for controlling release of drugs. The circuit comprises a signal generator, a frequency synthesizer, a pulse-width synthesizer, a spreading apparatus, a power amplifier, a branch circuit, a direct source with high voltage for controlled silicon's working, and a direct threshold voltage. The utility model has the advantages of simple circuits, better and steady performance, and lower cost.
Description
The utility model relates to a kind of microcapsules preparation facilities.
Microcapsules are as the immune isolating tool of histocyte transplantation treatment nerve/endocrine system disease, the novel form that the delivery vehicle of gene therapy and medicine control discharge, at biology, medical science and pharmaceutical field have crucial effect, the ball-type degree of microcapsules, particle diameter, factor such as homogeneity and preparative-scale is to guarantee that it has the key of applications well performance, and the precondition that guarantees above-mentioned factor is to prepare the microspheric drop that is complementary with it, therefore, surface tension when needing a kind of device that can produce the certain frequency electric field force to be used to overcome drop disengaging container, preparation microspheric drop, parameters such as its particle diameter and electric field force are inversely proportional to.
Present existing a kind of device, the high-frequency impulse frequency of its output is 10～100Hz, impulse amplitude is 15～25kv.The weak point of this equipment is: high frequency voltage is 25kz to the maximum, and this electric field force can't prepare drop or the microcapsules of particle diameter less than 170 μ m, and its application in clinical and other field is restricted; Single terminal output, maximum preparative capacibility is less than 50ml/h, and because the pulse shape distortion restriction makes gained drop or microcapsules particle diameter inhomogeneous; Do not have the direct current threshold voltage, make the drop of preparation or microcapsules particle diameter inhomogeneous; Output voltage is passed in time, forms expendable decay.
For solving above deficiency, the utility model provides a kind of large power high voltage pulse microcapsules preparing instrument, reaches the purpose of producing microcapsules by large power high voltage pulse.
The utility model large power high voltage pulse microcapsules preparing instrument, it is the device that a kind of electronic circuit principle prepares the microspheric drop, the drop of preparation forms microcapsules through chemical treatment, as the immune isolating tool of histocyte transplantation treatment nerve/endocrine system disease, the delivery vehicle of gene therapy and the novel form that medicine control discharges.
The main electronic circuit of the utility model is made up of with high-voltage DC power supply, adjustable direct current threshold voltage signal generator, frequency, pulsewidth synthesizer, expander, power amplification, branch circuit and controllable silicon work, and its connection is that signal generator is by V-F converter F
aImpulse generator F with an integrated circuit formation
bTwo parts are formed, by F
aF
bComponent frequency, pulsewidth synthesizer, F
aF
bSynthetic pulsewidth is the integer letter of 1ms, frequency is the rectangular pulse signal of 1～150Hz, synthesizer output directly is connected to expander, a signal is extended to 5～10 undistorted synchronous rectangular pulse signals simultaneously drives 10～20 lead-out terminals, these lead-out terminals are connected to power amplifier separately, power amplifier output connects the on-off circuit of being made up of controllable silicon, on-off circuit output, the highpowerpulse output that produces 15～35kv by coupling circuit driving high-tension transformer, under this type of impulse action, but 10～20 lead-out terminal prepared in batches diameters are even at 50～4000 μ m, the microspheric drop or the microcapsules of symmetry; Alternating current circuit is exported to branch circuit through rectifying and wave-filtering in addition, and the corresponding multichannel high voltage regulated power supply of branch circuit joins with on-off circuit respectively; Another road exchanges through rectifying and wave-filtering and connects branch circuit, and branch circuit is exported through the multichannel voltage controller power source, directly supplies with high-tension transformer (as shown in Figure 1) through the threshold voltage adjustment.
Advantage of the present utility model:
This equipment circuit is simple, superior performance, and function-stable, cost is low.Specific performance: direct current threshold voltage and adjustable is arranged, and power output is big, and a plurality of lead-out terminals of tool, preparative capacibility are greater than 1000ml/h, and particle diameter is adjustable between 50～4000 μ m, and microspheres prepared type drop or microcapsules uniform particle diameter, ball-type degree are good.
The utility model detailed structure is provided by following examples and accompanying drawing.
Fig. 1 is a large power high voltage pulse microcapsules preparing instrument overall block-diagram.
Fig. 2 is the overall electrical schematic diagram of large power high voltage pulse microcapsules preparing instrument.
Fig. 3 is a large power high voltage pulse microcapsules preparing instrument power unit electrical schematic diagram.
Electrical schematic diagram such as Fig. 2, shown in 3, the front is an input pulse, amplify through three grades of triodes, by transformer coupled control controllable silicon, controllable silicon output reaches the output of many group high pressure through step-up transformer, connecting with output has threshold voltage adjustments and power adjusting simultaneously, adjustable direct current threshold voltage, range of regulation+200V～+ 800V is variable, it is added in each road high-voltage pulse output and is formed on certain DC voltage, and the pulse output of stack 15～35kv is arranged, and forms to guarantee the ball-type drop, on 10～20 high-voltage pulse lead-out terminals, can and the line output same frequency, same pulsewidth, same-phase, different threshold values, the flash of degree of amplitude modulation.
Claims (3)
1. large power high voltage pulse microcapsules preparing instrument, it is characterized in that: this preparing instrument circuit is made up of with high-voltage DC power supply, adjustable direct current threshold voltage signal generator, frequency, pulsewidth synthesizer, expander, power amplification, branch circuit and controllable silicon work, and its connection is that signal generator is by V-F converter F
aImpulse generator F with an integrated circuit formation
bTwo parts are formed, by F
aF
bComponent frequency, pulsewidth synthesizer, F
aF
bSynthetic pulsewidth is the integer letter of 1ms, frequency is the rectangular pulse signal of 1～150Hz, synthesizer output directly is connected to expander, a signal is extended to 5～10 undistorted synchronous rectangular pulse signals simultaneously drives 10～20 lead-out terminals, these lead-out terminals are connected to power amplifier separately, power amplifier output connects the on-off circuit of being made up of controllable silicon, on-off circuit output, the highpowerpulse output that produces 15～35kv by coupling circuit driving high-tension transformer, under this type of impulse action, but 10～20 lead-out terminal prepared in batches diameters are even at 50～4000 μ m, the microspheric drop or the microcapsules of symmetry.
2. according to the described preparing instrument of claim 1, it is characterized in that: alternating current circuit is exported to branch circuit through rectifying and wave-filtering, and the corresponding multichannel high voltage regulated power supply of branch circuit joins with on-off circuit respectively; Another road exchanges through rectifying and wave-filtering and connects branch circuit, and branch circuit is exported through the multichannel voltage controller power source, directly supplies with high-tension transformer through the threshold voltage adjustment.
3. according to the described preparing instrument of claim 1, it is characterized in that: the front is an input pulse, amplify through three grades of triodes, by transformer coupled control controllable silicon, controllable silicon output reaches the output of many group high pressure through step-up transformer, connecting with output has threshold voltage adjustments and power adjusting simultaneously, adjustable direct current threshold voltage, range of regulation+200V～+ 800V is variable, it is added in each road high-voltage pulse output and is formed on certain DC voltage, the pulse output of stack 15～35kv is arranged, to guarantee that the ball-type drop forms, on 10～20 high-voltage pulse lead-out terminals, can and the line output same frequency, same pulsewidth, same-phase, different threshold values, the flash of degree of amplitude modulation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00253538 CN2480051Y (en) | 2000-12-22 | 2000-12-22 | Large power high-voltage pulse microcapsule preparation instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00253538 CN2480051Y (en) | 2000-12-22 | 2000-12-22 | Large power high-voltage pulse microcapsule preparation instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2480051Y true CN2480051Y (en) | 2002-03-06 |
Family
ID=33610968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00253538 Expired - Fee Related CN2480051Y (en) | 2000-12-22 | 2000-12-22 | Large power high-voltage pulse microcapsule preparation instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2480051Y (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106622055A (en) * | 2016-10-18 | 2017-05-10 | 上海理工大学 | Preparation device of high-voltage electric field microcapsules |
| CN112996590A (en) * | 2018-11-09 | 2021-06-18 | 福纳技术股份有限公司 | Microencapsulation using high voltage, low current, high frequency ac spray atomization |
-
2000
- 2000-12-22 CN CN 00253538 patent/CN2480051Y/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106622055A (en) * | 2016-10-18 | 2017-05-10 | 上海理工大学 | Preparation device of high-voltage electric field microcapsules |
| CN112996590A (en) * | 2018-11-09 | 2021-06-18 | 福纳技术股份有限公司 | Microencapsulation using high voltage, low current, high frequency ac spray atomization |
| CN112996590B (en) * | 2018-11-09 | 2024-04-09 | 福纳技术有限责任公司 | Microencapsulation using high voltage low current high frequency ac spray atomization |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20020306 Termination date: 20100122 |