CN2465177Y - Multi-optical fibre multi-color high-speed scanner for biological microquantity fluorescent realtime test - Google Patents
Multi-optical fibre multi-color high-speed scanner for biological microquantity fluorescent realtime test Download PDFInfo
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- CN2465177Y CN2465177Y CN 01208267 CN01208267U CN2465177Y CN 2465177 Y CN2465177 Y CN 2465177Y CN 01208267 CN01208267 CN 01208267 CN 01208267 U CN01208267 U CN 01208267U CN 2465177 Y CN2465177 Y CN 2465177Y
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Abstract
The utility model relates to a multi-optical fiber multi-color high-speed scanner for a biological microquantity fluorescent real-time test. The utility model comprises launching optical fibers, one end of each launching optical fiber is corresponding to each PCR reaction tube, and the other end of each launching optical fiber is aligned to a collecting mirror of one launching optical fiber; the collecting mirror of each launching optical fiber is corresponding to a collecting mirror of a coupling optical fiber, and the collecting mirror of each coupling optical fiber is corresponding to one coupling optical fiber; thus, a coupling optical fiber bundle is formed, and an output terminal of the coupling optical fiber bundle is corresponding to at least one photoelectric receiver. Sequential conducting devices are arranged between the collecting mirrors of the launching optical fiber and the collecting mirrors of the coupling optical fibers, and the collecting mirrors of the launching optical fiber are corresponding to the collecting mirrors of the coupling optical fibers. When the utility model is used, the utility model is favorable to the popularization of the biological microquantity fluorescent real-time test of the modern molecular diagnosis technology.
Description
The utility model relates to a kind of molecular biological modern molecular diagnostic techniques that belongs to, and is many optical fiber polychrome high-speed scanning device during the micro-fluorescence of biological PCR (PCR) detects in real time specifically.
In genetic engineering, the nucleic acid amplification technologies PCR (PCR) of in-vitro simulated natural dna replication dna process combines at the spectrum detection technique with the fluorescein effect, has formed real-time qualitative, quantitative PCR detection system.At present, directly use thin-walled PCR reaction tube to carry out the analogous instrument that stopped pipe detects principle in the world, comparatively typical 7700,5700 real-time quantitative PCR instrument as U.S. PE company, with the 17C-8740 type PCR instrument of Bic-RAD company, and the Rotor-Gene type PCR instrument of Australian Gotogenel company.
The scanning system that is adopted in 5700, the 7700 type real-time quantitative PCR instrument of U.S. PE company is to adopt the camera system of CCD (many fibre bundles top dot matrix is gathered light signal).After shooting, the fluorescence intensity of each PCR reaction is carried out image processing.Because the fluorescence intensity of different reactants after increasing in the PCR pipe changes different, the shading value difference of resulting image after fluorescence irradiation shooting, utilize computer system that this resulting image is carried out analyzing and processing again, show with colored squiggle at last.Therefore, the software processing of this instrument is very complicated, and instrument also so very expensive.Simultaneously, the light harvesting signal at PCR pipe top makes in the process of pcr amplification, for the interpolation that prevents the preceding mineral that use of reactant evaporation in the heating process produces difficulty.
And the scanning system in the Rotor-Gene type PCR instrument of Australian Gotogenel company is in air gas pcr amplification process, makes each PCR pipe rotation, carries out one by one scanning with fixing fluorescence detecting system again.Because air gas pcr amplification instrument is temperature controlling during the course, the skewness of poor accuracy, temperature; And, because the reactant in the PCR pipe can produce centrifugation under the situation of high-speed rotation, what make emitting fluorescence becomes very complicated and unstable with dynamic situation, and noise is big, the phenomenon of " lid jumps " often takes place in the PCR pipe, pollutes the reactant in the PCR pipe.Therefore this instrument its stability in use, repeatability is bad.
Polychrome signal acquiring system in above-mentioned in addition existing two kinds of typical instruments must just can be finished by a plurality of photelectric receivers.Equally also can increase the manufacturing cost of equipment.
At present, PCR real-time fluorescence detection diagnostic techniques has been used very extensively and ripe in modern molecule field.But, can not be satisfied with the demand of Chinese market far away because the costliness of above-mentioned instrument and the instability of performance make the popularization of this technology exist very big problem.
The purpose of this utility model is to provide many optical fiber polychrome high-speed scanning device in the detection in real time of a kind of biology trace fluorescence, supporting with the amplification PCR instrument of present existing stable metal heat conduction PCR pipe stopped pipe, produce stable performance, and can reduce the necessary instrument of its manufacturing cost significantly, help biology trace fluorescence and detect this modern molecular diagnostic techniques in real time and obtain promoting.
The purpose of this utility model is to realize like this, many optical fiber polychrome high-speed scanning device during a kind of biology trace fluorescence detects in real time, include the launching fiber of an end corresponding to each PCR reaction tube, the other end of each launching fiber is aimed at a launching fiber condenser, the corresponding coupling optical fiber condenser of each launching fiber condenser, the corresponding coupling optical fiber of described each coupling optical fiber condenser, constitute the coupling optical fiber bundle, the output terminal of this coupling optical fiber bundle is corresponding at least one photelectric receiver; Between corresponding mutually launching fiber condenser and coupling optical fiber condenser, be provided with the sequential turn-on device.
Described launching fiber condenser can be arranged in the periphery of a fixing A dish, the coupling optical fiber condenser corresponding with it is arranged in the fixedly periphery of B dish, between two dishes of A, B, be provided with rotary mid-game, the periphery of this mid-game is provided with a via corresponding to above-mentioned launching fiber condenser and coupling optical fiber condenser at least, to constitute the sequential turn-on device.Can be provided with a via in the described mid-game.Between the output terminal of coupling optical fiber bundle and photelectric receiver, be provided with the color filter dish, be provided with a kind of color filter at least on this color filter dish.This color filter dish can be rolling disc, and described color filter is along circumferentially distributing.This color filter dish can move along straight line, and described color filter distributes vertically.Via more than also can being provided with outside two in mid-game, and establish color filter in each via is provided with plural photelectric receiver in the output terminal correspondence of coupling optical fiber bundle.
The launching fiber condenser of described mutual correspondence and the lotus root between the coupling optical fiber condenser are closed in the gap, can correspondence be provided with light path catch switch, but this catch switch sequence switch, to constitute the sequential turn-on device.Should be mutually corresponding launching fiber condenser and coupling optical fiber condenser can arrange or be wire in the form of a ring and arrange.
Adjustable gaps between described launching fiber condenser and the coupling optical fiber condenser.
Principle of work of the present utility model is, use multiple beams of optical fiber, in each PCR reaction tube in the enterprising trip temperature cyclic process of pcr amplification instrument, the emitting fluorescence signal of amplification conducts to the launching fiber condenser by each light beams independently, close the sequenced transmission of realization luminous energy by carrying out efficient lotus root separately in order again with the mutually corresponding coupling optical fiber condenser of this launching fiber condenser.On photelectric receiver, just can collect a plurality of fluorescence intensity signals that are interruption like this by the wavelength color filter.So just formed many optical fiber high-velocity scanning that trace P CR detects, and be accompanied by the scanning of multi-wavelength, between the condenser that the lotus root of correspondence is closed, carry out conducting (perhaps switch) state of average rate, and constantly repeat down many optical fiber polychrome high-velocity scanning that each corresponding photelectric receiver all can form real-time minimum PCR detection.
The most significant effect of the present utility model is, directly utilize the fluorescence signal that reactant obtained in the fluorescence irradiation PCR pipe, therefore do not need extremely complicated computer processing system, with its scanning system that cooperates ripe at present metal heat-conducting, temperature control pcr amplification to use, simplify the complexity of instrument and to the requirement of software data processing, can with multiple present pcr amplification instrument adapted, realize regularly polychrome detection by quantitative, and therefore reduce its manufacturing cost widely.
In addition, the utility model can rapidly and accurately, directly make a plurality of PCR reaction tubes under the situation of stopped pipe, only with photelectric receiver of a light source, finish one by one according to the order of sequence, and qualitative, the quantitatively detection in real time of multi-wavelength simultaneously.Also can simplify device structure widely, and therefore reduce its manufacturing cost.
Can learn that by principle of work of the present utility model directly to the signals collecting of the real-time fluorescence Strength Changes of PCR reaction tube, change resulting signal after the resulting treatment of picture analysis by this fluorescence intensity, its stability and repeatability are better.
In sum, the utility model can help promoting promoting the use of of the modern Molecular Detection diagnostic techniques of trace P CR so that the cost of PCR detecting instrument, price reduce significantly.
The explanation of accompanying drawing drawing:
Fig. 1 structural representation of the present utility model;
The structural representation of A dish in Fig. 2 the utility model;
The structural representation of B dish in Fig. 3 the utility model;
The structural representation of mid-game in Fig. 4 the utility model;
The partial enlarged drawing at A place among Fig. 5 Fig. 1;
The mid-game structural representation of Fig. 6 the utility model embodiment 3;
The structural representation of Fig. 7 the utility model embodiment 4.
A kind of enforcement structural representation of color filter dish in Fig. 8 the utility model;
The another kind of color filter dish is implemented structural representation in Fig. 9 the utility model;
As follows below in conjunction with embodiment and accompanying drawing detailed description the utility model:
As Fig. 1, shown in Figure 5, the utility model includes the launching fiber 2 of an end corresponding to each PCR reaction tube 1, the other end of each launching fiber 2 is aimed at a launching fiber condenser 3, each launching fiber condenser 3 corresponding coupling optical fiber condenser 4, described each coupling optical fiber condenser 4 corresponding coupling optical fiber 51, constitute coupling optical fiber bundle 5, the output terminal of this coupling optical fiber bundle 5 is corresponding at least one photelectric receiver 6; Between mutually corresponding launching fiber condenser 3 and coupling optical fiber condenser 4, be provided with the sequential turn-on device.
As Fig. 1, Fig. 2, Fig. 3, shown in Figure 4, in the present embodiment, described launching fiber condenser 3 can be arranged in the periphery of a fixing A dish 8, the coupling optical fiber condenser 4 corresponding with it is arranged in the fixedly periphery of B dish 9, between two dishes of A, B, be provided with rotary mid-game 7, the periphery of this mid-game 7 is corresponding to the via 71 of above-mentioned launching fiber condenser 3 and coupling optical fiber condenser 4, to constitute the sequential turn-on device.Be separated with certain requirement between between A dish 8 and the B dish 9, this interval should be able to make the fluorescence signal with certain wavelength efficiently be coupled by launching fiber condenser 3, via 71 and coupled fiber condenser 4, realizes the transmission of energy.Coupling gap between this launching fiber condenser 3 and the coupled fiber condenser 4 can be regulated according to different situations.The fluorescence signal that the position of the via 71 of these mid-game 7 peripheries and size should can make reactant in some PCR reaction tubes 1 just is by this via 71 couplings, and in other the PCR reaction tube 1 fluorescence signal of reactant owing to there be blocking of mid-game 7 to be coupled.Like this, when driven by motor mid-game 7 is rotated, in a certain definite moment, have only the fluorescence signal of reactant in one group of PCR reaction tube 1 to be coupled by via 71, thereby realized sometime the section in, the fluorescence signal of all reactants is coupling separately successively in order, is convenient to photelectric receiver the reception of light signal is differentiated.
As Fig. 1, shown in Figure 8, between the output terminal of coupling optical fiber bundle 5 and photelectric receiver 6, be provided with color filter dish 10, be provided with a kind of color filter 101 on this color filter dish 10 at least.Color filter dish 10 can be rolling disc, and described color filter 101 is along circumferentially distributing.This color filter dish 10 has certain rotating ratio with mid-game 7, mid-game 7 whenever rotates a circle, multi-wavelength color filter dish 10 rotates an angle, the color filter 101 that makes color filter dish 10 aim at photelectric receiver 6 changes a slice just, to form many optical fiber high speed polychrome scanning that real-time minimum PCR detects under the situation that is implemented in a photelectric receiver.
The utility model is when implementing, with a light source irradiation 1 li of each PCR reaction tube of the enterprising trip temperature cyclic process of pcr amplification instrument, the emitting fluorescence signal of amplification conducts to launching fiber condenser 3 by independently respectively restrainting launching fiber 2, when the via 71 of mid-game 7 is aimed at this launching fiber condenser 3, close the sequenced transmission of realization luminous energy by advancing to imitate efficient lotus root separately in order with corresponding mutually coupling optical fiber condenser 4 fluorescence signal in via 71 of this launching fiber condenser 3.On photelectric receiver 6, just can collect a plurality of fluorescence intensity signals that are interruption like this by wavelength color filter 101.Set the rotating ratio of mid-game 7 and color filter dish 10, mid-game 7 is whenever rotated a circle, the color filter 101 of aiming at photelectric receiver 6 in the color filter dish 10 changes a slice, has so just formed many optical fiber high-velocity scanning that trace P CR detects.If mid-game 7 constantly repeats rotation with color filter dish 10 by the rotating ratio of setting, and is accompanied by the scanning of multi-wavelength, just realized many optical fiber polychrome high-velocity scanning that the real-time minimum PCR under a photelectric receiver detects.
The utility model is because the fluorescence signal that directly utilizes the reactant in the fluorescence irradiation PCR pipe 1 to obtain, therefore do not need extremely complicated computer processing system, with its scanning system that cooperates ripe at present metal heat-conducting, temperature control pcr amplification to use, simplify the complexity of instrument and to the requirement of software data processing, can with multiple present pcr amplification instrument adapted, realize regularly polychrome detection by quantitative, and therefore reduce its manufacturing cost widely.In addition, the utility model can rapidly and accurately, directly make a plurality of PCR reaction tubes 1 under the situation of stopped pipe, only with photelectric receiver 6 of a light source, finish one by one according to the order of sequence, and qualitative, the quantitatively detection in real time of multi-wavelength simultaneously, also can simplify device structure widely, and therefore reduce its manufacturing cost.Because the utility model is directly to the signals collecting of the real-time fluorescence Strength Changes of PCR reaction tube 1, change resulting signal after the resulting treatment of picture analysis by this fluorescence intensity, its stability and repeatability are better.Therefore, the utility model can help promoting promoting the use of of the modern Molecular Detection diagnostic techniques of trace P CR so that the cost of PCR detecting instrument, price reduce significantly.
The basic structure of present embodiment is identical with embodiment 1, is not described in detail in this.
The difference of present embodiment and embodiment 1 is, in the present embodiment, do not establish mid-game 7 between launching fiber condenser 3 and the coupled fiber condenser, but by be located at described mutual correspondence launching fiber condenser 3 and coupling optical fiber condenser 4 between a plurality of light path catch switches of closing in the gap of lotus root constitute the sequential turn-on device.These a plurality of light path catch switches can have programmed control, and it opens and closes in proper order, thereby forms unidirectional one by one continuous sweep.
As Fig. 2, shown in Figure 3, in the present embodiment, described mutual correspondence launching fiber condenser 3 and coupling optical fiber condenser 4 can be arranged in the form of a ring on corresponding A dish 8, the B dish 9.This launching fiber condenser 3 and coupling optical fiber condenser 4 also can be wire, rectangle or other shapes and be arranged on corresponding A dish 8, the B dish 9, as long as launching fiber condenser 3 and coupling optical fiber condenser 4 are corresponding one by one, can control the order coupling of fluorescence signal by program control light path washer switch, thereby realize the independent high-velocity scanning of many optical fiber that real-time minimum PCR detects.
Because present embodiment adopts a plurality of light path catch switches to constitute the sequential turn-on device, when detecting in real time, each switch will open and close thousands of times, and will be in fact also impracticable.
Because present embodiment is identical with the basic structure of embodiment 1, so present embodiment has the beneficial effect that embodiment 1 is had equally, do not repeat them here.
The basic structure of present embodiment is identical with embodiment 1, is not described in detail in this.
The difference of present embodiment and embodiment 1 is that in the present embodiment, described mid-game 7 is provided with a plurality of via 71, is provided with color filter 72 in each via 71, is provided with a plurality of photelectric receiver 6 in the output terminal correspondence of coupling optical fiber bundle 5.Present embodiment does not re-use color filter dish 10, and directly adds color filter 72 in a plurality of vias 7 of mid-game, utilizes the beam split mechanism of different wave length to adopt many photelectric receivers 6 to realize many optical fiber polychrome high-velocity scanning that real-time minimum PCR detects.The via 71 that only in mid-game 7, is provided with two shown in Figure 6 of present embodiment, during practical application a plurality of via 71 can be set in mid-game 7 as the case may be, and adopt corresponding light path system and a plurality of photelectric receiver 6 to realize the high-velocity scanning of many optical fiber polychrome.
Because present embodiment is identical with the basic structure of embodiment 1, so present embodiment has the beneficial effect that embodiment 1 is had equally, do not repeat them here.
The basic structure of present embodiment is identical with embodiment 1, is not described in detail in this.
As Fig. 7, shown in Figure 9, the difference of present embodiment and embodiment 1 is that in the present embodiment, described color filter dish 10 can move along straight line, and described color filter 101 distributes vertically.Present embodiment is when implementing, preestablish the rotating speed of mid-game 7 and the speeds match that color filter dish 10 moves along straight line, mid-game 7 is whenever rotated a circle, and the color filter 101 of aiming at photelectric receiver 6 in the color filter dish 10 changes a slice just, has so just formed many optical fiber high-velocity scanning that trace P CR detects.
Because present embodiment is identical with the basic structure of embodiment 1, so present embodiment has the beneficial effect that embodiment 1 is had equally, do not repeat them here.
The foregoing description is preferred embodiment of the present utility model, only is used to describe in detail the utility model, but not is used to limit the utility model.
Experimental results demonstrate, utilize basic structure of the present utility model and principle of work can realize that also biology trace ultraviolet light, visible or infrared light detect the high-velocity scanning of many optical fiber polychrome in real time.
Claims (10)
1, many optical fiber polychrome high-speed scanning device during a kind of biology trace fluorescence detects in real time, it is characterized in that, include the launching fiber of an end corresponding to each PCR reaction tube, the other end of each launching fiber is aimed at a launching fiber condenser, the corresponding coupling optical fiber condenser of each launching fiber condenser, the corresponding coupling optical fiber of described each coupling optical fiber condenser constitutes the coupling optical fiber bundle, the output terminal of this coupling optical fiber bundle is corresponding at least one photelectric receiver; Between corresponding mutually launching fiber condenser and coupling optical fiber condenser, be provided with the pagination conducting device.
2, many optical fiber polychrome high-speed scanning device during biology trace fluorescence according to claim 1 detects in real time, it is characterized in that described launching fiber condenser can be arranged in the periphery of a fixing A dish, the coupling optical fiber condenser corresponding with it is arranged in the fixedly periphery of B dish, between two dishes of A, B, be provided with rotary mid-game, the periphery of this mid-game is provided with a via corresponding to above-mentioned launching fiber condenser and coupling optical fiber condenser at least, to constitute the sequential turn-on device.
3, many optical fiber polychrome high-speed scanning device during biology trace fluorescence according to claim 2 detects in real time is characterized in that described mid-game is provided with a via.
4, many optical fiber polychrome high-speed scanning device during biology trace fluorescence according to claim 2 detects in real time, it is characterized in that described mid-game is provided with plural via, be provided with color filter in each via, be provided with plural photelectric receiver in the output terminal correspondence of coupling optical fiber bundle.
5, many optical fiber polychrome high-speed scanning device during biology trace fluorescence according to claim 1 detects in real time, it is characterized in that between the output terminal of coupling optical fiber bundle and photelectric receiver, being provided with the color filter dish, be provided with a kind of color filter at least on this color filter dish.
6, many optical fiber polychrome high-speed scanning device during biology trace fluorescence according to claim 5 detects in real time is characterized in that the color filter dish can be rolling disc, and described color filter is along circumferentially distributing.
7, many optical fiber polychrome high-speed scanning device during biology trace fluorescence according to claim 5 detects in real time is characterized in that the color filter dish can move along straight line, and described color filter distributes vertically.
8, many optical fiber polychrome high-speed scanning device during biology trace fluorescence according to claim 1 detects in real time, it is characterized in that described mutual correspondence the launching fiber condenser and the lotus root between the coupling optical fiber condenser close in the gap, correspondence is provided with light path catch switch, this catch switch can keep off sequence switch, to constitute the sequential turn-on device.
9, many optical fiber polychrome high-speed scanning device during biology according to claim 8 trace fluorescence detects in real time, it is characterized in that described mutual correspondence launching fiber condenser and coupling optical fiber condenser can arrange or be wire in the form of a ring and arrange.
10, many optical fiber polychrome high-speed scanning device during biology trace fluorescence according to claim 1 detects in real time is characterized in that the adjustable gaps between described launching fiber condenser and the coupling optical fiber condenser.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01208267 CN2465177Y (en) | 2001-03-06 | 2001-03-06 | Multi-optical fibre multi-color high-speed scanner for biological microquantity fluorescent realtime test |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01208267 CN2465177Y (en) | 2001-03-06 | 2001-03-06 | Multi-optical fibre multi-color high-speed scanner for biological microquantity fluorescent realtime test |
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| CN2465177Y true CN2465177Y (en) | 2001-12-12 |
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| CN 01208267 Expired - Fee Related CN2465177Y (en) | 2001-03-06 | 2001-03-06 | Multi-optical fibre multi-color high-speed scanner for biological microquantity fluorescent realtime test |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100335888C (en) * | 2004-12-20 | 2007-09-05 | 西安天隆科技有限公司 | Light path detection method for reat-time fluorescent quantitative gene amplification apparatus |
| CN102135495A (en) * | 2010-12-21 | 2011-07-27 | 亚亚科技股份有限公司 | Measuring device for micro-biological sample solution |
| CN101705280B (en) * | 2009-11-16 | 2012-05-02 | 杭州博日科技有限公司 | Method and device for quantitative PCR multi-wavelength fluorescence detection |
| CN104422678A (en) * | 2013-09-02 | 2015-03-18 | 霍夫曼-拉罗奇有限公司 | Apparatus for photometric measurement of biological liquids |
| CN113092428A (en) * | 2021-04-02 | 2021-07-09 | 安图实验仪器(郑州)有限公司 | Multiple fluorescence detection method, device, equipment and system |
-
2001
- 2001-03-06 CN CN 01208267 patent/CN2465177Y/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100335888C (en) * | 2004-12-20 | 2007-09-05 | 西安天隆科技有限公司 | Light path detection method for reat-time fluorescent quantitative gene amplification apparatus |
| CN101705280B (en) * | 2009-11-16 | 2012-05-02 | 杭州博日科技有限公司 | Method and device for quantitative PCR multi-wavelength fluorescence detection |
| CN102135495A (en) * | 2010-12-21 | 2011-07-27 | 亚亚科技股份有限公司 | Measuring device for micro-biological sample solution |
| CN104422678A (en) * | 2013-09-02 | 2015-03-18 | 霍夫曼-拉罗奇有限公司 | Apparatus for photometric measurement of biological liquids |
| CN104422678B (en) * | 2013-09-02 | 2018-11-06 | 霍夫曼-拉罗奇有限公司 | Biofluid photometric measurement instrument |
| CN113092428A (en) * | 2021-04-02 | 2021-07-09 | 安图实验仪器(郑州)有限公司 | Multiple fluorescence detection method, device, equipment and system |
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