CN2448361Y

CN2448361Y - Miniature fluidized bed medicine coating machine

Info

Publication number: CN2448361Y
Application number: CN 00249908
Authority: CN
Inventors: 傅崇东
Original assignee: Individual
Current assignee: Individual
Priority date: 2000-11-02
Filing date: 2000-11-02
Publication date: 2001-09-19
Anticipated expiration: 2010-11-02

Abstract

The utility model belongs to a device of pharmaceutical machinery, which particularly relates to a coating device. The utility model relates to a miniature fluidized bed medicine coating machine for laboratory research or small experiments, which is used for coating material samples which are 5g to 100g in general, particularly for coating small particles. The utility model can regulate and control coating temperature, coating rate and fluidizing air rate and ensure coating continuity and uniformity. The utility model has the advantages of material saving, low cost, high drying efficiency, short coating time, convenient operation, reliable effect, etc.

Description

Miniature fluidized-bed coating machine

This utility model belongs to pharmaceutical machine equipment, is specifically related to a kind of coating equipment.

In pharmaceuticals industry now, pharmaceutical equipment plays crucial effects to the exploitation of new product, the quality of the quality of the pharmaceutical preparations.At present domestic pharmaceutical technology and the very big gap of western developed country existence, the shortage of pharmaceutical equipment and backwardness are one of important reasons very.

Along with the development of pharmaceuticals industry, packaging technique obtains application more and more widely, and what it had been used for preparation improves all many-sides such as outward appearance, covering smell, moistureproof lucifuge and control release.Coating equipment commonly used at present is coating pan and fluid bed, but consider from the operability of drying efficiency and coating, fluid bed is better coating equipment, its advantage is: 1. material fully disperses, be specially adapted to small-particle such as microgranule, piller etc. are carried out coating, with coating pan adhesion caking very easily then; 2. the drying efficiency height can be used for the water-based material coating, and as aqueous solution, aqueous dispersion coating etc., the water-based material coating is the developing direction of packaging technique; 3. can shorten the coating operating time, raise labour efficiency.But at present domestic also do not have corresponding laboratory with microminiature fluidized bed coating equipment, therefore influenced research topic and exploration project the carrying out of laboratory stage, and then influenced the industrialization of product.

Known have more small-sized fluidized-bed coating machine abroad, and as the GPCG1.1 type of German Glatt company, but this equipment price is more than million people people's coin, and once drop into material and also need 500g, this consumption concerning laboratory research had still too much both been wasted raw material, increased research cost again.

The purpose of this utility model provides a kind of miniature fluidized-bed coating machine that can be used for laboratory research or lab scale, can be used for generally being no more than coating, packaging medicine coating, fluidized drying and the mixing etc. of 100g material sample.This equipment can be used for arriving less the coating of 5g material; Can regulate effectively and temperature, coating speed and fluidisation air quantity when controlling coating; Can guarantee the seriality and the uniformity of coating.

The purpose of this utility model is achieved in that

This miniature fluidized-bed coating machine comprises material trough, air distribution plate, temperature control part branch, gas delivery sections branch and hydrojet part.

Below in conjunction with accompanying drawing this utility model is elaborated.

Fig. 1 is this utility model cutaway view.Wherein 1 is material trough, the 2nd, and spray gun, the 3rd, air distribution plate, the 4th, peristaltic pump, the 5th, coating solution cistern, the 6th, gas compressor, the 7th, aerator, the 8th, deep bead, the 9th, electrical heating wire, the 10th, electronic temperature control device, the 11st, spacer ring, the 12nd, material temperature probe, the 13rd, air outlet drainage screen, the 14th, air outlet temperature probe, the 15th, air outlet.

Fig. 2 is an air distribution plate plane graph of the present utility model, and wherein 1 is hollow type, and 2 is plain edition.

Material trough of the present utility model is upper coarse and lower fine circular cone tubular, can adopt the rustless steel of clear glass or band transparent glass window to make, but visual monitoring coating process like this.According to the different sizes of how much material trough can being made of material input amount, the base diameter scope is 3-10cm, and the upper diameter scope is 10-25cm, and altitude range is 40-70cm.Do not need spacer ring can obtain good fluidized state in the material trough, therefore reduced the difficulty of processing and operation.If needed, when base diameter during, can in material trough, install the cylindric spacer ring that a diameter is not less than the both ends open of 5cm, height 10-20cm additional, to increase the order of Flow of Goods and Materials greater than 6cm.

Said air distribution plate is a pore opening and plectane pockety, places the material trough bottom, and the distribution of air flow board diameter is consistent with the material trough base diameter.Air distribution plate is made hollow type or plain edition.The center of hollow type air distribution plate is blank fully, the pore of distribution diameter 0.5-3mm on every side, and the pore spacing is not more than 5mm, and the diameter of hollow space is the 1/2-1/5 of whole distribution of air flow board diameter; The central distribution of plain edition air distribution plate has than gross blow hole, be distributed with on every side than spilehole, hole diameter is 0.5-3mm on every side, the pore spacing is not more than 5mm, the centre porosity diameter is 2-5 a times of hole diameter on every side, the pore spacing is not more than 5mm, and the diameter of core is the 1/2-1/5 of whole distribution of air flow board diameter.Air distribution plate of the present utility model can guarantee the circulation fluidized state that therefrom rises in the heart, descends around that material is good.

Said temperature control part branch is that highly sensitive temperature probe is placed the air outlet position, at any time the exit flow Temperature Feedback of being surveyed is returned the electronic temperature control device that is installed in the mainframe box, control the duty of electrical heating wire thus, as: heating with full power, half-power heat, 1/4 power heats, do not heat etc., guarantee the temperature-controlled precision of machine.A material temperature probe also can be installed, with material temperature in the monitoring coating process in material trough.

Said gas delivery sections branch is meant that aerator is transported to air in the material trough by deep bead, electrical heating wire and process air distribution plate, the air-flow that material is entered by the bottom blows floating and flows, and the air-flow rising is discharged by air outlet by the egress filtering net then.Regulate the air quantity that enters in the material trough by deep bead.

Said hydrojet part is connected to form by pipeline by spray gun, gas compressor and peristaltic pump.Spray gun places the material trough bottom, is positioned at the air distribution plate center, and Spray gun nozzle up.Spray gun can adopt rustless steel to make, and also can adopt glass blowing to form, and the Spray gun nozzle diameter is 0.2-1.5mm.Regulate and control the speed that coating solution is transported to Spray gun nozzle with peristaltic pump, the gases at high pressure of exporting with gas compressor atomize the coating solution in the spray gun.

During operation, in the material admixture hopper with the need coating, the air communication that aerator blows out is crossed air distribution plate promotion material and is moved upward, because the material trough upper diameter is bigger, so air velocity diminishes gradually with moving upward, after the material self gravitation has overcome air-flow thrust from bottom to top, material falls back to the bottom, and in whole process, material moves back and forth up and down in material trough, in this process, the atomizing coating solution that is upwards sprayed by spray gun has carried out coating to material.

This utility model is compared with external mini-plant, have save material, reduce cost, characteristics easy and simple to handle, be specially adapted to laboratory research and use; Compare with coating pan with the current experiments chamber, then have the following advantages: 1. material fully disperses and the Rapid Cycle motion, can be used for small-particle such as microgranule, piller etc. are carried out coating, and makes coating even; 2. the coating solution droplet of spray gun ejection contacts the distance weak point with material, and the hydrojet direction is identical with the goods fluid direction, so coating efficient height; 3. the drying efficiency height can be used for the water-based material coating, and can shorten the coating operating time, raises labour efficiency; 4. can accurately control coating temperature (± 0.5 ℃), overcome the uncertainty of artificial external heat; 5. can accurately control and regulate coating speed, overcome the randomness of manual spray gun coating; 6. can accurately control fluidisation and dry air quantity; 7. can reach the automatization and the seriality of coating process, reduce labor intensity; Product batch with criticize between favorable reproducibility; 9. connect a discharge pipe at the air outlet place, lead to outdoorly, it is outdoor that the coating solvent is discharged to, and reduces the harm to the experimenter; 10. cost is lower, and cost performance is higher; 11. have ease for operation.

Embodiment: use aqueous suspension that this miniature fluidized-bed coating machine carries out medicine ASA on 20g celphere (particle diameter is 0.5-0.7mm) the experiment of hydrojet packaging medicine coating and Aquacoat Aquacoat, Surelease and acrylic resin aqueous dispersion Eudragit to the coating experiment of 20g pastille piller (particle diameter is 0.8mm-1.2mm).The material trough and the spray gun of this miniature fluidized-bed coating machine all adopt glass to make, material trough base diameter 5cm, and upper diameter 15cm, height 45cm, nozzle diameter 0.5mm, air distribution plate are hollow type.The coating temperature generally is controlled at 32-35 ℃.Experimental result shows that the piller fluidisation is even, does not have adhesion phenomenon, the coated pellets good dispersion of preparation, smooth rounding; Packaging medicine and coating efficient show that all more than 85% coating efficient is very high.By medicament contg and the release in vitro degree of measuring 6 batches of coated pellets, the result shows the piller medicament contg, and evenly (RSD=0.55%, n=6), the release in vitro degree makes a variation little (the release curve of 6 batches of coated pellets overlaps substantially), proves the favorable reproducibility of coating.Drop into the 20g piller, when the coating weightening finish less than 20% the time, consuming time less than 40 minutes, and generally consuming time more than 4 hours with the coating pan coating.Because material trough is made by clear glass, so the fluidized state of piller can come into plain view in the coating process, monitors coating quality easily.This miniature fluidized-bed coating machine reached save material, reduce cost, purpose easy to operate, reliable for effect.

Claims

1, a kind of miniature fluidized-bed coating machine is characterized in that partly being made by material trough, air distribution plate, temperature control part branch, gas delivery sections branch and hydrojet.

2, by the described miniature fluidized-bed coating machine of claim 1, it is characterized in that described material trough is upper coarse and lower fine circular cone tubular, its base diameter scope is 3-10cm, and the upper diameter scope is 10-25cm, highly is 40-70cm.

3,, it is characterized in that described material trough adopts the rustless steel of clear glass or band transparent glass window to make by claim 1 and 2 described miniature fluidized-bed coating machines.

4, by claim 1 and 2 described miniature fluidized-bed coating machines, it is characterized in that not needing in the described material trough to add the spacer ring device.

5, by the described miniature fluidized-bed coating machine of claim 1, it is characterized in that described air distribution plate is a pore opening and plectane pockety, make hollow type or plain edition, the center of described hollow type air distribution plate is blank fully, distribution diameter is the pore of 0.5-3mm on every side, the pore spacing is not more than 5mm, and the diameter of hollow space is the 1/2-1/5 of whole distribution of air flow board diameter; The central distribution of described plain edition air distribution plate has than gross blow hole, be distributed with on every side than spilehole, hole diameter is 0.5-3mm on every side, the pore spacing is not more than 5mm, the centre porosity diameter is 2-5 a times of hole diameter on every side, the pore spacing is not more than 5mm, and the diameter of core is the 1/2-1/5 of whole distribution of air flow board diameter.