CN101862266A - Monodispersity gel microsphere forming device - Google Patents
Monodispersity gel microsphere forming device Download PDFInfo
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- CN101862266A CN101862266A CN 201010190558 CN201010190558A CN101862266A CN 101862266 A CN101862266 A CN 101862266A CN 201010190558 CN201010190558 CN 201010190558 CN 201010190558 A CN201010190558 A CN 201010190558A CN 101862266 A CN101862266 A CN 101862266A
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Abstract
The invention discloses a monodispersity gel microsphere forming device, comprising a constant flow pump, an atomizing spray head, an atomizing chamber and a vacuum pump, wherein an upper opening and a lower opening are arranged on the side wall of the atomizing chamber; a liquid outlet of the constant flow pump is communicated with a liquid inlet of the atomizing spray head; an air inlet of the atomizing spray head is communicated with the atmosphere; an outlet of the atomizing spray head is communicated with the atomizing chamber through the lower opening of the atomizing chamber; the atomizing chamber is communicated with a vacuum pump exhaust port through the upper opening; and the atomizing chamber contains solidification liquid. The invention has the advantages of simple structure, small volume, less consumption of solidification liquid and low manufacturing cost of microspheres. The invention can be used for preparing uniform microspheres or microcapsules with the grain size less than 150micrometers in large batch, has high production efficiency, low requirement on the cleanness of the surrounding environment and low energy consumption and can completely meet the industrial production requirement.
Description
Technical field
The present invention relates to a kind of Monodispersity gel microsphere forming device.
Background technology
Miniature balling-up technology is nearly new technique that was applied to pharmaceutical preparation in 30 years, a kind of known high-pressure electrostatic drop generating device, sol liquid pharmaceutical preparation is gone out by a fine needle orifice flow, under the high-pressure electrostatic impulse action, can form big or small symmetrical liquid drop, dropwise drop to and be solidified into gel micro-ball in the solidification liquid.For the high liquid of stickiness, this drop generating device is difficult to obtain particle diameter at the symmetrical liquid drop below 100 microns.The efficient that this high-pressure electrostatic drop generating device is produced microsphere is extremely low, and high-tension electricity has potential safety hazard in wet environment, and the operator is subject to electric shock, is in peril of one's life.Exist in the environment under organic volatile or the inflammable gas situation and cause fire easily.The efficient that the high-pressure electrostatic drop generating device is produced microsphere is extremely low, and working environment must high cleaning, no inflammable gas, makes it be difficult to be applied to the batch production batch process, only is applicable to that laboratory does theoretical research.
Another kind of known siphon (or gravity) transmission sprayer unit, it transmits feed fluid by siphon or gravity.This sprayer unit is not suitable for the medicinal liquid balling-up that contains more surfactant, because in this device, liquid is inhaled into by transfer pipeline and enters flow of the compressed gas, and in gas stream, be atomized, bubble, drop apart from impelling, has very big kinetic energy with high pressure draught length, should not be taken in by little container, if atomizer points to the smaller container of a splendid attire solidification liquid, the air-flow and the droplet impact solidification liquid of high-speed flight certainly will take place, cause solidification liquid and wherein microsphere splash.Contain surfactant if be atomized medicinal liquid, can produce a large amount of foams this moment, swims in the solidification liquid surface, is difficult to be solidified into the microsphere of big or small homogeneous, regular shape.This plant energy consumption is big, take up room big, the solidification liquid use amount is bigger, production cost is high, is difficult to produce qualified monodispersity gel micro-ball product.
Summary of the invention
The object of the present invention is to provide a kind of Monodispersity gel microsphere forming device, this device is that the liquid of 0.07Pa.s to 1.4Pa.s can be prepared microsphere or the microcapsule of particle diameter at 50 microns to 150 microns homogeneous in enormous quantities at stickiness.
For achieving the above object, the present invention is by the following technical solutions:
A kind of Monodispersity gel microsphere forming device, it comprises: constant flow pump, atomizer, aerochamber and vacuum pump, the sidewall of described aerochamber is provided with upper shed and under shed, be provided with the product outlet in the bottom of this aerochamber, the liquid outlet of described constant flow pump is communicated with the inlet of described atomizer, the air inlet of described atomizer is communicated with atmosphere, the outlet of this atomizer is communicated with described aerochamber chamber by described aerochamber under shed, this aerochamber chamber is communicated with a vacuum pump bleeding point by described upper shed, is loaded with solidification liquid in the described aerochamber chamber.
The position of described upper shed is not less than the position of described under shed.
The direction of described upper shed and described under shed direction roughly are 180 degree and are provided with.
One flow-stopping plate corresponding with upper shed is set in the described aerochamber.
The liquid outlet diameter of described atomizer is 250 μ m to 400 μ m.
The distance of the described solidification liquid upper surface of described under shed distance is 40cm to 100cm.
Described atomizer is a kind of cyclone type atomization of liquid shower nozzle that central damping effect is arranged.
The pressure of described aerochamber remains on 1KPa to 5KPa.
Beneficial effect of the present invention: it is consistent that the resulting Monodispersity gel microsphere forming device of the present invention utilizes the negative-pressure siphon principle sticky colloidal sol can be prepared into the shape size, ganoid gel micro-ball, produce gel micro-ball efficient height, the periphery environment cleanliness is less demanding, energy resource consumption is low, it can satisfy the suitability for industrialized production needs fully, 50 microns to 150 microns microspheres of uniform size or microcapsule can be prepared as required, the large-scale production needs of medicine, agricultural and biotechnology field can be satisfied;
The present invention is in an airtight hypobaric, and microsphere cleanliness factor height is pollution-free; It is simple in structure, and atomization process does not adopt the high pressure liquid pump, does not also adopt compressed air, only has atmospheric air and constant current liquid to enter atomizer, can make the viscolloid solution atomization become droplet of uniform size, and be frozen into the monodispersity gel micro-ball;
Microsphere producing device of the present invention is simple in structure, volume is small and exquisite, it is little to take up room, and the use amount of solidification liquid significantly reduces, and can reduce the medicine loss of making medicine carrying microballoons, and the microsphere producing device is adjusted easy accessibility, easy operating.
Description of drawings
Fig. 1 is the structural representation of Monodispersity gel microsphere forming device of the present invention.
The specific embodiment
As shown in Figure 1, a kind of Monodispersity gel microsphere forming device, it comprises: constant flow pump 1, atomizer 2, aerochamber 3 and vacuum pump 4, the sidewall of aerochamber 3 is provided with upper shed 31 and under shed 32, be provided with product outlet 34 in the bottom of aerochamber 3, the liquid outlet of constant flow pump 1 is communicated with the inlet of atomizer 2, the air inlet of atomizer 2 is communicated with atmosphere, the outlet of atomizer 2 is communicated with the chamber 33 of aerochamber 3 by aerochamber 3 under sheds 32, the chamber 33 of aerochamber 3 is communicated with a vacuum pump 4 bleeding points by upper shed 31, is loaded with solidification liquid 5 in the chamber 33 of aerochamber 3.
Aerochamber 3 is an airtight relatively aerochamber when work.
The pressure of aerochamber 3 remains on 1KPa to 5KPa.
The position of upper shed 31 is not less than the position of under shed 32.Upper shed 31 roughly is 180 ° of settings with under shed 32.
Prevent that microsphere from entering vacuum pump 4, a flow-stopping plate 41 corresponding with upper shed 31 is set in aerochamber 3.
The liquid outlet diameter of atomizer 2 is 250m to 400 μ m.
Under shed 32 is 40cm to 100cm apart from the distance of solidification liquid 5 upper surfaces.
Atomizer is a kind of cyclone type atomization of liquid shower nozzle with central damping effect.
The ratio of flow quantity and throughput increases with desire system gel micro-ball diameter, and ratio range changes because of the structure of atomizer is different.
The present invention is directed to thick liquid must can spray under hyperbar advances very much and produce the shortcoming of enough little particle diameter drop, utilize fluid mechanics principle and negative-pressure siphon phenomenon to do design, the cyclone type atomization of liquid shower nozzle horizontal setting of central damping effect is arranged in the aerochamber sidewall with a kind of, take out the indoor gas of mist eliminationization continuously by vacuum pump, outside atmospheric air flows into aerochamber through atomizer, keep aerochamber and be in a constant relatively low-pressure state, the atmospheric air short distance is quickened to flow into gas and is helped the formula nozzle.Avoided thus promoting thick liquid, caused the inhomogenous drawback of atomized drop, and then the thick liquid that reaches expection becomes the gel micro-ball effect of monodispersity, suitable size with high pressure air flow.
Fluid passage is positioned at the nozzle center position, and liquid and air meet when sticky sol liquid arrives jet expansion, begin to enter mixer and impact mixing mutually, and intensive energy exchange and momentum-exchange take place, and thick liquid has been atomized into drop substantially.Drop is in the airtight low pressure aerochamber of the confined space, and minification is atomized into less drop fast, falls into default solidification liquid, forms solid-state-microspherical or microcapsule.
More than be preferred embodiment of the present invention and design graphic; above-mentioned preferred embodiment and designing graphicly only illustrates; be not to be used to limit interest field of the present invention; all with equalization technological means or be the interest field that contained of the application's claim and the implementer does not all break away from protection scope of the present invention.
Claims (9)
1. Monodispersity gel microsphere forming device, it is characterized in that: it comprises: constant flow pump, atomizer, aerochamber and vacuum pump, the sidewall of described aerochamber is provided with upper shed and under shed, be provided with the product outlet in the bottom of aerochamber, the liquid outlet of described constant flow pump is communicated with the inlet of described atomizer, the air inlet of described atomizer is communicated with atmosphere, the outlet of this atomizer is communicated with described aerochamber chamber by described aerochamber under shed, this aerochamber chamber is communicated with a vacuum pump bleeding point by described upper shed, is loaded with solidification liquid in the described aerochamber chamber.
2. Monodispersity gel microsphere forming device according to claim 1 is characterized in that: the position of described upper shed is not less than the position of described under shed.
3. Monodispersity gel microsphere forming device according to claim 2 is characterized in that: described upper shed direction and described under shed direction roughly are 180 degree and are provided with.
4. according to the described Monodispersity gel microsphere forming device of claim 1 or 3, it is characterized in that: a flow-stopping plate corresponding with upper shed is set in the described aerochamber.
5. Monodispersity gel microsphere forming device according to claim 4 is characterized in that: the liquid outlet diameter of described atomizer is 250 μ m to 400 μ m.
6. Monodispersity gel microsphere forming device according to claim 5 is characterized in that: the distance of the described solidification liquid upper surface of described under shed distance is 40cm to 100cm.
7. Monodispersity gel microsphere forming device according to claim 1 is characterized in that: described atomizer is a kind of cyclone type atomization of liquid shower nozzle with central damping effect.
8. Monodispersity gel microsphere forming device according to claim 6 is characterized in that: described atomizer is a kind of cyclone type atomization of liquid shower nozzle with central damping effect.
9. according to each described Monodispersity gel microsphere forming device in the claim 1 to 8, it is characterized in that: the pressure of described aerochamber remains on 1KPa to 5KPa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201010190558A CN101862266B (en) | 2010-06-01 | 2010-06-01 | Monodispersity gel microsphere forming device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010190558A CN101862266B (en) | 2010-06-01 | 2010-06-01 | Monodispersity gel microsphere forming device |
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| CN101862266A true CN101862266A (en) | 2010-10-20 |
| CN101862266B CN101862266B (en) | 2012-10-10 |
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| CN201010190558A Expired - Fee Related CN101862266B (en) | 2010-06-01 | 2010-06-01 | Monodispersity gel microsphere forming device |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166504A (en) * | 2011-03-22 | 2011-08-31 | 中国人民解放军第三○九医院 | Gel microsphere quick forming device and method |
| CN107510600A (en) * | 2017-08-07 | 2017-12-26 | 苏州大学 | A kind of device and method for preparing medicinal solid particulate |
| CN109550966A (en) * | 2018-12-17 | 2019-04-02 | 云南驰宏资源综合利用有限公司 | A kind of siphon is vertically atomized the method and device thereof that blowing prepares zinc powder |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1197262A2 (en) * | 2000-10-13 | 2002-04-17 | JAPAN as represented by DIRECTOR GENERAL OF NATIONAL FOOD RESEARCH INSTITUTE, MINISTRY OF AGRICULTURE, FORESTRY AND FISHERIES | Method and apparatus for manufacturing microspheres |
| WO2006028959A2 (en) * | 2004-09-03 | 2006-03-16 | Imarx Therapeutics, Inc. | Apparatus and method to prepare a microsphere-forming composition |
| CN1907553A (en) * | 2006-07-20 | 2007-02-07 | 厦门大学 | Method for preparing microsphere with nitrogen aid and apparatus thereof |
| WO2007050078A1 (en) * | 2005-10-26 | 2007-05-03 | University Of North Dakota | High-yield methods for producing low-density microspheres |
| CN101229098A (en) * | 2002-09-11 | 2008-07-30 | 田边三菱制药株式会社 | Method for preparation of microsphere and apparatus therefor |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2719296Y (en) * | 2004-08-04 | 2005-08-24 | 上海现代药物制剂工程研究中心有限公司 | Apparatus for continuously preparing medicine-containing microsphere |
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2010
- 2010-06-01 CN CN201010190558A patent/CN101862266B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1197262A2 (en) * | 2000-10-13 | 2002-04-17 | JAPAN as represented by DIRECTOR GENERAL OF NATIONAL FOOD RESEARCH INSTITUTE, MINISTRY OF AGRICULTURE, FORESTRY AND FISHERIES | Method and apparatus for manufacturing microspheres |
| CN101229098A (en) * | 2002-09-11 | 2008-07-30 | 田边三菱制药株式会社 | Method for preparation of microsphere and apparatus therefor |
| WO2006028959A2 (en) * | 2004-09-03 | 2006-03-16 | Imarx Therapeutics, Inc. | Apparatus and method to prepare a microsphere-forming composition |
| WO2007050078A1 (en) * | 2005-10-26 | 2007-05-03 | University Of North Dakota | High-yield methods for producing low-density microspheres |
| CN1907553A (en) * | 2006-07-20 | 2007-02-07 | 厦门大学 | Method for preparing microsphere with nitrogen aid and apparatus thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166504A (en) * | 2011-03-22 | 2011-08-31 | 中国人民解放军第三○九医院 | Gel microsphere quick forming device and method |
| CN107510600A (en) * | 2017-08-07 | 2017-12-26 | 苏州大学 | A kind of device and method for preparing medicinal solid particulate |
| CN109550966A (en) * | 2018-12-17 | 2019-04-02 | 云南驰宏资源综合利用有限公司 | A kind of siphon is vertically atomized the method and device thereof that blowing prepares zinc powder |
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| CN101862266B (en) | 2012-10-10 |
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Granted publication date: 20121010 Termination date: 20200601 |