CN221302918U - Paclitaxel survey processing apparatus - Google Patents
Paclitaxel survey processing apparatusInfo
- Publication number
- CN221302918U CN221302918U CN202322784628.2U CN202322784628U CN221302918U CN 221302918 U CN221302918 U CN 221302918U CN 202322784628 U CN202322784628 U CN 202322784628U CN 221302918 U CN221302918 U CN 221302918U
- Authority
- CN
- China
- Prior art keywords
- test tube
- fixedly connected
- grinding
- paclitaxel
- driving wheel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229930012538 Paclitaxel Natural products 0.000 title claims abstract description 25
- 229960001592 paclitaxel Drugs 0.000 title claims abstract description 25
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title claims abstract description 25
- 238000000227 grinding Methods 0.000 claims abstract description 32
- 229910001220 stainless steel Inorganic materials 0.000 claims abstract description 13
- 239000010935 stainless steel Substances 0.000 claims abstract description 13
- 238000005259 measurement Methods 0.000 claims abstract description 12
- 238000003756 stirring Methods 0.000 claims abstract description 11
- 239000006166 lysate Substances 0.000 claims abstract description 10
- 230000005540 biological transmission Effects 0.000 claims description 3
- 238000003556 assay Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 4
- 239000000523 sample Substances 0.000 description 26
- 238000000034 method Methods 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000002414 normal-phase solid-phase extraction Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013077 target material Substances 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
Abstract
The utility model relates to the technical field of paclitaxel treatment, and discloses a paclitaxel measurement treatment device which comprises a base, wherein the top of the base is fixedly connected with a stand column, the middle part of the stand column is fixedly connected with a supporting plate, a test tube is arranged in the supporting plate, the top of the stand column is fixedly connected with a top plate, the top of the top plate is fixedly provided with a motor, and the lower surface of the top plate is provided with a grinding centrifugal device for centrifugally grinding a biological tissue sample and a lysate in the test tube. The motor rotates and drives the driving wheel connected with the motor to rotate, so that the driving wheel meshed with the driving wheel is driven to rotate, the sliding rod is driven to rotate, the stirring rod is driven to rotate in the test tube to stir the stainless steel ball to grind the biological tissue sample, the centrifugal effect is achieved, the sample is extracted for measurement after grinding, mechanical equipment is adopted to replace manual grinding, grinding efficiency is accelerated, the biological tissue sample is sufficiently crushed, and working efficiency is accelerated.
Description
Technical Field
The utility model relates to the technical field of paclitaxel treatment, in particular to a paclitaxel measurement treatment device.
Background
Currently, in the determination of paclitaxel in biological samples, one of the following biological matrix pretreatment devices, solid phase extraction columns, a commonly used sample pretreatment technique, can be used for extracting and enriching the target compounds.
When paclitaxel is measured, a sample (such as plant tissues or a pharmaceutical preparation) containing paclitaxel is taken out and crushed into fine particles, and then precipitation, centrifugation and extraction are carried out, wherein the prior art usually adopts manual grinding by using a grinding rod, so that the labor intensity of operators is increased while the working efficiency is low.
Disclosure of utility model
The utility model provides a paclitaxel measuring and processing device, which aims to solve the technical problems that manual grinding is usually carried out by using a grinding rod, the working efficiency is low, and the labor intensity of operators is increased.
The utility model is realized by adopting the following technical scheme: the utility model provides a taxol survey processing apparatus, includes the base, the top fixedly connected with stand of base, the middle part fixedly connected with backup pad of stand, the inside of backup pad is provided with the test tube, the top fixedly connected with roof of stand, the top fixed mounting of roof has the motor, and the lower surface of roof is provided with grinds centrifugal device for the centrifugal grinding of biological tissue sample and lysate in the test tube.
Through the technical scheme, mechanical equipment is used for replacing manual grinding, so that the paclitaxel sample can be fully ground, and the working efficiency is quickened.
As a further improvement of the scheme, the grinding centrifugal device comprises a storage disc fixedly connected to the lower surface of the top plate, a driving wheel in transmission connection with the output end of the motor is rotatably arranged in the storage disc, the surface of the driving wheel is connected with a driven wheel in a meshed manner, the bottom of the driven wheel is fixedly connected with a sliding rod, the surface of the sliding rod is slidably connected with a rubber plug, and the bottom of the sliding rod is fixedly connected with a stirring rod corresponding to the test tube.
Through the technical scheme, the plurality of groups of taxol samples can be centrifugally ground at the same time, so that the sampling speed is increased, and meanwhile, the accuracy of measurement is improved by various measurement.
As a further improvement of the scheme, the test tube comprises a column body, a valve is arranged at the bottom of the column body, a filter screen is arranged in the valve, and a bottom tube is connected to the bottom of the column body through screw threads.
Through above-mentioned technical scheme, the test tube adopts the connection setting, and accessible valve is opened and is filtered the stainless steel ball for the sample of grinding back taxol improves work efficiency.
As a further improvement of the scheme, the surface of the upright post is movably connected with a clamp, and one side of the clamp is fixedly connected with a bottom plate corresponding to the bottom pipe.
Through above-mentioned technical scheme, the clamp slides on the stand, can be used to the support to the test tube, drives the bottom plate and moves down when sliding down, is convenient for take out the test tube, makes things convenient for taking out of sample.
As a further improvement of the scheme, the stainless steel balls are added into the biological tissue sample and the lysate in the test tube during centrifugal grinding, and the rubber plug slides down on the surface of the sliding rod to seal the test tube during working.
By the technical scheme, the stainless steel balls are higher in hardness and density, and can provide stronger grinding force and impact force, so that target substances can be crushed, ground and mixed more effectively in the grinding process, and the grinding efficiency and effect are improved.
As a further improvement of the above scheme, the test tube penetrates through the support plate, and the test tube is detachably arranged.
Through the technical scheme, the complete taking out of the sample is quickened, the follow-up work is convenient to carry out, and the working efficiency is quickened.
Compared with the prior art, the utility model has the beneficial effects that:
According to the utility model, the driving wheel connected with the driving wheel is driven to rotate while the motor rotates, so that the driven wheel meshed with the driving wheel is driven to rotate, the sliding rod is driven to rotate, the stirring rod is driven to rotate in the test tube to stir the stainless steel balls to grind the biological tissue sample, the centrifugal effect is achieved, after grinding is finished, the valve can be opened to filter out the stainless steel balls, so that the sample enters the bottom tube, the sample is kept stand and deposited for a period of time, the clamp is slid downwards, the bottom plate drives the test tube to move downwards, the test tube is taken out, the bottom tube is taken out through threads, the sample is extracted for measurement, and the mechanical equipment is adopted to replace manual grinding to accelerate the grinding efficiency, so that the biological tissue sample is fully crushed, and the working efficiency is accelerated.
Drawings
FIG. 1 is a schematic perspective view of the present utility model;
FIG. 2 is a schematic diagram of the internal structure of the present utility model;
FIG. 3 is a schematic view of the joint between the driving wheel and the driven wheel according to the present utility model;
FIG. 4 is a schematic view of the structure of the test tube of the present utility model.
Main symbol description:
1. A base; 2. a column; 3. a support plate; 4. a test tube; 5. a top plate; 6. a motor; 7. a storage tray; 8. a driving wheel; 9. driven wheel; 10. a slide bar; 11. a rubber stopper; 12. a stirring rod; 13. a column; 14. a valve; 15. a bottom tube; 16. a thread; 17. a bottom plate; 18. and (5) clamping the clamp.
Detailed Description
The present utility model will be further described with reference to the accompanying drawings and detailed description, wherein it is to be understood that, on the premise of no conflict, the following embodiments or technical features may be arbitrarily combined to form new embodiments.
Example 1:
Please combine fig. 1-4, a paclitaxel survey processing apparatus of this embodiment, including base 1, the top fixedly connected with stand 2 of base 1, the middle part fixedly connected with backup pad 3 of stand 2, the inside of backup pad 3 is provided with test tube 4, the top fixedly connected with roof 5 of stand 2, the top fixed mounting of roof 5 has motor 6, and the lower surface of roof 5 is provided with grinds centrifugal device for biological tissue sample in the test tube 4 and the centrifugal grinding of schizolysis liquid.
Mechanical equipment is used for replacing manual grinding, so that the paclitaxel sample can be fully ground, and the working efficiency is quickened.
Please refer to fig. 1 and 2, the test tube 4 penetrates through the support plate 3, and the test tube 4 is detachably disposed.
The complete taking out of the sample is quickened, the follow-up work is convenient to carry out, and the working efficiency is quickened.
Referring to fig. 1, a clamp 18 is movably connected to the surface of the upright post 2, and a bottom plate 17 corresponding to the bottom pipe 15 is fixedly connected to one side of the clamp 18.
The clamp 18 slides on the stand column 2, can be used to the support of test tube 4, drives bottom plate 17 and moves down when sliding down, is convenient for take out test tube 4, makes things convenient for taking out of sample.
Referring to fig. 4, the test tube 4 includes a column 13, a valve 14 is disposed at the bottom of the column 13, a filter screen is disposed inside the valve 14, and a bottom tube 15 is screwed to the bottom of the column 13 by a screw 16.
The test tube 4 is connected, and the stainless steel ball can be opened and filtered through the valve 14, so that the sampling of the grinded paclitaxel is quickened, and the working efficiency is improved.
Example 2, the further improvement on the basis of example 1 is:
Referring to fig. 2 and 3, the grinding and centrifuging device includes a receiving tray 7 fixedly connected to the lower surface of the top plate 5, a driving wheel 8 in transmission connection with the output end of the motor 6 is rotatably installed in the receiving tray 7, a driven wheel 9 is engaged and connected to the surface of the driving wheel 8, a slide bar 10 is fixedly connected to the bottom of the driven wheel 9, a rubber plug 11 is slidingly connected to the surface of the slide bar 10, and a stirring rod 12 corresponding to the test tube 4 is fixedly connected to the bottom of the slide bar 10.
The method can carry out centrifugal grinding on a plurality of groups of taxol samples at the same time, so that the sampling speed is increased, and meanwhile, the accuracy of measurement is improved by a plurality of types of measurement.
The biological tissue sample and the lysate in the test tube 4 are added with stainless steel balls during centrifugal grinding, and a rubber plug 11 slides down the surface of a slide bar 10 to seal the test tube 4 during operation.
The higher hardness and density of the stainless steel balls provides stronger grinding and impact forces, which enable them to more effectively break up, grind and mix target materials during grinding, thereby improving grinding efficiency and effectiveness.
The implementation principle of the paclitaxel measurement processing device in the embodiment of the application is as follows: the biological tissue sample and the lysate are arranged in a test tube 4, the sample and the lysate are supported and placed in a supporting plate 3 by a bottom plate 17 and correspond to a stirring rod 12, a proper amount of stainless steel balls are placed in the sample and the lysate slides downwards to seal the test tube 4, a motor 6 is controlled to rotate, the motor 6 rotates and drives a driving wheel 8 connected with the sample and the lysate to rotate, so that a driven wheel 9 meshed with the driving wheel 8 is driven to rotate, a sliding rod 10 is driven to rotate, the stirring rod 12 is driven to rotate in the test tube 4 to stir the stainless steel balls to grind the biological tissue sample, a centrifugal effect is achieved, after grinding is finished, a valve 14 can be opened to filter the stainless steel balls, the sample enters a bottom tube 15, the sample is kept still to be precipitated for a period of time, a clamp 18 slides downwards, the bottom plate 17 drives the test tube 4 to move downwards, the test tube 4 is taken out, the bottom tube 15 is taken down by threads 16, and the sample is extracted for measurement.
The above embodiments are only preferred embodiments of the present utility model, and the scope of the present utility model is not limited thereto, but any insubstantial changes and substitutions made by those skilled in the art on the basis of the present utility model are intended to be within the scope of the present utility model as claimed.
Claims (6)
1. The utility model provides a taxol survey processing apparatus, includes base (1), its characterized in that, the top fixedly connected with stand (2) of base (1), the middle part fixedly connected with backup pad (3) of stand (2), the inside of backup pad (3) is provided with test tube (4), the top fixedly connected with roof (5) of stand (2), the top fixed mounting of roof (5) has motor (6), and the lower surface of roof (5) is provided with grinds centrifugal device for biological tissue sample and the centrifugal grinding of lysate in test tube (4).
2. The paclitaxel measurement processing device according to claim 1, wherein the grinding centrifugal device comprises a storage disc (7) fixedly connected to the lower surface of the top plate (5), a driving wheel (8) in transmission connection with the output end of the motor (6) is rotatably installed in the storage disc (7), a driven wheel (9) is connected to the surface of the driving wheel (8) in a meshed manner, a sliding rod (10) is fixedly connected to the bottom of the driven wheel (9), a rubber plug (11) is slidably connected to the surface of the sliding rod (10), and a stirring rod (12) corresponding to the test tube (4) is fixedly connected to the bottom of the sliding rod (10).
3. The paclitaxel assay processing device according to claim 2, wherein the test tube (4) comprises a column (13), a valve (14) is arranged at the bottom of the column (13), a filter screen is arranged inside the valve (14), and a bottom tube (15) is connected to the bottom of the column (13) through a screw (16) in a threaded manner.
4. The paclitaxel measuring and processing device according to claim 1, wherein a clamp (18) is movably connected to the surface of the upright post (2), and a bottom plate (17) corresponding to the bottom tube (15) is fixedly connected to one side of the clamp (18).
5. A paclitaxel assay device according to claim 3, wherein the biological tissue sample and the lysate in the test tube (4) are subjected to centrifugal grinding by adding stainless steel balls, and the rubber stopper (11) slides down the surface of the slide bar (10) to seal the test tube (4) during operation.
6. The paclitaxel measurement processing device according to claim 1, wherein the test tube (4) penetrates through the support plate (3), and the test tube (4) is detachably disposed.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN221302918U true CN221302918U (en) | 2024-07-09 |
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| Date | Code | Title | Description |
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| GR01 | Patent grant |