CN221252169U - Cell and biological sample low temperature transfer device - Google Patents

Abstract

The utility model discloses a biological sample low-temperature transfer device, which comprises: the bottom in the box body is provided with a cold source storage tank; the sample rack is connected with the inner side wall of the box body, the sample rack is positioned above the cold source storage tank, at least two storage tanks are arranged at the top of the sample rack, and the storage tanks are used for storing the sample storage boxes; the electric sample clamping device is arranged in the accommodating groove at one side in the box body, the electric sample clamping device is positioned at one side of the sample placing rack, the electric sample clamping device is used for clamping a biological sample tube in the sample storage box, at least two sample storage boxes can be placed in the two placing grooves, free combination under different use occasions is met, and the placing grooves are used for preventing the sample storage boxes from moving. The biological sample tube can be grabbed from the sample storage box through the electric sample clamping device, so that the problem that the time consumption is long because the biological sample tube needs to be manually taken is solved.

Description

Cell and biological sample low temperature transfer device

Technical Field

The utility model relates to the technical field of biological sample low-temperature transfer tools, in particular to a cell and biological sample low-temperature transfer device.

Background

In the field of cell biology research and important biological resource preservation, cell cryopreservation and other biological samples require long-term storage at low temperatures such as-80 ℃ or liquid nitrogen after finishing pretreatment. After the temperature of the cells and the biological samples is reduced, if the cells and the biological samples are transferred in different storage containers, the cell activity and the sample quality of the cells and the biological samples are affected due to temperature fluctuation. Therefore, a low-temperature transfer device is needed to realize rapid and accurate sample transfer at low temperature, and the sample quality is ensured.

The existing sample transfer apparatus generally can only meet the temperature maintenance of 1 conventional sample storage box, and the transfer process needs to be manually checked and taken one by one, which takes a long time.

Disclosure of utility model

In order to solve the problems that the sample transfer device in the prior art can generally only meet the temperature maintenance of 1 conventional sample storage box, and the transfer process needs to be manually checked and taken one by one, the time consumption is long, and the utility model provides a cell and biological sample low-temperature transfer device.

The technical scheme adopted by the utility model is as follows: a cell and biological sample cryogenic transfer device comprising:

the cold source storage tank is arranged at the bottom in the box body;

The sample placing rack is connected with the inner side wall of the box body, the sample placing rack is positioned above the cold source storage groove, at least two placing grooves are formed in the top of the sample placing rack, and the placing grooves are used for placing the sample storage boxes;

The electric sample clamping device is arranged in the first accommodating groove at one side in the box body, the electric sample clamping device is positioned at one side of the sample placing rack, and the electric sample clamping device is used for clamping a biological sample tube in the sample storage box.

Preferably, the motorized sample holding device comprises:

The first driving mechanism is arranged in the first accommodating groove;

The second driving mechanism is connected with the first driving mechanism, and the first driving mechanism is used for driving the second driving mechanism to displace in the X-axis direction;

The third driving mechanism is connected with the second driving mechanism and is used for driving the third driving mechanism to displace in the Z-axis direction;

The clamping mechanism is connected with the third driving mechanism, and the third driving mechanism is used for driving the clamping mechanism to displace in the Y-axis direction.

Preferably, the first driving mechanism includes:

a first supporting piece fixedly connected with the side wall of the first accommodating groove,

The first motor is fixed on the top of the first supporting piece;

One end of the first screw rod is connected with an output shaft of the first motor, the other end of the first screw rod is rotationally connected with the side wall of the first accommodating groove, and the first screw rod is arranged towards the X-axis direction;

the first moving block is connected with the first screw rod in a sliding manner;

The second supporting piece is fixedly connected with one side of the first moving block, which faces the sample placing frame, and the second driving mechanism is connected with the second supporting piece.

Preferably, the second driving mechanism includes:

the second motor is fixed on the top of the second supporting piece;

One end of the second screw rod is connected with an output shaft of the second motor, the other end of the second screw rod is rotationally connected with the top of the first accommodating groove, and the second screw rod is arranged towards the Y-axis direction;

the second moving block is connected with the second screw rod in a sliding manner;

The third supporting piece is fixedly connected with one side, facing the sample placing rack, of the second moving block, and the third driving mechanism is connected with the second supporting piece.

Preferably, the third driving mechanism includes:

the cylinder is fixed on the top of the third supporting piece;

The telescopic rod, the one end of telescopic rod with the output shaft of cylinder, the other end of telescopic rod with fixture connection.

Preferably, the clamping mechanism comprises:

the clamping frame is connected with the telescopic rod;

The clamping table, the clamping table with the clamping frame is connected, the top of clamping table is provided with a plurality of through-holes, a plurality of at least one of through-holes is the centre gripping hole, the lateral wall in centre gripping hole is provided with two at least second holding tanks relatively, be provided with the elastic component in the second holding tank, the one end of elastic component with the inside wall in second holding tank is connected, the other end and the centre gripping piece of elastic component are connected.

The beneficial effects of the utility model are as follows: two holding tanks can place two 9*9's sample storage box, and eight 5*5's sample storage box can be placed to many, satisfies the free combination under the different service scenarios, and the size of holding tank and the size adaptation of sample storage box prevent that the sample storage box from removing in the holding tank. The biological sample tube can be grabbed from the sample storage box through the electric sample clamping device, so that the problem that the time consumption is long because the biological sample tube needs to be manually taken is solved.

Drawings

FIG. 1 is a schematic perspective view of the case of the present utility model;

FIG. 2 is a schematic top view of the case of the present utility model;

FIG. 3 is an enlarged schematic view of the electric sample holding device of the present utility model;

FIG. 4 is an enlarged schematic view of the motorized sample holding device of the present utility model with the holding mechanism removed;

FIG. 5 is a schematic top view of the clamping mechanism 34 of the present utility model;

fig. 6 is a schematic perspective view of a clamping hole according to the present utility model.

Reference numerals: 1. a case; 11. a cold source storage tank; 12. a first accommodation groove; 2. a sample rack; 21. a placement groove; 3. an electric sample holding device; 31. a first driving mechanism; 311. a first support; 312. a first motor; 313. a first screw rod; 314. a first moving block; 315. a second support; 32. a second driving mechanism; 321. a second motor; 322. a second screw rod; 323. a second moving block; 324. a third support; 33. a third driving mechanism; 331. a cylinder; 332. a telescopic rod; 34. a clamping mechanism; 341. a clamping frame; 342. a clamping table; 343. a through hole; 344. a second accommodation groove; 345. an elastic member; 346. and a clamping piece.

Detailed Description

For the purpose of making apparent the objects, aspects and advantages of the present utility model, the following detailed description of the present utility model is given by way of illustration only and not by way of limitation, with reference to the accompanying examples and figures.

In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present utility model. However, it will be apparent to one of ordinary skill in the art that: no such specific details are necessary to practice the utility model. In other instances, well-known structures, circuits, materials, or methods have not been described in detail in order not to obscure the utility model.

Throughout the specification, references to "one embodiment," "an embodiment," "one example," or "an example" mean: a particular feature, structure, or characteristic described in connection with the embodiment or example is included within at least one embodiment of the utility model. Thus, the appearances of the phrases "in one embodiment," "in an example," or "in an example" in various places throughout this specification are not necessarily all referring to the same embodiment or example. Furthermore, the particular features, structures, or characteristics may be combined in any suitable combination and/or sub-combination in one or more embodiments or examples. Moreover, those of ordinary skill in the art will appreciate that the illustrations provided herein are for illustrative purposes and that the illustrations are not necessarily drawn to scale. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.

In the description of the present utility model, the terms "front", "rear", "left", "right", "upper", "lower", "vertical", "horizontal", "high", "low", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, merely to facilitate description of the present utility model and simplify description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the scope of the present utility model.

As shown in fig. 1 and 2, a cell and biological sample cryotransfer apparatus comprises: the cold source storage tank 11 is arranged at the bottom in the box body 1; the sample rack 2, the sample rack 2 is connected with the inside wall of the box 1, the sample rack 2 is located above the cold source storage tank 11, at least two placing grooves 21 are arranged at the top of the sample rack 2, a plurality of holes are formed in the two placing grooves 21, the sample rack is communicated with the cold source storage tank 11 through the holes, and the placing grooves 21 are used for placing sample storage boxes; the electric sample clamping device 3 is arranged in the first accommodating groove 12 on one side in the box body 1, the electric sample clamping device 3 is positioned on one side of the sample placing frame 2, and the electric sample clamping device 3 is used for clamping a biological sample tube in the sample storage box.

The inner side wall of the cold source storage tank 11 is provided with a vacuum heat insulation layer, and the cold source storage tank 11 can be filled with liquid nitrogen, dry ice, ice bags and other cold sources, so that different transfer temperature requirements are met.

It can be understood that the top of one side of the box body 1, which is close to the electric sample clamping device 3, is provided with a display screen, the bottom of the cold source storage tank 11 is provided with a temperature detection probe, the temperature detection probe is connected with the temperature display screen, and the display screen can display the temperature in the box body 1 in real time. It should be noted that, both the temperature detecting probe and the display screen are available, and the connection manner is well known to those skilled in the art.

In this embodiment, two 9*9 sample storage boxes can be placed in two placement grooves 21, and eight 5*5 sample storage boxes can be placed in many cases, so that the free combination under different use situations is satisfied, and the size of the placement groove 21 and the size of the sample storage box are adapted, so that the sample storage boxes are prevented from moving in the placement groove 21. The biological sample tube can be grasped from the sample storage box by the electric sample holding device 3, so that the problem that the time is long because the biological sample tube needs to be manually taken is solved.

As shown in fig. 3 and 4, the electric sample holding device 3 includes: a first driving mechanism 31, wherein the first driving mechanism 31 is arranged in the accommodating groove; a second driving mechanism 32, wherein the second driving mechanism 32 is connected with the first driving mechanism 31, and the first driving mechanism 31 is used for driving the second driving mechanism 32 to displace in the X-axis direction; a third driving mechanism 33, wherein the third driving mechanism 33 is connected with the second driving mechanism 32, and the second driving mechanism 32 is used for driving the third driving mechanism 33 to displace in the Z-axis direction; and a clamping mechanism 34, wherein the clamping mechanism 34 is connected with the third driving mechanism 33, and the third driving mechanism 33 is used for driving the clamping mechanism 34 to displace in the Y-axis direction.

As shown in fig. 3 and 4, the first driving mechanism 31 includes: the first supporting piece 311 is fixedly connected with the side wall of the first accommodating groove 12, and the first motor 312 is fixed on the top of the first supporting piece 311; a first screw rod 313, one end of the first screw rod 313 is connected with an output shaft of the first motor 312, the other end of the first screw rod 313 is rotatably connected with a side wall of the first accommodating groove 12, and the first screw rod 313 is arranged towards the X-axis direction; a first moving block 314, wherein the first moving block 314 is slidably connected with the first screw 313; the second support 315, the second support 315 is fixedly connected with one side of the first moving block 314 facing the sample rack 2, and the second driving mechanism 32 is connected with the second support 315.

As shown in fig. 3 and 4, the second driving mechanism 32 includes: a second motor 321, the second motor 321 being fixed on top of the second support 315; one end of the second screw rod 322 is connected with an output shaft of the second motor 321, the other end of the second screw rod 322 is rotatably connected with the top of the first accommodating groove 12, and the second screw rod 322 is arranged towards the Y-axis direction; the second moving block 323, the said second moving block 323 is connected with said second lead screw 322 slidably; the third support 324 is fixedly connected to the second moving block 323 at a side facing the sample rack 2, and the third driving mechanism 33 is connected to the second support 315.

As shown in fig. 3 and 4, the third driving mechanism 33 includes: a cylinder 331, the cylinder 331 being fixed on top of the third support 315; and one end of the telescopic rod 332 is connected with the output shaft of the air cylinder 331, and the other end of the telescopic rod 332 is connected with the clamping mechanism 34.

When the biological sample tube needs to be grasped, the position of the clamping mechanism 34 needs to be adjusted, at this time, the first motor 312 can be controlled to rotate to drive the first screw rod 313 to rotate, and along with the rotation of the first screw rod 313, the first moving block 314 performs displacement in the X-axis direction on the first screw rod 313, and the first moving block 314 drives the second driving mechanism 32 positioned on the second supporting member 315, the third driving mechanism 33 positioned on the third supporting member 324 and the clamping mechanism 34 connected with the third driving mechanism 33 to displace in the X-axis direction; by controlling the second motor 321 to rotate, the second motor 321 drives the second screw rod 322 to rotate, and along with the rotation of the second screw rod 322, the second moving block 323 performs displacement in the Z-axis direction on the second screw rod 322, and the second moving block 323 drives the third driving mechanism 33 positioned on the third supporting piece 324 and the clamping mechanism 34 connected with the third driving mechanism 33 to displace in the Z-axis direction; by controlling the actuation of the air cylinder 331, the air cylinder 331 drives the telescopic rod 332 to stretch and retract, and the telescopic rod 332 drives the clamping mechanism 34 to move in the Y-axis direction.

In summary, the clamping mechanism 34 can move up and down, left and right, and back and forth in three dimensions by the action of the first, second, and third driving mechanisms 31, 32, 33.

As shown in fig. 5 and 6, the clamping mechanism 34 includes: a clamping frame 341, wherein the clamping frame 341 is connected with the telescopic rod 332; the clamping table 342, the clamping table 342 with the clamping frame 341 is connected, the top of clamping table 342 is provided with a plurality of through-holes 343, a plurality of at least one of through-holes 343 is the centre gripping hole, the lateral wall in centre gripping hole is provided with two at least second holding tank 344 relatively, be provided with the elastic component 345 in the second holding tank 344, the one end of elastic component 345 with the inside wall of second holding tank 344 is connected, the other end of elastic component 345 is connected with clamping piece 346.

It should be noted that, in the sample storage cartridge in the prior art, there are a plurality of sample placement holes, such as the sample placement hole 9*9, in which a plurality of biological sample tubes are placed, respectively.

It will be appreciated that in the present application, the dimensions of the holding platform 342 and the sample storage cartridge are the same, the through holes 343 of the holding platform 342 and the sample placement holes on the sample storage cartridge are in one-to-one correspondence and are of the same dimensions, and at least one holding hole is provided in the through holes 343 in order to achieve gripping of a particular biological sample tube. The working principle is as follows:

When a specific biological sample tube on the sample storage box needs to be grabbed, for example, biological sample tubes at the center positions of 9*9 sample placement holes on the sample storage box need to be grabbed, the number of through holes on the clamping table 342 is 9*9, wherein the through holes at the center positions of 9*9 through holes on the clamping table 342 are arranged as clamping holes, the positions of the clamping table 342 can be adjusted to be right above the sample storage box through the actions of the first driving mechanism 31, the second driving mechanism 32 and the third driving mechanism 33, at the moment, the through holes 343 on the clamping table 342 are in one-to-one correspondence with the sample placement holes on the sample storage box, the clamping table 342 is controlled to move downwards through the second driving mechanism 32, the through holes of the clamping table 342 can be sleeved on the biological sample tube at the lower part, the biological sample tube at the center positions of the sample storage box is clamped by the clamping pieces 346 in the clamping tubes, and the elastic pieces 345 are used for providing the clamping force of the clamping pieces 346. The second driving mechanism 32 then controls the clamping table 342 to move upward, so that the biological sample tube clamped by the clamping plate 346 is grasped, and the remaining biological sample tube passes through the through hole without being separated from the sample storage box.

It should be noted that, in the unclamped state, the dimension between the two opposing clamping pieces 346 is smaller than the dimension of the biological sample tube, and when the top end of the biological sample tube contacts the two clamping pieces 346 in the clamped state, the two clamping pieces 346 are first pressed into the second accommodating groove 344, at this time, the elastic member 345 compresses, and the elastic member 345 has a reactive clamping force on the two clamping pieces. Since the dimension between the two holding pieces 346 disposed opposite to each other is smaller than the dimension of the biological sample tube in the unclamped state, the dimension of the two holding pieces 346 disposed opposite to each other, which is enclosed by the two holding pieces 346 disposed opposite to each other toward one side of the biological sample tube, is the same as the biological sample tube, i.e., the circular arc dimension of the two holding pieces 346 disposed opposite to each other, which is enclosed by the two holding pieces 346 disposed opposite to each other toward one side of the biological sample tube and one side away from the biological sample tube, is gradually smaller for convenience of the biological sample tube entering between the two holding pieces 346.

The foregoing examples merely illustrate specific embodiments of the utility model, which are described in greater detail and are not to be construed as limiting the scope of the utility model. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the utility model, which are all within the scope of the utility model.

Claims (6)

1. A cell and biological sample cryogenic transfer device, characterized in that: comprising the following steps:

The cold source storage tank comprises a box body (1), wherein a cold source storage tank (11) is arranged at the bottom in the box body (1);

the sample storage rack (2), the sample storage rack (2) is connected with the inner side wall of the box body (1), the sample storage rack (2) is located above the cold source storage groove (11), at least two storage grooves (21) are formed in the top of the sample storage rack (2), and the storage grooves (21) are used for storing sample storage boxes;

The electric sample clamping device (3) is arranged in a first accommodating groove (12) on one side in the box body (1), the electric sample clamping device (3) is positioned on one side of the sample placing rack (2), and the electric sample clamping device (3) is used for clamping a biological sample tube in the sample storage box.

2. The device for cryogenic transfer of cells and biological samples according to claim 1, wherein: the motorized sample holding device (3) comprises:

A first driving mechanism (31), wherein the first driving mechanism (31) is arranged in the first accommodating groove (12);

A second driving mechanism (32), wherein the second driving mechanism (32) is connected with the first driving mechanism (31), and the first driving mechanism (31) is used for driving the second driving mechanism (32) to displace in the X-axis direction;

A third driving mechanism (33), wherein the third driving mechanism (33) is connected with the second driving mechanism (32), and the second driving mechanism (32) is used for driving the third driving mechanism (33) to displace in the Z-axis direction;

And the clamping mechanism (34) is connected with the third driving mechanism (33), and the third driving mechanism (33) is used for driving the clamping mechanism (34) to displace in the Y-axis direction.

3. The device for cryogenic transfer of cells and biological samples according to claim 2, wherein: the first driving mechanism (31) includes:

A first supporting piece (311), wherein the first supporting piece (311) is fixedly connected with the side wall of the first accommodating groove (12),

-A first motor (312), said first motor (312) being fixed on top of said first support (311);

One end of the first screw rod (313) is connected with an output shaft of the first motor (312), the other end of the first screw rod (313) is rotationally connected with the side wall of the first accommodating groove (12), and the first screw rod (313) is arranged towards the X-axis direction;

A first moving block (314), wherein the first moving block (314) is in sliding connection with the first screw rod (313);

The second supporting piece (315), the second supporting piece (315) with first movable block (314) orientation one side rigid coupling of sample rack (2), second actuating mechanism (32) with second supporting piece (315) are connected.

4. A cell and biological sample cryotransfer apparatus according to claim 3, wherein: the second driving mechanism (32) includes:

-a second motor (321), the second motor (321) being fixed on top of the second support (315);

One end of the second screw rod (322) is connected with an output shaft of the second motor (321), the other end of the second screw rod (322) is rotationally connected with the top of the first accommodating groove (12), and the second screw rod (322) is arranged towards the Y-axis direction;

the second moving block (323), the said second moving block (323) is connected with said second lead screw (322) slidably;

The third supporting piece (324), the third supporting piece (324) with one side rigid coupling of second movable block (323) orientation sample rack (2), third actuating mechanism (33) with second supporting piece (315) are connected.

5. The device of claim 4, wherein: the third driving mechanism (33) includes:

-a cylinder (331), said cylinder (331) being fixed on top of said second support (315);

And one end of the telescopic rod (332) is connected with the output shaft of the air cylinder (331), and the other end of the telescopic rod (332) is connected with the clamping mechanism (34).

6. The device of claim 5, wherein: the clamping mechanism (34) comprises:

-a clamping frame (341), the clamping frame (341) being connected to the telescopic rod (332);

The clamping table (342), clamping table (342) with clamping frame (341) are connected, the top of clamping table (342) is provided with a plurality of through-holes (343), a plurality of at least one of through-holes (343) is the centre gripping hole, the lateral wall in centre gripping hole is provided with two at least second holding tanks (344) relatively, be provided with elastic component (345) in second holding tanks (344), the one end of elastic component (345) with the inside wall of second holding tanks (344) is connected, the other end and the centre gripping piece (346) of elastic component (345) are connected.