CN221078158U - Sampling device in S-alkanone production - Google Patents
Sampling device in S-alkanone production Download PDFInfo
- Publication number
- CN221078158U CN221078158U CN202322481961.6U CN202322481961U CN221078158U CN 221078158 U CN221078158 U CN 221078158U CN 202322481961 U CN202322481961 U CN 202322481961U CN 221078158 U CN221078158 U CN 221078158U
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- Prior art keywords
- sampling
- alkanone
- built
- production
- assembly
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- 238000005070 sampling Methods 0.000 title claims abstract description 87
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 14
- 238000006243 chemical reaction Methods 0.000 claims abstract description 17
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 238000003756 stirring Methods 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 16
- 238000007789 sealing Methods 0.000 claims description 11
- 230000003287 optical effect Effects 0.000 claims description 5
- 238000001514 detection method Methods 0.000 abstract description 5
- 239000012295 chemical reaction liquid Substances 0.000 description 8
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000007363 ring formation reaction Methods 0.000 description 2
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Abstract
The utility model discloses a sampling device in S-alkanone production, which comprises a built-in sampling head, a mixed sampling cavity, a reciprocating movement assembly and a negative pressure suction device, wherein the sampling head is arranged in the mixing sampling cavity; a reciprocating movement assembly is arranged in the reaction container; the built-in sampling head is arranged on the reciprocating assembly, and is driven by the reciprocating assembly to move up and down; one end of the flexible sampling tube is connected with the built-in sampling head, and the other end is connected with the sampling port on the reaction container; the mixed sampling cavity is connected with the sampling port through a conveying pipeline; the mixed sampling cavity is connected with the negative pressure suction device through a negative pressure pipeline. The utility model improves the accuracy of sampling detection.
Description
Technical Field
The utility model relates to the technical field of (S) -4-phenyl-2-oxazolidone production, in particular to a sampling device in S-oxazolidone production.
Background
The oxazolidinone chiral auxiliary is an important chiral drug intermediate, potassium tert-butoxide is added into an acylated liquid in a cyclization reaction under the protection of nitrogen in a synthesis process, the temperature is raised, toluene-alcohol is distilled out at normal pressure for about 2 hours, a reaction liquid is sampled, the temperature of the cyclization liquid is reduced after the reaction liquid is qualified, glacial acetic acid is added, water is then added, the temperature is raised and maintained at 60 ℃, standing is carried out for 30 minutes for layering, a water layer is separated into a water layer receiving tank, at least a quantity of toluene layer is concentrated, crystallization is carried out, and a finished product is obtained after drying.
Because the reaction liquid is placed in the container for a long time, the reaction liquid is slightly concentrated at different depths, and the existing sampling device can cause deviation between detection data and actual data when sampling and detecting.
Disclosure of utility model
The utility model aims to solve the technical problem of providing a sampling device in the production of S-alkanone, which improves the accuracy of sampling detection.
In order to solve the technical problems, the utility model adopts the following technical scheme: the sampling device in the S-alkanone production comprises a built-in sampling head, a mixed sampling cavity, a reciprocating component and a negative pressure suction device; a reciprocating movement assembly is arranged in the reaction container; the built-in sampling head is arranged on the reciprocating assembly, and is driven by the reciprocating assembly to move up and down; one end of the flexible sampling tube is connected with the built-in sampling head, and the other end is connected with the sampling port on the reaction container; the mixed sampling cavity is connected with the sampling port through a conveying pipeline; the mixed sampling cavity is connected with the negative pressure suction device through a negative pressure pipeline.
Further, the built-in sampling head comprises a columnar shell; a liquid channel is arranged in the columnar shell; the side wall of the columnar shell is provided with a plurality of liquid pumping holes communicated with the liquid channel; the columnar shell is fixed on the connecting seat; the connecting seat is driven by the reciprocating assembly to move up and down; the top of the columnar shell is connected with a flexible sampling tube; the flexible sampling tube is communicated with the liquid channel.
Further, the top and the bottom of the columnar shell are fixedly connected with conical heads.
Further, the reciprocating assembly comprises a screw; the connecting seat is in threaded connection with the screw rod; the two ends of the screw are rotationally connected with the top and the bottom of the reaction container; the optical axis section at the top of the screw rod extends out of the reaction container and is connected with the output end of the motor through a coupler; a guide shaft is arranged on one side of the guide shaft; the connecting seat is provided with a guide hole matched with the guide shaft.
Further, the mixing sampling cavity comprises a bottle body and a stirring assembly; the stirring assembly comprises a sealing cover; the sealing cover is rotatably provided with a stirring shaft; the stirring shaft is provided with a stirring paddle; the sealing cover is in threaded connection with the bottle body.
Further, a timing switch valve is arranged on the negative pressure pipeline.
The beneficial effects of the utility model are as follows:
1) According to the utility model, through the arrangement of the sampling head and the reciprocating assembly, the reciprocating assembly is utilized to drive the sampling head to move up and down, the reaction liquid with different depths is sucked, the accuracy of sampling and detecting the reaction liquid is improved, and the deviation of detection data caused by different concentrations of the reaction liquid at different depths is reduced.
2) The utility model has simple structure and easy operation, and the sampling liquid is fully mixed after entering the mixing sampling cavity for stirring, thereby improving the accuracy of sampling detection.
Drawings
The utility model is further described below with reference to the drawings and examples.
Fig. 1 is a schematic structural view of the present utility model.
Fig. 2 is a schematic diagram of a built-in sampling head.
FIG. 3 is a schematic diagram of a hybrid sampling chamber.
Detailed Description
The technical scheme of the present utility model will be clearly and completely described in the following detailed description.
Referring to fig. 1 and 2, a sampling device in the production of S-alkanone of the utility model comprises a built-in sampling head 1, a mixing sampling cavity 2, a reciprocating assembly 3 and a negative pressure suction device 4.
In the embodiment, a reciprocating movement assembly 3 is arranged in a reaction container; the shuttle assembly 3 of the present embodiment includes a screw 31; the built-in sampling head 1 is fixedly arranged on the connecting seat 15. The connecting seat 15 is in threaded connection with the screw 31; the screw 31 rotates to drive the connecting seat 15 to move up and down, so as to control the built-in sampling head 1 to move up and down.
The two ends of the screw 31 in this embodiment are optical axis sections, and the optical axis sections at the two ends are respectively rotatably connected with the top and bottom of the reaction vessel. The optical axis section at the top of the screw 31 extends out of the reaction vessel and is connected with the output end of the motor through a coupler; the motor is fixedly arranged at the top of the reaction vessel.
The present embodiment is further provided with a guide shaft 32 at one side of the screw 31; the connecting seat 15 is provided with a guide hole matched with the guide shaft, the connecting seat moves up and down along the guide shaft 32, and when the screw rod 31 rotates, the connecting seat does not rotate along with the screw rod under the limit of the guide shaft, so that the circumferential movement of the screw rod is converted into the axial movement of the connecting seat.
In this embodiment, a flexible sampling tube 5 is disposed in a reaction vessel, one end of the flexible sampling tube 5 is connected with a built-in sampling head 1, and the other end is connected with a sampling port 6 on the reaction vessel. The flexible sampling tube 5 can be a metal corrugated tube, and the flexible sampling tube 5 is arranged to achieve the purpose of not limiting the movement of the built-in sampling head 1.
The built-in sampling head 1 of the present embodiment includes a columnar housing 11; a liquid channel 12 is arranged in the columnar shell 11; the side wall of the cylindrical housing 11 is provided with a plurality of liquid suction holes 14 communicating with the liquid passage 12. The liquid-extracting hole 14 is horizontally arranged, and the reaction liquid with little depth of the liquid-extracting Kong Cha is extracted.
The columnar shell 11 is fixed on the connecting seat 15; the connecting seat 15 is driven by the reciprocating assembly 3 to move up and down; the top of the columnar shell 11 is connected with a flexible sampling tube 5; the flexible sampling tube 5 communicates with the liquid channel 12.
In order to reduce the resistance of the built-in sampling head 1 to move up and down, the top and bottom of the columnar shell 11 are fixedly connected with a conical head 13.
The mixed sampling cavity 2 of the embodiment is connected with a sampling port 6 through a conveying pipeline; the mixed sampling cavity 2 is connected with the negative pressure suction device 4 through a negative pressure pipeline 7. The mixing sampling cavity 2 comprises a bottle body 21 and a stirring assembly; the stirring assembly of this embodiment includes a sealing cover 22; the sealing cover is rotatably provided with a stirring shaft 23; the stirring shaft 23 is provided with a stirring paddle 24; the sealing cover 22 is in threaded connection with the bottle body 21, and an internal thread mouth in threaded connection with the sealing cover is arranged at the top of the bottle body 21. The conveying pipeline and the negative pressure pipe are detachably connected with the mixed sampling cavity.
The bottle body comprises a bottle body and a bottle cap, and the bottle cap is screwed with the cap body; the conveying pipeline and the negative pressure suction pipe are fixed on the cover body, and the sealing cover 22 is in threaded connection with the bottle cap.
Preferably, in this embodiment, the stirring assembly may be used for manual stirring or may be used for automatic stirring by using a motor to drive the stirring shaft.
Preferably, a timing switch valve is arranged on the negative pressure pipeline 7, and sampling analysis is performed at regular time through the timing switch valve.
The outer side wall of the reaction vessel of this embodiment is provided with a holder for placing the mixing sampling chamber 2.
The sampling liquid of this embodiment gets into and mixes the sampling chamber stirring back intensive mixing, improves the degree of accuracy that the sample detected.
The foregoing description of the preferred embodiments of the present utility model is not intended to limit the utility model, and those skilled in the art may make various modifications and equivalents within the spirit and scope of the utility model, and such modifications and equivalents should also be considered as falling within the scope of the technical solution of the present utility model.
Claims (6)
- Sampling device in S-alkanone production, its characterized in that: comprises a built-in sampling head (1), a mixing sampling cavity (2), a reciprocating assembly (3) and a negative pressure suction device (4); a reciprocating movement assembly (3) is arranged in the reaction container; the built-in sampling head (1) is arranged on the reciprocating assembly (3), and the reciprocating assembly (3) drives the built-in sampling head to move up and down; one end of the flexible sampling tube (5) is connected with the built-in sampling head (1), and the other end is connected with the sampling port (6) on the reaction container; the mixed sampling cavity (2) is connected with the sampling port (6) through a conveying pipeline; the mixing sampling cavity (2) is connected with the negative pressure suction device (4) through a negative pressure pipeline (7).
- 2. The sampling device for S-alkanone production of claim 1, wherein: the built-in sampling head (1) comprises a columnar shell (11); a liquid channel (12) is arranged in the columnar shell (11); the side wall of the columnar shell (11) is provided with a plurality of liquid suction holes (14) communicated with the liquid channel (12); the columnar shell (11) is fixed on the connecting seat (15); the connecting seat (15) is driven by the reciprocating component (3) to move up and down; the top of the columnar shell (11) is connected with a flexible sampling tube (5);the flexible sampling tube (5) is communicated with the liquid channel (12).
- 3. The sampling device for S-alkanone production of claim 2, wherein: the top and the bottom of the columnar shell (11) are fixedly connected with conical heads (13).
- 4. The sampling device for S-alkanone production of claim 1, wherein: the reciprocating assembly (3) comprises a screw (31); the connecting seat (15) is in threaded connection with the screw rod (31); the two ends of the screw are rotationally connected with the top and the bottom of the reaction container; the optical axis section at the top of the screw rod extends out of the reaction container and is connected with the output end of the motor through a coupler; a guide shaft (32) is arranged on one side of the guide shaft (31); the connecting seat (15) is provided with a guide hole matched with the guide shaft.
- 5. The sampling device for S-alkanone production of claim 1, wherein: the mixing sampling cavity (2) comprises a bottle body (21) and a stirring assembly; the stirring assembly comprises a sealing cover (22); the sealing cover is rotatably provided with a stirring shaft (23); a stirring paddle (24) is arranged on the stirring shaft (23); the sealing cover (22) is in threaded connection with the bottle body (21).
- 6. The sampling device for S-alkanone production of claim 1, wherein: the negative pressure pipeline (7) is provided with a timing switch valve.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN221078158U true CN221078158U (en) | 2024-06-04 |
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| GR01 | Patent grant |