CN221041029U - Capillary electrophoresis-electrospray ion source sampling mechanism - Google Patents
Capillary electrophoresis-electrospray ion source sampling mechanism Download PDFInfo
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- CN221041029U CN221041029U CN202322415767.8U CN202322415767U CN221041029U CN 221041029 U CN221041029 U CN 221041029U CN 202322415767 U CN202322415767 U CN 202322415767U CN 221041029 U CN221041029 U CN 221041029U
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- Prior art keywords
- sample injection
- sample
- capillary
- ion source
- sample cup
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- 230000007246 mechanism Effects 0.000 title claims abstract description 35
- 238000005070 sampling Methods 0.000 title claims description 25
- 238000002347 injection Methods 0.000 claims abstract description 76
- 239000007924 injection Substances 0.000 claims abstract description 76
- 238000007789 sealing Methods 0.000 claims abstract description 59
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 23
- 238000003780 insertion Methods 0.000 claims description 9
- 230000037431 insertion Effects 0.000 claims description 9
- 230000000694 effects Effects 0.000 abstract description 2
- 239000000523 sample Substances 0.000 description 91
- 239000004743 Polypropylene Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001503 joint Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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- Sampling And Sample Adjustment (AREA)
Abstract
The utility model provides a capillary electrophoresis-electrospray ion source sample injection mechanism, which relates to the technical field of mass spectrometers and comprises a sample cup assembly, a sample injection cover assembly and a moving assembly, wherein a plurality of reagent accommodating cavities are arranged in the sample cup assembly, the sample cup assembly is connected with the moving assembly, the sample injection cover assembly comprises a sample injection cover main body, a capillary, an electrode, a sample injection connector and a sealing assembly, the electrode is arranged on the sample injection cover main body, the sealing assembly comprises a sample injection sealing body, and the capillary penetrates through the sample injection sealing body. Compared with the traditional mode of inserting the capillary into the reagent holding cavity from the hole, the effect of avoiding capillary fracture and blockage is achieved, the sample cup assembly is effectively sealed, and then accurate sample injection is realized through air pressure, so that the instrument is more accurate.
Description
Technical Field
The utility model relates to the technical field of mass spectrometers, in particular to a capillary electrophoresis-electrospray ion source sample injection mechanism.
Background
Compared with a high-pressure liquid chromatograph, the whole capillary electrophoresis-electrospray device has the advantages that the volume is much smaller, the result is more accurate, the device is more convenient to be connected with a mass spectrometer, the sample injection precision of the capillary electrophoresis-electrospray device at the present stage is low, the precision error of the mass spectrometer is larger, and because the capillary is a vulnerable part, when the capillary is replaced at the present stage, the capillary is generally put into a sample cup through a jack, the situation of fracture easily occurs, and the capillary insertion hole is blocked.
Disclosure of utility model
The utility model aims to provide a capillary electrophoresis-electrospray ion source sampling mechanism which can realize simple replacement of a capillary, ensure the sampling precision through effective sealing and further ensure the precision of an instrument; different reagents can be effectively switched, and sample injection is completed.
In order to solve the problems, the utility model provides a capillary electrophoresis-electrospray ion source sampling mechanism, which comprises a sample cup assembly, a sampling cover assembly, a sample cup sealing mechanism and a moving assembly, wherein a plurality of reagent containing cavities are arranged in the sample cup assembly, the sample cup assembly is connected with the moving assembly, the sampling cover assembly comprises a sampling cover main body, a capillary tube, an electrode, a sampling connector and a sealing assembly, the electrode is arranged on the sampling cover main body, the sealing assembly comprises a sampling sealing body, the capillary tube penetrates through the sampling sealing body, the moving assembly is used for driving the sample cup assembly to switch the relative positions of the sample cup assembly and the sampling cover assembly, and the sample cup sealing mechanism is used for sealing the reagent containing cavities which are not matched with the sampling cover assembly.
According to an embodiment of the utility model, the sample injection sealing body is provided with a groove, the groove penetrates up and down, the side face of the groove is provided with an opening, the capillary tube can enter the groove along the radial direction of the groove through the side face opening of the groove, the sample injection cover body is provided with a capillary tube inserting hole for inserting the sample injection sealing body and the capillary tube, the diameter of the capillary tube inserting hole is larger than that of the capillary tube, and the sample injection sealing body is in interference fit with the capillary tube inserting hole.
According to one embodiment of the utility model, the sample cap body is mounted on a top plate, and a sample cup sealing mechanism is arranged on the top plate.
According to an embodiment of the utility model, the sample injection cover main body is provided with a sample injection sealing gasket pressing block.
According to an embodiment of the present utility model, the sealing assembly further includes a sample injection press block, the sample injection press block is mounted on the sample injection cover body, and the sample injection press block applies pressure to the sample injection sealing body.
According to an embodiment of the present utility model, the sample injection sealing body is columnar.
According to an embodiment of the present utility model, the sample injection sealing body is provided with a conical surface, and the capillary tube insertion hole is provided with a conical hole portion.
According to one embodiment of the utility model, the width of the side opening of the groove is larger than or equal to the diameter of the capillary.
According to one embodiment of the utility model, the inner diameter of the groove is larger than or equal to the diameter of the capillary.
According to one embodiment of the utility model, a sample cup placement cavity is arranged in the sample cup assembly, a sample cup is placed in the sample cup placement cavity, and the reagent containing cavity is arranged in the sample cup.
The utility model has the beneficial effects that when the capillary needs to be inserted and replaced, the capillary only needs to be inserted from the side opening of the groove, then the sample injection sealing body is inserted into the capillary insertion hole, and the sample injection pressing block is installed. The reagent may be switched by the motion assembly.
Drawings
The utility model will be further described with reference to the drawings and examples.
FIG. 1 is a schematic diagram of the overall structure of a capillary electrophoresis-electrospray ion source sampling mechanism;
FIG. 2 is a schematic diagram of the overall structure of a capillary electrophoresis-electrospray ion source sample injection sealing mechanism;
FIG. 3 is a schematic cross-sectional view of a sample cap assembly;
FIG. 4 is a schematic diagram of the sample injection seal structure;
Fig. 5 is a top view of the sample injection seal.
Detailed Description
The following description is presented to enable one skilled in the art to practice the utility model and is provided only to enable the utility model. The embodiments in the following description are by way of example only and other obvious variations will occur to those skilled in the art. The basic principles of the utility model defined in the following description may be applied to other embodiments, variations, modifications, equivalents, and other arrangements without departing from the spirit and scope of the utility model.
[ Example 1]
A capillary electrophoresis-electrospray ion source sample injection mechanism, as shown in figure 1, comprises a bracket, a sample cup assembly 200, a capillary electrophoresis-electrospray ion source sample injection sealing mechanism, a top plate 400 and a moving assembly 300, wherein the sample cup assembly 200 is connected with the moving assembly 300, a plurality of reagent accommodating cavities are arranged in the sample cup assembly 200, in the embodiment, three reagent accommodating cavities are arranged, three reagents can be filled, and the number of the reagent accommodating cavities can be adjusted according to the requirement.
As shown in fig. 1, the sample cup assembly comprises a main body, wherein a sample cup placing cavity is arranged in the main body, a sample cup 201 is placed in the sample cup placing cavity, and a reagent containing cavity is arranged in the sample cup 201, so that the sample cup 201 can be replaced and cleaned conveniently.
The capillary electrophoresis-electrospray ion source sample injection sealing mechanism comprises a sample injection cover assembly 100 as shown in fig. 2 and 3, wherein the sample injection cover assembly 100 comprises a sample injection cover main body 101, a capillary 102, an electrode 103 and a sealing assembly, the electrode 103 is arranged on the sample injection cover main body 101, the sealing assembly comprises a sample injection sealing body 104 as shown in fig. 4 and 5, a groove 105 is formed in the sample injection sealing body 104, the groove 105 penetrates up and down and is provided with an opening on the side surface, the capillary 102 can enter the groove along the radial direction of the capillary through the opening on the side surface of the groove 105, a capillary insertion hole 110 for inserting the sample injection sealing body 104 and the capillary 102 is formed in the sample injection cover main body 101, the diameter of the capillary insertion hole 110 is larger than that of the capillary 102, and the sealing body 104 is in interference fit with the capillary insertion hole 110.
As shown in fig. 1, a plurality of sample cup sealing mechanisms 401 are disposed on a top plate 400, a sample injection cover assembly 100 is disposed between the plurality of sample cup sealing mechanisms 401, optionally centrally disposed, the sample cup sealing mechanisms 401 are made of silica gel, plastics (such as PP polypropylene) and the like, and the sample cup sealing mechanisms 401 are used for sealing a reagent accommodating cavity which is not in butt joint with the sample injection cover assembly 100.
The motion assembly 300 comprises an X-axis and a Z-axis electric slide rail, when reagent is switched, the Z-axis slide rail acts to enable the sample cup assembly 200 to move downwards away from the top plate 400 until the capillary 102 and the electrode 103 are completely separated from the reagent accommodating cavity, the Z-axis slide rail drives the sample cup assembly 200 to move to enable the corresponding reagent accommodating cavity to move to the lower side of the sample cup assembly 100, then the Z-axis slide rail acts to enable the sample cup assembly 200 to move upwards, the sample cup assembly 200 is enabled to be in contact with the sample cup sealing mechanism 401 and the sample injection sealing pad pressing block 108, the sample injection sealing pad pressing block 108 is installed at the bottom of the sample cup body 101, and the material is the same as that of the sample cup sealing mechanism 401.
As shown in fig. 1, the electrode 103 and the sample injection connector 106 penetrate through the sample injection cover main body 101, the outer end of the sample injection connector 106 can be connected with a gas supply mechanism, the gas supply mechanism is a syringe, air is injected into the reagent accommodating cavity through the syringe, and the air pushes the sample solution or solvent in the reagent accommodating cavity to enter the capillary, so that accurate sample injection is realized, and the nano-level can be improved.
As shown in fig. 4 and 5, the sample injection sealing body 104 is cylindrical, made of hard silica gel or plastic (PP polypropylene), the groove 105 is formed on the outer circumferential wall of the sample injection sealing body 104 along the axial direction thereof, the inside of the groove 105 is a cylindrical cavity, the diameter of the groove can be equal to or smaller than or larger than the diameter of the capillary tube, preferably larger than the diameter of the capillary tube, and the width of the side opening of the groove 105 can be equal to or smaller than or larger than the diameter of the capillary tube 102, preferably larger than the diameter of the capillary tube. The sample injection sealing body 104 is provided with a conical surface, the conical surface is arranged at the bottom of the column, the capillary tube insertion hole 110 is provided with a conical hole part, the sample injection sealing body 104 is extruded, the capillary tube is locked, and the conical surface is attached to realize sealing.
Preferably, the sealing assembly further comprises a sample injection pressing block 107, the sample injection pressing block 107 is mounted on the sample injection cover main body 101, the sample injection pressing block 107 applies pressure to the sample injection sealing body 104, and the sample injection pressing block 107 is fixed on the sample injection cover main body 101 after the sample injection sealing body 104 is mounted, and the fixing mode is fastening or connecting and fixing through a connecting piece, such as bolt fixing. As shown in fig. 2, the sample injection block 107 is provided with a groove 109 for accommodating a capillary.
When needing to insert, change capillary 102, only need get into capillary 102 from recess 105's side opening, then insert into capillary insertion hole 110 with advance kind seal 104, install advance kind briquetting 107, compare in the mode that the capillary inserted reagent from the hole and hold the chamber with the capillary, reached the effect of avoiding capillary fracture to block up, be convenient for change wearing parts (capillary), the operating personnel of being convenient for, through advance kind briquetting 107 and advance kind seal 104's setting, effectually advance kind with sample cup subassembly 200, and then realize accurate introduction through atmospheric pressure, make the instrument more accurate introduction. The reagent may be switched by the motion assembly.
It will be appreciated by persons skilled in the art that the embodiments of the utility model described above and shown in the drawings are by way of example only and are not limiting. The objects of the present utility model have been fully and effectively achieved. The functional and structural principles of the present utility model have been shown and described in the examples and embodiments of the present utility model may be subject to any variations and modifications without departing from the principles.
Claims (10)
1. A capillary electrophoresis-electrospray ion source sampling mechanism is characterized in that: including sample cup subassembly (200), advance kind lid subassembly (100), sample cup sealing mechanism (401) and motion subassembly (300), be provided with a plurality of reagent in sample cup subassembly (200) and hold the chamber, sample cup subassembly (200) with motion subassembly (300) are connected, advance kind lid subassembly (100) including advance kind lid main part (101), capillary (102), electrode (103), advance kind connector (106) and seal assembly, electrode (103) are installed advance kind and cover main part (101) are last, seal assembly includes advances kind seal (104), capillary (102) pass advance kind seal (104), motion subassembly (300) are used for the drive sample cup subassembly (200) switch with advance the relative position of kind lid subassembly (100), sample cup sealing mechanism is used for holding the chamber with the reagent that advances kind lid subassembly (100) complex and seals.
2. The capillary electrophoresis-electrospray ion source sampling mechanism as recited in claim 1, wherein: the sample injection sealing body (104) is provided with a groove (105), the groove (105) penetrates up and down, an opening is formed in the side face of the groove, the capillary tube (102) can enter the groove along the radial direction of the groove through the side face opening of the groove (105), the sample injection cover main body (101) is provided with a capillary tube inserting hole (110) for the sample injection sealing body (104) and the capillary tube (102) to be inserted into, the diameter of the capillary tube inserting hole (110) is larger than that of the capillary tube (102), and the sample injection sealing body (104) is in interference fit with the capillary tube inserting hole (110).
3. The capillary electrophoresis-electrospray ion source sampling mechanism as recited in claim 2, wherein: the sample injection cover main body (101) is installed on the top plate (400), and the sample cup sealing mechanism (401) is arranged on the top plate (400).
4. A capillary electrophoresis-electrospray ion source sampling mechanism according to any of claims 1-3, wherein: and a sample injection sealing gasket pressing block (108) is arranged on the sample injection cover main body (101).
5. The capillary electrophoresis-electrospray ion source sampling mechanism as recited in claim 4, wherein: the sealing assembly further comprises a sample injection pressing block (107), the sample injection pressing block (107) is installed on the sample injection cover main body (101), and the sample injection pressing block (107) applies pressure to the sample injection sealing body (104).
6. A capillary electrophoresis-electrospray ion source sampling mechanism according to claim 2 or 3, wherein: the sample injection sealing body (104) is columnar.
7. The capillary electrophoresis-electrospray ion source sampling mechanism as recited in claim 6, wherein: the sample injection sealing body (104) is provided with a conical surface, and the capillary tube insertion hole (110) is provided with a conical hole part.
8. A capillary electrophoresis-electrospray ion source sampling mechanism according to any one of claims 2, 3 and 7, wherein: the width of the side opening of the groove (105) is larger than or equal to the diameter of the capillary tube (102).
9. A capillary electrophoresis-electrospray ion source sampling mechanism according to any one of claims 2, 3 and 7, wherein: the inner diameter of the groove (105) is larger than or equal to the diameter of the capillary tube (102).
10. The capillary electrophoresis-electrospray ion source sampling mechanism as recited in claim 1, wherein: a sample cup placement cavity is arranged in the sample cup assembly (200), a sample cup (201) is placed in the sample cup placement cavity, and a reagent containing cavity is arranged in the sample cup (201).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322415767.8U CN221041029U (en) | 2023-09-06 | 2023-09-06 | Capillary electrophoresis-electrospray ion source sampling mechanism |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322415767.8U CN221041029U (en) | 2023-09-06 | 2023-09-06 | Capillary electrophoresis-electrospray ion source sampling mechanism |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN221041029U true CN221041029U (en) | 2024-05-28 |
Family
ID=91170050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322415767.8U Active CN221041029U (en) | 2023-09-06 | 2023-09-06 | Capillary electrophoresis-electrospray ion source sampling mechanism |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN221041029U (en) |
-
2023
- 2023-09-06 CN CN202322415767.8U patent/CN221041029U/en active Active
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