CN209966387U - Micro sample collection tubes for automated sample injection - Google Patents

Abstract

A micro sample collection tube for automatic sample injection, which includes a tube body and a closed body. The tube body has a receiving cavity for receiving blood samples and a support part for inserting into the sample rack and the sample rack for supporting. One end of the accommodating cavity is opened to form an inlet, and the support portion is extended from the outer bottom wall of the accommodating cavity to the side away from the opening. The support part increases the length of the micro sample collection tube, so that it can be applied to a conventional sample rack, and is convenient for sticking barcodes on the micro sample collection tube. Moreover, the closure body has a puncture structure that enables the sampling device to pass through and be inserted into the accommodating cavity, so that the sampling device can pass through the closure body and enter the accommodating cavity without manual opening of the closure body, so that the micro sample collection tube is applicable for high-volume automated sampling operations.

Description

Micro sample collection tubes for automatic injection

technical field

The present application relates to a medical device, in particular to a micro sample collection tube for automatic sample injection.

Background technique

In the sample analysis process, the sample needs to be collected first. For example, blood sample assays require the collection of a certain amount of sample from a patient. There are two commonly used blood collection methods: venous blood collection and peripheral blood collection. Venous blood collection is suitable for adult patients; however, for infants, children or critically ill patients, it is sometimes difficult to collect blood by venous blood collection. In this case, peripheral blood is often collected. There are two ways to collect peripheral blood: (1) use a capillary to suck the peripheral blood into the capillary, and then inject the blood sample into the micro blood collection tube; (2) use a blood collection tube with a scraping end to scrape the peripheral blood into the blood collection tube.

The sealing body of most of the micro blood collection tubes currently on the market is made of hard materials such as plastic, and the sealing body and the tube body are connected by threads (which is conducive to deflation). The structure of the micro blood collection tube makes it unsuitable for sample aspiration needle puncture during blood collection, because the sample aspiration needle punctures the hard material will directly damage the sample aspiration needle or seriously affect the life of the sample aspiration needle, and the debris generated by puncturing the hard material will be removed. Blood collection tubes can contaminate blood samples. Therefore, it is generally necessary to open the closed body, and this operation needs to be performed manually, which is not conducive to the automatic injection method of large batches. Moreover, the micro blood collection tube is usually short and small, which is inconvenient for sticking barcodes. The depth of the placement cavity of the conventional sample rack for placing the blood collection tube is relatively large compared with the height of the micro blood blood collection tube, making it difficult for the micro blood blood collection tube to pass through the conventional sample holder. The sample holder is used for batch injection, and the sample holder specially designed for this kind of micro blood collection tube is generally made with fasteners on the upper part of the tube hole of the blood collection tube or a raised part in the lower part of the tube hole to increase the height of the micro blood collection tube to facilitate sample injection, but These two methods cannot solve the problem that the micro blood collection tube is inconvenient to post barcodes, which may cause the barcode information of the blood collection tube to be unable to be automatically recognized.

SUMMARY OF THE INVENTION

The present application provides a novel micro sample collection tube for automatic sample injection.

According to an aspect of the present application, an embodiment provides a micro sample collection tube for automatic sample injection, comprising:

A tube body, the tube body has a receiving cavity for accommodating blood samples and a support part for supporting when inserted into the sample rack, one end of the receiving cavity is opened to form an inlet, and the supporting part is formed from the outer bottom wall of the receiving cavity extend to the side away from the opening;

and a closure body for closing the inlet, the closure body has a puncturing structure capable of allowing the sampling device to pass through and be inserted into the accommodating cavity.

As a further improvement of the micro sample collection tube, the support portion includes a support side wall formed by extending downward from the edge of the outer bottom wall of the receiving cavity, and the support side wall encloses a cylindrical structure.

As a further improvement of the micro sample collection tube, the puncture structure includes a puncture area corresponding to the inlet of the receiving cavity, and at least the puncture area in the closed body is made of a flexible material that can be passed through by the sampling device.

As a further improvement of the micro sample collection tube, the closure body includes a cap body connected with the tube body and a capping film, the cap body has an annular top wall, and the capping membrane is sealingly mounted on the annular top wall. On the inner ring, at least a part of the cover film is a puncture area.

As a further improvement of the micro sample collection tube, the closure body adopts a cover film, the cover film is sealed and covered at the inlet of the tube body, and the suspended part of the cover film is the puncture area.

As a further improvement of the micro sample collection tube, the micro sample collection tube further includes a cover body, the cover body covers the closure body, so as to be able to prevent external contamination, such as dustproof.

As a further improvement of the micro sample collection tube, a cover body is also included, the cover body covers the cover film and the tube body, and the cover film has reserved openings for the capillary to enter and exit.

As a further improvement of the micro sample collection tube, the flexible material made of the puncture area is elastic, and the side part of the puncture area is provided with a through exhaust cutout, and the exhaust cutout is communicated with the receiving cavity for the purpose of Exhaust when the air pressure in the containment cavity is too high.

As a further improvement of the micro sample collection tube, the puncture area is provided with a cut that is convenient for piercing the puncture area.

As a further improvement of the micro sample collection tube, the puncture structure includes a puncture area corresponding to the inlet of the receiving cavity, and at least the puncture area in the closed body is made of a flexible material with elasticity, and the puncture area is provided with There is a through incision, the incision leads to the accommodating cavity, and is used for the sampling device to enter and exit the accommodating cavity through the incision.

As a further improvement of the micro sample collection tube, the closure body is made of an elastic material as a whole, and the tube body and the closure body are tightly fitted or clamped to be fixed.

As a further improvement of the micro sample collection tube, the closure body is made of rubber or rubber compounds.

As a further improvement of the micro sample collection tube, the closing body has a connecting cylinder for matching with the side wall of the receiving cavity and a diaphragm for sealing the interior of the connecting cylinder, and at least a part of the diaphragm is a puncture Area.

As a further improvement of the micro sample collection tube, a through cut is provided in the puncture area of the diaphragm, and the connecting cylinder has a radial dimension larger than that of the receiving cavity, so that the connecting cylinder can be loaded into the receiving cavity. The lumen can then be squeezed and cause the incision to remain closed after puncture.

As a further improvement of the micro sample collection tube, the closure body further includes an outer cylinder body and a top cover, the outer cylinder body is sleeved on the outer side of the connecting cylinder body, and is formed with the connecting cylinder body to clamp the side wall of the tube body The upper end of the outer cylinder and the upper end of the connecting cylinder are communicated through a top cover, and the top cover has an opening leading to the transverse spacer.

As a further improvement of the micro sample collection tube, the closure body has an outer cylinder, a connecting cylinder for matching with the side wall of the receiving cavity, and a diaphragm, at least a part of the diaphragm is a puncture area, and the The outer cylinder is located on the outside of the connecting cylinder, and is connected with the connecting cylinder to form a clamping cavity capable of clamping the side wall of the pipe body, and the upper end of the outer cylinder is higher than the upper end of the connecting cylinder , the part of the outer cylinder which is higher than the upper end of the connecting cylinder forms a receiving cavity for receiving the diaphragm.

As a further improvement of the micro sample collection tube, the inner cavity wall of the receiving cavity has a mounting groove or a mounting protrusion, and the diaphragm is snapped into the mounting groove or the diaphragm A snap-fit groove matched with the mounting protrusion is provided.

As a further improvement of the micro sample collection tube, the mounting grooves or mounting protrusions are annularly distributed on the inner cavity wall of the receiving cavity.

As a further improvement of the micro sample collection tube, the inner diameter of the installation groove is smaller than the outer diameter of the diaphragm, so that the groove wall of the installation groove can press the diaphragm.

As a further improvement of the micro sample collection tube, the installation groove has an upper side wall and a lower side wall, and the upper side wall and the lower side wall clamp the transverse spacer from the upper and lower sides of the transverse spacer, for the transverse spacer to be fixed in the installation groove.

As a further improvement of the micro sample collection tube, the micro sample collection tube includes a pressing member for pressing the diaphragm in the installation groove, and the installation groove has an upper side wall and a lower side wall, the lower side of the transverse spacer is placed on the lower side wall, the pressing member is pressed against the upper side of the transverse spacer, and the upper side wall presses the pressing member to make the transverse The spacer is fixed in the mounting groove.

As a further improvement of the micro sample collection tube, the pressing member has an opening leading to the diaphragm.

As a further improvement of the micro sample collection tube, the micro sample collection tube further includes a cover body, and the cover body covers the closure body.

As a further improvement of the micro sample collection tube, the receiving cavity has a bottom in the shape of a paraboloid of revolution, a semi-ellipsoid, a hemisphere or an inverted cone.

As a further improvement of the micro sample collection tube, the tube body further includes a scraper for scraping blood, and the scraper protrusion is provided at the entrance of the receiving cavity.

As a further improvement of the micro sample collection tube, the length A of the tube body ranges from: 45mm≤A≤90mm.

As a further improvement of the micro sample collection tube, the range of the volume V of the receiving cavity is: 0.2ml≤V≤2ml.

According to an aspect of the present application, an embodiment provides a micro sample collection tube for automatic sample injection, which includes:

A tube body, the tube body has a receiving cavity for accommodating blood samples and a support part for supporting when inserted into the sample rack, one end of the receiving cavity is opened to form an inlet, and the supporting part is formed from the outer bottom wall of the receiving cavity extend to the side away from the opening;

and a closure body detachably connected with the opening of the pipe body, the closure body is made of rubber or rubber compound, the closure body includes a transverse spacer, and the transverse spacer is radially arranged in the receiving cavity of the pipe body.

As a further improvement of the micro sample collection tube, the diaphragm has a through cut.

As a further improvement of the micro sample collection tube, the incision is two intersecting elongated slits, the intersection of which is located in the center of the diaphragm.

As a further improvement of the micro sample collection tube, the cutout is provided on the side of the diaphragm.

As a further improvement of the micro sample collection tube, the closure body has a connecting cylinder for matching with the side wall of the accommodating cavity, the diaphragm seals the interior of the connecting cylinder, and the connecting cylinder has a larger diameter than the accommodating cavity. The radial dimension enables the connecting cylinder to be squeezed after being loaded into the accommodating cavity and urges the incision to remain closed after puncturing.

As a further improvement of the micro sample collection tube, the closure body further includes an outer cylinder body and a top cover, the outer cylinder body is sleeved on the outer side of the connecting cylinder body, and is formed with the connecting cylinder body to clamp the side wall of the tube body The upper end of the outer cylinder and the upper end of the connecting cylinder are communicated through a top cover, and the top cover has an opening leading to the transverse spacer.

As a further improvement of the micro sample collection tube, a part of the opening of the tube body forms a plate-shaped protrusion. As a further improvement of the micro sample collection tube, the value range of the length A of the micro sample collection tube is: 45mm≤A≤90mm; the range of the volume V of the receiving cavity is: 0.5ml≤V≤1.5ml.

The micro sample collection tube according to the above embodiments includes a tube body and a closing body. The tube body has a accommodating cavity for accommodating blood samples and a support portion for inserting into the sample rack and the sample rack for supporting. One end of the accommodating cavity is opened to form an inlet, and the support portion extends from the outer bottom wall of the accommodating cavity to the side away from the opening. The support portion increases the length of the micro sample collection tube, so that it can be applied to a conventional sample rack, and is convenient for sticking barcodes on the micro sample collection tube. Moreover, the closure body has a puncture structure that enables the sampling device to pass through and be inserted into the accommodating cavity, so that the sampling device can pass through the closure body and enter the accommodating cavity without manual opening of the closure body, so that the micro sample collection tube is applicable for high-volume automated sampling operations.

Description of drawings

1 and 2 are schematic diagrams of the micro sample collection tube in two states of being closed and opened in an embodiment of the application;

3 is a cross-sectional view of a micro sample collection tube in a closed state in an embodiment of the application;

4 is a cross-sectional view of a closed body in an embodiment of the application;

5 is a schematic diagram of a cross cut on a closure body in an embodiment of the application;

6 is a schematic diagram of a font-shaped exhaust port on a closed body in an embodiment of the application;

FIG. 7 is a schematic diagram of inserting a sampling needle into the closed body shown in FIG. 6 according to an embodiment of the application;

Figures 8a and 8b are schematic structural diagrams of separate designs of the cap body and the cover film in the closure body according to an embodiment of the application;

FIG. 9 and FIG. 10 are schematic structural diagrams of a closure body using a cover film in an embodiment of the application;

11 and 12 are schematic structural diagrams of a cut on a cover film according to an embodiment of the application;

Figure 13 is a structural schematic diagram of using capillary blood collection when the closure body shown in Figures 11 and 12 is used;

Figure 14 and Figure 15 are schematic structural diagrams of a closure body using a cover film with a cutout in an embodiment of the application;

16 is a schematic structural diagram of a micro sample collection tube in an embodiment of the application;

Figure 17 is an exploded view of the micro sample collection tube shown in Figure 16;

Figure 18 is a cross-sectional view of the micro sample collection tube shown in Figure 16;

19 is a cross-sectional view of the outer cylinder and the connecting cylinder in the micro sample collection tube;

Fig. 20 is the schematic diagram of the diaphragm in the micro sample collection tube;

21 is an exploded view of a micro sample collection tube in an embodiment of the application;

FIG. 22 is a cross-sectional view of the microsample collection tube shown in FIG. 21 .

Detailed ways

Wherein similar elements in different embodiments have used associated similar element numbers. In the following embodiments, many details are described so that the present application can be better understood. However, those skilled in the art will readily recognize that some of the features may be omitted under different circumstances, or may be replaced by other elements, materials, and methods. In some cases, some operations related to the present application are not shown or described in the specification, in order to avoid the core part of the present application from being overwhelmed by excessive description, and for those skilled in the art, these are described in detail. The relevant operations are not necessary, and they can fully understand the relevant operations according to the descriptions in the specification and general technical knowledge in the field.

Additionally, the features, acts, or characteristics described in the specification may be combined in any suitable manner to form various embodiments. At the same time, the steps or actions in the method description can also be exchanged or adjusted in order in a manner obvious to those skilled in the art. Therefore, the various sequences in the specification and drawings are only for the purpose of clearly describing a certain embodiment and are not meant to be a necessary order unless otherwise stated, a certain order must be followed.

The serial numbers themselves, such as "first", "second", etc., for the components herein are only used to distinguish the described objects, and do not have any order or technical meaning. The "connection" and "connection" mentioned in this application, unless otherwise specified, include both direct and indirect connections (connections).

This embodiment provides a micro sample collection tube that can be applied to an automatic feeding sample analyzer, especially a micro sample collection tube suitable for a blood analyzer.

The micro sample collection tube includes a tube body and a closing body for closing the tube body. The tube body has an accommodating cavity for accommodating blood samples and a support portion for supporting when inserted into the sample holder. One end of the accommodating cavity is opened to form an inlet, and the supporting portion extends from the outer bottom wall of the accommodating cavity to the side away from the opening. Extended settings. The closure body and the tube body may be fixed in a detachable or non-detachable manner, and the closure body has a puncture structure that enables the sampling device to pass through and be inserted into the accommodating cavity.

Wherein, the puncturing structure that enables the sampling device to pass through and insert into the accommodating cavity can be realized by providing a material that can be pierced by the sampling device or an opening through which the sampling device can pass.

The support part of the micro-sample collection tube increases the length of the micro-sample collection tube, so that it can be applied to a conventional sample rack, and it is convenient for the micro-sample collection tube to paste barcodes. Moreover, the closure body has a puncture structure that enables the sampling device to pass through and be inserted into the accommodating cavity, so that the sampling device can pass through the closure body and enter the accommodating cavity without manual opening of the closure body, so that the micro sample collection tube is applicable for high-volume automated sampling operations.

The present invention will be further described in detail below through specific embodiments in conjunction with the accompanying drawings.

Example 1:

This embodiment provides a micro sample collection tube.

Please refer to FIGS. 1-3 , the micro sample collection tube 1 includes a tube body 2 and a closing body 3 .

The tube body 2 has a accommodating cavity 21 for accommodating blood samples and a support portion 23 for inserting into the sample holder for supporting. One end of the accommodating cavity 21 is opened to form an inlet. The support portion 23 is extended from the outer bottom wall of the accommodating cavity 21 to the side away from the opening, and the collected peripheral blood can be accommodated in the accommodating cavity 21 through the inlet for use.

The closing body 3 is detachably connected with the pipe body 2, and encloses the receiving cavity 21 to form a closed cavity. Referring to FIG. 3 , in an embodiment, the puncturing structure includes a puncturing area 31 corresponding to the inlet of the receiving cavity 21 , and at least the puncturing area 31 in the sealing body 3 is made of a flexible material that can be pierced by a sampling device, such as This flexible material can be a variety of film-like cover films such as paper film, plastic film and tin film, and can also be a kind of elastic flexible material such as silicone and rubber. The puncture area 31 can be pierced and entered into the receiving cavity 21 .

Referring to FIGS. 3-5 , in one embodiment, the flexible material made of the puncturing area 31 has elasticity, such as a rubber material. The puncturing area 31 is provided with a through cut 311 , and the cut 311 communicates with the receiving cavity 21 , so that the sampling device can enter the receiving cavity 21 through the closing body 3 .

Wherein, the incision 311 can be in a closed state during the non-sampling period, and during automatic sampling, the incision 311 is deformed and split under the action of the sampling needle, so that the sampling needle can pass through the incision 311 to complete the sampling. After the sampling is completed, the sampling needle is retracted, and at this time, the side walls on both sides of the incision 311 return to a closed state under the action of the material properties.

Moreover, after the incision 311 is provided in the flexible material with elasticity, the incision 311 can be stretched when the air pressure of the accommodating cavity 21 is higher than that of the outside, and the gas in the accommodating cavity 21 can be released, so that the air pressure in the accommodating cavity 21 and the air pressure in the accommodating cavity 21 can be The external air pressure approaches or reaches equilibrium, so as to prevent the closing body 3 from falling off the pipe body due to the difference in internal and external pressure. That is, the cutout 311 can have both the function of inserting the sampling device into the accommodating cavity 21 and the function of exhausting air to the outside.

Specifically, please refer to FIGS. 3 and 4 , when the closing body 3 covers the tube body 2 , the puncture area 31 will be gradually put into the entrance of the receiving cavity 21 . During this process, the air pressure in the receiving cavity 21 will continue to increase. . Under the action of the air pressure difference between the inside and outside of the accommodating cavity 21, the closed body 3 will be deformed in the direction of Z1. When the deformation reaches a certain level, the sealing effect of the incision 311 will be destroyed, and the air will run out of the accommodating cavity 21 and out of the accommodating cavity 21. The air pressure in the accommodating cavity 21 decreases. Finally, when the pressure difference between the inside and outside reaches the same or close, the closure body 3 recovers its deformation towards the Z2 direction under the action of the elastic restoring force, and the incision 311 forms the sealing effect again.

During the process that the closing body 3 continues to enter the receiving cavity 21 , the above closing body 3 is deformed toward the Z1 direction, and then the process of restoring the deformation toward the Z2 direction under the action of the elastic restoring force may be repeated several times. Finally, when the closing body 3 stops entering the accommodating cavity 21, the remaining air pressure in the accommodating cavity 21 may still be greater than the air pressure outside the accommodating cavity 21, but the remaining air pressure difference cannot overcome the closing body 3 and the tube body 2. Therefore, the closing body 3 cannot be pushed in the direction of breaking away from the tubular body 2 .

The incision 311 can be in various shapes such as elongated, crescent-shaped, wavy, gate-shaped, flat oval, or I-shaped. The incisions 311 may be more than one, and they may be arranged in a cross shape or in a line in parallel, and may also be arranged in other ways.

Preferably, as shown in FIG. 5 , in an embodiment, the incision 311 includes two intersecting elongated slits, and the intersection is formed in the center of the puncture area 31 , which is convenient for the sampling needle to pass through, with less resistance, and is more convenient for the sampling needle The balance of internal and external pressures during sampling.

In addition, please refer to FIGS. 6 and 7 , in other embodiments, the middle of the puncture area 31 can be completely closed, and the sampling needle 4 of the sampling device can directly pierce the middle of the puncture area 31 and enter the receiving cavity 21 to complete the sampling, Instead of being inserted into the receiving cavity 21 through the incision 311 .

Please continue to refer to FIG. 6 , further, a side part of the puncture area 31 is provided with a through exhaust slit 312 , and the exhaust slit 312 communicates with the receiving cavity 21 for exhausting when the air pressure in the receiving cavity 21 is too high . At this time, the exhaust cutout 312 does not serve as a channel for the sampling device to pass through the closed body 3, and it mainly plays the role of exhaust.

As shown in FIGS. 6 and 7 , the exhaust cutout 312 mainly used for exhaust gas can be arranged in one or more side portions of the puncture area 31 in a line shape. The advantage of avoiding the center of the puncture area 31 by the exhaust cut 312 is to prevent external debris from falling into the tube body 2 through the gap formed by the sampling needle 4 during the sampling process.

Of course, for the solution in which the puncture area 31 is not provided with the incision 311 for the sampling device to enter and exit, the puncture area 31 may also be provided with an incision which is convenient for piercing the puncture area 31 . The incision does not penetrate through the puncture area 31, which can not only ensure the sealing of the puncture area 31, but also facilitate the puncturing of the sampling device.

The micro sample collection tube 1 is covered with the sealing body 3 after collecting blood. In the subsequent sample suction operation, the sampling device automatically passes through the puncture area 31 and enters the receiving cavity 21 without manual opening of the sealing body 3, so that the micro sample collection tube 1 is closed. The sample collection tube 1 is suitable for large-scale automatic sample injection operations.

Further, the fixing between the closing body 3 and the pipe body 2 may adopt tight fitting, snap connection or other various detachable fixing methods.

Referring to FIGS. 3 and 4 , in an embodiment, the closing body 3 has a connecting cylinder 32 for cooperating with the side wall of the receiving cavity 21 and a transverse partition 33 for sealing the interior of the connecting cylinder 32 . At least a part of the diaphragm 33 is the puncture area 31, that is, a part or all of the diaphragm 33 may correspond to the opening of the receiving cavity 21, and the part corresponding to the opening serves as the puncture area 31 for the sampling device to pierce or pass through. .

Specifically, please refer to FIGS. 3-5 , the incision 311 is provided through the diaphragm 33 , and the connecting cylinder 32 has a radial dimension d slightly larger than that of the receiving cavity 21 , so that the connecting cylinder 32 is loaded into the receiving cavity 21 . It can then be squeezed and cause the incision 311 to remain closed. The closed body 3 can be fixedly connected by means of the tight fit between the connecting cylinder 32 and the cavity wall of the receiving cavity 21 .

After the connecting cylinder 32 is loaded into the accommodating cavity 21 , the cavity wall of the accommodating cavity 21 squeezes the connecting cylinder 32 , thereby shrinking the connecting cylinder 32 , thereby causing the diaphragm 33 connected to the connecting cylinder 32 to be squeezed and deformed. The incision 311 is kept closed, the sealing effect at the incision 311 is improved, and the problem of leakage and contamination of the blood sample caused by the incision 311 being not tightly sealed can be avoided. Usually, in the way of screwing and fixing the closing body 3 and the pipe body, the incision 311 is closed only by the material restoring force of the side walls on both sides of the incision 311 . The size is designed so that a pre-tightening force can be given to the connecting cylinder 32, and the pre-tightening force can be transmitted to the diaphragm 33 through the connecting cylinder 32, thereby deforming the diaphragm 33 and exerting a closing force on the incision 311, not only The sealing effect at the incision 311 can be improved, and the structure of the closure body 3 can be simplified, so that the closure body 3 can be fixed with the tube body 2 and the incision 311 can be sealed at the same time.

With this sealing method, even if the micro sample collection tube 1 is turned upside down, the blood sample in the accommodating cavity 21 will not easily flow out of the accommodating cavity 21 . The incision 311 is squeezed to form a sealing effect, which can also isolate the environment inside and outside the micro sample collection tube 1, so that the sample is not polluted, the water in the sample does not volatilize, and the measurement will not be caused by the volatilization of the water in the plasma stored for a long time. The result is distorted.

Referring to FIG. 4 , in an embodiment, the diaphragm 33 is disposed along the radial direction of the connecting cylinder 32 . In other embodiments, the transverse spacer 33 may also be slightly inclined relative to the nozzle. The connecting cylinder 32 can be a cylindrical or cubic cylinder structure, and the transverse spacer 33 is correspondingly circular or square. In addition, please refer to FIG. 4 , the transverse spacer 33 may be disposed at the bottom of the connecting cylinder 32 .

The diaphragm 33 can be designed as a sheet-like structure. The transverse spacer 33 and the connecting cylinder 32 can be integrally formed or fixedly connected by a separate structure.

Further, in one embodiment, at least the diaphragm 33 is made of a reversibly deformable polymer elastic material (also referred to as a polymer material). In other embodiments, the entire closure body 3 can also be made of a polymer elastic material (also referred to as a polymer material).

Further, in one embodiment, at least the diaphragm 33 is made of rubber or rubber compounds. This material has good deformability and resilience. In other embodiments, the closure body 3 can also be made of rubber or rubber compounds as a whole.

The tube body 2 itself can be made of an inelastic polymer compound, such as plastic.

Further, please refer to FIGS. 3 and 4, in one embodiment, the enclosure 3 further includes an outer cylinder 34 and a top cover 35, the outer cylinder 34 is sleeved on the outside of the connecting cylinder 32, and is connected with the connecting cylinder 34. 32 forms a clamping cavity 36 that can clamp the side wall of the tube body 2, thereby improving the fixing effect of the sealing body 3 and the tube body 2. When the sampling needle passes through the sealing body 3, it can prevent the sealing body 3 from being squeezed in from the nozzle. accommodating cavity 21 . The upper end of the outer cylinder 34 and the upper end of the connecting cylinder 32 are communicated through a top cover 35 , and the top cover 35 has an opening leading to the transverse spacer 33 . The structural closure body 3 can be better installed on the pipe body 2 without falling off easily.

Referring to FIG. 3 , in one embodiment, the receiving cavity 21 has a bottom 211 in the shape of a paraboloid of revolution, a semi-ellipsoid, a hemisphere or an inverted cone, and the blood sample can slide down to the receiving cavity 21 along the wall of the receiving cavity 21 . bottom 211.

Referring to FIGS. 2 and 3 , in one embodiment, the supporting portion 23 includes a supporting side wall extending downward from the edge of the outer bottom wall of the receiving cavity 21 , the supporting side wall enclosing a cylindrical structure. This cylindrical structure is easier to realize from the point of view of injection molding.

Further, in an embodiment, the length A of the pipe body 2 takes a value in the range: 45mm≤A≤90mm. In an embodiment, the range of the volume V of the accommodating cavity 21 can be selected as: 0.2ml≤V≤2ml. Preferably, in an embodiment, the range of the volume V of the receiving cavity is: 0.5ml≤V≤1.5ml.

On the other hand, please refer to FIG. 2 , in one embodiment, the tube body 2 further includes a blood scraper 22 for scraping blood, and the blood scraper 22 is convexly disposed at the entrance of the receiving cavity 21 . Using the scraper 22 can help scrape the tip into the micro sample collection tube 1 . Of course, in other embodiments, the blood scraping plate 22 may be not provided, but blood is collected by a capillary glass tube.

Embodiment 2

This embodiment also provides a micro sample collection tube that can be applied to an automatic feeding sample analyzer.

Please refer to Figures 8a and 8b, Figure 8a shows a cross-sectional view of the microsample collection tube 1 in an exploded state, and Figure 8b shows a cross-sectional view of the microsample collection tube 1 in an assembled state, the microsample collection tube 1 includes Tube body 2 and closure body 3. The difference between the structure shown in this embodiment and the first embodiment is that the closing body 3 includes a cap body 37 and a capping film 38 connected with the pipe body 2 . The cap body 37 has an annular top wall, and the cover film 38 can be sealingly mounted on the inner ring of the annular top wall by, for example, gluing.

The part of the cover film 38 corresponding to the opening of the receiving cavity 21 of the tube body 2 is the puncture area 31, and the puncture area 31 may be a part or the whole of the cover film 38. The piercing area 31 allows the sampling device to pass through and aspirate the sample.

Please continue to refer to FIGS. 8 a and 8 b , the cap body 37 and the cover film 38 are designed as separate bodies, and are fixedly connected through a fixing structure. This structure allows the cap body 37 to be made of other materials, such as plastic. The cover film 38 can adopt various films such as paper film, plastic film and tin film. The cover film 38 can be a closed structure, and can also be provided with a cutout to facilitate the entry and exit of the sampling device. Incisions may also be provided on the cover film 38 of the closed structure to facilitate the sampling device to pierce the cover film 38 . The cap body 37 and the tube body 2 are detachably fixed, and the fixing method can be tight fit or snap connection.

Taking a blood sample as an example, the micro sample collection tube can first open the sealing body 3 during the blood collection process, put the blood sample into the receiving cavity 21 , and then cover the sealing body 3 . After that, the sampling needle of the sampling device can directly pierce the puncture area 31 of the cover film 38, thereby realizing sample aspiration.

Embodiment 3

This embodiment also provides a micro sample collection tube that can be applied to an automatic feeding sample analyzer.

Please refer to FIGS. 9 and 10 , the micro sample collection tube 1 includes a tube body 2 and a closing body 3 . The difference between this embodiment and the first embodiment is that the closure body 3 adopts a cover film 38 . The cover film 38 seals and covers the inlet of the tube body 2 and encloses the receiving cavity 21 to form a sealed cavity. The suspended portion of the cover film 38 is the puncture area 31 .

The cover film 38 can be made of a flexible material that can be pierced by capillary tubes as a whole or in a suspended part, for example, various films such as paper film, plastic film and tin film can be used.

Taking a blood sample as an example, since the micro sample collection tube 1 can be pierced by a capillary, the capillary can be used to suck the peripheral blood into the capillary during the blood collection process, and then, as shown in Figure 10, the blood sample can be injected into the micro sample collection by using the capillary 5. inside tube 1. After the capillary 5 is removed, an opening is left on the cover film 38, and the opening can be used for the sampling needle of the sampling device to enter and exit, thereby realizing sample aspiration.

Further, in order to improve the efficiency of the capillary 5 piercing the cover film 38, please refer to FIGS. 11 and 12. In an embodiment, the puncture area 31 of the cover film 38 is provided with a notch for piercing the puncture area 31. 39. As shown in FIGS. 12 and 13 , the incision 39 does not penetrate the cover film 38 , but it reduces the thickness of the cover film 38 , so that the capillary 5 can quickly pierce the puncture area 31 .

Embodiment 4

This embodiment provides another micro sample collection tube that can be applied to an automatic feeding type sample analyzer.

The difference between this embodiment and the third embodiment is that, please refer to FIGS. 14 and 15 , the micro sample collection tube 1 includes a tube body 2 , a closing body and a cover body 6 .

The closure body also uses a cover film 38, as shown in the third embodiment. The cover film 38 covers the opening of the receiving cavity 21 of the tubular body 2 . The cover film 38 has a reserved opening 310, the opening 310 communicates with the receiving cavity 21, and is used for the entry and exit of the capillary 5 and the sampling device. At this time, in the blood collection process and the sampling device suction process, the capillary 5 and the sampling device do not need to pierce the cover film 38, but can directly enter and exit the storage cavity 21 from the reserved opening 310, thereby improving work efficiency.

The cover body 6 is covered on the cover film 38 and the tube body 2, which can be detachably connected with the tube body 2 to seal the reserved opening 310, so as to prevent dust and sample leakage. .

Embodiment 5

This embodiment provides another micro sample collection tube that can be applied to an automatic feeding type sample analyzer.

The difference between this embodiment and the first embodiment is that, please refer to FIGS. 16-19 , the micro sample collection tube 1 includes a tube body 2 and a sealing body 3 . The closing body 3 has an outer cylinder 34 , a connecting cylinder 32 for matching with the side wall of the accommodating cavity 21 , and a transverse spacer 33 . At least a part of the diaphragm 33 is the puncture area 31, and the structure of the puncture area 31 can refer to the structure shown in any of the above embodiments, for example, the puncture area 31 can be made of a flexible material or a flexible material with elasticity. The puncture area 31 can also be provided with an exhaust cutout, which is used to facilitate the exhaust of the gas inside the pipe body 2 when the closing body 3 is installed.

Referring to FIG. 19 , the outer cylinder 34 is located on the outer side of the connecting cylinder 32 and is connected with the connecting cylinder 32 to form a clamping cavity 36 capable of clamping the side wall of the pipe body. The clamping cavity 36 can clamp the tube body 2 from the inner and outer sides of the side wall of the tube body 2 to improve the fixing effect of the sealing body 33 and the tube body 2. When the sampling needle passes through the sealing body 33, the sealing body 33 can be prevented from being separated from the tube. The mouth is squeezed into the receiving cavity 2121 .

The upper end of the outer cylinder 34 is higher than the upper end of the connecting cylinder 32 , and the part of the outer cylinder 34 higher than the upper end of the connecting cylinder 32 forms a receiving cavity 341 for receiving the diaphragm 33 . 33 is installed in the inner cavity 3412 of the receiving cavity 341 . The diaphragm 33 can be fixedly installed in the inner cavity 3412 of the receiving cavity 341 , or can be detachably installed in the inner cavity 3412 of the receiving cavity 341 .

This split structure enables the outer cylinder 34 and the connecting cylinder 32 to be made of different materials from the diaphragm 33, for example, the outer cylinder 34 and the connecting cylinder 32 are made of plastic. The cover film 38 may be made of rubber or a rubber compound or the like.

Further, please refer to FIG. 19 , in an embodiment, the inner cavity wall of the receiving cavity 341 has an installation groove 3411 , and the transverse spacer 33 is clamped in the installation groove 3411 . The transverse spacer 33 can be made of a flexible material with elasticity, and can be elastically deformed during extrusion, so the transverse spacer 33 can be inserted into the installation groove 3411 . After the transverse spacer 33 is inserted into the installation groove 3411, the transverse spacer 33 restores its shape before deformation, and is clamped by the groove wall of the installation groove 3411 to prevent it from falling off. In an alternative not shown embodiment, the inner cavity wall of the receiving cavity 341 has a mounting protrusion, and the transverse spacer 33 has a snap-fit groove matched with the mounting protrusion.

In one embodiment, the mounting grooves 3411 are annularly distributed on the inner cavity wall of the receiving cavity 341 , so that the edges of the diaphragm 33 are all accommodated in the mounting grooves 3411 . In some embodiments, the mounting groove 3411 may also be distributed in the form of a plurality of grooves on a plurality of positions of the inner cavity wall of the receiving cavity 341 , and the corresponding grooves of the diaphragm 33 The edge is protruded toward the installation groove 3411, so as to realize a fixed connection.

Preferably, in an embodiment, the transverse spacer 33 is made of rubber or rubber compounds. The inner diameter of the installation groove 3411 is preferably smaller than the outer diameter of the transverse spacer 33, so that the groove wall of the installation groove 3411 can squeeze the edge of the transverse spacer 33 to shrink the transverse spacer 33 toward the middle. The inner diameter of the installation groove 3411 refers to the diameter of the annular surface formed by the bottom wall of the installation groove 3411 . Referring to FIG. 20 , especially when the transverse spacer 33 has a through cutout 311 , the groove wall of the installation groove 3411 presses the transverse spacer 33 , so that the cutout 311 is in a sealed state.

Referring to FIG. 20 , in an embodiment, the puncture area 31 of the diaphragm 33 is provided with a through cut 311 . The incision 311 can be a cross groove and can be arranged in the middle of the puncturing area 31 . Of course, the incision 311 can also be set at the edge of the puncture area 31, and its shape can be various shapes such as elongated, crescent, wavy, gate-shaped, flat oval, or I-shaped. The incisions 311 may be more than one, and they may be arranged in a cross shape or in a line in parallel, and may also be arranged in other ways.

Further, please refer to FIGS. 18 and 19 , the mounting groove 3411 has an upper side wall 3413 and a lower side wall 3414 , and the upper side wall 3413 and the lower side wall 3414 clamp the transverse spacer from the upper and lower sides of the transverse spacer 33 33, so that the transverse spacer 33 is fixed in the installation groove 3411.

21 and 22, in one embodiment, the micro sample collection tube 1 further includes a pressing member 320 for pressing the diaphragm 33 in the installation groove 3411. In order to facilitate the entry and exit of the sampling device, the pressing member 320 has an opening leading to the transverse spacer 33 . The mounting groove 3411 has an upper side wall 3413 and a lower side wall 3414 , the lower side of the transverse spacer 33 is placed on the lower side wall 3414 , the pressing member 320 is pressed against the upper side of the transverse spacer 33 , the upper side The wall 3413 presses the pressing member 320 so that the diaphragm 33 is fixed in the mounting groove 3411 . The pressing member 320 can be made of elastic material, such as plastic, with a certain amount of elasticity.

The above specific examples are used to illustrate the present invention, which are only used to help understand the present invention, and are not intended to limit the present invention. For those skilled in the art to which the present invention pertains, according to the idea of the present invention, several simple deductions, modifications or substitutions can also be made.

Claims (35)

1. A micro sample collection tube for automatic sample introduction, comprising:

the blood sample collecting device comprises a tube body and a blood sample collecting device, wherein the tube body is provided with a containing cavity for containing a blood sample and a supporting part for supporting when being inserted into a sample rack, an inlet is formed in one end of the containing cavity through an opening, and the supporting part extends from the bottom wall of the outer side of the containing cavity to one side far away from the opening;

and a closure for closing the inlet, the closure having a piercing structure for enabling a sampling device to be inserted through and into the receiving cavity.

2. The micro sample collection tube of claim 1, wherein the support portion comprises a support sidewall extending downward from an edge of the bottom wall outside the receiving cavity, and the support sidewall forms a cylindrical structure.

3. The micro sample collection tube of claim 1, wherein the piercing structure comprises a piercing region corresponding to the inlet of the receiving cavity, and wherein at least the piercing region of the closure is made of a flexible material that is capable of being passed through by a sampling device.

4. The micro sample collection tube of claim 3, wherein the closure body comprises a cap body coupled to the tube body, the cap body having an annular top wall, and a cover film sealingly mounted to an inner ring of the annular top wall, the cover film having at least a portion that is a puncture area.

5. The micro sample collection tube of claim 3, wherein the closure member comprises a cover film, the cover film is sealed and covers the inlet of the tube body, and the hanging portion of the cover film is the puncture area.

6. The micro sample collection tube of any one of claims 1-5, further comprising a cap that caps the closure.

7. The micro sample collection tube of claim 5, further comprising a cap covering the capping film and the tube body, the capping film having a pre-formed opening for capillary access.

8. The micro sample collection tube of claim 3, wherein the flexible material forming the piercing area is elastic, and the piercing area is provided at a side thereof with a vent slit extending therethrough, the vent slit communicating with the receiving cavity for venting air when the air pressure in the receiving cavity is too high.

9. A micro sample collection tube according to any of claims 3 to 5, wherein the piercing area is provided with a cut facilitating piercing of the piercing area.

10. The micro sample collection tube of claim 1, wherein the piercing structure comprises a piercing region corresponding to the inlet of the receiving cavity, at least the piercing region of the closure body is made of a flexible material having elasticity, and the piercing region is provided with a through-cut opening leading to the receiving cavity for allowing a sampling device to enter and exit the receiving cavity through the cut opening.

11. The micro sample collection tube of claim 3, 8 or 10, wherein the closure is integrally formed of a resilient material, and the tube is tightly or snap-fit to the closure.

12. The micro sample collection tube of claim 11, wherein the closure is made of rubber or a rubber compound.

13. The micro sample collection tube of claim 3, 8 or 10, wherein the closure body has a connector body for engaging a sidewall of the receiving chamber and a septum for sealing an interior of the connector body, at least a portion of the septum being a puncture area.

14. The micro sample collection tube of claim 13, wherein the septum has a cut-out formed therethrough in the piercing region, and wherein the connector body has a radial dimension greater than the receiving cavity such that the connector body can be squeezed when received in the receiving cavity and urge the cut-out to remain closed after piercing.

15. The micro sample collection tube according to claim 13, wherein the closure further comprises an outer barrel that fits over the outer side of the connector barrel and forms a clamping cavity with the connector barrel that clamps the sidewall of the tube body, wherein the upper end of the outer barrel and the upper end of the connector barrel communicate through the cap, and wherein the cap has an opening to the septum.

16. The micro sample collection tube according to claim 3, 8 or 10, wherein the closure body comprises an outer barrel, a connecting barrel for engaging with the sidewall of the receiving cavity, and a cross-partition, at least a portion of the cross-partition is a piercing region, the outer barrel is located outside the connecting barrel and connected with the connecting barrel to form a clamping cavity capable of clamping the sidewall of the tube body, the upper end of the outer barrel is higher than the upper end of the connecting barrel, and the portion of the outer barrel higher than the upper end of the connecting barrel forms a receiving cavity for receiving the cross-partition.

17. The micro sample collection tube of claim 16, wherein the inner cavity wall of the receiving cavity has a mounting groove or a mounting protrusion, and the cross partition is snapped into the mounting groove or the cross partition is provided with a snapping groove matching with the mounting protrusion.

18. The micro sample collection tube of claim 17, wherein the mounting recesses or projections are annularly distributed on the inner lumen wall of the receiving cavity.

19. The micro sample collection tube of claim 17 or 18, wherein the mounting groove has an inner diameter smaller than an outer diameter of the septum to allow a groove wall of the mounting groove to compress the septum.

20. The micro sample collection tube of claim 17 or 18, wherein the mounting recess has upper and lower sidewalls that sandwich the septum from both the upper and lower sides of the septum for securing the septum within the mounting recess.

21. The micro sample collection tube of claim 17 or 18, wherein the micro sample collection tube comprises a compression member for compressing the septum in the mounting groove, the mounting groove having an upper sidewall and a lower sidewall, the lower side of the septum resting on the lower sidewall, the compression member abutting against the upper side of the septum, the upper sidewall compressing the compression member to secure the septum within the mounting groove.

22. The micro sample collection tube of claim 21, wherein the constriction has an opening to the septum.

23. The micro sample collection tube of claim 17 or 18, further comprising a cap that caps the closure.

24. The micro sample collection tube according to any one of claims 1 to 5, wherein the receiving cavity has a bottom in the shape of a paraboloid of revolution, a semi-ellipsoid, a hemisphere, or an inverted cone.

25. The micro sample collection tube according to any one of claims 1 to 5, wherein the tube body further comprises a scraping plate for scraping blood, the scraping plate protrusion being provided at an inlet of the receiving cavity.

26. The micro sample collection tube according to any one of claims 1 to 5, wherein the length A of the tube body ranges from: a is more than or equal to 45mm and less than or equal to 90 mm.

27. A micro sample collection tube according to any of claims 1 to 5, wherein the volume V of the receiving cavity is in the range: v is more than or equal to 0.2ml and less than or equal to 2 ml.

28. A micro sample collection tube for automatic sample introduction, characterized in that it comprises:

the blood sample collecting device comprises a tube body and a blood sample collecting device, wherein the tube body is provided with a containing cavity for containing a blood sample and a supporting part for supporting when being inserted into a sample rack, an inlet is formed in one end of the containing cavity through an opening, and the supporting part extends from the bottom wall of the outer side of the containing cavity to one side far away from the opening;

and the closing body is detachably connected with the opening of the pipe body, the closing body is made of rubber or rubber compound, and the closing body comprises a transverse partition body which is radially arranged in the accommodating cavity of the pipe body.

29. The micro sample collection tube of claim 28, wherein the septum has a cut therethrough.

30. The micro sample collection tube of claim 29, wherein the slit is two intersecting elongated slits, the intersection point of which is located at the center of the septum.

31. The micro sample collection tube of claim 29, wherein the notch is disposed on a side of the septum.

32. The micro sample collection tube according to any one of claims 29-31, wherein the closure body comprises a connector body for engaging a sidewall of the receiving cavity, wherein the septum seals the interior of the connector body, and wherein the connector body has a radial dimension greater than the receiving cavity such that the connector body can be compressed when received in the receiving cavity and urge the slit to remain closed after piercing.

33. The micro sample collection tube according to claim 32, wherein the closure further comprises an outer barrel that fits over the outer side of the connector barrel and forms a clamping cavity with the connector barrel that clamps the sidewall of the tube body, wherein the upper end of the outer barrel and the upper end of the connector barrel communicate through the cap, and wherein the cap has an opening to the septum.

34. The micro sample collection tube of claim 28, wherein a portion of the opening of the tube body forms a plate-like protrusion.

35. A micro sample collection tube according to any of claims 28 to 31, wherein the length a of the micro sample collection tube is in the range: a is more than or equal to 45mm and less than or equal to 90 mm; the volume V of the accommodating cavity is in the range: v is more than or equal to 0.5ml and less than or equal to 1.5 ml.

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