CN220940808U - Adjustable pipetting component and sample application equipment with same - Google Patents

Adjustable pipetting component and sample application equipment with same Download PDF

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Publication number
CN220940808U
CN220940808U CN202322747267.4U CN202322747267U CN220940808U CN 220940808 U CN220940808 U CN 220940808U CN 202322747267 U CN202322747267 U CN 202322747267U CN 220940808 U CN220940808 U CN 220940808U
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axis
moving block
screw
axis moving
fixing seat
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CN202322747267.4U
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Chinese (zh)
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丁健
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Shenzhen Weidian Biotechnology Co ltd
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Shenzhen Weidian Biotechnology Co ltd
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Abstract

The utility model discloses an adjustable pipetting component and spotting equipment, wherein the pipetting component comprises a Z-direction adjusting structure and a spotting structure; the Z-direction adjusting structure is provided with a screw rod sliding rail fixing seat capable of moving along the Z direction, and a Y-axis moving block is arranged on the screw rod sliding rail fixing seat; the X-axis moving block is arranged on the Y-axis moving block, and the sample application structure is integrated on the X-axis moving block; at least one first U-shaped hole is formed in the matching position of the screw rod sliding rail fixing seat and the Y-axis moving block; at least one second U-shaped hole is arranged at the matching position of the X-axis moving block and the Y-axis moving block. According to the adjustable pipetting assembly, the fine adjustment of the spotting structure in the Y direction and the X direction is realized through the U-shaped holes on the screw rod sliding rail fixing seat and the X-axis moving block, the spotting structure can be fixed after the adjustment is performed through screw fixation, and the fine adjustment of the position of the single pipetting assembly is realized. Ensuring the accuracy of the sample application track and ensuring that the pipetting meets the requirements.

Description

Adjustable pipetting component and sample application equipment with same
Technical Field
The utility model relates to the technical field of medical equipment, in particular to a pipetting component capable of realizing XY position adjustment and a semiautomatic spotting device with the pipetting component for synchronously spotting multiple cards.
Background
With the rapid development of science and technology, biochemical, immune and molecular detection are all faced with the requirement of improving detection efficiency, and the transfer, addition and pipetting operations of samples or reagents are not separated in the processes. Currently, there are batch pipetting systems that perform suction and discharge operations simultaneously by arranging a plurality of pipettes side by side, such as in groups of four and eight.
In the prior art, the authorized bulletin number CN101332439B discloses an automatic pipetting workstation, and although the prior art can realize the movement of XYZ axes of a pipetting system, the positions of a plurality of pipettes are relatively fixed, the position of a single pipettor can not be adjusted, the precision of pipetting tracks is low, and the requirements of different pipetting positions can not be met. The liquid transfer positions of the biochips with different specifications are required to be different in sample application, and the sample application positions of the biochips are narrow, so that finer adjustable liquid transfer components are required to finish sample application.
Therefore, based on the above technical problems, a person skilled in the art is required to develop an adjustable pipetting assembly and a spotting device with the same.
Disclosure of utility model
The utility model aims to provide a pipetting component capable of realizing micro-adjustment of an XY position and a semiautomatic spotting device with the pipetting component, wherein the adjustable pipetting component can realize the precise adjustment of the X-direction and the Y-direction of a single pipetting component through a U-shaped hole (oblong hole), so that the precision of a spotting track can be ensured, and the pipetting meets the requirements.
In order to achieve the above object, the present utility model provides the following technical solutions:
An adjustable pipetting assembly of the utility model comprises:
a Z-direction adjusting structure; and
The sample application structure is integrated with the Z-direction adjusting structure;
The Z-direction adjusting structure is provided with a screw rod sliding rail fixing seat capable of moving along the Z direction, and a Y-axis moving block is arranged on the screw rod sliding rail fixing seat;
An X-axis moving block is arranged on the Y-axis moving block, the sample application structure is integrated with the X-axis moving block, and the sample application structure is provided with sample application needles;
The Y-axis moving block is assembled in the first U-shaped hole through a screw and the screw slide rail fixing seat, and the screw can move along the extending direction of the first U-shaped hole so as to adjust the Y-direction position of the Y-axis moving block;
The X-axis moving block is provided with at least one second U-shaped hole at the matching position of the Y-axis moving block, the X-axis moving block is assembled in the second U-shaped hole through a screw and the Y-axis moving block, and the screw can move along the extending direction of the second U-shaped hole so as to adjust the X-direction position of the X-axis moving block.
Further, the Z-direction adjustment structure includes:
A Z-axis base;
The screw rod sliding rail fixing seat is connected with the Z-axis sliding rail in a sliding manner along the Z direction; and
The output end of the Z-axis screw rod motor is provided with a Z-axis screw rod, and the Z-axis screw rod is in threaded connection with the screw rod sliding rail fixing seat so as to drive the screw rod sliding rail fixing seat to move along the Z direction;
The lower end of the Z-axis screw rod is provided with a bearing seat, the Z-axis screw rod is rotationally connected with the bearing seat through a bearing, and the bearing is provided with a bearing baffle.
Further, a Z-axis origin sensor is arranged on the side face of the Z-axis screw rod motor, and an induction piece matched with the Z-axis origin sensor is arranged on the side face of the screw rod sliding rail fixing seat.
Further, an L-shaped groove is formed in the front side of the screw rod sliding rail fixing seat, and an L-shaped part matched with the L-shaped groove is formed at the upper part of the Y-axis moving block;
The side of the Y-axis moving block is provided with a first mounting hole, the side of the screw rod sliding rail fixing seat is provided with a first U-shaped hole, and the Y-axis moving block is connected with the screw rod sliding rail fixing seat through threads in the first U-shaped hole and the first mounting hole in a screw connection mode.
Further, the lower part of the Y-axis moving block is provided with a second mounting hole, and the X-axis moving block and the Y-axis moving block are connected with the second U-shaped hole and the second mounting hole through screws in a threaded mode.
Further, a ranging sensor is assembled and fixed on one side of the sample application structure through a ranging fixing piece;
the distance measuring sensor and the X-axis moving block synchronously move.
The utility model also discloses a sample application device, which comprises:
The device comprises a device base, wherein a reagent card tray is arranged in the device base, and a plurality of reagent cards are placed on the reagent card tray;
a Y-axis screw module and an X-axis screw module;
The X-axis screw module is connected with the Y-axis screw module to adjust the Y-direction position of the X-axis screw module through the Y-axis screw module;
The pipetting assembly is integrated on the X-axis screw module;
The X-direction position of the pipetting component is adjusted through the X-axis screw module.
Further, the device base is provided with two groups of reagent card trays along the horizontal direction, namely a left reagent card tray and a right reagent card tray;
The left side reagent card tray and the right side reagent card tray are respectively provided with a plurality of reagent cards, and the pipetting component performs sample application operation on one group of reagent card trays.
Further, the spotting device further comprises:
test tube, shaking machine and liquid injection pump;
The side of pipetting component is provided with the hose mounting, pipetting component's sample application needle passes through the hose and is connected with the injection pump.
In the technical scheme, the adjustable pipetting component and the sample application device provided by the utility model have the following beneficial effects:
According to the adjustable pipetting assembly, the fine adjustment of the spotting structure in the Y direction and the X direction is realized through the U-shaped holes on the screw rod sliding rail fixing seat and the X-axis moving block, the spotting structure can be fixed after the adjustment is performed through screw fixation, and the fine adjustment of the position of the single pipetting assembly is realized. Ensuring the accuracy of the sample application track and ensuring that the pipetting meets the requirements.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings required for the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments described in the present utility model, and other drawings may be obtained according to these drawings for a person having ordinary skill in the art.
FIG. 1 is a schematic diagram of an adjustable pipetting assembly according to an embodiment of the utility model;
FIG. 2 is an exploded view of an adjustable pipetting assembly in accordance with an embodiment of the utility model;
Fig. 3 is a schematic structural view of a screw slide fixing seat of an adjustable pipetting assembly according to an embodiment of the utility model;
FIG. 4 is a schematic view of a Y-axis motion block of an adjustable pipetting assembly according to an embodiment of the utility model;
FIG. 5 is a schematic view of an X-axis motion block of an adjustable pipetting assembly according to an embodiment of the utility model;
FIG. 6 is a schematic diagram of a spotting device according to an embodiment of the present utility model;
FIG. 7 is a schematic diagram of a reagent card tray and reagent cards of the spotting apparatus according to the embodiment of the present utility model;
FIG. 8 is a schematic diagram of an integrated structure of a pipetting module and an X-direction screw module and a Y-direction screw module of a spotting device according to an embodiment of the utility model;
Fig. 9 is a schematic diagram showing an operating state of a pipetting module of the spotting apparatus according to an embodiment of the utility model.
Reference numerals illustrate:
10. A pipetting assembly; 20. a sample application device;
1. A Z-direction adjusting structure; 2. a sample application structure;
101. A Z-axis base; 102. a Z-axis sliding rail; 103. screw rod slide rail fixing seat; 104. a Z-axis screw motor; 105. a Z-axis screw rod; 106. a Z-axis origin sensor; 107. an induction piece; 108. a bearing seat; 109. a bearing; 110. a bearing baffle; 111. a Z-axis oil shield;
10301. An L-shaped groove; 10302. a first U-shaped hole;
201. A sample application needle; 202. an X-axis moving block; 203. a Y-axis moving block;
20201. A second U-shaped hole;
20301. An L-shaped part; 20302. a first mounting hole; 20302. a second mounting hole;
301. a ranging fixture; 302. a ranging sensor;
401. a hose fixing member; 402. a hose;
5. An equipment base; 6. a reagent card tray; 8. a test tube; 9. shaking up machine;
601. a reagent card;
701. A Y-axis screw rod module; 702. an X-axis screw rod module.
Detailed Description
In order to make the technical scheme of the present utility model better understood by those skilled in the art, the present utility model will be further described in detail with reference to the accompanying drawings.
First, referring to fig. 1 to 5;
An adjustable pipetting assembly is disclosed in one embodiment, the pipetting assembly 10 comprising:
a Z-direction adjusting structure 1; and
The sample application structure 2 is integrated with the Z-direction adjusting structure 1;
The Z-direction adjusting structure 1 is provided with a screw slide rail fixing seat 103 capable of moving along the Z direction, and a Y-axis moving block 203 is arranged on the screw slide rail fixing seat 103;
The X-axis moving block 202 is arranged on the Y-axis moving block 203, the sample application structure 2 is integrated on the X-axis moving block 202, and the sample application structure 2 is provided with a sample application needle 201;
at least one first U-shaped hole 10302 is formed in the matching position of the screw rod sliding rail fixing seat 103 and the Y-axis moving block 203, the Y-axis moving block 203 is assembled in the first U-shaped hole 10302 through a screw and the screw rod sliding rail fixing seat 103, and the screw can move along the extending direction of the first U-shaped hole 10302 so as to adjust the Y-direction position of the Y-axis moving block 203;
At least one second U-shaped hole 20201 is arranged at the matching position of the X-axis moving block 202 and the Y-axis moving block 203, the X-axis moving block 202 is assembled in the second U-shaped hole 20201 through a screw and the Y-axis moving block 203, and the screw can move along the extending direction of the second U-shaped hole 20201 so as to adjust the X-direction position of the X-axis moving block 202.
Specifically, the pipetting component 10 disclosed in the first embodiment includes a Z-direction adjusting structure 1 and a spotting structure 2, where the Z-direction adjusting structure 1 drives the screw slide fixing seat 103 to move along the Z-direction and drives the spotting structure 2 to move. In order to realize fine adjustment of the spotting structure 2 in the Y direction and the X direction, so that spotting of the spotting structure meets requirements, the screw slide rail fixing seat 103 of the first embodiment is processed with a first U-shaped hole 10301, and the X-axis moving block 202 is processed with a second U-shaped hole 20201. During installation, the Y-axis movable block 203 is installed in the first U-shaped hole 10301 of the screw rod slide rail fixing seat 103 through a screw, and the installation position can be adjusted along the Y direction due to the long round hole structure of the first U-shaped hole 10301, and after adjustment, the screw can be screwed down again to complete fixation. Similarly, the X-axis moving block 202 is also fastened by adjusting the position of the X-axis moving block 203 by screws.
Preferably, the Z-direction adjustment structure 1 of the first embodiment includes:
a Z-axis base 101;
The Z-axis sliding rail 102 is fixed on the Z-axis base 101, and the screw rod sliding rail fixing seat 103 is connected with the Z-axis sliding rail 102 in a sliding manner along the Z direction; and
The Z-axis screw motor 104, wherein the output end of the Z-axis screw motor 104 is provided with a Z-axis screw 105, and the Z-axis screw 105 is in threaded connection with the screw slide rail fixing seat 103 so as to drive the screw slide rail fixing seat 103 to move along the Z direction;
The lower end of the Z-axis screw rod 105 is provided with a bearing seat 108, the Z-axis screw rod 105 is rotatably connected with the bearing seat 108 through a bearing 109, and the bearing 109 is provided with a bearing baffle 110.
In order to monitor the moving stroke of the screw slide rail fixing seat 103, a Z-axis origin sensor 106 is disposed on the side of the Z-axis screw motor 104 in the first embodiment, and an induction piece 107 used in cooperation with the Z-axis origin sensor 106 is disposed on the side of the screw slide rail fixing seat 103.
Preferably, an L-shaped groove 10301 is formed on the front side of the screw sliding rail fixing seat 103 in the first embodiment, and an L-shaped portion 20301 matching with the L-shaped groove 10301 is formed on the upper portion of the y-axis moving block 203;
The side of the Y-axis moving block 203 is provided with a first mounting hole 20302, the side of the screw sliding rail fixing seat 103 is provided with a first U-shaped hole 10302, and the Y-axis moving block 203 and the screw sliding rail fixing seat 103 are connected with the first U-shaped hole 10302 and the first mounting hole 20302 through screws in a threaded manner.
At the same time, the upper part of the Y-axis moving block 203 is designed into an L-shaped part 20301 matched with the L-shaped groove 10301, and the L-shaped part 20301 is embedded into the L-shaped groove 10301 in a connection mode, so that the Y-direction position can be adjusted only, and the Y-direction position and the Z-direction position cannot be moved, thereby ensuring the adjustment precision.
Preferably, the lower part of the Y-axis moving block 203 of the first embodiment has a second mounting hole 20303, and the x-axis moving block 202 and the Y-axis moving block 203 are connected to the second U-shaped hole 20201 and the second mounting hole 20302 by screws.
Preferably, one side of the spotting structure 2 of the first embodiment is equipped with a distance measuring sensor 302 via a distance measuring fixing member 301; the distance measuring sensor 302 moves in synchronization with the X-axis moving block 202. The distance of the print needle 201 from the reagent card 601 can be accurately monitored by the distance measuring sensor 302 moving in synchronization with the X-axis moving block 202 (i.e., the print structure).
The first U-shaped hole 10302 and the second U-shaped hole 20201 of the first embodiment are preferably two.
Second embodiment, see FIGS. 6-9
The utility model also discloses a spotting device 20 comprising:
A device base 5, wherein a reagent card tray 6 is arranged in the device base 5, and a plurality of reagent cards 601 are placed on the reagent card tray 6;
A Y-axis lead screw module 701 and an X-axis lead screw module 702;
The X-axis screw module 702 is connected with the Y-axis screw module 701 to adjust the Y-direction position of the X-axis screw module 702 through the Y-axis screw module 701;
The pipetting assembly 10 described above is integrated onto the X-axis lead screw module 702;
the pipetting assembly 10 adjusts the position in the X-direction by means of an X-axis screw module 702.
In the second embodiment, the X-axis screw module 702, the Y-axis screw module 701 and the Z-direction adjusting structure 1 are used to realize the adjustment of the sample application assembly in three directions of XYZ. With Y axle lead screw module 701 as main regulation subassembly, X axle lead screw module 702 is connected in Y axle lead screw module 701 in order to realize the Y position control of X axle lead screw module 702, pipetting component 10 is connected in order to realize X position control with X axle lead screw module 702, finally the spotting structure 2 realizes Z position control through Z to adjusting structure 1.
Preferably, the device base 5 of the second embodiment is provided with two groups of reagent card trays 6 along the horizontal direction thereof, namely a left reagent card tray and a right reagent card tray;
A plurality of reagent cards 601 are placed on the left reagent card tray and the right reagent card tray, and the pipetting assembly 10 performs a sample application operation on one group of reagent card trays 6.
In order to improve the spotting efficiency, the apparatus of the second embodiment has two sets of reagent card trays 6, namely a left reagent card tray and a right reagent card tray, and in operation, the reagent card 601 is placed in the corresponding reagent card tray 6 in a manual manner, and the reagent card 601 and the reagent card tray 6 are placed at corresponding positions of the apparatus, and the start button is pressed to start spotting. Firstly, the pipetting component 10 samples the reagent cards 601 in one group of reagent card trays 6, after the sample is finished, the reagent cards are moved to the other group of reagent card trays 6 to continue the sample application, and the sample-finished reagent card trays 6 and the reagent cards 601 are taken out and put into the reagent cards 601 and the reagent card trays 6 to be sample-applied again, and the sample application is finished.
Preferably, the spotting apparatus 20 of the second embodiment further includes:
Test tube 8, shaking machine 9 and infusion pump;
The lateral surface of the pipetting assembly 10 is provided with a hose fixing member 401, and the sample application needle 201 of the pipetting assembly 10 is connected to the infusion pump by a hose 402.
In the technical scheme, the adjustable pipetting component and the sample application device provided by the utility model have the following beneficial effects:
According to the adjustable pipetting assembly, fine adjustment of the spotting structure in the Y direction and the X direction is realized through U-shaped holes on the screw rod sliding rail fixing seat 103 and the X-axis moving block 202, the spotting structure 2 can be fixed through screw fixation after adjustment, and fine adjustment of the position of the single pipetting assembly 10 is realized. Ensuring the accuracy of the sample application track and ensuring that the pipetting meets the requirements.
While certain exemplary embodiments of the present utility model have been described above by way of illustration only, it will be apparent to those of ordinary skill in the art that modifications may be made to the described embodiments in various different ways without departing from the spirit and scope of the utility model. Accordingly, the drawings and description are to be regarded as illustrative in nature and not as restrictive of the scope of the utility model, which is defined by the appended claims.

Claims (9)

1. An adjustable pipetting assembly, characterized in that the pipetting assembly (10) comprises:
a Z-direction adjusting structure (1); and
A sample application structure (2) integrated with the Z-direction adjusting structure (1);
The Z-direction adjusting structure (1) is provided with a screw rod sliding rail fixing seat (103) capable of moving along the Z direction, and a Y-axis moving block (203) is arranged on the screw rod sliding rail fixing seat (103);
An X-axis moving block (202) is arranged on the Y-axis moving block (203), the sample application structure (2) is integrated with the X-axis moving block (202), and the sample application structure (2) is provided with a sample application needle (201);
The screw rod sliding rail fixing seat (103) and the Y-axis moving block (203) are provided with at least one first U-shaped hole (10302) at the matching position, the Y-axis moving block (203) and the screw rod sliding rail fixing seat (103) are assembled in the first U-shaped hole (10302) through a screw, and the screw can move along the extending direction of the first U-shaped hole (10302) so as to adjust the Y-direction position of the Y-axis moving block (203);
The X-axis moving block (202) and the Y-axis moving block (203) are provided with at least one second U-shaped hole (20201) at the matching position, the X-axis moving block (202) and the Y-axis moving block (203) are assembled in the second U-shaped hole (20201) through a screw, and the screw can move along the extending direction of the second U-shaped hole (20201) so as to adjust the X-direction position of the X-axis moving block (202).
2. An adjustable pipetting assembly according to claim 1, wherein the Z-direction adjustment structure (1) comprises:
A Z-axis base (101);
The Z-axis sliding rail (102) is fixed on the Z-axis base (101), and the screw rod sliding rail fixing seat (103) is connected with the Z-axis sliding rail (102) in a sliding manner along the Z direction; and
The Z-axis screw motor (104), the output end of the Z-axis screw motor (104) is provided with a Z-axis screw (105), and the Z-axis screw (105) is in threaded connection with the screw slide rail fixing seat (103) so as to drive the screw slide rail fixing seat (103) to move along the Z direction;
the lower end of the Z-axis screw rod (105) is provided with a bearing seat (108), the Z-axis screw rod (105) is rotatably connected with the bearing seat (108) through a bearing (109), and the bearing (109) is provided with a bearing baffle (110).
3. An adjustable pipetting assembly according to claim 2, wherein a Z-axis origin sensor (106) is provided on the side of the Z-axis lead screw motor (104), and an induction piece (107) is provided on the side of the lead screw slide fixing seat (103) for cooperating with the Z-axis origin sensor (106).
4. The adjustable pipetting assembly according to claim 2, wherein an L-shaped groove (10301) is formed on the front side of the screw slide fixing seat (103), and an L-shaped portion (20301) matched with the L-shaped groove (10301) is formed on the upper portion of the Y-axis moving block (203);
The side of the Y-axis moving block (203) is provided with a first mounting hole (20302), the side of the screw sliding rail fixing seat (103) is provided with a first U-shaped hole (10302), and the Y-axis moving block (203) and the screw sliding rail fixing seat (103) are connected with the first U-shaped hole (10302) and the first mounting hole (20302) through screws.
5. An adjustable pipetting assembly according to claim 2 or 4, wherein the Y-axis movement block (203) has a second mounting hole (20303) in a lower portion thereof, and the X-axis movement block (202) and the Y-axis movement block (203) are connected to the second U-shaped hole (20201) and the second mounting hole (20303) by screws.
6. An adjustable pipetting assembly according to claim 2, wherein one side of the spotting structure (2) is fitted with a distance measuring sensor (302) by means of a distance measuring fixture (301);
the distance measuring sensor (302) moves synchronously with the X-axis moving block (202).
7. A spotting device, the spotting device (20) comprising:
A device base (5), wherein a reagent card tray (6) is arranged in the device base (5), and a plurality of reagent cards (601) are placed on the reagent card tray (6);
A Y-axis screw module (701) and an X-axis screw module (702);
The X-axis screw module (702) is connected with the Y-axis screw module (701) to adjust the Y-direction position of the X-axis screw module (702) through the Y-axis screw module (701);
-characterized in that the X-axis screw module (702) has integrated thereon a pipetting assembly (10) according to any one of claims 1 to 6;
The pipetting assembly (10) adjusts the position in the X direction through the X-axis screw module (702).
8. Spotting device according to claim 7, characterized in that the device base (5) is provided with two sets of the reagent card trays (6) in its horizontal direction, a left reagent card tray and a right reagent card tray, respectively;
The left side reagent card tray and the right side reagent card tray are respectively provided with a plurality of reagent cards (601), and the pipetting component (10) performs sample application operation on one group of reagent card trays (6).
9. The spotting device according to claim 7, characterized in that the spotting device (20) further comprises:
a test tube (8), a shaking machine (9) and a liquid injection pump;
The lateral surface of the pipetting assembly (10) is provided with a hose fixing piece (401), and the sample application needle (201) of the pipetting assembly (10) is connected with a liquid injection pump through a hose (402).
CN202322747267.4U 2023-10-11 2023-10-11 Adjustable pipetting component and sample application equipment with same Active CN220940808U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202322747267.4U CN220940808U (en) 2023-10-11 2023-10-11 Adjustable pipetting component and sample application equipment with same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202322747267.4U CN220940808U (en) 2023-10-11 2023-10-11 Adjustable pipetting component and sample application equipment with same

Publications (1)

Publication Number Publication Date
CN220940808U true CN220940808U (en) 2024-05-14

Family

ID=91013353

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202322747267.4U Active CN220940808U (en) 2023-10-11 2023-10-11 Adjustable pipetting component and sample application equipment with same

Country Status (1)

Country Link
CN (1) CN220940808U (en)

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