CN220887551U

CN220887551U - Exosome extractor

Info

Publication number: CN220887551U
Application number: CN202322774569.0U
Authority: CN
Inventors: 张葆鑫; 郝廷; 裴志伟; 薛飞
Original assignee: Second Affiliated Hospital Of Inner Mongolia Medical University
Current assignee: Second Affiliated Hospital Of Inner Mongolia Medical University
Priority date: 2023-10-16
Filing date: 2023-10-16
Publication date: 2024-05-03
Anticipated expiration: 2033-10-16

Abstract

The utility model discloses an exosome extractor, in particular to the technical field of exosome extraction, which comprises a box body, wherein a supporting leg is arranged at the bottom of the box body, a protective cover is arranged at the top of the box body, the protective cover is movably connected with the surface of the box body, a frame is arranged in the box body, a vibrating assembly is arranged between the frame and the box body, the vibrating assembly comprises a vibrating motor arranged at one side of the box body, grooves are formed in the inner walls of two sides of the box body, two ends of the frame are positioned in the grooves, the output end of the vibrating motor is in transmission connection with the frame, and telescopic rods are arranged in the two grooves. According to the utility model, the ultrasonic vibration rod is arranged, when the box body needs to be cleaned, clear water is firstly conveyed into the box body, then the ultrasonic vibration rod is started to drive the clear water to vibrate, so that the interior of the box body can be cleaned, the influence of inconvenient cleaning of dead angles in the box body is reduced, and the box body can be reused.

Description

Exosome extractor

Technical Field

The utility model relates to the technical field of exosome extraction, in particular to an exosome extractor.

Background

Exosomes refer to small vesicles containing complex RNAs and proteins, now referring to disc vesicles with diameters of 40-100nm, and various cells can secrete exosomes under normal and pathological conditions, and mainly originate from multivesicles formed by the invagination of intracellular lysosome particles, and are released into extracellular matrix after fusion of the outer membrane of the multivesicles with cell membranes.

The utility model patent of patent publication number CN218710412U discloses an exosome extractor, and this structure carries out a lot of to the exosome mother liquor in the extraction element body through first extraction mechanism and second extraction mechanism, improves the exosome purity of extracting, and through limiting plate, connecting spring and reset spring, vibration first milipore filter and second milipore filter about, avoid the exosome mother liquor to adhere on the milipore filter, improve the extraction efficiency of exosome.

However, when the structure is in practical use, although the ultrafiltration membrane can be prevented from being blocked, after the extracellular body is extracted, the extraction device body is required to be cleaned for continuous use, otherwise, the quality of raw materials can be influenced, and the extraction of the extracellular body can be influenced because the ultrafiltration membrane is manually cleaned by a worker usually, the ultrafiltration membrane cannot be cleaned without any cleaning dead angle.

Disclosure of utility model

In order to overcome the problems of the prior art, the present utility model provides an exosome extractor to solve the problems set forth in the background art.

In order to achieve the above purpose, the present utility model provides the following technical solutions: the utility model provides an exosome extractor, includes the box, the bottom half is provided with the supporting leg, the box top is provided with the protecting cover, protecting cover and box surface swing joint, be provided with the frame in the box, be provided with vibration subassembly between frame and the box, be favorable to improving the efficiency to the raw materials is drawed.

Preferably, the vibration subassembly is including setting up the vibrating motor in box one side, the recess has all been seted up to box both sides inner wall, the frame both ends all are located inside the recess, vibrating motor's output and frame transmission are connected, two the inside telescopic link that all is provided with of recess, the quantity of telescopic link sets up to a plurality of, telescopic link one end and frame surface fixed connection, the telescopic link outside is provided with the spring, the one end and the recess inner wall fixed connection of spring are favorable to preventing the raw materials and block up the filter plate.

Preferably, the top of the box body is provided with an ultrasonic vibration rod, and the output end of the ultrasonic vibration rod penetrates through the surface of the box body and extends into the box body, so that the inside of the box body is cleaned.

Preferably, the frame top is provided with the filter plate, the filter plate top is provided with the cross pole, the quantity of cross pole sets up to two, two the cross pole bottom all runs through the filter plate surface and extends to the filter plate bottom, the frame surface is opened and is provided with the cross hole, the quantity of cross hole sets up to two, two the cross pole bottom all is located inside the cross hole, two the cross pole outside all is provided with the gag lever post, the gag lever post is located the filter plate top, the cross pole top is provided with the pull ring, pull ring bottom and cross pole fixed surface are connected, are favorable to dismantling the filter plate.

Preferably, the frame bottom is provided with the drainage board, the drainage board sets up to the slope form, drainage board both sides all with box inner wall fixed connection, be favorable to preventing that the raw materials from piling up.

Preferably, the surface of the box body is provided with a discharge port, and a valve is arranged in the discharge port, so that the discharge of raw materials is facilitated.

Preferably, the number of the supporting legs is multiple, and the tops of the supporting legs are connected with the surface of the box body through bolts, so that the supporting legs can be detached and installed conveniently.

The utility model has the technical effects and advantages that:

1. Through setting up vibration subassembly, start vibrating motor, drive the frame vibration, make telescopic link and spring produce the flexible, through the elasticity of spring, can increase the frequency that the frame vibrates, the frame drives the filter plate and produces the vibration, can reduce the probability that the raw materials blockked up the filter plate, can improve the efficiency to the raw materials extraction;

2. Through setting up the ultrasonic vibration stick, when needs wash the box, at first carry the clear water to the box is inside, then start the ultrasonic vibration stick, drive clear water and produce the vibration, can clear up the box is inside, has reduced the inconvenient influence of box inside dead angle clearance, can carry out repeatedly usable to the box.

Drawings

Fig. 1 is a schematic diagram of the overall structure of the present utility model.

Fig. 2 is a schematic cross-sectional view of the present utility model.

Fig. 3 is a schematic view of a frame and groove connection structure according to the present utility model.

Fig. 4 is a schematic structural view of a vibration assembly according to the present utility model.

Fig. 5 is a schematic view of the structure of the connection between the frame and the filter plate according to the present utility model.

The reference numerals are: 1. a case; 2. support legs; 3. a protective cover; 4. a frame; 5. a vibration motor; 6. a groove; 7. a telescopic rod; 8. a spring; 9. an ultrasonic vibration rod; 10. a cross bar; 11. a cross hole; 12. a limit rod; 13. a pull ring; 14. a drainage plate; 15. a discharge port; 16. a valve; 17. a filter plate.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

The exosome extractor as shown in the accompanying drawings 1-5 comprises a box body 1, wherein supporting legs 2 are arranged at the bottom of the box body 1, a protective cover 3 is arranged at the top of the box body 1, the protective cover 3 is movably connected with the surface of the box body 1, a frame 4 is arranged in the box body 1, and a vibration assembly is arranged between the frame 4 and the box body 1.

As shown in the attached figure 3, the vibration assembly comprises a vibration motor 5 arranged on one side of the box body 1, grooves 6 are formed in the inner walls of two sides of the box body 1, two ends of a frame 4 are located inside the grooves 6, the output end of the vibration motor 5 is in transmission connection with the frame 4, telescopic rods 7 are arranged inside the two grooves 6, the number of the telescopic rods 7 is multiple, one ends of the telescopic rods 7 are fixedly connected with the surface of the frame 4, springs 8 are arranged on the outer sides of the telescopic rods 7, one ends of the springs 8 are fixedly connected with the inner walls of the grooves 6, the vibration motor 5 is started, the frame 4 is driven to move, the telescopic rods 7 and the springs 8 are enabled to stretch, the moving frequency of the frame 4 can be increased, vibration can be generated on raw materials, and the filter plate 17 is prevented from being blocked by raw materials.

As shown in fig. 2, an ultrasonic vibration rod 9 is arranged at the top of the box body 1, the output end of the ultrasonic vibration rod 9 penetrates through the surface of the box body 1 and extends into the box body 1, and the ultrasonic vibration rod 9 is started to vibrate the inside of the box body 1 so as to clean the box body 1.

As shown in fig. 5, the top of the frame 4 is provided with a filter plate 17, the top of the filter plate 17 is provided with two cross rods 10, the bottom of each cross rod 10 penetrates through the surface of the filter plate 17 and extends to the bottom of the filter plate 17, the surface of the frame 4 is provided with two cross holes 11, the bottom of each cross rod 10 is located inside each cross hole 11, the outer sides of the two cross rods 10 are provided with a limiting rod 12, the limiting rods 12 are located at the top of the filter plate 17, the top of each cross rod 10 is provided with a pull ring 13, the bottom of each pull ring 13 is fixedly connected with the surface of each cross rod 10, when the filter plate 17 needs to be cleaned, the pull rings 13 are rotated to drive the cross rods 10 to rotate, so that the cross rods 10 are separated from the cross holes 11, the filter plate 17 can be separated from the frame 4, and the filter plate 17 can be taken out from the inside the box 1.

As shown in fig. 2, the bottom of the frame 4 is provided with a drainage plate 14, the drainage plate 14 is inclined, two sides of the drainage plate 14 are fixedly connected with the inner wall of the box body 1, and the drainage plate 14 can incline raw materials to one side to prevent the raw materials from being accumulated in the box body 1.

As shown in fig. 1 and 2, the surface of the box body 1 is provided with a discharge opening 15, a valve 16 is arranged in the discharge opening 15, and when raw materials are required to be discharged, the valve 16 in the discharge opening 15 is opened, so that the discharge speed of the raw materials can be controlled by adjusting the valve 16.

As shown in figure 1, the number of the supporting legs 2 is multiple, the top of the supporting legs 2 is connected with the surface of the box body 1 through bolts, and the supporting legs 2 can be separated from the box body 1 by rotating the bolts, so that the supporting legs 2 can be replaced conveniently.

The working principle of the utility model is as follows: when the novel filter plate type filter is used, firstly, raw materials to be extracted are conveyed into the box body 1, when the raw materials fall on the filter plate 17, the raw materials can be filtered through the impact force of the raw materials, the density of the filter plate 17 is small, the raw materials are easy to block on the filter plate 17, the filter plate 17 cannot circulate, the efficiency of filtering the raw materials is influenced, the vibrating motor 5 is started to transmit power to the frame 4, the frame 4 is driven to move in the groove 6, the filter plate 17 can be driven to move, the frame 4 drives the telescopic rod 7 to stretch in the moving process, the spring 8 stretches, the elastic force of the spring 8 can generate rebound power for the frame 4, the moving frequency of the frame 4 is increased, the speed of the raw materials passing through the filter plate 17 can be increased, the probability of blocking the filter plate 17 by the raw materials is reduced, the filtered raw materials fall on the top of the drainage plate 14, the valve 16 in the discharge port 15 is opened, the raw materials can be discharged, the raw materials can be prevented from being stacked at the bottom of the box body 1 due to the inclined drainage plate 14, and the raw materials are prevented from being discharged inconveniently, and the raw materials are wasted;

When other raw materials are required to be extracted after the raw materials are discharged, the box body 1 is required to be cleaned, and the box body 1 is not convenient to clean in all directions due to the fact that staff usually clean the box body manually, raw material residues are easy to cause, the continuous use of the box body 1 is affected, clear water is firstly conveyed into the box body 1, then the ultrasonic vibration rod 9 is started, the clear water can be driven to vibrate, the interior of the box body 1 can be cleaned, the raw material residues are avoided, the filter plate 17 is driven to vibrate through the vibration motor 5, the filter plate 17 can be prevented from being blocked, the box body 1 can be cleaned through the ultrasonic vibration rod 9, and the box body 1 can be reused.

Finally: the above embodiments are merely illustrative of the principles of the present utility model and its effectiveness, and are not intended to limit the utility model. Modifications and variations may be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the utility model. Accordingly, it is intended that all equivalent modifications and variations of the utility model be covered by the claims, which are within the ordinary skill of the art, be within the spirit and scope of the present disclosure.

Claims

1. An exosome extractor, includes box (1), its characterized in that: the novel anti-vibration box is characterized in that supporting legs (2) are arranged at the bottom of the box body (1), a protective cover (3) is arranged at the top of the box body (1), the protective cover (3) is movably connected with the surface of the box body (1), a frame (4) is arranged inside the box body (1), and a vibration assembly is arranged between the frame (4) and the box body (1).

2. An exosome extractor according to claim 1, wherein: vibration subassembly is including setting up vibrating motor (5) in box (1) one side, all open in box (1) both sides inner wall and be provided with recess (6), frame (4) both ends all are located inside recess (6), the output and the frame (4) transmission of vibrating motor (5) are connected, two inside telescopic link (7) that all are provided with of recess (6), the quantity of telescopic link (7) sets up to a plurality of, telescopic link (7) one end and frame (4) fixed surface connection, the telescopic link (7) outside is provided with spring (8), the one end and the recess (6) inner wall fixed connection of spring (8).

3. An exosome extractor according to claim 1, wherein: the ultrasonic vibration rod (9) is arranged at the top of the box body (1), and the output end of the ultrasonic vibration rod (9) penetrates through the surface of the box body (1) and extends into the box body (1).

4. An exosome extractor according to claim 1, wherein: the utility model discloses a filter plate, including frame (4), filter plate (17) top is provided with cross pole (10), the quantity of cross pole (10) sets up to two, two cross pole (10) bottom all runs through filter plate (17) surface and extends to filter plate (17) bottom, frame (4) surface is opened and is provided with cross hole (11), the quantity of cross hole (11) sets up to two, two cross pole (10) bottom all is located cross hole (11) inside, two cross pole (10) outside all is provided with gag lever post (12), gag lever post (12) are located filter plate (17) top, cross pole (10) top is provided with pull ring (13), pull ring (13) bottom and cross pole (10) fixed surface are connected.

5. An exosome extractor according to claim 1, wherein: the bottom of the frame (4) is provided with a drainage plate (14), the drainage plate (14) is inclined, and two sides of the drainage plate (14) are fixedly connected with the inner wall of the box body (1).

6. An exosome extractor according to claim 1, wherein: the surface of the box body (1) is provided with a discharge opening (15), and a valve (16) is arranged in the discharge opening (15).

7. An exosome extractor according to claim 1, wherein: the number of the supporting legs (2) is multiple, and the tops of the supporting legs (2) are connected with the surface of the box body (1) through bolts.