CN220887488U - Microorganism fermentation mechanism for sodium hyaluronate gel production - Google Patents
Microorganism fermentation mechanism for sodium hyaluronate gel production Download PDFInfo
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- CN220887488U CN220887488U CN202322283474.9U CN202322283474U CN220887488U CN 220887488 U CN220887488 U CN 220887488U CN 202322283474 U CN202322283474 U CN 202322283474U CN 220887488 U CN220887488 U CN 220887488U
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- sodium hyaluronate
- fermentation
- wind
- motor
- hyaluronate gel
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- 238000000855 fermentation Methods 0.000 title claims abstract description 82
- 230000004151 fermentation Effects 0.000 title claims abstract description 82
- 229920002385 Sodium hyaluronate Polymers 0.000 title claims abstract description 49
- 229940010747 sodium hyaluronate Drugs 0.000 title claims abstract description 49
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 title claims abstract description 49
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 14
- 244000005700 microbiome Species 0.000 title claims abstract description 9
- 238000003756 stirring Methods 0.000 claims abstract description 29
- 230000000694 effects Effects 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 238000004804 winding Methods 0.000 claims description 11
- 229910000831 Steel Inorganic materials 0.000 claims description 10
- 230000000813 microbial effect Effects 0.000 claims description 10
- 239000010959 steel Substances 0.000 claims description 10
- 244000309464 bull Species 0.000 claims description 4
- 239000000203 mixture Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- 241000883990 Flabellum Species 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model relates to the technical field of sodium hyaluronate gel production equipment, and discloses a microorganism fermentation mechanism for sodium hyaluronate gel production, which comprises a fermentation tank and a top cover, wherein the outer surface of the bottom of the top cover is rotationally connected with a rotating shaft, the outer surface of the top cover is fixedly provided with a first motor, the outer surface of the rotating shaft is fixedly connected with a plurality of stirring paddles, the outer surface of the rotating shaft is fixedly sleeved with a helical blade, the outer surface of the rotating shaft is fixedly sleeved with a driving bevel gear, the outer surface of the driving bevel gear is movably meshed with two driven bevel gears, and the outer surfaces of two rotating rods are fixedly sleeved with stirring paddles. This microorganism fermentation mechanism is used in sodium hyaluronate gel production drives helical blade and stirring rake through first motor drive pivot to drive the leaf through setting up initiative bevel gear and driven bevel gear and drive and turn, reached the purpose that can prevent that sodium hyaluronate of fermentation cylinder bottom from piling up, improve mixing effect.
Description
Technical Field
The utility model relates to the technical field of sodium hyaluronate gel production equipment, in particular to a microbial fermentation mechanism for sodium hyaluronate gel production.
Background
Sodium hyaluronate gel, namely sodium hyaluronate (also called sodium hyaluronate), is a glycosaminoglycan widely applied to the fields of biological medicine, biological materials, functional foods, cosmetics and the like, and is a medical glue, and three refining methods of the hyaluronic acid are as follows: the method has the characteristics of high cost, low yield, limitation of raw material resources and incapability of meeting market demands, and the method for producing hyaluronic acid by using the microbial fermentation method has the characteristics of no limitation of raw material resources, low cost and high yield, and the microbial fermentation method needs to use a fermentation device.
The conventional fermentation device for producing sodium hyaluronate gel generally performs stirring and mixing through straight sheet-shaped blades, but sodium hyaluronate at the bottom of a fermentation tank body cannot perform stirring and mixing through the straight sheet-shaped blades, so that the mixing is uneven, and the sequence of fermentation liquor injected from the top of fermentation equipment and sodium hyaluronate is different, and stirring and mixing through fan blades are difficult, so that the microbial fermentation mechanism for producing sodium hyaluronate gel is provided.
Disclosure of utility model
Aiming at the defects of the prior art, the utility model provides a microbial fermentation mechanism for producing sodium hyaluronate gel, which aims to solve the problems that the prior fermentation device for producing sodium hyaluronate gel in the prior art is generally stirred and mixed by straight sheet blades, but sodium hyaluronate at the bottom of a fermentation tank body cannot be stirred and mixed by the straight sheet blades, so that the mixing is uneven, the sequence of fermentation liquor injected from the top of fermentation equipment and sodium hyaluronate is different, and stirring and mixing by the fan blades are difficult.
In order to achieve the above purpose, the present utility model provides the following technical solutions: the utility model provides a sodium hyaluronate gel production is with microorganism fermentation mechanism, includes fermentation cylinder and top cap, the top surface fixed intercommunication of fermentation cylinder has into the hopper, the bottom surface rotation of top cap is connected with the pivot, the top surface fixed mounting of top cap has first motor, the output and the pivot fixed connection of first motor, the surface fixed connection of pivot has a plurality of stirring rake, the surface fixed cover of pivot is equipped with helical blade, the surface fixed cover of pivot is equipped with drive bevel gear, drive bevel gear's surface activity meshing has two driven bevel gears, two driven bevel gear's surface all fixedly connected with bull stick, two the surface of bull stick all fixed cover is equipped with the stirring rake;
The fermentation cylinder's the equal fixedly connected with fixed plate of left and right sides surface, two the equal fixedly connected with riser of top surface of fixed plate, two the surface rotation that the riser is relative is connected with the wind-up roll, the right side the surface fixed mounting of riser has the second motor, the output and the wind-up roll fixed connection of second motor, the fixed surface cover of wind-up roll is equipped with two wind-up rolls, two the equal activity of surface of wind-up roll is around being equipped with the steel cable, the top surface fixedly connected with lug of top cap, two the one end that the wind-up roll was kept away from to the steel cable is respectively with two lug fixed connection.
Preferably, the outer surface of the fermentation tank is fixedly sleeved with a sleeve, and the outer surface of the top of the sleeve is fixedly communicated with a water inlet pipe.
By adopting the technical scheme, hot water is conveyed into the sleeve through the water inlet pipe, so that the temperature in the sleeve is increased.
Preferably, the bottom surface fixed intercommunication of fermentation cylinder has row material pipe, telescopic surface fixed intercommunication has the outlet pipe, the valve is all installed to row material pipe and the inside of outlet pipe.
By adopting the technical scheme, the valve in the discharge pipe is opened, so that the fermented material is discharged through the discharge pipe, and the valve in the water outlet pipe is opened, so that hot water is discharged from the water outlet pipe.
Preferably, the bottom outer surface of the top cover is fixedly connected with two connecting plates, and the two rotating rods are respectively connected with the outer surfaces of the two connecting plates in a rotating way.
By adopting the technical scheme, the two rotating rods are supported by the two connecting plates.
Compared with the prior art, the utility model has the beneficial effects that:
1. This microorganism fermentation mechanism is used in sodium hyaluronate gel production drives helical blade and stirring rake through first motor drive pivot to drive bevel gear and driven bevel gear through setting up and drive the blade rotation that turns, reached and to prevent that sodium hyaluronate of fermentation cylinder bottom from piling up, improve the purpose of mixing the effect, solved current fermentation device is used in sodium hyaluronate gel production, stir through straight flaky blade generally and mix, but sodium hyaluronate in fermentation cylinder bottom, can not stir through straight flaky blade and mix, cause mixing inhomogeneous, and the order of fermentation liquor and sodium hyaluronate that follow fermentation equipment top was poured into is different, mix comparatively difficult problem through the flabellum stirring.
2. This microorganism fermentation mechanism is used in sodium hyaluronate gel production drives the wind-up roll through the second motor drive and makes the steel cable rolling for the top cap breaks away from the fermentation cylinder top, has reached the inside and multiple part of being convenient for to the fermentation cylinder wash, in order to avoid influencing the effect of fermentation work next time.
Drawings
FIG. 1 is a schematic elevational view of the present utility model;
FIG. 2 is a schematic elevational cross-sectional view of the present utility model;
Fig. 3 is an enlarged schematic view of the structure of fig. 2a according to the present utility model.
In the figure: 1. a fermentation tank; 2. a top cover; 3. a rotating shaft; 4. a first motor; 5. stirring paddles; 6. a helical blade; 7. a drive bevel gear; 8. a driven bevel gear; 9. a rotating rod; 10. turning over the leaves; 11. a fixing plate; 12. a vertical plate; 13. a wind-up roll; 14. a second motor; 15. a winding wheel; 16. a steel rope; 17. lifting lugs; 18. feeding into a hopper; 19. a sleeve; 20. a water inlet pipe.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Example 1:
Referring to fig. 1-3, a microorganism fermentation mechanism for producing sodium hyaluronate gel comprises a fermentation tank 1 and a top cover 2, wherein the top outer surface of the fermentation tank 1 is fixedly communicated with a feeding hopper 18, sodium hyaluronate and fermentation liquor are conveyed into the fermentation tank 1 through the feeding hopper 18, a sleeve 19 is fixedly sleeved on the outer surface of the fermentation tank 1, a water inlet pipe 20 is fixedly communicated with the top outer surface of the sleeve 19, hot water is conveyed through the water inlet pipe 20 to raise the temperature inside the fermentation tank 1, a rotating shaft 3 is rotatably connected to the bottom outer surface of the top cover 2, a first motor 4 is fixedly arranged on the top outer surface of the top cover 2, the output end of the first motor 4 is fixedly connected with the rotating shaft 3, the first motor 4 is started, the first motor 4 drives the rotating shaft 3 to rotate, a plurality of stirring paddles 5 are fixedly connected to the outer surface of the rotating shaft 3, a helical blade 6 is fixedly sleeved on the outer surface of the rotating shaft 3, the rotating shaft 3 drives the stirring paddles 5 and the helical blades 6 to rotate, when the stirring paddles 5 rotate, sodium hyaluronate and fermentation broth are in mixed contact, when the helical blades 6 rotate, sodium hyaluronate at the bottom is conveyed upwards to prevent the sodium hyaluronate at the bottom of the fermentation tank 1 from accumulating, so that mixed fermentation is uneven, a driving bevel gear 7 is fixedly sleeved on the outer surface of the rotating shaft 3, when the rotating shaft 3 rotates, the rotating shaft 3 drives the driving bevel gear 7 to rotate, two driven bevel gears 8 are movably meshed on the outer surface of the driving bevel gear 7, rotating rods 9 are fixedly connected with the outer surfaces of the two driven bevel gears 8, the driving bevel gears 7 drive the driven bevel gears 8 to rotate, the rotating rods 9 rotate, stirring paddles 5 are fixedly sleeved on the outer surfaces of the two rotating rods 9, the rotating rods 9 rotate the stirring blades 10 to primarily mix the sodium hyaluronate newly injected upwards with the fermentation broth, the fermentation tank has the advantages that the sodium hyaluronate and the fermentation broth are mixed more uniformly, the outer surface of the bottom of the fermentation tank 1 is fixedly communicated with a discharge pipe, the outer surface of the sleeve 19 is fixedly communicated with a water outlet pipe, valves are arranged in the discharge pipe and the water outlet pipe, and after the completion, the valves in the discharge pipe are opened, so that materials are discharged.
Working principle: when the fermentation tank is used, sodium hyaluronate and fermentation liquor are conveyed into the fermentation tank 1 through the feeding hopper 18, hot water is conveyed through the water inlet pipe 20, the temperature inside the fermentation tank 1 is increased, the first motor 4 is started, the first motor 4 drives the rotating shaft 3 to rotate, the rotating shaft 3 drives the stirring paddles 5 and the spiral blades 6 to rotate, when the stirring paddles 5 rotate, sodium hyaluronate and fermentation liquor are enabled to be in mixed contact, when the spiral blades 6 rotate, sodium hyaluronate at the bottom is enabled to be conveyed upwards, sodium hyaluronate at the bottom of the fermentation tank 1 is prevented from accumulating, mixing fermentation is uneven, when the rotating shaft 3 rotates, the rotating shaft 3 drives the driving bevel gear 7 to rotate, the driving bevel gear 7 drives the driven bevel gear 8 to rotate, the rotating rod 9 enables the stirring blades 10 to rotate, the newly injected sodium hyaluronate and fermentation liquor are primarily mixed, the sodium hyaluronate and the fermentation liquor are enabled to be mixed evenly, and after the stirring is completed, a valve in the material discharging pipe is opened.
Compared with the related art, the microbial fermentation mechanism for producing the sodium hyaluronate gel has the following beneficial effects: the purpose that can prevent that sodium hyaluronate of fermentation cylinder 1 bottom from piling up, improve mixing effect has been reached, has solved current fermenting installation for sodium hyaluronate gel production, generally stirs the mixture through straight flaky blade, but sodium hyaluronate in fermentation cylinder 1 body bottom, can't stir the mixture through straight flaky blade, causes mixing inhomogeneous to the order of fermentation broth and sodium hyaluronate injected from fermentation equipment top is different, stirs the comparatively difficult problem of mixing through the flabellum.
Example 2:
referring to fig. 1-3, the outer surfaces of the left and right sides of the fermenter 1 are fixedly connected with fixing plates 11, the top outer surfaces of the two fixing plates 11 are fixedly connected with vertical plates 12, the opposite outer surfaces of the two vertical plates 12 are rotationally connected with a winding roller 13, the outer surface of the right vertical plate 12 is fixedly provided with a second motor 14, after fermentation is completed, the second motor 14 is started, the output end of the second motor 14 is fixedly connected with the winding roller 13, the winding roller 13 is fixedly sleeved with two winding wheels 15, the second motor 14 drives the winding roller 13 to rotate, the winding wheels 15 are driven to rotate, the outer surfaces of the two winding wheels 15 are movably wound with steel ropes 16, the top outer surface of the top cover 2 is fixedly connected with two lifting lugs 17, one end of the two steel ropes 16, which is far away from the winding wheels 15, is fixedly connected with the two lifting lugs 17, the winding wheels 15 rotate, the top cover 2 is driven by the steel ropes 16 to move upwards, the top cover 2 drives parts such as a rotating shaft 3 and the like, the top cover 2 is separated from the fermenter 1, the top cover 1 is driven by the rotating shaft 5 and the top cover 2 is cleaned after the top cover is reversely, and the top cover 2 is cleaned, and the top cover 2 is driven and the top of the fermenter is cleaned.
Working principle: after the fermentation is completed, the second motor 14 is started, the second motor 14 is driven forward, the second motor 14 drives the wind-up roller 13 to rotate, the wind-up roller 15 is driven to rotate, the steel rope 16 drives the top cover 2 to move upwards, the top cover 2 drives parts such as the rotating shaft 3 and the like to move upwards, the top cover 2 is separated from the fermentation tank 1, the inside of the fermentation tank 1, the rotating shaft 3, the stirring paddles 5 and the like are cleaned, and after the cleaning is completed, the second motor 14 is driven in the reverse direction, so that the top cover 2 is put on the fermentation tank 1.
Compared with the related art, the microbial fermentation mechanism for producing the sodium hyaluronate gel has the following beneficial effects: the effect that the interior and various parts of the fermentation tank 1 are convenient to clean so as not to influence the next fermentation work is achieved.
The above-mentioned respective means concerning the use of the apparatus are different in selection and use according to actual practice, and various parameters are referred to, and the function according to the apparatus used corresponds to the effect achieved.
Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Claims (4)
1. The utility model provides a sodium hyaluronate gel production is with microorganism fermentation mechanism, includes fermentation cylinder (1) and top cap (2), its characterized in that: the top surface fixed communication of fermentation cylinder (1) has into hopper (18), the bottom surface rotation of top cap (2) is connected with pivot (3), the top surface fixed mounting of top cap (2) has first motor (4), the output and the pivot (3) fixed connection of first motor (4), the surface fixed connection of pivot (3) has a plurality of stirring rake (5), the surface fixed winding of pivot (3) is equipped with helical blade (6), the surface fixed cover of pivot (3) is equipped with initiative bevel gear (7), the surface activity meshing of initiative bevel gear (7) has two driven bevel gears (8), two driven bevel gears (8)'s surface all fixedly connected with bull stick (9), two the surface of bull stick (9) all fixed cover is equipped with stirring rake (5);
The fermentation cylinder (1) the equal fixedly connected with fixed plate (11) of left and right sides surface, two the equal fixedly connected with riser (12) of top surface of fixed plate (11), two the surface rotation that riser (12) is relative is connected with wind-up roll (13), the right side the surface fixed mounting of riser (12) has second motor (14), the output and wind-up roll (13) fixed connection of second motor (14), the fixed cover of surface of wind-up roll (13) is equipped with two wind-up rolls (15), two the surface of wind-up roll (15) is all movable around being equipped with steel cable (16), the top surface fixedly connected with two lugs (17) of top cap (2), two the one end that wind-up roll (15) were kept away from to steel cable (16) is respectively with two lug (17) fixed connection.
2. The microbial fermentation mechanism for producing sodium hyaluronate gel according to claim 1, wherein: the outer surface of the fermentation tank (1) is fixedly sleeved with a sleeve (19), and the outer surface of the top of the sleeve (19) is fixedly communicated with a water inlet pipe (20).
3. The microbial fermentation mechanism for producing sodium hyaluronate gel according to claim 2, wherein: the outer surface of the bottom of the fermentation tank (1) is fixedly communicated with a discharge pipe, the outer surface of the sleeve (19) is fixedly communicated with a water outlet pipe, and valves are arranged in the discharge pipe and the water outlet pipe.
4. The microbial fermentation mechanism for producing sodium hyaluronate gel according to claim 1, wherein: the bottom outer surface of the top cover (2) is fixedly connected with two connecting plates, and the two rotating rods (9) are respectively connected with the outer surfaces of the two connecting plates in a rotating mode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322283474.9U CN220887488U (en) | 2023-08-24 | 2023-08-24 | Microorganism fermentation mechanism for sodium hyaluronate gel production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322283474.9U CN220887488U (en) | 2023-08-24 | 2023-08-24 | Microorganism fermentation mechanism for sodium hyaluronate gel production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220887488U true CN220887488U (en) | 2024-05-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322283474.9U Active CN220887488U (en) | 2023-08-24 | 2023-08-24 | Microorganism fermentation mechanism for sodium hyaluronate gel production |
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| Country | Link |
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| CN (1) | CN220887488U (en) |
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2023
- 2023-08-24 CN CN202322283474.9U patent/CN220887488U/en active Active
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