CN220745965U - Incubator - Google Patents
Incubator Download PDFInfo
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- CN220745965U CN220745965U CN202322428020.6U CN202322428020U CN220745965U CN 220745965 U CN220745965 U CN 220745965U CN 202322428020 U CN202322428020 U CN 202322428020U CN 220745965 U CN220745965 U CN 220745965U
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- incubator
- box body
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 7
- 238000009423 ventilation Methods 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 2
- 244000005700 microbiome Species 0.000 abstract description 9
- 238000012258 culturing Methods 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- 238000003306 harvesting Methods 0.000 abstract description 3
- 239000007789 gas Substances 0.000 description 14
- 238000004113 cell culture Methods 0.000 description 4
- 238000011109 contamination Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000011072 cell harvest Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The present utility model provides an incubator comprising: a box body, an air deflector and a fan; the air deflector comprises a first section, a second section, a third section and a fourth section, wherein the first section is obliquely arranged, the second section is horizontally arranged, the third section is obliquely arranged, the fourth section is vertically arranged, the airtight space of the box body is divided into an inner cavity and an outer cavity, an air channel with upper inlet and lower outlet is formed, and the air channel is driven by the fan to circularly flow between the inner cavity and the outer cavity along the air channel. The incubator disclosed by the utility model can enable gas to flow rapidly through the air channels which are arranged in the upper part and the lower part, so that the uniformity of the temperature and humidity in the incubator and the concentration of the gas can be improved, cells in the incubator can be quickly subjected to a proper living environment, the cell harvesting rate and the cell culturing efficiency can be further improved, and meanwhile, microorganisms generated in the culturing process are prevented from diffusing upwards, so that the safety of cell culturing is improved.
Description
Technical Field
The utility model relates to the technical field of incubators, in particular to an incubator.
Background
Along with continuous innovation and rapid development of life technology, the dependence of human life medicine science on biological products is gradually enhanced, the traditional method for extracting biological products from animal tissues by biochemical technology cannot meet the market demand, cells are extracted from animal tissues to be cultivated in vitro on a large scale, a large-capacity cell factory incubator is suitable for large-scale cultivation and preparation of adherent cells, the market demand can be met, and however, the temperature, humidity and CO inside the incubator can be met 2 The concentration of the cells rapidly and accurately reaches the living environment of the cells, and the incubator of the large-capacity cell factory on the market has the problems that the temperature and humidity in the incubator and the uniformity of the gas concentration are poor, the stable and reliable living environment cannot be provided for the cells, the cell survival rate and the cell harvest rate are low, and the like.
Disclosure of Invention
The utility model aims to provide an incubator, which has the advantages that the uniformity of temperature and humidity and gas concentration in the incubator can be improved, so that cells in the incubator can quickly obtain a proper living environment, and the yield of the cells is improved.
In order to solve the problems in the prior art, the present utility model provides an incubator comprising: the air conditioner comprises a box body, an air deflector and a fan;
the inside of the box body is hollow, the air deflector is arranged in the box body and along the top wall and the side wall of the box body, and the air deflector divides the closed space of the box body into an inner cavity and an outer cavity and forms an air channel;
the air deflector comprises a first section, a second section, a third section and a fourth section, wherein the first section is obliquely arranged, the second section is horizontally arranged, the third section is obliquely arranged, the fourth section is vertically arranged, the first section is connected with the top wall of the box body, the fourth section is connected with the bottom wall of the box body, the second section and the top wall of the box body are provided with a first preset interval, and the fourth section and the side wall of the box body are provided with a second preset interval;
the first section and the fourth section are respectively provided with a plurality of air guide holes, the inner cavity and the outer cavity are mutually communicated through the plurality of air guide holes, and the fan is arranged in the outer cavity and is used for pushing airflow to circularly flow between the inner cavity and the outer cavity.
Optionally, the air deflector is formed by splicing an upper air duct plate and a back air duct plate.
Optionally, the upper duct plate includes integrally formed first and second sections, and the back duct plate includes integrally formed third and fourth sections; or alternatively
The upper duct plate includes integrally formed first, second and third sections, and the back duct plate includes integrally formed fourth section.
Optionally, at least one air inlet is arranged on the second section, and the air inlet is used for being connected with an external air source;
the plurality of air guide holes on the first section and the fourth section are arranged in an array, and the arrangement length is equal to the width of the inner cavity.
Optionally, the fan is a cross-flow fan, the cross-flow fan is arranged at the corner of the back and the top of the box body, and the length of the blade of the cross-flow fan is the same as the width of the inner cavity.
Optionally, the first preset interval and the second preset interval are set according to the volume of the incubator, the ventilation frequency and the set wind speed.
Optionally, the method further comprises: at least one of a humidity sensor, a temperature sensor and a CO2 concentration sensor, wherein,
the humidity sensor, the temperature sensor and the CO2 concentration sensor are all arranged on the second section of the air deflector.
Optionally, the method further comprises: a rail mount, a bracket, and a cell factory;
the cell factory is characterized in that the guide rail base, the support and the cell factory are arranged in the inner cavity, the guide rail base is fixed on the bottom wall of the box body, the support is connected with the guide rail base in a sliding mode, the cell factory is arranged on the support, a first air port and a second air port are formed in the cell factory, and the cell factory is communicated with the inner cavity of the incubator through the first air port and/or the second air port.
Optionally, the cell factory is a multi-layer structure, and the number of the cell factories is a plurality; the cell factories are independently arranged or are sequentially connected in series through the sealing pipeline.
Optionally, the incubator further comprises:
the door opening mechanism is connected with the box door of the box body,
the heating device is positioned in the inner cavity;
the heat preservation device is positioned on the inner wall of the box body;
and the water disc is positioned in the inner cavity and is close to the air guide hole of the fourth section.
As described above, the incubator of the utility model has the following beneficial effects: according to the incubator disclosed by the utility model, the air flows rapidly through the air channels which are arranged in the upper part and the lower part, so that the uniformity of the temperature and the humidity in the incubator and the concentration of the air is improved, the cells in the incubator can rapidly obtain a proper living environment, and the cell harvesting rate and the cell culturing efficiency are further improved. In addition, the air duct with the upper inlet and the lower outlet can reduce the pollution risk of microorganisms and improve the safety of cell culture.
Drawings
FIG. 1 is a perspective view of an incubator of the present utility model.
FIG. 2 is a side view of the incubator of the present utility model.
Description of element numbers: 1. box body 2, inner cavity 3, upper air duct plate 4, humidity sensor 5, temperature sensor 6, CO 2 Concentration sensor 7, fan, 8, back wind channel board, 9, water tray, 10, frame, 11, guide rail base, 12, cell mill, 13, wind-guiding hole.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
The preferred embodiments in the following description are by way of example only and other obvious variations will occur to those skilled in the art. The basic principles of the utility model defined in the following description may be applied to other embodiments, variations, modifications, equivalents, and other technical solutions without departing from the spirit and scope of the utility model.
It will be appreciated by those skilled in the art that in the present disclosure, the terms "longitudinal," "transverse," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," etc. refer to an orientation or positional relationship based on that shown in the drawings, which is merely for convenience of description and to simplify the description, and do not indicate or imply that the apparatus or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore the above terms should not be construed as limiting the present utility model.
Example 1
Referring to fig. 1 and 2, the present utility model provides an incubator, comprising: the box body 1, the air deflector and the fan 7;
the inside of the box body 1 is hollow, the air deflector is arranged in the box body 1 and along the top wall and the side wall of the box body 1, and the air deflector divides the closed space of the box body 1 into an inner cavity 2 and an outer cavity and forms an air channel;
the air deflector comprises a first section (not shown) which is obliquely arranged, a second section (not shown) which is horizontally arranged, a third section (not shown) which is obliquely arranged and a fourth section (not shown) which is vertically arranged, wherein the first section is connected with the top wall of the box body 1, the fourth section is connected with the bottom wall of the box body 1, the second section and the top wall of the box body 1 have a first preset interval, and the fourth section and the side wall of the box body 1 have a second preset interval;
the first section and the fourth section are respectively provided with a plurality of air guide holes, the inner cavity and the outer cavity are mutually communicated through the plurality of air guide holes, and the fan 7 is arranged in the outer cavity and is used for pushing airflow to circularly flow between the inner cavity and the outer cavity.
Specifically, the air deflector and the fan 7 are both located in the box 1, the air in the inner cavity 2 is sucked into the air duct by the fan 7, the air is guided to be inclined upwards by the air guiding holes (reference numerals are not shown in the figure) of the first section, then the air flows from top to bottom along the air duct, the air is guided to be horizontal by the air guiding holes 13 of the fourth section, and the air reenters the inner cavity 2.
According to the incubator disclosed by the utility model, the air flows rapidly through the air channels which are arranged in the upper part and the lower part, so that the uniformity of the temperature and the humidity in the incubator and the concentration of the air is improved, the cells in the incubator can rapidly obtain a proper living environment, and the cell harvesting rate is further improved. Meanwhile, the flow of the gas accelerates the material exchange in the culture environment and improves the culture efficiency of the cells.
In addition, microbial contamination is a very serious problem during cell culture and can adversely affect cell growth and experimental results. Therefore, the design of the air duct also needs to take into account how to reduce the risk of contamination by microorganisms. In the incubator that this embodiment provided, the design scheme of going up and going down is adopted in the wind channel, and when the gaseous follow-up down flows in the wind channel, the microorganism can follow gaseous flow and deposit down, consequently can avoid microorganism to spread upwards, and the air current can produce the disturbance to the microorganism in the culture environment when flowing down from last moreover, and this kind of disturbance can destroy the biomembrane of microorganism, leads to microorganism to lose the protection, finally dies. Thus, the efficiency and safety of cell culture are improved.
Example two
With continued reference to fig. 1 and 2, the present embodiment further provides an incubator, and the specific structure of the incubator in the present embodiment includes the following more specific structure based on the incubator in the first embodiment.
As an example, the plurality of air guide holes on the first section and the fourth section are all arranged in an array, and the axis of the air guide hole is consistent with the thickness direction of the air guide plate. Preferably, the arrangement length of the plurality of air guide holes on the first section and the fourth section is equal to the width of the inner cavity.
The air deflector is formed by splicing an upper air duct plate 3 and a back air duct plate 8 as an example.
In one example, the upper duct plate 3 includes integrally formed first and second sections, and the back duct plate 8 includes integrally formed third and fourth sections.
In another example, the upper duct plate 3 includes integrally formed first, second and third sections, and the back duct plate 8 includes integrally formed fourth section.
By way of example, the second section is provided with at least one air inlet (not shown in the figures) for connection to an external air source. The air provided by the external air source enters the inner cavity from the air inlet, enters the outer cavity through the air guide holes of the upper air duct plate 3, and then returns to the inner cavity again after passing through the air guide holes 13 of the back air duct plate 8. That is, the gas entering the inner cavity flows through the air guide hole of the first section, the gap between the second section and the box body 1, the gap between the third section and the box body 1, the gap between the fourth section and the box body 1, and the air guide hole 13 of the fourth section in sequence, and then returns to the inner cavity again, thus directionally circulating.
By way of example, the incubator further has an air outlet (not shown), the position of which is not limited; the air outlet is connected with a one-way valve (not shown in the figure); when the air pressure of the incubator reaches a set value, the one-way valve is opened, and the incubator is exhausted. Specifically, the air inlet and the air outlet may be both disposed in the second section of the air deflector.
As an example, the number of the air inlets may be set according to actual needs, preferably, in this embodiment, the number of the air inlets may be three, and the three air inlets may be respectively used for connecting and inputting three different gases, such as CO 2 Compressed air and N 2 。
As an example, the fan 7 is a cross-flow fan, and the cross-flow fan is disposed at a corner between the back and the top of the box 1, and the whole is a cylindrical structure, and an axis of the cylindrical structure is disposed along a width direction of the inner cavity. Preferably, the length of the blade of the cross-flow fan is the same as the width of the inner cavity.
As an example, the first preset interval and the second preset interval are set according to the volume of the incubator, the ventilation frequency, and the set wind speed.
Specifically, the air volume required per hour in the incubator=the cross-sectional area of the air duct (m 2 ) X wind speed (m/s) 3600(s) =volume of the incubator (m 3 ) X ventilation times per hour (times/hour); wherein the ventilation times are generally designed to be 200 times/hour. The wind speed is too high and the noise is large, so that the wind speed is generally set to be less than 6 m/s.
As an example, the incubator may further include: humidity sensor 4, temperature sensor 5 and CO 2 At least one of the concentration sensors 6, wherein,
the humidity sensor 4, the temperature sensor 5 and the CO 2 The concentration sensors 6 are all arranged on the second section of the air deflector.
As an example, the incubator may further include: a rail mount 11, a bracket 10 and a cell factory 12;
the guide rail base 11, the bracket 10 and the cell factory 12 are all arranged in the inner cavity, the guide rail base 11 is fixed on the bottom wall of the box body 1, the bracket 10 is in sliding connection with the guide rail base 11, and the cell factory 12 is installed on the bracket 10.
Wherein the cell factory 12 is provided with a first air port and a second air port, and the culture space in the cell factory 12 can be communicated with the inner cavity 2 of the incubator through the first air port and/or the second air port. Specifically, the cell factory 12 may communicate with the inner cavity 2 of the incubator only through the first gas port, may communicate with the inner cavity 2 of the incubator only through the second gas port, and may also communicate with the inner cavity 2 of the incubator through the first gas port and the second gas port.
By way of example, if neither the first gas port nor the second gas port is connected to an external gas source, the cell factory 12 communicates with the inner cavity 2 through the first gas port and the second gas port; when an external air source is connected to the cell factory 12 via a pipeline, one of the first and second air ports is used for air intake, and the other air port is used for air exhaust.
As an example, the cell factory 12 is plural in number.
In one example, a plurality of the cell factories 12 can be provided independently.
In another example, a plurality of the cell factories 12 can be serially connected in sequence via a sealed pipeline.
As an example, the incubator may further include:
a door opening mechanism (not shown) connected to the door of the case 1,
a heating device (not shown) located within the interior cavity;
a heat insulating means (not shown) located on the inner wall of the case 1;
a water tray 9, wherein the water tray 9 is positioned in the inner cavity and is used for water injection and humidification. The water tray 9 is close to the air guide hole 13 of the fourth section, and air flow entering the inner cavity from the air guide hole 13 directly blows against the water tray 9, so that the humidifying speed of the incubator can be improved.
By way of example, the door is located on the front of the housing, and the cell factory 12 can be accessed by opening the door.
As an example, the heating means may include, but is not limited to, heating means such as a heating wire or a heating rod.
As an example, the heat-insulating means may comprise a heat-insulating coating applied to the inner wall of the tank 1; of course, in other examples, the heat preservation device may also be wrapped outside the case 1.
Specifically, in this embodiment, 2 guide rail bases 11 are disposed in the incubator, each guide rail base 11 includes two linear guide rails disposed side by side, a frame 10 is mounted on each guide rail base 11, 4 cell factories 12 are disposed on each frame 10, 8 cell factories 12 are all of a multi-layer structure (for example, 40 layers), each cell factory 12 is a single individual, and is a closed culture space, two small cylinders (i.e., a first air port and a second air port) disposed at the top of the incubator can be connected with a closed pipeline, a plurality of cell factories 12 can be connected in series through the closed pipeline to form a whole, the water tray 9 is disposed between the 2 guide rail bases 11, a back air duct plate 8 mounted in the inner cavity 2 and the back air duct are mounted at the back, discrete air guide holes 13 are opened below the back air duct plate 8, the back and the top of the inner cavity 2 are mounted with the fan 7, the motor of the fan 7 is mounted at the outer side of the incubator 1, the temperature sensor is mounted at the air duct section 3, the air inlet section is opened at the air inlet section 3, and the air outlet section 3 is opened at the air outlet section 3, and the air duct section 3 is opened at the top of the air duct section 3 2 A concentration sensor 6.
The air duct (namely the upper air duct and the back air duct) adopts a design scheme of up-in and down-out, so that microorganisms can be prevented from diffusing upwards, and the efficiency and the safety of cell culture are improved. Moreover, the arrangement length of the air guide holes and the blade length of the cross-flow fan both cover the width of the whole inner cavity 2, and the design scheme can effectively ensure the temperature, humidity and CO in the cavity 2 The concentration is uniform and stable, and the yield and the culture efficiency of the cells are further improved.
It will be evident to those skilled in the art that the utility model is not limited to the details of the foregoing illustrative embodiments, and that the present utility model may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the utility model being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.
Claims (10)
1. An incubator, comprising: the air conditioner comprises a box body, an air deflector and a fan;
the inside of the box body is hollow, the air deflector is arranged in the box body and along the top wall and the side wall of the box body, and the air deflector divides the closed space of the box body into an inner cavity and an outer cavity and forms an air channel;
the air deflector comprises a first section, a second section, a third section and a fourth section, wherein the first section is obliquely arranged, the second section is horizontally arranged, the third section is obliquely arranged, the fourth section is vertically arranged, the first section is connected with the top wall of the box body, the fourth section is connected with the bottom wall of the box body, the second section and the top wall of the box body are provided with a first preset interval, and the fourth section and the side wall of the box body are provided with a second preset interval;
the first section and the fourth section are respectively provided with a plurality of air guide holes, the inner cavity and the outer cavity are mutually communicated through the plurality of air guide holes, and the fan is arranged in the outer cavity and is used for pushing airflow to directionally circulate and flow between the inner cavity and the outer cavity.
2. The incubator of claim 1, wherein the air deflection plate is formed by splicing an upper air duct plate and a back air duct plate.
3. The incubator of claim 2, wherein the upper duct plate comprises integrally formed first and second sections, and the back duct plate comprises integrally formed third and fourth sections; or alternatively
The upper duct plate includes integrally formed first, second and third sections, and the back duct plate includes integrally formed fourth section.
4. Incubator according to claim 1, characterized in that the second section is provided with at least one air inlet for connection to an external air source;
the plurality of air guide holes on the first section and the fourth section are arranged in an array, and the arrangement length is equal to the width of the inner cavity.
5. The incubator of claim 1, wherein the fans are cross flow fans disposed at corners of the back and top of the incubator, and wherein the cross flow fans have blades of the same length as the width of the inner chamber.
6. The incubator of claim 1, wherein the first preset distance and the second preset distance are set according to a volume of the incubator, a ventilation frequency, and a set wind speed.
7. Incubator according to claim 1, characterized in thatFurther comprising: humidity sensor, temperature sensor and CO 2 At least one of the concentration sensors, wherein,
the humidity sensor, the temperature sensor and the CO 2 The concentration sensors are all arranged on the second section of the air deflector.
8. The incubator of claim 1, further comprising: a rail mount, a bracket, and a cell factory;
the cell factory is characterized in that the guide rail base, the support and the cell factory are arranged in the inner cavity, the guide rail base is fixed on the bottom wall of the box body, the support is connected with the guide rail base in a sliding mode, the cell factory is arranged on the support, a first air port and a second air port are formed in the cell factory, and the cell factory is communicated with the inner cavity of the incubator through the first air port and/or the second air port.
9. The incubator of claim 8, wherein the cell factory is a multi-layered structure, the cell factory being a plurality of cell factories; the cell factories are independently arranged or are sequentially connected in series through the sealing pipeline.
10. The incubator of claim 1, further comprising:
the door opening mechanism is connected with the box door of the box body,
the heating device is positioned in the inner cavity;
the heat preservation device is positioned on the inner wall of the box body;
and the water disc is positioned in the inner cavity and is close to the air guide hole of the fourth section.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322428020.6U CN220745965U (en) | 2023-09-06 | 2023-09-06 | Incubator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322428020.6U CN220745965U (en) | 2023-09-06 | 2023-09-06 | Incubator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220745965U true CN220745965U (en) | 2024-04-09 |
Family
ID=90564489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322428020.6U Active CN220745965U (en) | 2023-09-06 | 2023-09-06 | Incubator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220745965U (en) |
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2023
- 2023-09-06 CN CN202322428020.6U patent/CN220745965U/en active Active
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