CN220657575U - Automatic reaction mechanism based on micro-fluidic chip - Google Patents

Abstract

The utility model relates to the field of medical equipment, in particular to an automatic reaction mechanism based on a microfluidic chip. The automatic reaction mechanism based on the microfluidic chip comprises an objective table for bearing the microfluidic chip and a pressing module for pressing the vesicle of the microfluidic chip, wherein the pressing module comprises a pressing piece for pressing, and a pressing transmission mechanism for controlling the pressing piece to move relative to the microfluidic chip and pressing the microfluidic chip is arranged on the pressing module. Due to the mechanical pressing mode, the same force is used for conveniently controlling each pressing, the size of the pressing piece is reduced conveniently to adapt to a smaller micro-fluidic chip, manual intervention can be avoided, bacteria are prevented from being introduced, and the problems that the micro-fluidic chip is small in size and needs to be manually pressed to cause accurate control and bacteria are easy to be introduced in the prior art are solved.

Description

Automatic reaction mechanism based on micro-fluidic chip

Technical Field

The utility model relates to the field of medical equipment, in particular to an automatic reaction mechanism based on a microfluidic chip.

Background

The microfluidic chip technology integrates basic operation units of sample preparation, reaction, separation, detection and the like in biological, chemical and medical analysis processes on a micron-scale chip to complete the whole analysis process.

The chip itself can not carry out automatic analysis, only integrate the component that carries out the analysis on the chip, as shown in fig. 1, be provided with annotate liquid mouth 12 on the chip and be used for injecting into the chip inside with the sample liquid, the chip is inside to be provided with the runner 13 that supplies the sample to flow, runner 13 staggered arrangement still is provided with vesicle 11 in the flow process of runner 13, the interior detection reagent that is used for carrying out the reaction with the sample that presets of vesicle 11, press the surface of vesicle 11 can make the detection reagent in the vesicle 11 flow to corresponding runner in, and then make detection reagent and sample mix. In order to facilitate the reaction of the reagent, magnetic beads are further provided in the vesicle 11, and the magnetic beads may be mixed with the sample to attach the sample to the magnetic beads, and then the movement of the magnetic beads is monitored to obtain the operation of the sample. Meanwhile, a packaging film is arranged on the chip to seal the flow channel so as to avoid pollution. Meanwhile, different outlets are arranged at the tail end of the flow channel, so that sample monitoring and waste liquid collecting are respectively carried out. In addition, in order to facilitate the flow of the liquid, a jack 14 is further provided on the microfluidic chip, and suction is performed through the jack 14 to form a negative pressure in the flow channel 13, so that the flow of the sample is facilitated.

In the prior art, although a microfluidic chip exists, the microfluidic chip is controlled by manpower, the pressing force, the pressing time and the liquid injection amount are all manually operated, the microfluidic chip is smaller, the accuracy under the manual operation is problematic, when the detection is performed, if the pressing force is too large, adverse effects and even damage can be caused to a packaging film on the chip, the pressing force is small, the outflow amount of a detection reagent is small, the reaction process is influenced, and bacteria are easily brought into a destructive test by manual control.

Disclosure of Invention

The utility model aims to provide an automatic reaction mechanism based on a microfluidic chip, which is used for solving the problems that in the prior art, the microfluidic chip is small in size, accurate control is difficult to perform and bacteria are easy to introduce because the microfluidic chip needs to be pressed manually.

In order to achieve the above purpose, the automatic reaction mechanism based on the microfluidic chip in the utility model adopts the following technical scheme:

the utility model provides an automatic reaction mechanism based on micro-fluidic chip, includes the objective table that is used for bearing micro-fluidic chip and is used for pressing the module that presses of pressing of micro-fluidic chip's vesicle, presses the module including the pressing piece that presses, is provided with the transmission mechanism that presses that is used for controlling the pressing piece and removes for micro-fluidic chip and press to micro-fluidic chip on pressing the module.

The beneficial effects of the technical scheme are that: the utility model provides an automatic reaction mechanism based on a microfluidic chip, which is convenient for supporting and bearing the microfluidic chip by arranging an objective table and is convenient for carrying out the subsequent reaction; the pressing module is arranged to press the vesicle, so that the reagent in the microfluidic chip can be separated from the original reagent and react with the sample; the position of the pressing piece is adjusted through the pressing transmission mechanism, so that the pressing piece can move relative to the micro-fluidic chip, the vesicle of the micro-fluidic chip can be pressed, the pressing mode is mechanical, the pressing piece is convenient to control to use the same force every time, the pressing piece is convenient to reduce in size to adapt to the smaller micro-fluidic chip, manual intervention can be avoided, bacteria are avoided being introduced, and the problems that the micro-fluidic chip is small in size and needs to be manually pressed, accurate control is difficult to perform and bacteria are easy to introduce in the prior art are solved.

Further, the pressing transmission mechanism comprises a pressing lifting mechanism capable of controlling the pressing contact to lift and a pressing moving mechanism capable of controlling the pressing contact to horizontally move.

The beneficial effects of the technical scheme are that: the pressing lifting mechanism presses the movable plate, and the movable plate can move to the corresponding position by the pressing moving mechanism.

Further, the pressing moving mechanism comprises two groups of screw nut mechanisms moving on the horizontal plane, and the pressing lifting mechanism is arranged on any one of the two groups of screw nut mechanisms.

The beneficial effects of the technical scheme are that: the installation structure is simple, and the movement of a plurality of degrees of freedom in the space is convenient to realize.

Further, the pressing piece is a pressing post, and the end of the pressing post forms a pressing contact with a pressing function.

The beneficial effects of the technical scheme are that: the pressing contact is accurate in pressing, and the micro-fluidic chip with small area is convenient to press.

Further, the microfluidic chip-based automatic reaction mechanism further comprises a magnet assembly for fixing magnetic beads in vesicles of the microfluidic chip.

The beneficial effects of the technical scheme are that: the magnetic bead is convenient to combine with the magnetic bead in the micro-fluidic chip so as to be convenient for detecting the sample.

Further, the magnet assembly comprises a magnet which is arranged on the objective table in a penetrating way and is used for being fixed with the magnetic beads.

The beneficial effects of the technical scheme are that: because the micro-fluidic chip is not large in size, the magnetic beads in the vesicles are not large in size, and the magnet penetrates through the object stage to facilitate the pulling-in of the distance between the magnet and the magnetic beads, so that the magnetic force on the magnetic beads is improved.

Further, the automatic reaction mechanism based on the microfluidic chip further comprises a chip cabin for storing the microfluidic chip, wherein the chip cabin is arranged on one side of the objective table and is provided with a feeding structure for pushing the chip in the chip cabin onto the objective table.

The beneficial effects of the technical scheme are that: the method is convenient for carrying out multiple reactions, can continuously detect different microfluidic chips or different microfluidic chips in the same batch, and has high detection efficiency.

Further, the chip cabin comprises baffle plates which are arranged vertically to each other, an avoidance opening is formed in one side, facing the objective table, of the baffle plates, and the height of the avoidance opening is larger than that of a single microfluidic chip and smaller than that of two microfluidic chips.

The beneficial effects of the technical scheme are that: the stirring is convenient, and only a single microfluidic chip can be stirred.

Further, the feeding structure comprises a mounting seat capable of reciprocating and a feeding member hinged to the mounting seat, a stop member used for limiting the rotation limit of the feeding member is arranged on the mounting seat, an elastic member is connected between the feeding member and the mounting seat, the feeding member is provided with a pushing surface and an avoidance inclined surface, the pushing surface is used for pushing a lowermost chip to move for feeding under the drive of the mounting seat, the avoidance inclined surface is used for being in press fit with a newly fallen chip to enable the feeding member to rotate so as to avoid the chip when the feeding member rotates so as to avoid the chip, and the elastic member is used for being stressed to deform when the feeding member rotates so as to provide reset power for the restoration of the feeding member to the stop fit with the stop member.

The beneficial effects of the technical scheme are that: the automatic feeding is convenient, and the unidirectional feeding can be only carried out in the feeding process, so that the microfluidic chip is prevented from flowing out from other positions.

Further, the automatic reaction mechanism based on the microfluidic chip further comprises a suction module for being inserted into the runner of the microfluidic chip to perform suction, an insert for being inserted into the runner is arranged on the suction module, and an air passage is arranged on the insert.

The beneficial effects of the technical scheme are that: the flow channel is convenient to suck, so that negative pressure is formed in the flow channel, and power is provided for the flow of liquid.

Drawings

Fig. 1 is a schematic structural diagram of a microfluidic chip in the prior art;

FIG. 2 is a schematic structural diagram of an automatic reaction mechanism based on a microfluidic chip according to embodiment 1 of the present utility model;

FIG. 3 is a schematic diagram of the structure of a chip module of an embodiment 1 of an automatic reaction mechanism based on a microfluidic chip according to the present utility model;

fig. 4 is a schematic structural diagram of a pressing module of an embodiment 1 of an automatic reaction mechanism based on a microfluidic chip in the present utility model;

fig. 5 is a schematic structural diagram of a pumping module of embodiment 1 of an automatic reaction mechanism based on a microfluidic chip in the present utility model;

fig. 6 is a schematic structural view of the stage and the discard pushing mechanism of the automatic reaction mechanism based on the microfluidic chip of example 1 in the present utility model.

In the figure: 1. a microfluidic chip; 11. a vesicle; 12. a liquid injection port; 13. a flow passage; 14. a jack; 15. a reaction zone; 2. a chip compartment; 21. a baffle; 22. a synchronous belt; 23. a push plate mounting seat; 24. a push plate; 25. a baffle column; 26. a spring; 27. a carrying plate; 3. a pressing module; 31. pressing the column; 32. pressing the moving mechanism; 33. pressing the lifting mechanism; 4. a pin assembly; 41. a contact pin; 42. reinforcing ribs; 5. a pipetting pump module; 6. an objective table; 61. a magnet lifting structure; 62. a magnet; 63. perforating; 64. a pulling piece; 65. discarding the transmission structure; 66. a first chute; 67. a second chute; 68. a frame; 7. a platform plate.

Detailed Description

The features and capabilities of the present utility model are described in further detail below in connection with the examples.

In example 1 of an automatic reaction mechanism (hereinafter referred to as an automatic reaction mechanism) based on a microfluidic chip in the present utility model:

in this embodiment, be provided with the objective table that bears micro-fluidic chip in automatic reaction mechanism, be used for injecting the transfer pump module of waiting to detect the sample, be used for squeezing the inside detection reagent's of micro-fluidic chip pressing the module, be used for carrying out the suction module that pumps to the gas in the micro-fluidic chip, annotate the liquid in the testing process, the flow of liquid, detect the combination etc. of reagent and sample all have this automatic reaction mechanism to control for the reaction is automatic, need not operate by the manual work, avoided micro-fluidic chip itself size is less and need manual carry out pressing the problem that the operation leads to be difficult for carrying out accurate control and easy introducing bacterium among the prior art.

Specifically, as shown in fig. 2, the automatic reaction mechanism in this embodiment includes a stage 6 for carrying the microfluidic chip 1, a chip bay 2 for storing the chip, a suction module for drawing negative pressure on the microfluidic chip 1 to power the flow of liquid in the microfluidic chip 1, a pressing module 3 for pressing the detection reagent of the microfluidic chip 1, and a transfer pump for injecting liquid into the microfluidic chip 1 and a transfer pump transmission mechanism for controlling the movement of the transfer pump. The automatic reaction mechanism further comprises a platform plate 7, and the objective table 6, the chip cabin 2, the suction module and the pressing module 3 are all arranged on the platform plate 7. The specific position of the microfluidic chip 1 is fixed during reaction, and the movement of other modules and mechanisms is based on the relative movement of the stage 6, so that the microfluidic chip 1 can react on the stage 6 under the action of the suction module and the pressing module 3 to detect corresponding sample information.

As shown in fig. 3, the chip deck 2 is provided on one side of the stage 6 and serves to push the chip in the chip deck 2 onto the stage 6. Specifically, the chip module 2 includes three vertically arranged baffles 21 and a bearing plate 27 fixedly connected with the baffles 21, the three baffles 21 are vertically arranged in pairs, the three baffles 21 form openings, an observation window capable of observing the number of the microfluidic chips 1 is formed at the openings, and in order to avoid the microfluidic chips 1 from sliding down from the openings, a closing-in structure (not shown in the figure) is arranged at the openings, so that the microfluidic chips 1 cannot slide down from the openings. The middle of the three baffles 21 is respectively connected with the two baffles 21 at the edge, an avoidance opening (not shown in the figure) for enabling the microfluidic chip 1 to pass through is arranged at the bottom of the middle baffle 21, and the height of the avoidance opening is more than that of a single microfluidic chip 1 and less than that of two microfluidic chips 1, so that only one microfluidic chip 1 can pass through at a time.

In order to realize automatic feeding of the microfluidic chip 1, a feeding structure is arranged in the chip cabin 2. Specifically, a feeding transmission structure and a feeding part rotationally arranged on the feeding transmission structure are arranged at the bottom of the chip cabin 2, the feeding transmission structure is a synchronous belt 22 in the embodiment, the feeding part is a push plate 24 with one end being a wedge-shaped section, the push plate 24 is provided with a pushing surface and an avoidance inclined surface, the mounting seat is a push plate mounting seat 23, the push plate 24 is mounted on the synchronous belt 22 through the push plate mounting seat 23, and the push plate 24 is rotatably and hingedly mounted on the push plate mounting seat 23. A stopper member in stop fit with the push plate 24 and a spring 26 connected to the push plate 24 and the push plate mount 23 respectively are provided on a side of the push plate mount 23 away from the stage 6, and the stopper member is a stopper post 25 in this embodiment. When the push plate 24 carries out feeding, the wedge-shaped section of the push plate 24 is matched with the side edge of the microfluidic chip 1 at the lowest position in a stop way, and then the microfluidic chip 1 is pushed out from the avoidance port, when the push plate 24 returns, the push plate 24 can overcome the elasticity of the spring 26 to rotate because the push plate 24 can rotate and the chip can not be pushed out reversely, so that the avoidance inclined plane of the push plate 24 contacts with the bottom of the microfluidic chip 1 and returns, and when the return is in place, the push plate 24 is separated from contact with the bottom of the microfluidic chip 1, returns to the initial state under the action of the spring 26, and is convenient for pushing next time.

As shown in fig. 4, the pressing module 3 includes a pressing post 31 for pressing a specific portion of the microfluidic chip 1, and a pressing contact is formed at an end of the pressing post 31, and the pressing module 3 further includes a pressing transmission mechanism capable of controlling movement of the pressing contact with respect to the microfluidic chip 1. The micro-fluidic chip 1 is integrated with a vesicle 11 of a pretreatment liquid capable of reacting, that is, the pretreatment liquid is arranged in the vesicle 11, and in the use process, the pretreatment liquid in the vesicle 11 needs to be extruded. The pressing transmission mechanism comprises a pressing lifting mechanism 33 capable of controlling the pressing contact to lift and a pressing moving mechanism 32 capable of controlling the pressing contact to horizontally move, the pressing lifting mechanism 33 in the embodiment is a vertically arranged screw-nut mechanism, the pressing moving mechanism 32 comprises two groups of horizontally and mutually vertically arranged screw-nut mechanisms, the pressing contact can be enabled to move to the upper side of the corresponding vesicle 11 through the arrangement of the two groups of horizontally arranged screw-nut mechanisms, the pressing contact can vertically move through the vertically arranged screw-nut mechanisms, when the pressing contact is located above the vesicle 11, the pressing contact can vertically move again, and the vesicle 11 can be extruded to carry out extrusion of pretreatment liquid.

As shown in fig. 2, the pipetting module 5 includes a pipetting pump for injecting liquid into the microfluidic chip 1 and a pipetting pump driving mechanism (not shown in the drawing) for controlling the pipetting pump to move, in which the pipetting pump can draw sample liquid to inject the sample into the microfluidic chip 1, and meanwhile, in the reaction process, the end of the pipetting pump can be inserted into the liquid injection port 12 of the microfluidic chip 1 to block the liquid injection port 12 of the microfluidic chip 1, so as to avoid the sample flowing out without flowing into the microfluidic chip 1.

As shown in fig. 5, the suction module is a pin assembly 4 including a plug and a suction seat, and the suction seat is provided with a lifting structure for lifting movement of the plug, which in this embodiment is a screw-nut mechanism, on which the plug is fixedly disposed. The plug is hollow contact pin 41, contact pin 41 is connected with the trachea, and contact pin 41 can be used as a part of the trachea to insert the micro-fluidic chip, and because two jacks are arranged, a certain runner is selected selectively to enable a sample to move. In order to increase the structural strength of the suction mount, a reinforcing rib 42 is therefore also provided on the suction mount.

As shown in fig. 6, since the magnetic beads are preset in the micro-fluidic chip 1, the magnetic beads are mixed with the sample, so that the sample is attached to the magnetic beads, and the movement of the sample can be known through the movement of the magnetic beads, so that the process of the sample can be mastered from time to time. That is, by pressing the vesicles, the magnetic beads enter the reaction region 15 to bind with the sample, and then the magnetic beads are reacted and detected. In order to facilitate the fixation of the magnetic beads in the reaction area 15, a magnet 62 assembly for combining with the magnetic beads in the micro-fluidic chip 1 is further arranged at the bottom of the objective table 6, a magnet lifting structure 61 is arranged on the magnet 62 assembly, and since the magnetic beads are arranged in the micro-fluidic chip 1 and the volume of the magnetic beads is not large, in order to facilitate the adsorption of the magnetic beads by the magnet 62 assembly, a through hole 63 for the magnet 62 in the magnet 62 assembly to pass through is arranged on the objective table 6, in this embodiment, the magnet lifting structure 61 is a straight-acting electric push rod assembly, and the magnet 62 is arranged at the end part of the electric push rod and moves linearly along with the movement of the electric push rod.

As shown in fig. 6, the stage 6 is provided with an inlet for the chip to enter and an outlet for the chip to be discarded and discharged, and a reaction station for carrying out the reaction of the microfluidic chip 1 on the stage 6. The import corresponds the setting with the dodge mouth of chip cabin 2, and is provided with the first spout 66 that supplies push pedal 24 to carry out the propelling movement on objective table 6, still is provided with the abandonment pushing mechanism that supplies to give up the chip on objective table 6, abandonment pushing mechanism including wearing to establish the abandonment of objective table 6 and supply waste gas to dial the abandonment transmission structure 65 that the piece removed, abandonment transmission structure 65 is screw nut mechanism, abandonment is dialled the piece 64. The poking piece 64 is fixedly connected with a nut of the screw nut mechanism, and the poking piece 64 can be driven to move under the movement of the screw nut so as to poke the chip into the abandoned position. In order to limit the chip, a frame 68 is arranged at the edge part of the objective table 6, and the objective table 6 and the bearing plate 27 are positioned at the same height so as to facilitate the movement of the carrying microfluidic chip 1 from the chip cabin 2 to the objective table 6. In order to facilitate the movement of the paddle 64, a second chute 67 is provided on the stage 6 for the paddle 64 to move. The end of the second chute 67 is an outlet, and a waste liquid collecting box can be arranged at the outlet of the objective table 6 to collect the reacted microfluidic chip 1 when in use, so that environmental pollution is avoided.

In example 2 of the microfluidic chip-based automatic reaction mechanism in the present utility model: for the setting of the automatic reaction mechanism based on the micro-fluidic chip, this embodiment proposes a new arrangement form, and is different from embodiment 1 in that the suction module is no longer provided in this embodiment, but the liquid flows by itself.

In example 3 of the microfluidic chip-based automatic reaction mechanism in the present utility model: aiming at the arrangement of the chip cabins, the embodiment provides a novel arrangement form, and unlike the embodiment 1, the chip cabins in the embodiment are formed by splicing a vertically arranged net-shaped structure, and the avoiding opening is arranged on the net-shaped structure.

In example 4 of the microfluidic chip-based automatic reaction mechanism in the present utility model: for the arrangement of the chip cabin, this embodiment proposes a new arrangement form, unlike embodiment 1, in which the height of the avoiding opening in the chip cabin is equal to the height of the single microfluidic chip.

In example 5 of the microfluidic chip-based automatic reaction mechanism in the present utility model: for the setting of the automatic reaction mechanism based on the microfluidic chip, this embodiment proposes a new arrangement form, unlike embodiment 1, in this embodiment, no chip module is set any more, only a single microfluidic chip can be reacted, and after the reaction is finished, the operation is performed manually, and the chip is taken away and a new microfluidic chip is placed.

In example 6 of the microfluidic chip-based automatic reaction mechanism in the present utility model: for the arrangement of the magnet assembly, this embodiment proposes a new arrangement form, unlike embodiment 1, in which the magnet assembly is no longer disposed on the stage, and the magnet and the microfluidic chip are disposed on two sides of the stage, respectively.

In example 7 of the microfluidic chip-based automatic reaction mechanism in the present utility model: for the setting of the automatic reaction mechanism based on the microfluidic chip, this embodiment proposes a new arrangement form, unlike embodiment 1, in this embodiment, no magnet assembly is provided, and the magnet assembly is configured by the user.

In example 8 of the microfluidic chip-based automatic reaction mechanism in the present utility model: as for the arrangement of the pressing transmission mechanism, this embodiment proposes a new arrangement form, unlike embodiment 1, in which the pressing moving mechanism is fixedly arranged on the nut of the screw nut mechanism of the pressing lifting mechanism.

In example 9 of the microfluidic chip-based automatic reaction mechanism in the present utility model: for the setting of pressing the module, this embodiment proposes a new layout, unlike embodiment 1 in this embodiment, pressing the module no longer sets up pressing the moving mechanism, only sets up pressing the elevating system, every time place, all makes the contact that presses on the module aim at the top of the vesicle of micro-fluidic chip.

In example 10 of the microfluidic chip-based automatic reaction mechanism in the present utility model: in view of the arrangement of the pressing module, this embodiment proposes a new arrangement, unlike embodiment 1, in which the pressing member is no longer provided as a pressing post but as a pressing block, the end of which constitutes the pressing contact.

In example 11 of the microfluidic chip-based automatic reaction mechanism in the present utility model: for the arrangement of the feeding structure, this embodiment proposes a new arrangement form, unlike embodiment 1, in which the feeding member in the feeding structure is a feeding rod; of course, in other embodiments the stop member may be a stop projection; of course, in other embodiments, the elastic member may be a torsion spring disposed on the hinge shaft of the feeding member and the mounting base.

The above description is only a preferred embodiment of the present utility model, and the patent protection scope of the present utility model is defined by the claims, and all equivalent structural changes made by the specification and the drawings of the present utility model should be included in the protection scope of the present utility model.

Claims (10)

1. An automatic reaction mechanism based on a microfluidic chip, which is characterized in that: including being used for bearing the objective table (6) of micro-fluidic chip (1) and being used for pressing the pressing module (3) of vesicle (11) of micro-fluidic chip (1), pressing module (3) are including the pressing piece that presses, are provided with on pressing module (3) and are used for controlling the pressing piece and remove and press the transmission mechanism that presses of micro-fluidic chip (1) for micro-fluidic chip (1), press transmission mechanism including can controlling the pressing lifting mechanism (33) that presses the piece to go up and down.

2. The microfluidic chip-based automatic reaction mechanism according to claim 1, wherein: the pressing transmission mechanism comprises a pressing moving mechanism (32) for controlling the pressing piece to move horizontally.

3. The microfluidic chip-based automatic reaction mechanism according to claim 2, wherein: the pressing moving mechanism (32) comprises two groups of screw nut mechanisms which are horizontally and vertically arranged, and the pressing lifting mechanism (33) is arranged on any one of the two groups of screw nut mechanisms.

4. A microfluidic chip based automated reaction mechanism according to any one of claims 1-3, wherein: the pressing piece is a pressing post (31), and the end part of the pressing post (31) forms a pressing contact with a pressing function.

5. A microfluidic chip based automated reaction mechanism according to any one of claims 1-3, wherein: the automatic reaction mechanism based on the micro-fluidic chip further comprises a magnet (62) component for fixing magnetic beads in vesicles (11) of the micro-fluidic chip (1).

6. The microfluidic chip-based automatic reaction mechanism according to claim 5, wherein: the magnet (62) component comprises a magnet (62), and the magnet (62) is arranged on the objective table (6) in a penetrating way and is used for being fixed with the magnetic beads.

7. A microfluidic chip based automated reaction mechanism according to any one of claims 1-3, wherein: the automatic reaction mechanism based on the micro-fluidic chip further comprises a chip cabin (2) for storing the micro-fluidic chip (1), wherein the chip cabin (2) is arranged on one side of the objective table (6) and is provided with a feeding structure for pushing the chip in the chip cabin (2) onto the objective table (6).

8. The microfluidic chip-based automatic reaction mechanism according to claim 7, wherein: the chip cabin (2) comprises baffle plates (21) which are arranged vertically to each other, one side of each baffle plate (21) facing the objective table (6) is provided with an avoidance opening, and the height of each avoidance opening is not smaller than the height of each single microfluidic chip (1) and is smaller than the heights of two microfluidic chips (1).

9. The microfluidic chip-based automatic reaction mechanism according to claim 7, wherein: the feeding structure comprises a mounting seat capable of reciprocating and a feeding member hinged to the mounting seat, a stop member used for limiting the rotation limit of the feeding member is arranged on the mounting seat, an elastic member is connected between the feeding member and the mounting seat, the feeding member is provided with a pushing surface and an avoidance inclined surface, the pushing surface is used for pushing a chip at the lowest position to move for feeding under the drive of the mounting seat, the avoidance inclined surface is used for being in press fit with a newly fallen chip to enable the feeding member to rotate so as to avoid the chip when the feeding member resets, and the elastic member is used for being stressed to deform when the feeding member rotates so as to restore to provide reset power with the stop cooperation of the stop member.

10. A microfluidic chip based automated reaction mechanism according to any one of claims 1-3, wherein: the automatic reaction mechanism based on the micro-fluidic chip further comprises a suction module used for being inserted into a runner (13) of the micro-fluidic chip (1) to perform suction, an insert used for being inserted into the runner (13) is arranged on the suction module, and an air channel is arranged on the insert.