CN220656555U - Device for purifying and producing low molecular weight heparin sodium from crude heparin sodium - Google Patents
Device for purifying and producing low molecular weight heparin sodium from crude heparin sodium Download PDFInfo
- Publication number
- CN220656555U CN220656555U CN202322222194.7U CN202322222194U CN220656555U CN 220656555 U CN220656555 U CN 220656555U CN 202322222194 U CN202322222194 U CN 202322222194U CN 220656555 U CN220656555 U CN 220656555U
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- CN
- China
- Prior art keywords
- heparin sodium
- filter
- filter box
- filter screen
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920000669 heparin Polymers 0.000 title claims abstract description 47
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 title claims abstract description 46
- 229960001008 heparin sodium Drugs 0.000 title claims abstract description 32
- 239000003055 low molecular weight heparin Substances 0.000 title claims abstract description 14
- 229940127215 low-molecular weight heparin Drugs 0.000 title claims abstract description 14
- 230000007246 mechanism Effects 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 13
- 238000000746 purification Methods 0.000 claims abstract description 13
- 239000012043 crude product Substances 0.000 claims abstract description 10
- 238000001914 filtration Methods 0.000 claims abstract description 9
- 230000000149 penetrating effect Effects 0.000 claims abstract description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000000047 product Substances 0.000 claims description 3
- 230000037431 insertion Effects 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 239000012535 impurity Substances 0.000 description 6
- 239000002994 raw material Substances 0.000 description 4
- 241000220317 Rosa Species 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 206010051055 Deep vein thrombosis Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 208000010378 Pulmonary Embolism Diseases 0.000 description 1
- 206010047249 Venous thrombosis Diseases 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
Landscapes
- Filtration Of Liquid (AREA)
Abstract
The utility model discloses a device for purifying and producing low molecular weight heparin sodium by using a heparin sodium crude product, which relates to the technical field of heparin sodium crude product purification and comprises a filter box and a material pipe fixedly penetrating through the upper end of the inside of the filter box, wherein a cross rod is rotatably penetrated in the inside of the filter box, a connecting ring is fixedly sleeved on the wall of the cross rod, a plurality of filter screens which are symmetrically arranged in a surrounding manner are fixedly arranged on the outer side wall of the connecting ring, discharge holes are formed in the lower end of the inside of the filter box, supporting plates are fixedly arranged at two ends of the bottom of the filter box, a rotary positioning mechanism for limiting the position of the filter screens is arranged at the rear end of the cross rod, and a baffle is arranged at the lower end of the outer side of the filter box in a contact manner. According to the filter box, the filter screen, the material pipes, the discharge holes, the cross bars, the connecting rings, the filter screen and the rotary positioning mechanism, the filter screens can be rotated and switched for use, so that the filter screen can be cleaned after a crude product at one end of the filter screen is lifted, and the filter screen can be ensured to perform stable purification and filtration work.
Description
Technical Field
The utility model relates to the technical field of heparin sodium crude product purification, in particular to a device for producing low molecular weight heparin sodium by purifying heparin sodium crude product.
Background
Heparin sodium is a commonly used anticoagulant, belongs to heparin medicines, is commonly used for preventing and treating deep vein thrombosis, pulmonary embolism and coagulation problems after heart operation, and is required to be purified in the production process.
Through retrieving, patent number CN211339358U discloses a purification equipment for crude heparin sodium, and this equipment can realize making the raw materials impurity that the filter screen intercepted in the purification process concentrate together and handle for raw materials impurity is difficult for scattered pile up on the filter screen, thereby is difficult for influencing the filtration progress of raw materials impurity.
When a large amount of crude heparin sodium falls down to filter, the impurity in heparin sodium can receive the action of gravity and imbeds in the mesh of filter screen inside, can't roll to the lower extreme of filter screen, leads to the filter screen to reduce for a long time filter effect, and the filter screen sets up in the device inside simultaneously, is inconvenient for dismantle the clearance.
Disclosure of Invention
The utility model is provided in view of the problems of the existing heparin sodium crude product purification production low molecular weight heparin sodium device.
Therefore, the utility model aims to provide a device for purifying and producing low molecular weight heparin sodium from crude heparin sodium, which solves the problems that when the crude heparin sodium falls down in a large amount for filtering, impurities in the heparin sodium can be embedded into meshes in a filter screen under the action of gravity and cannot fall down to the lower end of the filter screen for completing collection.
In order to achieve the above object, the present utility model provides the following technical solutions:
the device comprises a filter box and a material pipe fixedly penetrating through the upper end of the inside of the filter box, wherein a cross rod is penetrated through the inside of the filter box in a rotating way, a connecting ring is fixedly sleeved on the rod wall of the cross rod, a plurality of filter screens which are arranged in a surrounding symmetrical way are fixedly arranged on the outer side wall of the connecting ring, discharge holes are formed in the lower end of the inside of the filter box, support plates are fixedly arranged at two ends of the bottom of the filter box, the cross rod can drive the filter screens to rotate, so that the purified filter screens can be rotated out for cleaning, and the continuous working of the filter screens is ensured;
the rear end of the cross rod is provided with a rotary positioning mechanism for limiting the position of the filter screen;
the lower end of the outer side of the filter box is in contact with a baffle plate, and the lower end of the baffle plate is provided with an elastic limiting mechanism for limiting the position of the baffle plate.
Preferably, the rotation positioning mechanism comprises a rotating plate, the rear end outside of the cross rod is fixedly sleeved with the rotating plate, a plurality of jacks which are arranged in a surrounding symmetrical mode are arranged in the outside of the rotating plate, a chute is arranged on the back side of the filter box, an inserting block is fixedly arranged on the inner wall of the chute through a first spring, the end part of the inserting block is inserted into the jacks, the inserting block and the jacks are inserted, and the positions of the cross rod and the filter screen can be fixed after the cross rod drives the filter screen to rotate and switch.
Preferably, the insert block is L-shaped, and the sliding hole is formed in the insert block, the fixing rod is arranged in the sliding hole in a sliding mode, the fixing rod is fixedly arranged in the sliding groove, and the insert block transversely moves to be limited and supported through sliding fit of the sliding hole and the fixing rod.
Preferably, the elastic limiting mechanism comprises a connecting plate, a movable groove is formed in the lower end of the side wall of the filtering box, the bottom of the inner wall of the movable groove is fixedly connected with the connecting plate through a telescopic rod sleeved with a second spring, the baffle is fixedly connected with the end part of the connecting plate, and the telescopic rod and the second spring are arranged to stably support the baffle.
Further, one side of the baffle plate, which is contacted with the filter screen, is arranged in an inclined plane, and the filter screen can push the baffle plate in the rotating process.
Preferably, the two supporting plates are provided with a placing groove on one side close to each other, and the two placing grooves are internally provided with a material receiving box in a joint manner, so that heparin sodium after purification and filtration can be collected.
In the technical scheme, the utility model has the technical effects and advantages that:
1. according to the utility model, through the filter box, the filter screen, the material pipe, the discharge hole, the cross rod, the connecting ring, the filter screen and the rotation positioning mechanism, the plurality of filter screens can be rotated and switched for use, so that the filter screen can be cleaned after the crude product of one end of the filter screen is lifted, and the filter screen can be ensured to perform stable purification and filtration work.
2. According to the utility model, by the baffle and the elastic limiting mechanism, after the crude product is filtered, heparin sodium is prevented from leaking out of the lower end of the interior of the filter box as much as possible.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments described in the present utility model, and other drawings may be obtained according to these drawings for a person having ordinary skill in the art.
FIG. 1 is a schematic diagram of the structure of the present utility model;
FIG. 2 is a rear view of FIG. 1 of the present utility model;
FIG. 3 is an enlarged schematic view of portion A of FIG. 1 in accordance with the present utility model;
fig. 4 is a schematic perspective view of the insert block of fig. 2 according to the present utility model.
Reference numerals illustrate:
1. a filter box; 2. a material pipe; 3. a cross bar; 4. a connecting ring; 5. a filter screen; 6. a support plate; 7. a baffle; 8. a rotating plate; 9. a first spring; 10. inserting blocks; 11. a fixed rod; 12. a connecting plate; 13. a second spring; 14. a telescopic rod; 15. and (5) receiving a material box.
Detailed Description
In order to make the technical scheme of the present utility model better understood by those skilled in the art, the present utility model will be further described in detail with reference to the accompanying drawings.
The embodiment of the utility model discloses a device for purifying and producing low molecular weight heparin sodium by using a crude heparin sodium product.
Example 1
The utility model provides a device for purifying and producing low-molecular-weight heparin sodium by using crude heparin sodium products, which is shown in figures 1-3, and comprises a filter box 1 and a material pipe 2 fixedly penetrating through the upper end inside the filter box 1, wherein a cross rod 3 is rotatably penetrated in the filter box 1, a connecting ring 4 is fixedly sleeved on the rod wall of the cross rod 3, a plurality of filter screens 5 which are symmetrically arranged in a surrounding manner are fixedly arranged on the outer side wall of the connecting ring 4, discharge holes are formed in the lower end inside the filter box 1, support plates 6 are fixedly arranged at two ends of the bottom of the filter box 1, a placing groove is formed in the side, close to each other, of the two support plates 6, and a material receiving box 15 is jointly placed in the two placing grooves.
Before purifying heparin sodium, pouring crude heparin sodium into the filter box 1 from the material pipe 2, filtering through the filter screen 5 after the crude heparin sodium enters the filter box 1, enabling impurities to stay on the surface of the filter screen 5, enabling purified heparin sodium to enter the material receiving box 15 through the discharging hole, enabling the filter screens 5 to rotate and switch through rotating the cross rod 3 after a certain time of the filter screen 5 in the filter box 1, enabling the filter screen 5 subjected to filtering to be capable of being rotated out of the filter box 1 and cleaned fully, avoiding the filter screen 5 from being blocked as much as possible, and guaranteeing sustainable operation of crude heparin sodium purification.
Example 2
Embodiment 2 can carry out fixed in position to filter screen 5 after a plurality of filter screens 5 rotate on the basis of embodiment 1, as shown in fig. 1-2 and fig. 4, the rear end of horizontal pole 3 is equipped with the rotation positioning mechanism that is used for restricting filter screen 5 position, rotation positioning mechanism includes rotating plate 8, the rear end outside of horizontal pole 3 is located to the fixed cover of rotating plate 8, a plurality of jack that are encircling the symmetry setting have been seted up in the outside of rotating plate 8, the spout has been seted up to the dorsal part of rose box 1, the inner wall of spout is fixed through first spring 9 and is equipped with insert 10, insert 10's tip inserts in the jack, insert 10 is L shape setting, and the slide hole has been seted up inside, slide hole inside slip wears to have dead lever 11, dead lever 11 is fixed in locating the spout.
Before the position of the filter screen 5 is switched, the insert block 10 is pulled, under the sliding fit of the fixed rod 11 and the sliding hole, the insert block 10 extrudes the first spring 9 and pulls out from the jack on the outer side of the rotating plate 8, at the moment, the transverse rod 3 can drive the filter screens 5 to rotate and transpose, the insert block 10 is loosened after the position of the filter screen 5 is determined, the insert block 10 is inserted into the jack again through the elastic force of the first spring 9, and the positions of the transverse rod 3 and the filter screen 5 are fixed.
Example 3
Embodiment 3 in order to avoid the raw materials from leaking from the lower end of the filter tank 1 in the heparin sodium purification process as much as possible on the basis of embodiment 1-2, as shown in fig. 1 and 3, the lower end of the outer side of the filter tank 1 is contacted with a baffle 7, one side of the baffle 7 contacted with the filter screen 5 is in an inclined plane, the lower end of the baffle 7 is provided with an elastic limiting mechanism for limiting the position of the baffle 7, the elastic limiting mechanism comprises a connecting plate 12, the lower end of the side wall of the filter tank 1 is provided with a movable groove, the bottom of the inner wall of the movable groove is fixedly connected with the connecting plate 12 through a telescopic rod 14 sleeved with a second spring 13, and the baffle 7 is fixedly connected with the end part of the connecting plate 12.
Through the contact of baffle 7 and the outside lower extreme of rose box 1, can carry out spacingly to the heparin sodium after the purification, avoid heparin sodium to leak from the inside lower extreme of rose box 1 as far as possible, and when filter screen 5 rotates, filter screen 5 can be with baffle 7 inclined plane contact for baffle 7 receives to press and compress telescopic link 14 and second spring 13, after filter screen 5 and baffle 7 separation, through the elasticity of second spring 13, can promote baffle 7 to the normal position again, guarantee that spacing work sustainable and stable goes on.
While certain exemplary embodiments of the present utility model have been described above by way of illustration only, it will be apparent to those of ordinary skill in the art that modifications may be made to the described embodiments in various different ways without departing from the spirit and scope of the utility model. Accordingly, the drawings and description are to be regarded as illustrative in nature and not as restrictive of the scope of the utility model, which is defined by the appended claims.
Claims (6)
1. The device for purifying and producing the low molecular weight heparin sodium by using the heparin sodium crude product comprises a filter box (1) and a material pipe (2) fixedly penetrating through the upper end inside the filter box (1), and is characterized in that a cross rod (3) is rotatably penetrated in the filter box (1), a connecting ring (4) is fixedly sleeved on the rod wall of the cross rod (3), a plurality of filter screens (5) which are symmetrically arranged in a surrounding manner are fixedly arranged on the outer side wall of the connecting ring (4), discharge holes are formed in the lower end inside the filter box (1), and support plates (6) are fixedly arranged at two ends of the bottom of the filter box (1);
the rear end of the cross rod (3) is provided with a rotation positioning mechanism for limiting the position of the filter screen (5);
the lower end of the outer side of the filter box (1) is in contact with a baffle plate (7), and an elastic limiting mechanism for limiting the position of the baffle plate (7) is arranged at the lower end of the baffle plate (7).
2. The heparin sodium crude purification production low molecular weight heparin sodium device according to claim 1, wherein the rotation positioning mechanism comprises a rotating plate (8), the rotating plate (8) is fixedly sleeved on the outer side of the rear end of the cross rod (3), a plurality of jacks which are arranged in a surrounding symmetrical mode are formed in the outer side of the rotating plate (8), a sliding groove is formed in the back side of the filtering box (1), an inserting block (10) is fixedly arranged on the inner wall of the sliding groove through a first spring (9), and the end portion of the inserting block (10) is inserted into the jacks.
3. The device for purifying and producing low molecular weight heparin sodium by using the heparin sodium crude product according to claim 2, wherein the insertion block (10) is L-shaped, a sliding hole is formed in the insertion block, a fixing rod (11) is arranged in the sliding hole in a sliding manner, and the fixing rod (11) is fixedly arranged in the sliding groove.
4. The heparin sodium crude purification production low molecular weight heparin sodium device according to claim 1, wherein the elastic limiting mechanism comprises a connecting plate (12), a movable groove is formed in the lower end of the side wall of the filter box (1), the bottom of the inner wall of the movable groove is fixedly connected with the connecting plate (12) through a telescopic rod (14) sleeved with a second spring (13), and the baffle (7) is fixedly connected with the end part of the connecting plate (12).
5. The device for purifying and producing low molecular weight heparin sodium from crude heparin sodium according to claim 1, wherein one side of the baffle (7) contacting the filter screen (5) is arranged in an inclined plane.
6. The device for purifying and producing low molecular weight heparin sodium by using the crude heparin sodium product according to claim 1, wherein the two supporting plates (6) are provided with a placing groove on one side close to each other, and a material receiving box (15) is arranged in the two placing grooves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322222194.7U CN220656555U (en) | 2023-08-18 | 2023-08-18 | Device for purifying and producing low molecular weight heparin sodium from crude heparin sodium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322222194.7U CN220656555U (en) | 2023-08-18 | 2023-08-18 | Device for purifying and producing low molecular weight heparin sodium from crude heparin sodium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220656555U true CN220656555U (en) | 2024-03-26 |
Family
ID=90339227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322222194.7U Active CN220656555U (en) | 2023-08-18 | 2023-08-18 | Device for purifying and producing low molecular weight heparin sodium from crude heparin sodium |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220656555U (en) |
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2023
- 2023-08-18 CN CN202322222194.7U patent/CN220656555U/en active Active
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