CN220608864U - Microneedle nonwoven fabric - Google Patents
Microneedle nonwoven fabric Download PDFInfo
- Publication number
- CN220608864U CN220608864U CN202320303991.5U CN202320303991U CN220608864U CN 220608864 U CN220608864 U CN 220608864U CN 202320303991 U CN202320303991 U CN 202320303991U CN 220608864 U CN220608864 U CN 220608864U
- Authority
- CN
- China
- Prior art keywords
- microneedle
- patch layer
- patch
- carrier
- matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000004745 nonwoven fabric Substances 0.000 title claims abstract description 24
- 239000011159 matrix material Substances 0.000 claims abstract description 34
- 239000003814 drug Substances 0.000 claims abstract description 25
- 239000000853 adhesive Substances 0.000 claims abstract description 22
- 230000001070 adhesive effect Effects 0.000 claims abstract description 22
- 229940079593 drug Drugs 0.000 claims abstract description 6
- 239000003292 glue Substances 0.000 claims description 6
- 239000002390 adhesive tape Substances 0.000 claims description 5
- 235000010410 calcium alginate Nutrition 0.000 claims description 4
- 239000000648 calcium alginate Substances 0.000 claims description 4
- 229960002681 calcium alginate Drugs 0.000 claims description 4
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims description 4
- 239000000835 fiber Substances 0.000 claims description 4
- 229920003043 Cellulose fiber Polymers 0.000 claims description 3
- 241000381602 Vachellia nebrownii Species 0.000 claims description 3
- 238000004026 adhesive bonding Methods 0.000 claims description 2
- 230000035699 permeability Effects 0.000 abstract description 10
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract description 4
- 210000000707 wrist Anatomy 0.000 abstract description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract description 2
- 239000001569 carbon dioxide Substances 0.000 abstract description 2
- 239000000017 hydrogel Substances 0.000 abstract description 2
- 229910052760 oxygen Inorganic materials 0.000 abstract description 2
- 239000001301 oxygen Substances 0.000 abstract description 2
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 9
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 9
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 9
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 9
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 9
- 238000003860 storage Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The utility model discloses a microneedle non-woven fabric, which relates to non-woven fabrics and aims at solving the problems that when a drug-loaded microneedle patch is attached to a position such as a wrist, dislocation is easy to cause due to movement, and the air permeability of an attached position is poor due to a patch layer after the patch is attached, and the technical scheme is as follows: the patch comprises a patch layer, wherein one side of the patch layer is provided with a carrier microneedle matrix, the patch layer is provided with an adhesive part positioned at the center and the periphery of the carrier microneedle matrix, and one side of the patch layer, which is back to the carrier microneedle matrix, is provided with a removable film. According to the utility model, the patch layer is subjected to hydrogelation and drug adsorption, and the hydrogel layer formed by the patch layer has good oxygen permeability and carbon dioxide permeability, so that the patch layer has good adhesion capability and good air permeability when being adhered to the surface of skin.
Description
Technical Field
The present utility model relates to nonwoven fabrics, and more particularly, to a microneedle nonwoven fabric.
Background
Microneedles have found great medical applications, and nonwoven fabrics are often the drug carrier materials for skin treatment and care, so some patches with microneedles are beginning to appear on the market.
A medicine carrying microneedle patch disclosed in China patent with publication number of CN216497013U is technically characterized in that: the adhesive patch comprises a PDMS microneedle array, a PDMS medicine carrying base layer and an adhesive patch layer, wherein the PDMS microneedle array is positioned on the PDMS medicine carrying base layer, the adhesive patch layer is adhered and arranged on the other side of the PDMS medicine carrying base layer far away from the PDMS microneedle array, a medicine storage small chamber is arranged in the PDMS medicine carrying base layer, and an opening of the medicine storage small chamber is covered and isolated by adhesive paper.
According to the technical scheme, the medicine carrying capacity is improved by adopting the mode of the medicine storage small chamber, and the PDMS for manufacturing the micro needle has air permeability and vapor permeability, but the medicine carrying micro needle patch is adhered to the skin surface through the patch layer compounded on the surface of the medicine carrying micro needle patch, but when the medicine carrying micro needle patch is adhered to the position such as a wrist, the dislocation is easily caused due to movement, and the air permeability of an adhered part is poor due to the patch layer after the medicine carrying micro needle patch is adhered.
There is therefore a need to propose a new solution to this problem.
Disclosure of Invention
Aiming at the defects existing in the prior art, the utility model aims to provide a microneedle non-woven fabric.
The technical aim of the utility model is realized by the following technical scheme: the microneedle non-woven fabric comprises a patch layer, wherein a carrier microneedle matrix is arranged on one side of the patch layer, an adhesive part positioned at the center and the periphery of the carrier microneedle matrix is arranged on the patch layer, and a removable film is arranged on one side of the patch layer, which faces away from the carrier microneedle matrix.
The utility model is further provided with: the patch layer is formed by water thorn of calcium alginate-containing fibers and cellulose fibers into an integrated structure, and the carrier microneedle matrix is compounded on one side of the patch layer into an integrated structure.
The utility model is further provided with: the carrier microneedle matrix consists of 50-200 drug-permeable microneedles which are adjacent to each other, and the needle tip distance of the drug-permeable microneedles is 500-2000 mu m.
The utility model is further provided with: the drug permeable microneedle is cone or cone-like.
The utility model is further provided with: the center that glues the portion of gluing includes glues with the surrounding edge subsides that are rectangle shape that returns, the center glues and be located carrier matrix central region, surrounding edge subsides are located the periphery of carrier microneedle matrix.
The utility model is further provided with: the adhesive part is a medical adhesive tape, and the medical adhesive tape is used for providing adhesive force for adhering to the skin to limit the deflection of the patch layer.
In summary, the utility model has the following beneficial effects:
the carrier microneedle matrix on one side of the patch layer realizes the basic effect of the knitted patch, and the patch layer is provided with the sticky part positioned in the center and the periphery of the carrier microneedle matrix, so that when the microneedle non-woven fabric is stuck on the skin surface, the microneedle non-woven fabric can be stuck on the skin surface through the sticky part, the problem that the patch made of the microneedle non-woven fabric is deviated during use is solved, the arranged removable film can protect the non-woven fabric before use, and when the patch is used, after the patch is stuck through the sticky part, medicines are continuously dripped into the patch layer.
Drawings
FIG. 1 is a schematic diagram of the structure of the present utility model;
fig. 2 is an enlarged schematic view of a portion a of fig. 1.
In the figure: 1. a patch layer; 2. drug permeable microneedles; 3. center sticking; 4. and (5) surrounding edge pasting.
Detailed Description
The present utility model will be described in detail below with reference to the accompanying drawings and examples.
Examples: the microneedle non-woven fabric comprises a patch layer 1, wherein a carrier microneedle matrix is arranged on one side of the patch layer 1, an adhesive part positioned at the center and the periphery of the carrier microneedle matrix is adhered to the patch layer 1, a removable film is adhered to one side of the patch layer 1, which is opposite to the carrier microneedle matrix, in the embodiment, the carrier microneedle matrix is made into an integrated structure by adopting a reverse molding process, then the patch layer 1 prepared by a hydroentangling process is covered on the carrier microneedle matrix which is not demoulded, the patch layer 1 and the carrier microneedle matrix are connected to form an integrated structure, and the removable film is adhered to the surface of the patch layer 1 to realize dust protection of the patch layer 1 when the patch layer 1 is not in use.
When the adhesive patch is used, one side with the carrier microneedle matrix can be adhered to the skin surface, and the patch layer 1 is pressed and adhered to the skin surface, as the adhesive part positioned at the center and the periphery of the carrier microneedle matrix is arranged on the patch layer 1, the adhesive strength between the patch layer 1 and the skin can be increased, and the adhesive part is positioned at the center and the periphery of the carrier microneedle matrix, so that the situation that the microneedle non-woven fabric is not easy to deviate after being adhered can be realized.
The patch layer 1 is formed by water thorn containing calcium alginate fibers and cellulose fibers into an integrated structure, the carrier microneedle matrix is compounded on one side of the patch layer 1 into an integrated structure, and when the patch layer 1 is made of the calcium alginate fibers, the patch layer 1 can absorb the state of the water gel of a medicine refrigerator when the medicine permeates the patch layer 1, so that a good skin pasting effect is achieved between the patch layer 1 and the skin, more medicine can be adsorbed, and the carrier microneedle matrix is used for injecting the medicine into the skin.
The carrier microneedle matrix comprises 50-200 drug-permeable microneedles 2 to form a needle cluster, the needle tip distance of the adjacent drug-permeable microneedles 2 is 500-2000 μm, and the drug-permeable microneedles 2 are cone-shaped or cone-like.
In this embodiment, the adhesive portion includes a central adhesive patch 3 with a peripheral edge patch 4 having a rectangular shape, the central adhesive patch 3 is located in a central area of the carrier matrix, the peripheral edge patch 4 is located at a periphery of the carrier microneedle matrix, and the adhesive portion is a medical adhesive tape for providing an adhesive force for adhering to the skin to limit the offset of the patch layer 1.
In this embodiment, a microneedle negative template is prepared by using a metal microneedle template as a positive mold, PDMS monomers a and B are mixed and poured into a film guiding template, after vacuumizing to eliminate bubbles, heating and standing, when the solution is in a semi-solidification state, a patch layer 1 obtained by water jet processing and drying is tiled on the negative template, after secondary vacuumizing, demolding is performed after waiting for solidification, and finally a center adhesive patch 3 and a surrounding edge patch 4 are stuck on the patch layer 1, and a removable film is stuck on the surface of the patch layer 1.
When the patch is used, people only need to take the microneedle non-woven fabric, the side with the removable film is back to the wrist direction, then the side with the carrier microneedle matrix of the microneedle non-woven fabric is stuck to the wrist and the patch layer 1 is pressed to enable the sticky part to be stuck on the skin surface, so that the microneedle non-woven fabric can be firmly stuck on and at the appointed position, then the removable film is uncovered, the medicine with filling can be dripped to the patch layer 1, the patch layer 1 is enabled to be gelled, the medicine is adsorbed, and the patch layer 1 has good adhesion capability and good air permeability when being stuck on the skin surface because the hydrogel layer formed by the patch layer 1 has good oxygen permeability and carbon dioxide permeability.
The above description is only a preferred embodiment of the present utility model, and the protection scope of the present utility model is not limited to the above examples, and all technical solutions belonging to the concept of the present utility model belong to the protection scope of the present utility model. It should be noted that modifications and adaptations to the present utility model may occur to one skilled in the art without departing from the principles of the present utility model and are intended to be within the scope of the present utility model.
Claims (6)
1. Microneedle non-woven fabrics, its characterized in that: the patch comprises a patch layer, wherein a carrier microneedle matrix is arranged on one side of the patch layer, an adhesive part positioned at the center and the periphery of the carrier microneedle matrix is arranged on the patch layer, and a removable film is arranged on one side of the patch layer, which is opposite to the carrier microneedle matrix.
2. The microneedle nonwoven fabric of claim 1, wherein: the patch layer is formed by water thorn of calcium alginate-containing fibers and cellulose fibers into an integrated structure, and the carrier microneedle matrix is compounded on one side of the patch layer into an integrated structure.
3. The microneedle nonwoven fabric of claim 2, wherein: the carrier microneedle matrix consists of 50-200 drug-permeable microneedles which are adjacent to each other, and the needle tip distance of the drug-permeable microneedles is 500-2000 mu m.
4. The microneedle nonwoven fabric of claim 3, wherein: the drug permeable microneedle is cone or cone-like.
5. The microneedle nonwoven fabric of claim 1, wherein: the center that glues the portion of gluing includes glues with the surrounding edge subsides that are rectangle shape that returns, the center glues and be located carrier matrix central region, surrounding edge subsides are located the periphery of carrier microneedle matrix.
6. The microneedle nonwoven fabric of claim 5, wherein: the adhesive part is a medical adhesive tape, and the medical adhesive tape is used for providing adhesive force for adhering to the skin to limit the deflection of the patch layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320303991.5U CN220608864U (en) | 2023-02-21 | 2023-02-21 | Microneedle nonwoven fabric |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320303991.5U CN220608864U (en) | 2023-02-21 | 2023-02-21 | Microneedle nonwoven fabric |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220608864U true CN220608864U (en) | 2024-03-19 |
Family
ID=90227629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320303991.5U Active CN220608864U (en) | 2023-02-21 | 2023-02-21 | Microneedle nonwoven fabric |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220608864U (en) |
-
2023
- 2023-02-21 CN CN202320303991.5U patent/CN220608864U/en active Active
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant |