CN220545617U

CN220545617U - Acute lung injury model construction device

Info

Publication number: CN220545617U
Application number: CN202322190100.2U
Authority: CN
Inventors: 郭显; 金发光; 高嘉营; 李艳; 王新新
Original assignee: Air Force Medical University of PLA
Current assignee: Air Force Medical University of PLA
Priority date: 2023-08-15
Filing date: 2023-08-15
Publication date: 2024-03-01
Anticipated expiration: 2033-08-15

Abstract

The utility model discloses an acute lung injury model construction device, which comprises a model box body, an interface, a placement box, a linear movement mechanism and a cover body, wherein the interface is arranged on the model box body; the top of the model box body is provided with a water filling port, the side wall of the model box body is provided with a through port, and a first box door is arranged in the through port; the interface is arranged on the model box body and is positioned beside the first box door, and a valve is arranged on the interface; the placing box is arranged in the model box body, a placing opening is formed in the side wall, opposite to the through opening, of the placing box, a sliding groove is formed in the inner top surface of the placing opening, a second box door is connected in a sliding mode in the sliding groove, and a plurality of water permeable holes are formed in the second box door; the linear moving mechanism is arranged on the model box body, and the output end of the linear moving mechanism is connected with the placing box and is used for driving the placing box to move towards the direction facing the through hole; the cover body is fixed on the placement box and is positioned at the outer side around the placement opening. According to the utility model, when the animal is required to be taken out after the experiment is finished, the drainage amount is reduced, so that the drainage time is shortened, and the aim of improving the experiment efficiency is fulfilled.

Description

Acute lung injury model construction device

Technical Field

The utility model relates to the technical field of experimental equipment for medical pathology research, in particular to a device for constructing an acute lung injury model.

Background

Acute lung injury is a damage to alveolar epithelial cells and capillary endothelial cells caused by various direct and indirect injury factors, can cause diffuse pulmonary interstitial and alveolar edema, and can develop into acute respiratory distress syndrome with extremely high mortality disability rate.

Drowning is one of the etiologies of acute lung injury and is classified into freshwater drowning and seawater drowning. When the seawater is drowned, the hypertonic seawater can cause local hypertonic state after being absorbed into the alveolar spaces, so that interstitial spaces and capillary liquid enter the alveolar spaces to cause and aggravate pulmonary edema. At present, when the simulation research is carried out on the drowning acute lung injury caused by seawater, the method of constructing an acute lung injury animal model is generally adopted, animals are placed into an experiment box, water is injected into the experiment box, the acute lung injury caused by the drowning of the animals is caused, the pathology is simulated by using the animal model, and the pathogenesis is studied deeply.

Among the prior art, the patent of publication No. CN214908552U discloses an acute lung injury animal model construction device, through placing the animal in settling the cage, then will settle the cage and fix in the toolbox, pour into water into the toolbox through the water inlet, construct acute lung injury animal model, but it needs to discharge completely the water in the toolbox and just can take out the animal after the experiment is ended, drainage process time overlength influences experimental efficiency, and when carrying out the experiment of next time, needs whole reinjection of water, comparatively loaded down with trivial details moreover.

Disclosure of Invention

The utility model aims to provide an acute lung injury model building device, which reduces the drainage in the prior art when animals need to be taken out after the experiment is ended, so as to reduce the drainage time and achieve the aim of improving the experiment efficiency.

The technical scheme of the utility model is as follows: an acute lung injury model construction device comprises a model box body, an interface, a placement box, a linear movement mechanism and a cover body; the top of the model box body is provided with a water filling port, a through port is formed in the side wall of one side of the model box body, and a first box door is arranged in the through port; the interface is arranged on the model box body and is positioned beside the first box door, the interface is communicated with the interior of the model box body, a valve is arranged on the interface, and the interface is used for being connected with an external water pump; the placing box is arranged in the model box body, a placing opening is formed in the side wall, which is opposite to the through opening, of the placing box, a sliding groove is formed in the inner top surface of the placing opening, a second box door is connected in the sliding groove in a sliding mode, and a plurality of water permeable holes are formed in the second box door; the linear moving mechanism is arranged on the model box body, and the output end of the linear moving mechanism is connected with the placing box and is used for driving the placing box to move towards the direction facing the through hole; the cover body is fixed on the placement box and positioned at the outer side of the periphery of the placement opening.

Preferably, the linear movement mechanism comprises a driving motor, a screw rod and a nut seat; the driving motor is fixed on the outer side wall of the model box body and is positioned right above the through hole; the screw rod is horizontally arranged at the inner side of the model box body, and one end of the screw rod extends out of the model box body and is connected with the output shaft of the driving motor; the nut seat is sleeved and connected on the screw rod, and the bottom of the nut seat is fixed with the top of the placing box through a plurality of connecting rods.

Preferably, a bearing seat is connected to the inner wall of the model box, and one end of the screw rod, which is far away from the driving motor, is rotationally connected with the bearing seat.

Preferably, the cover body is a first sealing air bag, the first sealing air bag is rectangular frame-shaped, and the first sealing air bag is fixed at the edges around the placement box.

Preferably, a second sealing air bag is fixed on the inner wall of the model box body provided with the through hole, the shape of the second sealing air bag is the same as that of the first sealing air bag, the second sealing air bag is opposite to the first sealing air bag, and when the first sealing air bag is in contact with the second sealing air bag, the second sealing air bag can be tightly sleeved on the outer side of the first sealing air bag.

Preferably, the second box door is opposite to the side wall of the first box door, and a handle is fixed on the side wall of the second box door.

Preferably, the mounting groove is arranged on the inner top surface of the through hole, the top of the first box door is slidably clamped in the mounting groove, the first box door is in sliding sealing connection with the through hole, and the handle is fixed on the outer side of the first box door.

Preferably, a transparent observation window is arranged on the first box door.

Compared with the prior art, the utility model has the beneficial effects that:

1. according to the utility model, through the cover body, when the placing box approaches the through hole of the model box, the cavity between the placing hole and the through hole is sealed, so that when an animal is taken out, only the interface is connected with an external water pump, and the seawater in the placing box is pumped out, and the seawater in the model box is not required to be completely pumped out, thereby improving the experimental efficiency.

2. When the experiment is carried out next time, a large amount of seawater is not required to be injected into the model box body again, and only after the first box door and the second box door are closed, the placing box is driven to be away from the through hole by the linear displacement mechanism, the seawater in the placing box can automatically enter the placing box through the water permeable hole arranged on the second box door, so that animals can immediately produce seawater drown, a new experiment is carried out quickly, and the experiment efficiency is improved.

Drawings

FIG. 1 is a schematic view showing the internal structure of a mold box of the present utility model;

FIG. 2 is a schematic view of the internal structure of the model box of the present utility model in front cross-section;

fig. 3 is a schematic view of the internal structure of the placement box in the present utility model.

Detailed Description

The following describes embodiments of the present utility model in detail with reference to fig. 1 to 3. In the description of the utility model, it should be understood that the terms "center," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate or are based on the orientation or positional relationship shown in the drawings, merely to facilitate describing the utility model and simplify the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the utility model.

The terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first", "a second" may include one or more such features, either explicitly or implicitly; in the description of the utility model, unless otherwise indicated, the meaning of "a plurality" is two or more.

Example 1

As shown in fig. 1 to 3, an embodiment of the present utility model provides an acute lung injury model building apparatus, which includes a model housing 1, an interface 3, a placement box 4, a linear movement mechanism, and a cover 5; the top of the model box body 1 is provided with a water filling port 11, a through port 12 is formed in the side wall of one side of the model box body 1, and a first box door 2 is arranged in the through port 12; the interface 3 is arranged on the model box body 1 and is positioned beside the first box door 2, the interface 3 is communicated with the interior of the model box body 1, a valve is arranged on the interface 3, and the interface 3 is used for being connected with an external water pump; the placing box 4 is arranged in the model box body 1, a placing opening 41 is formed in the side wall, opposite to the through opening 12, of the placing box 4, a sliding groove 42 is formed in the inner top surface of the placing opening 41, a second box door 43 is connected in a sliding manner in the sliding groove 42, and a plurality of water permeable holes 44 are formed in the second box door 43; the linear moving mechanism is arranged on the model box body 1, and the output end of the linear moving mechanism is connected with the placing box 4 and is used for driving the placing box 4 to move towards the direction facing the through hole 12; the cover 5 is fixed on the placement box 4 and is positioned outside the periphery of the placement opening 41.

In this embodiment, when constructing an acute lung injury animal model, the first door 2 is opened, then the placing box 4 is driven by the linear moving mechanism to move to the through hole 12, then the second door 43 is lifted upwards, the animal is placed in the placing box 4, then the second door 43 is put down, the first door 2 is closed, then the placing box 4 is driven by the linear moving mechanism to move away from the through hole 12, meanwhile, the seawater is injected into the model box 1 through the water filling hole 11, and the seawater is made to permeate the placing box 4, because the second door 43 is provided with the plurality of water permeable holes 44, the seawater enters the placing box 4 from the water permeable holes 44, the animal in the placing box 4 is made to drown in the seawater, when the animal is required to be taken out, the placing box 4 is driven by the linear moving mechanism to the through hole 12, the cover 5 is made to contact and buckled on the inner wall of the model box 1 due to the existence of the cover 5, the cavity between the placing port 41 and the through port 12 is sealed by the cover body 5, the interface 3 is also positioned at the inner side of the cover body 5, the interface 3 is connected with an external water pump, a valve is opened, the seawater in the placing box 4 is pumped out by the water pump, then the first box door 2 is opened, the second box door 43 is lifted upwards, the animals are taken out from the placing box 4, the whole taking-out process only needs to pump the seawater in the placing box 4, the seawater in the model box 1 is not required to be completely pumped out, and in the next experiment, only new animals are required to be placed in the placing box 4, then the second box door 43, the first box door 2 and the valve are respectively closed, the placing box 4 is driven to be removed from the through port 12 by the linear moving mechanism, the seawater in the model box 1 can automatically enter the placing box 4 immediately, need not to carry out the water injection to model box 1 in a large number through water filling port 11 often any more, only need carry out suitable moisturizing to model box 1 in can, compared with prior art, reduced the water pumping water injection work, especially in the follow-up experimentation, can be immediately drowned the process to the animal, need not to reinjection water from zero, consequently improved experimental efficiency.

Example 2

The present embodiment defines a specific structure of a linear movement mechanism on the basis of embodiment 1, and as shown in fig. 1 and 2, the linear movement mechanism includes a drive motor 61, a screw 62, and a nut holder 63; the driving motor 61 is fixed on the outer side wall of the model box body 1 and is positioned right above the through hole 12; the lead screw 62 is horizontally arranged on the inner side of the model box body 1, and one end of the lead screw 62 extends out of the model box body 1 and is connected with an output shaft of the driving motor 61; the nut seat 63 is sleeved and connected to the screw rod 62, and the bottom of the nut seat 63 is fixed with the top of the placement box 4 through a plurality of connecting rods.

When the placing box 4 is driven to move through the linear moving mechanism, the driving motor 61 is controlled to rotate to drive the screw rod 62 to rotate, the rotary motion is converted into linear movement when the screw rod 62 rotates, so that the nut seat 63 is driven to horizontally move, the placing box 4 is driven to synchronously move through a plurality of connecting rods when the nut seat 63 moves, and the moving direction of the placing box 4 can be controlled to be close to or far away from the through hole 12 through controlling the rotating direction of the driving motor 61.

Further, in some embodiments, in order to keep the rotation of the screw 62 smooth, a bearing housing 7 is connected to the inner wall of the mold case 1, and an end of the screw 62 remote from the driving motor 61 is rotatably connected to the bearing housing 7.

Specifically, as shown in fig. 1, the cover body 5 is a first sealing air bag, the first sealing air bag is rectangular frame-shaped and is fixed at the edges around the placement box 4, and when the placement box 4 is close to the through hole 12, the first sealing air bag is used to attach to the inner wall of the model box 1, so that the space between the side wall of the placement box 4 with the placement hole 41 and the inner wall of the model box 1 is enclosed, and the subsequent process of extracting seawater in the placement box 4 is facilitated.

Further, in some embodiments, in order to improve the tightness of the first sealing air bag, a second sealing air bag 8 is fixed on the inner wall of the mold box 1 provided with the through hole 12, the shape of the second sealing air bag 8 is the same as that of the first sealing air bag, the second sealing air bag 8 is opposite to the first sealing air bag, and when the first sealing air bag contacts with the second sealing air bag 8, the second sealing air bag 8 can be closely sleeved on the outer side of the first sealing air bag.

In this implementation, be fixed with second sealed gasbag 8 on the inner wall that model box 1 was equipped with through-hole 12, second sealed gasbag 8 and first sealed gasbag are rectangular frame form, and the size of second sealed gasbag 8 is greater than the size of first sealed gasbag, in fact second sealed gasbag 8 are located the outside all around of first sealed gasbag, when placing case 4 and first sealed gasbag through the drive of linear movement mechanism and remove through-hole 12 department, the inner wall all around of second sealed gasbag 8 can hug closely the outer wall all around of first sealed gasbag, and the inner wall all around of second sealed gasbag 8 is equipped with sealed rubber sleeve, utilize second sealed gasbag parcel to seal first sealed gasbag, thereby can prevent that first sealed gasbag can't hug closely model box 1, make the problem that the gap between first sealed gasbag and the model box 1 exposes for the sea water in the model box 1 appear.

Further, in some embodiments, as shown in fig. 1 and 3, the second door 43 is lifted for convenience, and thus a handle 431 is fixed to a side wall of the second door 43 facing the first door 2.

Further, in some embodiments, in order to facilitate opening the first door 2, a mounting groove is formed in the inner top surface of the through hole 12, the top of the first door 2 is slidably clamped in the mounting groove, a sealing ring is arranged in the mounting groove, concave sealing rubber strips are respectively arranged on the inner walls of the two sides and the inner wall of the bottom of the through hole 12, the first door 2 is slidably and hermetically connected with the through hole 12 through the concave sealing rubber strips, and a handle 21 is fixed on the outer side of the first door 2.

Further, in some embodiments, in order to be able to facilitate the observation of the experimental procedure, a transparent observation window 22 is embedded in the first door 2.

The foregoing disclosure is only illustrative of the preferred embodiments of the present utility model, but the embodiments of the present utility model are not limited thereto, and any variations within the scope of the present utility model will be apparent to those skilled in the art.

Claims

1. The utility model provides an acute lung injury model construction device, includes model box (1), and the top of model box (1) is equipped with water filling port (11), and through-hole (12) have been seted up to one side lateral wall of model box (1), are equipped with first chamber door (2) in through-hole (12), and its characterized in that still includes:

the interface (3) is arranged on the model box body (1) and is positioned beside the first box door (2), the interface (3) is communicated with the inside of the model box body (1), the interface (3) is connected with a valve, and the interface (3) is used for being connected with an external water pump;

the placing box (4) is arranged in the model box body (1), a placing opening (41) is formed in the side wall, which is opposite to the through opening (12), of the placing box (4), a sliding groove (42) is formed in the inner top surface of the placing opening (41), a second box door (43) is connected in a sliding manner in the sliding groove (42), and a plurality of water permeable holes (44) are formed in the second box door (43);

the linear moving mechanism is arranged on the model box body (1), and the output end of the linear moving mechanism is connected with the placing box (4) and is used for driving the placing box (4) to move towards the direction facing the through hole (12);

and the cover body (5) is fixed on the placement box (4) and is positioned at the outer side of the periphery of the placement opening (41).

2. The apparatus for constructing an acute lung injury model according to claim 1, wherein the linear movement mechanism comprises:

the driving motor (61) is fixed on the outer side wall of the model box body (1) and is positioned right above the through hole (12);

the screw rod (62) is horizontally arranged on the inner side of the model box body (1), and one end of the screw rod (62) extends to the outside of the model box body (1) and is connected with an output shaft of the driving motor (61);

the nut seat (63) is sleeved and connected onto the screw rod (62), and the bottom of the nut seat (63) is fixed with the top of the placement box (4) through a plurality of connecting rods.

3. The acute lung injury model building device according to claim 2, wherein a bearing seat (7) is connected to the inner wall of the model box (1), and one end of the screw rod (62) far away from the driving motor (61) is rotatably connected with the bearing seat (7).

4. The acute lung injury model building device according to claim 1, wherein the cover body (5) is a first sealing air bag, and the first sealing air bag is rectangular frame-shaped and is fixed at the peripheral edges of the placement box (4).

5. The device for constructing the acute lung injury model according to claim 4, wherein a second sealing air bag (8) is fixed on the inner wall of the model box body (1) provided with the through hole (12), the shape of the second sealing air bag (8) is the same as that of the first sealing air bag, the second sealing air bag (8) is opposite to the first sealing air bag, and when the first sealing air bag is contacted with the second sealing air bag (8), the second sealing air bag (8) can be tightly sleeved on the outer side of the first sealing air bag.

6. The device for constructing an acute lung injury model according to claim 5, wherein a handle (431) is fixed on the side wall of the second door (43) opposite to the first door (2).

7. The acute lung injury model building device according to claim 6, wherein an installation groove is formed in the inner top surface of the through hole (12), the top of the first box door (2) is slidably clamped in the installation groove, the first box door (2) is slidably and hermetically connected with the through hole (12), and a handle (21) is fixed on the outer side of the first box door (2).

8. The device for constructing the acute lung injury model according to claim 7, wherein a transparent observation window (22) is arranged on the first box door (2).