CN220505284U - Peristaltic pump tubing system for sample processor and sample processor - Google Patents
Peristaltic pump tubing system for sample processor and sample processor Download PDFInfo
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- CN220505284U CN220505284U CN202321464138.8U CN202321464138U CN220505284U CN 220505284 U CN220505284 U CN 220505284U CN 202321464138 U CN202321464138 U CN 202321464138U CN 220505284 U CN220505284 U CN 220505284U
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- 230000002572 peristaltic effect Effects 0.000 title claims abstract description 154
- 238000004140 cleaning Methods 0.000 claims abstract description 108
- 239000012530 fluid Substances 0.000 claims abstract description 87
- 239000007788 liquid Substances 0.000 claims abstract description 66
- 238000005070 sampling Methods 0.000 claims abstract description 35
- 238000005086 pumping Methods 0.000 claims abstract description 6
- 238000004891 communication Methods 0.000 claims description 28
- 238000005406 washing Methods 0.000 claims description 8
- 239000002245 particle Substances 0.000 description 18
- 238000000034 method Methods 0.000 description 17
- 238000001514 detection method Methods 0.000 description 8
- 238000010926 purge Methods 0.000 description 6
- 239000002699 waste material Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 239000004005 microsphere Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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Abstract
The present disclosure relates to peristaltic pump tubing systems for sample processors and sample processors including peristaltic pump tubing systems. The peristaltic pump tubing system includes: a peristaltic pump; a sampling line via which the peristaltic pump is capable of pumping a sample in a sample source into a flow cell of the sample processor; a cleaning fluid line connecting a cleaning fluid source to the peristaltic pump; and a switching device configured to control on-off of the cleaning liquid pipeline and on-off of the sampling pipeline. The peristaltic pump tubing system and sample processor according to the present disclosure have significantly improved operating efficiency and are capable of avoiding erroneous operation due to manual replacement of the container.
Description
Technical Field
The present disclosure relates to a fluid tubing system with peristaltic pump, a method for purging a peristaltic pump. In particular, the present disclosure relates to a fluid tubing system with peristaltic pump for a sample processor such as a flow cytometer/analyzer, and a method of cleaning the peristaltic pump of a sample processor.
Background
The statements in this section merely provide background information related to the present disclosure and may not necessarily constitute prior art.
Sample processors are commonly used for analyzing liquid samples comprising small aerosols (e.g. biological particles, non-biological particles) or cells and/or for sorting particles or cells therein. During operation of some known sample processors, samples are transported by peristaltic pumps into a flow cell for detection or sorting.
After sample analysis or sorting is completed, the peristaltic pump may have sample (particularly some particles in the sample) remaining therein. Therefore, the peristaltic pump needs to be cleaned for the processing of the next sample. For some samples, peristaltic pumps may be purged with sheath fluid and the desired residue requirements may be achieved. However, for some samples, such as microspheres (beads), the use of sheath fluid alone to clean the peristaltic pump may be difficult to achieve the desired residue requirements, e.g., less than 0.1%.
In the existing sample processing apparatus, it is necessary to manually replace the sample container or sampling line with a container or cleaning line containing a cleaning liquid different from the sheath liquid, and then use the cleaning liquid to clean the peristaltic pump. Sometimes, multiple exchanges may be required between the sample container/sampling line and the cleaning liquid container/cleaning line. Thus, peristaltic pump cleaning of the sample processor is time consuming, inefficient, and may be subject to mishandling, etc.
Disclosure of Invention
The general summary of the disclosure is provided in this section rather than the full scope of the disclosure or the full disclosure of all features of the disclosure.
In view of the above-described problems with existing sample processors, it is an object of the present disclosure to provide a peristaltic pump tubing system for a sample processor.
According to one aspect of the present disclosure, a peristaltic pump tubing system for a sample processing meter is provided. The peristaltic pump tubing system includes: a peristaltic pump; a sampling line via which the peristaltic pump is capable of pumping a sample in a sample source into a flow cell of the sample processor; a cleaning fluid line connecting a cleaning fluid source to the peristaltic pump; and a switching device configured to control on-off of the cleaning liquid pipeline and on-off of the sampling pipeline.
In some embodiments according to the present disclosure, the switching device is a reversing valve that is switchable between a first position allowing communication between the sample source and the flow cell and a second position allowing communication between the peristaltic pump and the cleaning fluid source.
In some embodiments according to the present disclosure, the reversing valve is a three-way reversing valve having a first port connected to the peristaltic pump, a second port connected to the source of cleaning fluid, and a third port connected to the flow cell or the source of sample, and the three-way reversing valve is switchable between the first position communicating the first port with the third port and the second position communicating the first port with the second port.
In some embodiments according to the present disclosure, the switching device includes a first switching valve disposed in the sampling line and a second switching valve disposed in the cleaning liquid line.
In some embodiments according to the present disclosure, the switching device is an automatically controllable switching device.
In some embodiments according to the present disclosure, the peristaltic pump tubing system further comprises: and a sheath fluid line connecting a sheath fluid source to the peristaltic pump, wherein the switching device is further configured to control on-off of the sheath fluid line.
In some embodiments according to the present disclosure, the switching device is a four-way reversing valve having a first port connected to the peristaltic pump, a second port connected to the source of cleaning fluid, a third port connected to the flow cell or sample source, and a fourth port connected to the source of sheath fluid. The four-way selector valve switches between the first position in which the first port communicates with the third port, the second position in which the first port communicates with the second port, and the third position in which the first port communicates with the fourth port.
According to another aspect of the present disclosure, a method for cleaning a peristaltic pump of a sample processing meter is provided, wherein the peristaltic pump is for pumping a sample in a sample source into a flow cell of the sample processing meter via a sampling line. The method comprises the following steps: providing a cleaning fluid line connecting a source of cleaning fluid to the peristaltic pump; a switching device is arranged in the cleaning liquid pipeline; controlling the sampling pipeline to be communicated and controlling the cleaning liquid pipeline to be interrupted for sampling through the switching device; and after sample processing is finished, controlling the sampling pipeline to be interrupted and controlling the cleaning liquid pipeline to be communicated through the switching device so as to clean the peristaltic pump by using cleaning liquid.
In some embodiments according to the present disclosure, the method further comprises: the peristaltic pump is purged with sheath fluid.
In some embodiments according to the present disclosure, the cleaning step of the cleaning liquid and the cleaning step of the sheath liquid are alternately switched and performed a predetermined number of times by the switching device.
In some embodiments according to the present disclosure, the sheath fluid is supplied from the flow cell to the peristaltic pump via the sampling line.
In some embodiments according to the present disclosure, the peristaltic pump is rotated in a first direction to sample. And rotating the peristaltic pump in a second direction opposite the first direction to wash the peristaltic pump with sheath fluid.
In some embodiments according to the present disclosure, the switching device is a three-way reversing valve having a first port connected to the peristaltic pump, a second port connected to the source of cleaning fluid, and a third port connected to the flow cell or the source of sample. The three-way reversing valve is switchable between a first position in which the first port communicates with the second port and a second position in which the first port communicates with the third port.
In some embodiments according to the present disclosure, the sheath fluid is supplied to the peristaltic pump via a sheath fluid line connected from a sheath fluid source to the peristaltic pump.
In some embodiments according to the present disclosure, the switching device is a four-way reversing valve having a first port connected to the peristaltic pump, a second port connected to the source of cleaning fluid, a third port connected to the flow cell or sample source, and a fourth port connected to the source of sheath fluid. The four-way reversing valve switches between a first position in which the first port communicates with the second port, a second position in which the first port communicates with the third port, and a third position in which the first port communicates with the fourth port.
In some embodiments according to the present disclosure, the switching device includes a first switching valve disposed in the sampling line and a second switching valve disposed in the cleaning liquid line.
In some embodiments according to the present disclosure, the switching device is automatically controlled.
According to yet another aspect of the present disclosure, there is provided a sample processor comprising the peristaltic pump tubing system described above.
With the peristaltic pump tubing system, method and sample processor according to the present disclosure described above, the supply of cleaning fluid can be easily controlled by setting the position of the cleaning fluid tubing and controlling the switching device. The sample source is not required to be manually replaced by a cleaning liquid source containing cleaning liquid, so that the time required for replacement can be saved, the efficiency of the sample treatment instrument can be improved, and the incorrect operation caused by manual replacement can be avoided.
The switching device can be automatically controlled, so that the efficiency of the sample processing instrument can be further improved.
The sample line can be used to both supply sample for processing and sheath fluid for cleaning, thus simplifying the line system and hence the structure of the sample processor.
The foregoing and other objects, features and advantages of the present disclosure will be more fully understood from the following detailed description, which is given by way of illustration only, and thus is not to be taken in a limiting sense of the accompanying drawings of the present disclosure.
Drawings
The features and advantages of one or more embodiments of the present disclosure will become more readily appreciated from the following description, taken in conjunction with the accompanying drawings, in which:
FIG. 1 is a schematic diagram of a peristaltic pump tubing system according to an embodiment of the present disclosure;
FIG. 2 is a schematic diagram of a peristaltic pump tubing system according to another embodiment of the present disclosure;
FIG. 3 is a schematic diagram of a peristaltic pump tubing system according to yet another embodiment of the present disclosure;
FIG. 4 is a schematic diagram of a peristaltic pump tubing system according to yet another embodiment of the present disclosure; and
fig. 5 is a flow chart of a method for cleaning a peristaltic pump of a sample processing meter according to an embodiment of the present disclosure.
Detailed Description
The present disclosure will be described in detail by way of exemplary embodiments with reference to the accompanying drawings. Like reference numerals refer to like parts and assemblies throughout the several views. The following detailed description of the present disclosure is merely for purposes of illustration and is in no way limiting of the disclosure, its application or uses. The embodiments described in this specification are not exhaustive and are only some of the many possible embodiments. The exemplary embodiments may be embodied in many different forms and should not be construed as limiting the scope of the present disclosure. In some example embodiments, well-known processes, well-known device structures, and well-known techniques may not be described in detail.
A peristaltic pump tubing system 10 according to an embodiment of the present disclosure will be described below with reference to fig. 1. Peristaltic pump tubing system 10 is used to supply or drain fluid (such as a sample, sheath fluid, or cleaning fluid) to or from a flow cell FC of a sample processor (not shown).
As shown in fig. 1, peristaltic pump tubing system 10 includes peristaltic pump 11, sampling tubing 12, switching device 13, and cleaning fluid tubing 14.
The sampling line 12 connects the sample source 1 containing the sample to the flow cell FC. The sample source 1 may be, for example, a container, a bottle, a kit, or the like for containing a sample. The sample contains small suspended particles to be detected or sorted in the flow cell FC, for example, biological particles such as extracellular vesicles, or non-biological particles such as microspheres (beads).
Peristaltic pump 11 is disposed in sampling line 12 and is used to pump the sample in sample source 1 via sampling line 12 into flow cell FC for processing (e.g., detecting or sorting) particles in the sample in flow cell FC.
A cleaning fluid line 14 connects the source of cleaning fluid 2 to the peristaltic pump 11. The cleaning liquid source 2 is, for example, a container, a tank, a tub or the like containing cleaning liquid. As used herein, "cleaning fluid" refers to a solution or solvent other than sheath fluid used to flush a sample. The cleaning fluid may be selected or changed depending on the sample.
The switching device 13 is configured to control the on-off of the cleaning liquid line 14 and the on-off of the sampling line 12. The supply of the different fluids is controlled by controlling the on-off of the cleaning fluid line 14 and the on-off of the sampling line 12. When sampling line 12 is in communication and wash fluid line 14 is interrupted, fluid (e.g., sample in the sample source or fluid within the flow cell) is allowed to flow between sample source 1 and flow cell FC via sampling line 12 while preventing wash fluid from flowing through wash fluid line 14. When the cleaning liquid line 14 is in communication and the sampling line 12 is interrupted, the cleaning liquid within the cleaning liquid source 2 is allowed to be supplied to the peristaltic pump 11 while preventing fluid from flowing from the sample source 1 to the flow cell FC or from the flow cell FC to the sample source 1. That is, the switching device 13 is used to control communication of one of the cleaning liquid line 14 and the sampling line 12 while controlling interruption of the other of the cleaning liquid line 14 and the sampling line 12.
The switching device 13 may be an automatically controlled switching device, for example an electronically or electromagnetically controlled switching device.
In the example shown in fig. 1, the switching device 13 is a three-way reversing valve 16 provided between the peristaltic pump 11, the cleaning liquid source 2 and the flow cell FC. The reversing valve 16 is switchable between a first position allowing communication between the sample source 1 and the flow cell FC and a second position allowing communication between the peristaltic pump 11 and the cleaning fluid source 2. The reversing valve 16 has a first port 16a connected to the peristaltic pump 11, a second port 16b connected to the source of cleaning liquid 2, and a third port 16c connected to the flow cell FC. The reversing valve 16 is switchable between a first position in which the first port 16a is in communication with said third port 16c (i.e. in which the sample source 1 is in communication with the flow cell FC, as shown in fig. 1) and a second position in which the first port 16a is in communication with the second port 16b (i.e. in which the peristaltic pump 11 is in communication with the source 2 of cleaning fluid).
When the sample source 1 is placed in communication with the flow cell FC as shown in fig. 1, the peristaltic pump 11 may be rotated in one direction (e.g., counter-clockwise) to thereby pump the sample from the sample source 1 into the flow cell FC for detection or sorting of the sample, etc.
When the sample source 1 is placed in communication with the flow cell FC as shown in fig. 1, the peristaltic pump 11 may be rotated in another opposite direction (e.g., clockwise) thereby causing fluid in the flow cell FC to flow to the sample source 1. For example, by rotating peristaltic pump 11 clockwise, sheath fluid in flow cell FC is passed through sampling line 12 and to a purge station 17 at sample source 1, thereby purging peristaltic pump 11 and sampling line 12. The sheath fluid wash waste may flow into the wash station 17 and may then be discharged under the influence of the pump 18.
When the peristaltic pump 11 is put in communication with the source of cleaning liquid 2, the peristaltic pump 11 may be rotated clockwise, thereby supplying the cleaning liquid in the source of cleaning liquid 2 to the peristaltic pump 11 and flowing through the peristaltic pump 11, thereby cleaning the peristaltic pump 11 by the cleaning liquid. The waste liquid from the washing of peristaltic pump 11 can flow via the section of sample line 12 from peristaltic pump 11 to sample source 1 into washing station 17 and can then be discharged under the action of pump 18.
According to the peristaltic pump tubing system 10 described above, the on-off of the cleaning liquid tubing 14 can be easily controlled by providing the cleaning liquid tubing 14 and controlling the position of the switching device 13. Therefore, the sample source is not required to be manually replaced by the cleaning liquid source containing the cleaning liquid, so that the time required for replacing can be saved, the efficiency of the sample treatment instrument can be improved, and the misoperation caused by manual replacement can be avoided.
A peristaltic pump tubing system 20 according to another embodiment of the present disclosure will be described below with reference to fig. 2. As shown in fig. 2, peristaltic pump tubing system 20 includes peristaltic pump 21, sampling tubing 22, cleaning fluid tubing 24, and switching device 13. Peristaltic pump tubing system 20 shown in fig. 2 differs from peristaltic pump tubing system 10 shown in fig. 1 in the location of switching device 13.
As shown in fig. 2, the switching device 13 is a three-way reversing valve 26, which is arranged between the peristaltic pump 21, the cleaning liquid source 2 and the sample source 1. The three-way reversing valve 26 has a first port 26a connected to the peristaltic pump 21, a second port 26b connected to the source of cleaning fluid 2, and a third port 26c connected to the source of sample 1. The three-way reversing valve 26 is switchable between a first position in which the first port 26a is in communication with the third port 26c (i.e., in which the sample source 1 is in communication with the flow cell FC, as shown in fig. 2), and a second position in which the first port 26a is in communication with the second port 26b (i.e., in which the peristaltic pump 21 is in communication with the source 2).
When the sample source 1 is brought into communication with the flow cell FC as shown in fig. 2, the peristaltic pump 21 may be rotated in a counterclockwise direction, thereby pumping the sample in the sample source 1 into the flow cell FC for detection or sorting of the sample, or the like.
When the sample source 1 is placed in communication with the flow cell FC as shown in fig. 2, the peristaltic pump 21 may be rotated in a clockwise direction, thereby causing sheath fluid in the flow cell FC to flow to the sample source 1 for purging the peristaltic pump 21 and sample tube 22 with sheath fluid. The sheath fluid wash waste may flow into a wash station 27 located at the sample source 1 and may then be discharged under the influence of a pump 28.
When the peristaltic pump 21 is put in communication with the cleaning liquid source 2, the peristaltic pump 21 may be rotated counterclockwise, thereby supplying the cleaning liquid in the cleaning liquid source 2 to the peristaltic pump 21 and flowing through the peristaltic pump 21, thereby cleaning the peristaltic pump 21 by the cleaning liquid. The waste liquid purged from peristaltic pump 21 may flow into flow cell FC via a section of sample line 22 from flow cell FC to peristaltic pump 21 and be discharged through a discharge line (not shown) connected to flow cell FC.
A peristaltic pump tubing system 30 according to yet another embodiment of the present disclosure will be described below with reference to fig. 3. As shown in fig. 3, peristaltic pump tubing 30 includes peristaltic pump 31, sampling tubing 32, cleaning fluid tubing 34, and switching device 13. Peristaltic pump tubing system 30 shown in fig. 3 differs from peristaltic pump tubing system 10 shown in fig. 1 in the configuration of switching device 13.
As shown in fig. 3, the switching device 13 includes a first switching valve 35 provided in the sampling line 32 and a second switching valve 36 provided in the cleaning liquid line 34.
When the first switch valve 35 is closed to put the sample source 1 in communication with the flow cell FC, the peristaltic pump 31 may be rotated in a counterclockwise direction, thereby pumping the sample in the sample source 1 into the flow cell FC for detection or sorting of the sample, etc.
When the first switch valve 35 is closed to place the sample source 1 in communication with the flow cell FC, the peristaltic pump 31 may be rotated in a clockwise direction, thereby causing sheath fluid in the flow cell FC to flow to the sample source 1 for purging the peristaltic pump 31 and sample tubing 32 with sheath fluid.
When the second on-off valve 36 is closed to communicate the peristaltic pump 31 with the cleaning liquid source 2, the peristaltic pump 31 may be rotated counterclockwise, thereby supplying the cleaning liquid in the cleaning liquid source 2 to the peristaltic pump 31 and flowing through the peristaltic pump 31, thereby cleaning the peristaltic pump 31 by the cleaning liquid.
A peristaltic pump tubing system 40 according to a further embodiment of the present disclosure will be described below with reference to fig. 4. In peristaltic pump tubing systems as shown in fig. 1-3, the sample tubing may also be used as sheath tubing, i.e., when the peristaltic pump is rotated in the opposite direction to the sampling. In the peristaltic pump tubing system 40 shown in fig. 4, a sheath fluid tubing 43 is provided separately from the sample tubing 42 to purge the peristaltic pump 41 with sheath fluid, and the switching device 13 is further configured to control on and off of the sheath fluid tubing 43.
As shown in fig. 4, a sheath fluid line 43 connects the sheath fluid source 3 containing sheath fluid to the peristaltic pump 41. The switching device 13 is a four-way reversing valve 46. The four-way reversing valve 46 has a first port 46a connected to the peristaltic pump 41, a second port 46b connected to the cleaning liquid source 2, a third port 46c connected to the flow cell FC, and a fourth port 46d connected to the sheath liquid source 3. The four-way selector valve 46 is switched between a first position in which the first port 46a communicates with the third port 46c, a second position in which the first port 46a communicates with the second port 46b, and a third position in which the first port 46a communicates with the fourth port 46d.
When the four-way reversing valve 46 is in the first position, the first port 46a communicates with the third port 46c, and the peristaltic pump 41 rotates in a counterclockwise direction to pump the sample in the sample source 1 into the flow cell FC for detection or sorting of the sample, or the like.
When the four-way reversing valve 46 is in the second position, the first port 46a communicates with the second port 46b, i.e., the cleaning liquid source 2 communicates with the peristaltic pump 41, whereby the cleaning liquid in the cleaning liquid source 2 can be supplied to the peristaltic pump 41 via the cleaning liquid line 44 to clean the peristaltic pump 41 with the cleaning liquid. This process is the same as the example shown in fig. 1 and will not be described in detail.
When the four-way reversing valve 46 is in the third position, the first port 46a communicates with the fourth port 46d, i.e., the sheath fluid source 3 communicates with the peristaltic pump 41. When the peristaltic pump 41 rotates clockwise, the sheath fluid in the sheath fluid source 3 is drawn into the peristaltic pump 41 and flows through the peristaltic pump 41. In this way, peristaltic pump 41 is purged by the sheath fluid. The waste liquid from the washing of peristaltic pump 41 may flow via the section of sample line 42 from peristaltic pump 41 to sample source 1 into washing station 47, and may then be discharged under the influence of pump 48.
It should be understood that peristaltic pump tubing systems according to the present disclosure should not be limited to the specific examples shown in the figures, but may be varied as desired so long as the functions described herein are enabled.
The present disclosure also relates to a sample processor comprising the peristaltic pump tubing system described above. The peristaltic pump tubing system delivers the sample and sheath fluid into the flow cell through fluidic components including peristaltic pumps and valves, etc., such that the sheath fluid surrounds the sample in the flow cell and particles contained in the sample can flow linearly through the flow cell in a single column to acquire signals of the particles one by one. As the particles pass through the detection zone, the particles are illuminated by a light source (typically a laser light source) of an optical detection system. The illumination may cause particles in the sample to emit scattered light (e.g., produce a side-scattered light signal or a forward-scattered light signal). In some cases, the sample may include fluorescent particles that may emit a fluorescent signal in response to the irradiation. These signals are collected by an optical detection system. The collected signals of the particles are processed and analyzed by a sample analysis system to obtain information of the detected particles.
A method for cleaning a peristaltic pump of a sample processing meter according to an embodiment of the present disclosure will be described with reference to fig. 5. Fig. 5 is a flowchart of a method S10 for cleaning a peristaltic pump of a sample processing meter according to an embodiment of the present disclosure.
As shown in fig. 5, the method S10 includes providing a cleaning solution line connecting a cleaning solution source to the peristaltic pump (step S11) and providing a switching device in the cleaning solution line (step S13). By providing a cleaning liquid line that supplies cleaning liquid to the peristaltic pump, there is no need to reuse the sample line to provide cleaning liquid, and thus there is no need to replace the sample source with a cleaning liquid source. By providing the switching means, the cleaning step of the cleaning liquid and the supply step of other fluid (e.g., sample or sheath liquid) can be switched conveniently, thereby improving efficiency. Preferably, the switching means can be controlled automatically. Thus, the fluid supply and the switching can be automatically performed, the running time of the sample processor can be obviously shortened, and the working efficiency is greatly improved.
After the peristaltic pump tubing system is set up, the sampling tubing may then be controlled by the switching device to communicate and control the interruption of the cleaning fluid tubing to sample (step S15). Under the action of the peristaltic pump, the sample is supplied from the sample source to the flow cell via the sample line in order to process (e.g., detect or sort) the particles in the sample.
After the sample is processed, the various lines and various pumps need to be cleaned. In particular, in step S17, the sampling line is controlled to be interrupted and the cleaning liquid line is controlled to be communicated by the switching device to clean the peristaltic pump with the cleaning liquid. The cleaning fluid may be selected based on the particles detected in the sample to effectively clean the peristaltic pump and fluid tubing.
In addition, the method S10 may further include washing the peristaltic pump with the sheath fluid (step S19). Sheath fluid may be provided by peristaltic pump counter-rotation via the sample tubing (as shown in fig. 1-3), or may be provided by an additional sheath fluid tubing (as shown in fig. 4).
Step S17 and step S19 may be alternately switched and performed a predetermined number of times to meet the cleaning requirement. The predetermined number of times and/or the duration of the individual washing steps may vary depending on the washing requirements.
It should be understood that the method for cleaning a peristaltic pump of a sample processing meter according to the present disclosure should not be limited to the specific examples shown in the drawings or described herein, but may be varied as desired. The various steps of the method are not necessarily performed in the order described, but may be adapted as desired.
While the present disclosure has been described with reference to exemplary embodiments, it is to be understood that the present disclosure is not limited to the specific embodiments described and illustrated in detail herein. Various changes may be made to the exemplary embodiments by those skilled in the art without departing from the scope defined by the claims. Features from the various embodiments may be combined with one another without conflict. Alternatively, a certain feature of the embodiment may be omitted.
Claims (8)
1. A peristaltic pump tubing system for a sample processor, the peristaltic pump tubing system comprising:
a peristaltic pump;
a sampling line via which the peristaltic pump is capable of pumping a sample in a sample source into a flow cell of the sample processor;
a cleaning fluid line connecting a cleaning fluid source to the peristaltic pump; and
and the switching device is configured to control the on-off of the cleaning liquid pipeline and the on-off of the sampling pipeline.
2. The peristaltic pump tubing system of claim 1 wherein the switching device is a reversing valve that is switchable between a first position allowing communication between the sample source and the flow cell and a second position allowing communication between the peristaltic pump and the cleaning fluid source.
3. The peristaltic pump tubing system of claim 2 wherein the reversing valve is a three-way reversing valve having a first port connected to the peristaltic pump, a second port connected to the source of cleaning fluid, and a third port connected to the flow cell or the source of sample, and the three-way reversing valve is switchable between the first position communicating the first port with the third port and the second position communicating the first port with the second port.
4. Peristaltic pump tubing system according to claim 1, characterized in that the switching means comprise a first switching valve arranged in the sampling line and a second switching valve arranged in the washing liquid line.
5. Peristaltic pump tubing system according to any one of claims 1 to 4, characterized in that the switching device is an automatically controllable switching device.
6. Peristaltic pump tubing system according to claim 1 or 2, characterized in that it further comprises:
a sheath fluid line connecting a sheath fluid source to the peristaltic pump,
wherein, the switching device is also configured to control the on-off of the sheath liquid pipeline.
7. The peristaltic pump tubing system of claim 6 wherein the switching device is a four-way reversing valve having a first port connected to the peristaltic pump, a second port connected to the source of cleaning fluid, a third port connected to the flow cell or sample source, and a fourth port connected to the sheath fluid source, the four-way reversing valve being switchable between a first position in which the first port is in communication with the third port, a second position in which the first port is in communication with the second port, and a third position in which the first port is in communication with the fourth port.
8. A sample processor, characterized in that it comprises a peristaltic pump tubing system according to any one of claims 1 to 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321464138.8U CN220505284U (en) | 2023-06-09 | 2023-06-09 | Peristaltic pump tubing system for sample processor and sample processor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321464138.8U CN220505284U (en) | 2023-06-09 | 2023-06-09 | Peristaltic pump tubing system for sample processor and sample processor |
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| Publication Number | Publication Date |
|---|---|
| CN220505284U true CN220505284U (en) | 2024-02-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321464138.8U Active CN220505284U (en) | 2023-06-09 | 2023-06-09 | Peristaltic pump tubing system for sample processor and sample processor |
Country Status (1)
| Country | Link |
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| CN (1) | CN220505284U (en) |
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2023
- 2023-06-09 CN CN202321464138.8U patent/CN220505284U/en active Active
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