CN220385633U - Small animal transcranial magnetic stimulation device - Google Patents
Small animal transcranial magnetic stimulation device Download PDFInfo
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- CN220385633U CN220385633U CN202321619102.2U CN202321619102U CN220385633U CN 220385633 U CN220385633 U CN 220385633U CN 202321619102 U CN202321619102 U CN 202321619102U CN 220385633 U CN220385633 U CN 220385633U
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- 238000011491 transcranial magnetic stimulation Methods 0.000 title claims abstract description 36
- 241001465754 Metazoa Species 0.000 title claims abstract description 26
- 238000009423 ventilation Methods 0.000 claims abstract description 22
- 230000007246 mechanism Effects 0.000 claims abstract description 16
- 238000012544 monitoring process Methods 0.000 claims abstract description 4
- 230000003014 reinforcing effect Effects 0.000 claims description 7
- 239000000523 sample Substances 0.000 claims description 3
- 238000010171 animal model Methods 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 8
- 230000000638 stimulation Effects 0.000 abstract description 7
- 241000699670 Mus sp. Species 0.000 abstract description 6
- 238000011160 research Methods 0.000 abstract description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 21
- 210000005036 nerve Anatomy 0.000 description 4
- 230000009471 action Effects 0.000 description 2
- 230000037237 body shape Effects 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
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- 210000004556 brain Anatomy 0.000 description 1
- 230000007177 brain activity Effects 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
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- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 1
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- 230000007774 longterm Effects 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008035 nerve activity Effects 0.000 description 1
- 229910052755 nonmetal Inorganic materials 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Abstract
The utility model discloses a small animal transcranial magnetic stimulation device, which comprises an output mechanism, a fixing mechanism, a positioning assembly and a ventilation part, wherein the output mechanism is connected with the fixing mechanism; the output mechanism comprises a signal generating component and an electromagnet; the signal generating component is used for outputting and monitoring waveform current; the electromagnet is electrically connected with the signal generating assembly to generate a variable magnetic field; the fixing mechanism comprises a non-magnetic tube and a fixer; one end of the non-magnetic tube is open, and a chute is arranged on the non-magnetic tube; the fixer is arranged in the nonmagnetic pipe; the positioning component is fixedly arranged on the fixer; the fixer is detachably connected with the non-magnetic tube; the ventilation part is arranged at one end of the nonmagnetic pipe; the electromagnet is mounted on the non-magnetic tube and is disposed adjacent to the air permeable portion. The utility model can realize long-time fixation and good fixation effect on experimental mice or other experimental animals, so that the electromagnet can accurately stimulate the appointed parts of the experimental mice or other experimental animals, the stimulation precision is improved, and convenience is provided for the research of the experimental animals.
Description
Technical Field
The utility model relates to the technical field of magnetic stimulation, in particular to a small animal transcranial magnetic stimulation device.
Background
Transcranial Magnetic Stimulation (TMS) is a noninvasive nerve modulation technology, can influence brain activities, and has good application prospects in diagnosis and treatment of nerve and mental diseases. However, the action mechanism of TMS is not clear, and the TMS effect is partially effective, especially the dose-dependent effect is not clear, such as the relationship among the stimulus intensity, the frequency and the action effect; and TMS long-term safety remains to be demonstrated. In view of the above, animal transformation studies are urgently needed to play a key role.
In the prior art, the animal model research can realize invasive nerve signal recording, and reveal the nerve action mechanism of TMS from the brain nerve level of individuals and groups. TMS can be applied to animal models, the system researches the dose-dependent response of TMS, compares the effect of modulation modes such as different stimulation waveforms, intensities, frequencies and the like, and provides a reference for a standardized TMS accurate scheme. Small animals such as mice have a short life span and can track the effect of TMS on the overall life span.
For this purpose, a small animal transcranial magnetic stimulation device is proposed.
Disclosure of Invention
The utility model aims to provide a small animal transcranial magnetic stimulation device, which aims to solve or improve at least one of the technical problems.
In order to achieve the above object, the present utility model provides the following solutions: the utility model provides a small animal transcranial magnetic stimulation device, comprising:
the output mechanism comprises a signal generating component and an electromagnet; the signal generating component is used for outputting and monitoring waveform current; the electromagnet is electrically connected with the signal generating assembly to generate a variable magnetic field;
a fixing mechanism comprising a non-magnetic tube and a fixer; one end of the non-magnetic pipe is open, a chute is formed in the non-magnetic pipe, and the chute is communicated with the open position; the fixer is arranged in the nonmagnetic pipe and is in sliding connection with the chute;
the positioning assembly is fixedly arranged on the fixer; the fixer is detachably connected with the non-magnetic tube through the positioning assembly;
the ventilation part is arranged at one end of the nonmagnetic pipe far away from the opening;
wherein the electromagnet is mounted on the non-magnetic tube and is disposed adjacent to the air permeable portion.
According to the small animal transcranial magnetic stimulation device provided by the utility model, the signal generation assembly comprises a signal generator and an oscilloscope; a power amplifier is arranged in the signal generator;
the signal generator is electrically connected with the power amplifier, two ends of the power amplifier are respectively and electrically connected with the electromagnet through leads, and two ends of a probe of the oscilloscope are respectively and electrically connected with the two leads; one of the leads is provided with a switch.
According to the small animal transcranial magnetic stimulation device provided by the utility model, the through groove is transversely formed in the fixer, and the section of the fixer is circular.
According to the small animal transcranial magnetic stimulation device provided by the utility model, the positioning component comprises a screw and a nut; the screw rod is fixedly arranged on the outer wall of the fixer, and one end of the screw rod connected with the fixer penetrates through the sliding groove and extends out of the nonmagnetic pipe; the nut is in threaded connection with the screw rod and is positioned outside the nonmagnetic pipe.
According to the small animal transcranial magnetic stimulation device provided by the utility model, the ventilation part comprises a plurality of ventilation holes, and the ventilation holes are formed in one end of the non-magnetic pipe away from the opening; the electromagnet is arranged close to the air holes.
According to the small animal transcranial magnetic stimulation device provided by the utility model, the non-magnetic pipe is provided with the circular mounting opening, and the electromagnet is mounted in the circular mounting opening.
According to the small animal transcranial magnetic stimulation device provided by the utility model, the opening end of the non-magnetic pipe is fixedly provided with the reinforcing ring, and the reinforcing ring is provided with the notch communicated with the chute.
The utility model discloses the following technical effects:
the utility model outputs waveform current through the signal generating component, and the electromagnet generates magnetic fields of different modes according to different types of current output by the signal generating component, so as to perform transcranial magnetic stimulation on experimental mice or other experimental animals in the non-magnetic tube;
when the experimental mouse is fixed by the fixing mechanism, the experimental mouse is placed in the non-magnetic tube, the fixing device slides in the non-magnetic tube along the sliding groove, the position of the fixing device is adjusted according to the body shape of the experimental mouse, so that the fixing device is contacted with the tail part of the experimental mouse, the position of the fixing device is locked by the positioning component, the experimental mouse breathes outside air by the ventilation part, the long-time fixing and good fixing effect of the experimental mouse are realized, the appointed part of the experimental mouse is stimulated by using the electromagnet, the stimulation precision is improved, and convenience is provided for the study of small animals.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present utility model, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of the structure of a small animal transcranial magnetic stimulation device according to the present utility model;
FIG. 2 is an enlarged view of a portion of FIG. 1A;
FIG. 3 is an enlarged view of a portion of B in FIG. 1;
FIG. 4 is a front view of a non-magnetic tube according to the present utility model;
wherein, 1, an electromagnet; 2. a non-magnetic tube; 3. a holder; 4. an opening; 5. a chute; 6. a signal generator; 7. an oscilloscope; 8. a lead wire; 9. a switch; 10. a through groove; 11. a screw; 12. a nut; 13. ventilation holes; 14. a circular mounting port; 15. a reinforcing ring; 16. notch.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
In order that the above-recited objects, features and advantages of the present utility model will become more readily apparent, a more particular description of the utility model will be rendered by reference to the appended drawings and appended detailed description.
Referring to fig. 1-4, the present utility model provides a small animal transcranial magnetic stimulation device comprising:
the output mechanism comprises a signal generating component and an electromagnet 1; the signal generating component is used for outputting and monitoring waveform current; the electromagnet 1 is electrically connected with the signal generating component and generates a variable magnetic field; the front, back, left and right positions of the electromagnet 1 can be adjusted according to actual use requirements so as to ensure that the central position of the electromagnet 1 is over against the skull of an experimental mouse or other experimental animals; in the present embodiment, the position adjustment manner of the electromagnet 1 is not particularly limited;
a fixing mechanism comprising a non-magnetic tube 2 and a fixer 3; one end of the non-magnetic tube 2 is provided with an opening 4, the non-magnetic tube 2 is provided with a chute 5, and the chute 5 is communicated with the opening 4; the fixer 3 is arranged in the nonmagnetic pipe 2 and is connected with the chute 5 in a sliding way; the section size of the non-magnetic tube 2 is slightly larger than that of the experimental mouse, and the experimental mouse can be tightly wrapped; the fixer 3 and the positioning component can slide along the chute 5 and deviate from along the tail end of the chute 5 to realize the separation from the fixer 3;
the positioning component is fixedly arranged on the fixer 3; the fixer 3 is detachably connected with the non-magnetic tube 2 through a positioning component;
the ventilation part is arranged at one end of the nonmagnetic pipe 2 far away from the opening 4;
wherein the electromagnet 1 is arranged on the non-magnetic tube 2 and is arranged close to the ventilation part;
the utility model outputs waveform current through the signal generating component, the electromagnet 1 generates magnetic fields with different modes according to different types of current output by the signal generating component, and then transcranial magnetic stimulation is carried out on experimental mice or other experimental animals in the non-magnetic pipe 2;
when the experimental mouse is fixed by the fixing mechanism, the experimental mouse is placed in the non-magnetic tube 2, the fixing device 3 slides in the non-magnetic tube 2 along the sliding groove 5, the position of the fixing device 3 is adjusted according to the body shape of the experimental mouse, so that the fixing device 3 is contacted with the tail part of the experimental mouse, the position of the fixing device 3 is locked by the positioning component, the mouse breathes outside air by the aid of the ventilation part, long-time fixing and good fixing effects of the experimental mouse are achieved, the appointed part of the experimental mouse is accurately stimulated by the electromagnet 1, stimulation precision is improved, and convenience is provided for research of small animals.
According to the further optimization scheme, the non-magnetic pipe 2, the fixing device 3, the reinforcing ring 15, the screw 11 and the nut 12 are all made of non-magnetic materials, and in the embodiment, the non-magnetic pipe is preferably made of non-metal materials such as hard plastics, the magnetic field is not influenced, and the magnetic stimulation experiment is not influenced.
Further optimizing scheme, the signal generating assembly comprises a signal generator 6 and an oscilloscope 7; a power amplifier is arranged in the signal generator 6; the power amplifier can be selectively installed according to actual use requirements;
the signal generator 6 is electrically connected with the power amplifier, two ends of the power amplifier are respectively electrically connected with the electromagnet 1 through leads 8, and two ends of a probe of the oscilloscope 7 are respectively electrically connected with the two leads 8; one of the leads 8 is provided with a switch 9;
wherein, the signal generator 6 can output arbitrary waveform current, frequency and voltage with wide modulation range and fine setting; the signal power is amplified by a power amplifier and is connected with the electromagnet 1 by a lead 8, and the electromagnet 1 can respond to a current setting mode to generate magnetic fields of different modes.
Further optimizing scheme transversely has seted up logical groove 10 on the fixer 3 to the cross-section of fixer 3 is the ring form, through the logical groove 10 that sets up the center, and the size of logical groove 10 is less than the size of experimental mouse buttock and is greater than the external diameter of experimental mouse tail, is convenient for wear out experimental mouse's tail, improves experimental mouse fixed process's comfort level, realizes effective fixed for a long time.
Further optimizing scheme, the positioning assembly comprises a screw 11 and a nut 12; the screw rod 11 is fixedly arranged on the outer wall of the fixer 3, and one end of the screw rod 11 connected with the fixer 3 penetrates through the chute 5 and extends out of the nonmagnetic pipe 2; the nut 12 is screwed on the screw 11 and is positioned outside the non-magnetic tube 2; the screw 11 is in sliding connection along the chute 5, and when the fixer 3 moves to a required position, the nut 12 is screwed, so that the nut 12 is abutted with the outer wall of the non-magnetic tube 2, the position of the fixer 3 is fixed, and the operation is simple and convenient.
Further optimizing scheme, the ventilation part comprises a plurality of ventilation holes 13, and the ventilation holes 13 are arranged at one end of the nonmagnetic pipe 2 far away from the opening 4; the electromagnet 1 is arranged close to the ventilation holes 13; the experimental mice breathe outside air conveniently through the plurality of ventilation holes 13.
In a further optimized scheme, a circular mounting opening 14 is formed in the nonmagnetic pipe 2, and the electromagnet 1 is mounted in the circular mounting opening 14.
In a further optimization scheme, the reinforcement ring 15 is fixedly arranged at the open end 4 of the non-magnetic tube 2 and is used for improving the structural strength of the non-magnetic tube 2; the reinforcing ring 15 is provided with a notch 16 communicated with the chute 5, so that the screw 11 can slide into the chute 5 along the notch 16.
Further optimizing scheme, electromagnet 1 and circular installing port 14 all are provided with a plurality of, realize the magnetic stimulation in a plurality of positions.
Further optimizing scheme, can use TMS coil to replace electro-magnet 1, through the accurate stimulated experiment mouse of TMS coil.
In the description of the present utility model, it should be understood that the terms "longitudinal," "transverse," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate or are based on the orientation or positional relationship shown in the drawings, merely to facilitate description of the present utility model, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present utility model.
The above embodiments are only illustrative of the preferred embodiments of the present utility model and are not intended to limit the scope of the present utility model, and various modifications and improvements made by those skilled in the art to the technical solutions of the present utility model should fall within the protection scope defined by the claims of the present utility model without departing from the design spirit of the present utility model.
Claims (7)
1. A small animal transcranial magnetic stimulation device, comprising:
the output mechanism comprises a signal generating component and an electromagnet (1); the signal generating component is used for outputting and monitoring waveform current; the electromagnet (1) is electrically connected with the signal generating assembly and generates a variable magnetic field;
the fixing mechanism comprises a non-magnetic tube (2) and a fixer (3); one end of the non-magnetic tube (2) is open (4), a chute (5) is formed in the non-magnetic tube (2), and the chute (5) is communicated with the open (4); the fixer (3) is arranged in the non-magnetic tube (2) and is in sliding connection with the chute (5);
the positioning assembly is fixedly arranged on the fixer (3); the fixer (3) is detachably connected with the non-magnetic tube (2) through the positioning component;
the ventilation part is arranged at one end of the non-magnetic tube (2) far away from the opening (4);
wherein the electromagnet (1) is mounted on the non-magnetic tube (2) and is arranged close to the ventilation part.
2. The small animal transcranial magnetic stimulation device of claim 1, wherein: the signal generating assembly comprises a signal generator (6) and an oscilloscope (7); a power amplifier is arranged in the signal generator (6);
the signal generator (6) is electrically connected with the power amplifier, two ends of the power amplifier are respectively and electrically connected with the electromagnet (1) through leads (8), and two ends of a probe of the oscilloscope (7) are respectively and electrically connected with the two leads (8); one of the leads (8) is provided with a switch (9).
3. The small animal transcranial magnetic stimulation device of claim 1, wherein: the fixer (3) is transversely provided with a through groove (10), and the section of the fixer (3) is circular.
4. The small animal transcranial magnetic stimulation device of claim 1, wherein: the positioning assembly comprises a screw (11) and a nut (12); the screw rod (11) is fixedly arranged on the outer wall of the fixer (3), and one end of the screw rod (11) connected with the fixer (3) penetrates through the sliding groove (5) and extends out of the nonmagnetic pipe (2); the nut (12) is in threaded connection with the screw (11) and is positioned outside the non-magnetic tube (2).
5. The small animal transcranial magnetic stimulation device of claim 1, wherein: the ventilation part comprises a plurality of ventilation holes (13), and the ventilation holes (13) are formed in one end of the nonmagnetic pipe (2) away from the opening (4); the electromagnet (1) is arranged close to the ventilation holes (13).
6. The small animal transcranial magnetic stimulation device of claim 1, wherein: a circular mounting opening (14) is formed in the non-magnetic tube (2), and the electromagnet (1) is mounted in the circular mounting opening (14).
7. The small animal transcranial magnetic stimulation device of claim 1, wherein: the opening (4) end of the non-magnetic pipe (2) is fixedly provided with a reinforcing ring (15), and the reinforcing ring (15) is provided with a notch (16) communicated with the chute (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321619102.2U CN220385633U (en) | 2023-06-25 | 2023-06-25 | Small animal transcranial magnetic stimulation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321619102.2U CN220385633U (en) | 2023-06-25 | 2023-06-25 | Small animal transcranial magnetic stimulation device |
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| Publication Number | Publication Date |
|---|---|
| CN220385633U true CN220385633U (en) | 2024-01-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321619102.2U Active CN220385633U (en) | 2023-06-25 | 2023-06-25 | Small animal transcranial magnetic stimulation device |
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| Country | Link |
|---|---|
| CN (1) | CN220385633U (en) |
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2023
- 2023-06-25 CN CN202321619102.2U patent/CN220385633U/en active Active
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