CN203524672U - Magnetic sensor based system for acquiring weak biomagnetic signals - Google Patents

Magnetic sensor based system for acquiring weak biomagnetic signals Download PDF

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Publication number
CN203524672U
CN203524672U CN201320445048.4U CN201320445048U CN203524672U CN 203524672 U CN203524672 U CN 203524672U CN 201320445048 U CN201320445048 U CN 201320445048U CN 203524672 U CN203524672 U CN 203524672U
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circuit
module
signal
voltage
magnetic
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吴小玲
王旋
王延花
敦煌俊秋
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Nanjing University
Nanjing Medical University
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Nanjing Medical University
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Abstract

The utility model relates to a magnetic sensor based system for acquiring weak biomagnetic signals. The magnetic sensor based system comprises a magnetic sensor array module, a sensor interface module, a signal conditioning module, an MCU (microprogrammed control unit) control module, a host computer and a power management module, wherein the magnetic sensor array module comprises a high-performance MI (magnetoimpedance) magnetic sensor, a self-adaption calibrating circuit and a work state indicating circuit; the multiple simulation signal shifting circuit of the sensor interface module transmits output signals of a sensor array to the signal conditioning module in turn; and the preposed programmable instrument amplification circuit and a secondary fixed gain amplification circuit of the signal conditioning module amplify a weak signal voltage amplitude output by the sensor array and filter interference signals by a low-pass filter circuit. The RS 232 serial port communication circuit of the MCU control module sends digital signals after A/D conversion is transmitted to the host computer.

Description

A kind of weak biological magnetic signal acquisition system based on Magnetic Sensor
Technical field
This utility model relates to a kind of harmless non-contact biological information acquiring technology, utilizes high-performance magnetism sensor array to obtain organism field signal.This utility model belongs to the biomedical information acquisition technical field in biomedical engineering.
Background technology
In biological magnetic field, contain abundant relevant organism internal and the information of tissue.There is three major types in the source of the generation of biological magnetic: 1, biological electromagnetic field.Organism Organ and tissue aprowl can produce the bioelectric processes such as electronics transmission, ion-transfer, neuroelectricity activity, these bio electricity processes can produce bioelectric current, thereby produce corresponding faint biological magnetic field, as core field, brain magnetic field, neural magnetic field, flesh magnetic field etc.2, induced field.The bio-tissue such as liver, spleen is comprised of " Magnetic Bio-materials ", and the magnetic field producing under the effect of earth's magnetic field and other external magnetic fields is exactly induced field.3, remnant field.Magnetic iron ore (Fe 3o 4) powder, the microgranule of ferromagnetic material of class enter stomach, intestinal system, by respiratory tract, entered pulmonary etc. by esophagus, be magnetized, thereby produce remnant field under the effect of these magnetisable material outside magnetic field.
Bio electricity is the electrochemical activity of excitable cell, and bio electricity can produce biological magnetic, so the physiologic information of biological power reflection, biological magnetic also can reflect.But the physiologic information of biological magnetic reflection, bio electricity but not necessarily can reflect.So biological magnetic has obvious advantage in clinical practice.Brain magnetic signal is compared with EEG signals, it is advantageous that: (1) brain magnetic signal gathers without reference point, without with contact skin, there will not be artifact; (2) brain magnetic signal can directly reflect the active state of field source in brain, more can accurately determine intensity and the position of field source; (3) vision inducting brain magnetic, brainstem auditory evoked brain magnetic etc. have very strong specificity, can tell cell colonys different in tissue and function.With magnetization lung magnetic signal, deduct degaussing lung magnetic signal and obtain remnant field that ferromagnetism the pollutes scattergram in lung, significant for the diagnosis of pulmonary's occupation disease.The collection of retina magnetic signal not with experimenter's contact skin, avoided the problem of contact potential and reference point, and more information can be provided.
The intensity of biological magnetic field is generally all very faint.Geomagnetic field intensity is about 10 -4t, magnetic field intensity is about 10 -11t to 10 -6t, core field intensity is about 10 -10t is approximately 10 from carbuncle in the occipital region magnetic field intensity -12t, brings out brain magnetic field and retina magnetic field intensity is about 10 -13t.Faint biological magnetic field signal is buried among environment magnetic noise, and general detection instrument cannot detect, and along with scientific and technical development, problem is progressively resolved.The G.Balule of 1963 Nian You U.S. Syracuse universities and B.Mefee utilize one group of coil of 2,000,000 circles to be recorded to the mcg-signals of human body for the first time.At present, organism magnetic field detection is all that its magnetic field detection sensitivity can reach 10 by superconducting quantum interference device (SQUID) (SQUID, Superconducting Quantum Interference Device) -16t.Also have that measurement bandwidth is wide, low noise advantages simultaneously.But the application of SQUID must be carried out under the environment of low temperature, conventionally adopts liquid helium to carry out cooling.This makes the operation and maintenance of SQUID expensive.The existence of chiller also makes there is certain distance between SQUID probe and human body in addition, and this also has a certain impact for improving resolution.
Utility model content
Technical problem to be solved: provide a kind of cheap for above problem this utility model, the low and simple weak biological magnetic signal acquisition system based on Magnetic Sensor of regular maintenance expense.
Technical scheme: provide a kind of weak biological magnetic signal acquisition system based on Magnetic Sensor for above not enough this utility model, it is characterized in that: comprise array of magnetic sensors module, sensor interface module, signal condition module, MCU control module, host computer, power management module;
Described array of magnetic sensors module comprises: sensor array and sensor peripheral circuit; Described sensor array comprises high-performance MI(Magnetoimpedance) Magnetic Sensor; Described sensor peripheral circuit comprises adaptive calibration circuit and working state indicating circuit; Described adaptive calibration circuit can be calibrated Magnetic Sensor, recovers optimum performance; Whether normally described working state indicating circuit can judge system operation by the light on and off of light emitting diode;
Described sensor interface module comprises: on multichannel analog signals commutation circuit and circuit board, weld elastic probe and standard connector; Described multichannel analog signals commutation circuit is sent to signal condition module in turn by the output signal of sensor array; Described elastic probe is connected with the output lead of high-performance magnetism sensor array; The connector of standard is directly connected with the signal condition module of rear end, and the surrounding of all small-signal cablings is all surrounded by ground wire;
Described signal condition module comprises: signal pre-processing module and A/D change-over circuit; Described signal pre-processing module comprises preposition programmable instrumentation amplifying circuit, secondary fixed gain amplifying circuit, low-pass filter circuit; Preposition programmable instrumentation amplifying circuit and secondary fixed gain amplifying circuit amplify the small-signal voltage magnitude of sensor array output by low-pass filter circuit filtering interference signals; Described A/D change-over circuit, is converted to digital signal by analogue signal;
Described MCU control module comprises: RS232 serial communication circuit and signal controlling module; Described RS232 serial communication circuit is sent to host computer by the digital signal after A/D conversion; Described signal controlling module comprises multichannel analog signals control switching circuit and A/D conversion control circuit;
Power management module is total system power supply.
Described preposition programmable instrumentation amplifying circuit is amplified to mV level by the small-signal voltage magnitude of sensor array output; Described secondary fixed gain amplifying circuit, amplification is 100, output voltage amplitude scope is: 0.8~5V; Described low-pass filter circuit is selected active five rank low-pass filter circuits; Described A/D change-over circuit, adopts 16 A/D converters of high-performance multichannel.
Described host computer refers to install the PC of LABVIEW Virtual Instrument Development software, utilizes LabVIEW Virtual Instrument Development software to programme and receives the data that RS232 serial communication circuit transmits, and data are processed.
Described power management module comprises transforming circuit and mu balanced circuit; Described voltage changing module is by be converted to ± 12V of 220V alternating voltage changing voltage DC voltage; Described Voltage stabilizing module by conversion after ± be converted to ± 5V of 12V DC voltage DC voltage, then by conversion after 5V DC voltage be converted to respectively 1.8V, 2.5V and 3.3V voltage; Wherein ± 5V DC voltage is preposition programmable instrumentation amplifying circuit, secondary fixed gain amplifying circuit, low-pass filter circuit and the power supply of A/D change-over circuit; 1.8V is sensor power supply; 2.5V is adaptive calibration circuit, working state indicating circuit power supply; 3.3V is the power supply of MCU controller.
Described a kind of weak biological magnetic signal acquisition system based on Magnetic Sensor, also comprises two switches; Whether one is power switch, control the components and parts of whole system and work, and another is virtual switch, is positioned at the human-computer interaction interface of host computer Virtual Instrument Development, controls when to start to set up and communicates by letter and carry out data acquisition and processing.
Beneficial effect: the weak biological magnetic signal acquisition system that this utility model provides is just can collect weak biological magnetic signal by a kind of high-performance MI Magnetic Sensor, this system can room temperature be used and cheap, and regular maintenance is simple.
Accompanying drawing explanation
Fig. 1 is the structured flowchart of this utility model system;
Fig. 2 is the concrete structure schematic diagram of this utility model system;
Fig. 3 is the hardware driving flow chart of this utility model system.
The specific embodiment
Below in conjunction with accompanying drawing, this utility model is described in further detail.
As illustrated in fig. 1 and 2, a kind of weak biological magnetic signal acquisition system based on Magnetic Sensor that this utility model provides, comprises array of magnetic sensors module, sensor interface module, signal condition module, MCU control module, host computer (PC), power management module;
Array of magnetic sensors module comprises: sensor array and sensor peripheral circuit; Described sensor array is by high-performance MI(Magnetoimpedance) Magnetic Sensor forms; Described sensor peripheral circuit comprises adaptive calibration circuit and working state indicating circuit; Described adaptive calibration circuit can be calibrated Magnetic Sensor, recovers optimum performance; Whether normally described working state indicating circuit can judge system operation by the light on and off of light emitting diode;
Sensor interface module comprises: on multichannel analog signals commutation circuit and circuit board, weld elastic probe and standard connector; Described multichannel analog signals commutation circuit is sent to signal condition module in turn by the output signal of sensor array; Described elastic probe is connected with the output lead of high-performance magnetism sensor array; The connector of standard can directly be connected with the signal condition module of rear end, and the surrounding of all small-signal cablings is all surrounded by ground wire;
Signal condition module comprises: signal pre-processing module and A/D change-over circuit; Described signal pre-processing module comprises preposition programmable instrumentation amplifying circuit, secondary fixed gain amplifying circuit, low-pass filter circuit; Preposition programmable instrumentation amplifying circuit and secondary fixed gain amplifying circuit amplify the small-signal voltage magnitude of sensor array output by low-pass filter circuit filtering interference signals;
Described preposition programmable instrumentation amplifying circuit is amplified to mV level by the small-signal voltage magnitude of sensor array output; Described secondary fixed gain amplifying circuit, amplification is 100, output voltage amplitude scope is: 0.8~5V; Described low-pass filter circuit is selected active five rank low-pass filter circuits; Described A/D change-over circuit, adopts 16 A/D converters of high-performance multichannel.
Control module comprises: RS232 serial communication circuit and signal controlling module; Described RS232 serial communication circuit is sent to host computer by the digital signal after A/D conversion; Described signal controlling module comprises multichannel analog signals control switching circuit and A/D conversion control circuit;
Host computer refers to install the PC of LABVIEW Virtual Instrument Development software, utilizes LabVIEW Virtual Instrument Development software to programme and receives the data that RS232 serial communication circuit transmits, and data are processed.
Whole system power management module comprises transforming circuit and mu balanced circuit;
Described voltage changing module is by be converted to ± 12V of 220V alternating voltage changing voltage DC voltage;
Described Voltage stabilizing module by conversion after ± be converted to ± 5V of 12V DC voltage DC voltage, then by conversion after 5V DC voltage be converted to respectively 1.8V, 2.5V and 3.3V voltage; Wherein ± 5V DC voltage is preposition programmable instrumentation amplifying circuit, secondary fixed gain amplifying circuit, low-pass filter circuit and the power supply of A/D change-over circuit; 1.8V is sensor power supply; 2.5V is adaptive calibration circuit, working state indicating circuit power supply; 3.3V is the power supply of MCU controller;
Described system comprises two switches; Whether one is power switch, control the components and parts of whole system and work, and another is virtual switch, is positioned at the human-computer interaction interface of host computer Virtual Instrument Development, controls when to start to set up and communicates by letter and carry out data acquisition and processing.
As shown in Figure 3, while specifically using this utility model system, it is in 400000 the screened room of being made by 80% iron-nickel alloy that array of magnetic sensors module, the sensor interface module of this system are positioned over to pcrmeability.First after opening power switch, system hardware initializes then system working procedure initialization; Next is opened upper computer software and opens virtual switch, system made communication, pre-heating system all sensors that resets; Then distinguish Acquisition Error data and normal data, data upload to host computer is processed.
The foregoing is only preferred embodiment of the present utility model, be not restricted to this utility model, for a person skilled in the art, this utility model can have various modifications and variations.All within spirit of the present utility model and principle, any modification of doing, be equal to replacement, improvement etc., within all should being included in claim scope of the present utility model.

Claims (5)

1. the weak biological magnetic signal acquisition system based on Magnetic Sensor, is characterized in that: comprise array of magnetic sensors module, sensor interface module, signal condition module, MCU control module, host computer, power management module;
Described array of magnetic sensors module comprises: sensor array and sensor peripheral circuit; Described sensor array comprises high-performance MI(Magnetoimpedance) Magnetic Sensor; Described sensor peripheral circuit comprises adaptive calibration circuit and working state indicating circuit; Described adaptive calibration circuit can be calibrated Magnetic Sensor, recovers optimum performance; Whether normally described working state indicating circuit can judge system operation by the light on and off of light emitting diode;
Described sensor interface module comprises: on multichannel analog signals commutation circuit and circuit board, weld elastic probe and standard connector; Described multichannel analog signals commutation circuit is sent to signal condition module in turn by the output signal of sensor array; Described elastic probe is connected with the output lead of high-performance magnetism sensor array; The connector of standard is directly connected with the signal condition module of rear end, and the surrounding of all small-signal cablings is all surrounded by ground wire;
Described signal condition module comprises: signal pre-processing module and A/D change-over circuit; Described signal pre-processing module comprises preposition programmable instrumentation amplifying circuit, secondary fixed gain amplifying circuit, low-pass filter circuit; Preposition programmable instrumentation amplifying circuit and secondary fixed gain amplifying circuit amplify the small-signal voltage magnitude of sensor array output by low-pass filter circuit filtering interference signals; Described A/D change-over circuit, is converted to digital signal by analogue signal;
Described MCU control module comprises: RS232 serial communication circuit and signal controlling module; Described RS232 serial communication circuit is sent to host computer by the digital signal after A/D conversion; Described signal controlling module comprises multichannel analog signals control switching circuit and A/D conversion control circuit;
Power management module is total system power supply.
2. a kind of weak biological magnetic signal acquisition system based on Magnetic Sensor according to claim 1, is characterized in that: described preposition programmable instrumentation amplifying circuit is amplified to mV level by the small-signal voltage magnitude of sensor array output; Described secondary fixed gain amplifying circuit, amplification is 100, output voltage amplitude scope is: 0.8~5V; Described low-pass filter circuit is selected active five rank low-pass filter circuits; Described A/D change-over circuit, adopts 16 A/D converters of high-performance multichannel.
3. a kind of weak biological magnetic signal acquisition system based on Magnetic Sensor according to claim 1, it is characterized in that: described host computer refers to install the PC of LABVIEW Virtual Instrument Development software, utilize LabVIEW Virtual Instrument Development software to programme and receive the data that RS232 serial communication circuit transmits, and data are processed.
4. a kind of weak biological magnetic signal acquisition system based on Magnetic Sensor according to claim 1, is characterized in that: described power management module comprises transforming circuit and mu balanced circuit; Described voltage changing module is by be converted to ± 12V of 220V alternating voltage changing voltage DC voltage; Described Voltage stabilizing module by conversion after ± be converted to ± 5V of 12V DC voltage DC voltage, then by conversion after 5V DC voltage be converted to respectively 1.8V, 2.5V and 3.3V voltage; Wherein ± 5V DC voltage is preposition programmable instrumentation amplifying circuit, secondary fixed gain amplifying circuit, low-pass filter circuit and the power supply of A/D change-over circuit; 1.8V is sensor power supply; 2.5V is adaptive calibration circuit, working state indicating circuit power supply; 3.3V is the power supply of MCU controller.
5. a kind of weak biological magnetic signal acquisition system based on Magnetic Sensor according to claim 1, is characterized in that: also comprise two switches; Whether one is power switch, control the components and parts of whole system and work, and another is virtual switch, is positioned at the human-computer interaction interface of host computer Virtual Instrument Development, controls when to start to set up and communicates by letter and carry out data acquisition and processing.
CN201320445048.4U 2013-07-24 2013-07-24 Magnetic sensor based system for acquiring weak biomagnetic signals Withdrawn - After Issue CN203524672U (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103405231A (en) * 2013-07-24 2013-11-27 南京医科大学 Magnetic sensor based system and method for acquiring weak biomagnetic signals
CN103954828A (en) * 2014-05-05 2014-07-30 广东美的暖通设备有限公司 Voltage detection circuit and device based on single-phase PFC
CN105182259A (en) * 2015-08-04 2015-12-23 南京信息工程大学 Space magnetic field intensity distributed synchronous detection device and method
CN105919599A (en) * 2016-05-31 2016-09-07 南京医科大学 Finger motion detection and identification system and method based on magnetic sensors
CN108415316A (en) * 2018-02-06 2018-08-17 中国船舶重工集团公司第七六研究所 A kind of signal precision conditioning of high-noise environment and Acquisition Circuit

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103405231A (en) * 2013-07-24 2013-11-27 南京医科大学 Magnetic sensor based system and method for acquiring weak biomagnetic signals
CN103405231B (en) * 2013-07-24 2015-04-15 南京医科大学 Magnetic sensor based system and method for acquiring weak biomagnetic signals
CN103954828A (en) * 2014-05-05 2014-07-30 广东美的暖通设备有限公司 Voltage detection circuit and device based on single-phase PFC
CN105182259A (en) * 2015-08-04 2015-12-23 南京信息工程大学 Space magnetic field intensity distributed synchronous detection device and method
CN105919599A (en) * 2016-05-31 2016-09-07 南京医科大学 Finger motion detection and identification system and method based on magnetic sensors
CN108415316A (en) * 2018-02-06 2018-08-17 中国船舶重工集团公司第七六研究所 A kind of signal precision conditioning of high-noise environment and Acquisition Circuit

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