CN220340035U

CN220340035U - Reaction cup, gripper device and sample analyzer

Info

Publication number: CN220340035U
Application number: CN202321099638.6U
Authority: CN
Inventors: 肖华; 梁国绿
Original assignee: Shenzhen Dymind Biotechnology Co Ltd
Current assignee: Shenzhen Dymind Biotechnology Co Ltd
Priority date: 2023-05-08
Filing date: 2023-05-08
Publication date: 2024-01-12
Anticipated expiration: 2033-05-08

Abstract

The embodiment of the utility model discloses a reaction cup, a gripper device and a sample analyzer, wherein the reaction cup is provided with a containing cavity and an opening communicated with the containing cavity, the bottom wall of the containing cavity is provided with a convex structure, so that the liquid level of liquid needs to be ensured to meet the requirements in order to ensure the accuracy of signal detection, and the convex structure can occupy part of the space at the lower part of the containing cavity, so that the use of liquid amount can be reduced, the consumption of samples and reagents can be reduced on the premise of not changing a signal detection system, and the accuracy of signal detection is ensured.

Description

Reaction cup, gripper device and sample analyzer

Technical Field

The utility model relates to the technical field of sample detection, in particular to a reaction cup, a gripper device and a sample analyzer.

Background

The reaction cup is used in-vitro diagnosis equipment, such as biochemical analyzer, immunity analyzer, coagulation analyzer, etc. for blood sample and urine detection. The top of the reaction cup is provided with an opening, so that the liquid-separating needle can conveniently enter the liquid-separating device.

In the reaction process of sample analysis, the signal detection area is generally arranged in an area above the bottom of the reaction cup, so that the liquid level in the reaction cup is required to be sufficient, the liquid level reaches a certain height, signals in the reaction process can be reliably collected by the detection system, the liquid level in the reaction cup can be reduced when the consumption of samples and reagents in the reaction cup is reduced, the liquid level is insufficient, and the sample detection sensitivity is reduced.

Disclosure of Invention

The utility model aims to provide a reaction cup, a gripper device and a sample analyzer, and aims to solve the problems that in the existing sample analysis, when the consumption of samples and reagents in the reaction cup is reduced, the liquid amount in the reaction cup is insufficient, and the sample detection sensitivity is reduced.

In a first aspect, the utility model provides a reaction cup, wherein the reaction cup is provided with a containing cavity and an opening communicated with the containing cavity, and the bottom wall of the containing cavity is provided with a protruding structure.

In one embodiment, the reaction cup comprises a first cup body, a second cup body and a reducing body for connecting the first cup body and the second cup body, wherein the first cup body is positioned on one side of the opening;

the radial dimension of the first cup body is larger than that of the second cup body, the radial dimension of the variable-diameter body is gradually reduced from the first cup body to the second cup body, and the second cup body is used for being irradiated by measuring light.

In one embodiment, the cross section of the outer wall and the cross section of the inner wall of the second cup are circular.

In one embodiment, the cross section of the inner wall of the first cup body is circular.

In one embodiment, the cross section of the outer wall and the cross section of the inner wall of the reducing body are both circular.

In one embodiment, the cross section of the outer wall of the first cup is circular.

In one embodiment, a circular annular flange for being matched and clamped with the grabbing device is arranged on the cup body of the reaction cup.

In a second aspect, the present utility model also provides a gripper apparatus comprising:

the clamping jaw is used for clamping the reaction cup in any embodiment, and is provided with a clamping position used for being matched and clamped with the circular annular flange; and

and the driving mechanism is connected with the clamping jaw and used for driving the clamping jaw to move.

In a third aspect, the present utility model also provides a sample analyzer comprising:

a housing;

the gripper device of the embodiment is arranged in the shell and is used for transferring the reaction cup;

the liquid separation device is arranged in the shell and is used for distributing a sample and a reagent into the reaction cup; and

the detection assembly is arranged in the shell and is used for carrying out optical detection on the sample in the reaction cup transferred to the detection position by the gripper device.

In one embodiment, the sample analyzer further comprises a table disposed inside the housing;

the workbench is provided with a sample storage position for storing samples, a reagent storage position for storing reagents, a first storage position for storing the reaction cup, a second storage position for storing the magnetic bead cup, an incubation position for incubating the reaction cup and/or the samples in the magnetic bead cup, a reagent adding position for dripping reagents into the reaction cup and/or the magnetic bead cup, and a cup throwing position for throwing away the reaction cup and/or the magnetic bead cup.

The embodiment of the utility model has the following beneficial effects:

by adopting the reaction cup, the bottom wall of the accommodating cavity is provided with the bulge structure, so that the liquid level of liquid needs to be ensured to meet the requirement for ensuring the accuracy of signal detection, and the bulge structure can occupy part of the space at the lower part of the accommodating cavity, so that the use of liquid amount can be reduced, the consumption of samples and reagents can be reduced on the premise of not changing a signal detection system, and the accuracy of signal detection is ensured.

The utility model discloses a handle device and a sample analyzer, wherein the handle device is used for transferring a reaction cup, a detection component is used for optically detecting samples in the reaction cup transferred from the handle device to a detection position, and the bottom wall of a reaction cup accommodating cavity is provided with a convex structure which can occupy part of the space at the lower part of the accommodating cavity, so that the use of liquid amount can be reduced, the consumption of samples and reagents can be reduced on the premise of not changing a signal detection system, and the accuracy of signal detection is ensured.

Drawings

In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the utility model, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

Wherein:

FIG. 1 is a schematic view of a reaction cup in one embodiment.

FIG. 2 is another angular schematic view of the cuvette of FIG. 1.

FIG. 3 is a cross-sectional view of the cuvette of FIG. 1.

Fig. 4 is a schematic diagram of a sample analyzer of one embodiment.

Reference numerals: 110. a receiving chamber; 111. a bump structure; 120. an opening; 130. a first cup; 140. a second cup; 150. a reducing body; 160. a circular annular flange;

210. a gripper device; 220. incubation position; 230. a first placement bit; 240. a cup throwing position; 250. a second placement bit; 260. adding a reagent position; 270. a cleaning pool; 280. a reagent storage location; 290. sample storage bits.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

It should be noted that all directional indicators (such as up, down, left, right, front, and rear … …) in the embodiments of the present utility model are merely used to explain the relative positional relationship, movement, etc. between the components in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indicators are correspondingly changed.

Furthermore, the description of "first," "second," etc. in this disclosure is for descriptive purposes only and is not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions of the embodiments may be combined with each other, but it is necessary to base that the technical solutions can be realized by those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be considered to be absent and not within the scope of protection claimed in the present utility model.

Referring to fig. 1 to 3, the reaction cup of an embodiment is mainly used as a reaction container in optical detection, the reaction cup is provided with a receiving cavity 110 and an opening 120 communicated with the receiving cavity 110, the bottom wall of the receiving cavity 110 is provided with a protrusion structure 111, in order to ensure the accuracy of signal detection, so that the liquid level of the liquid needs to be ensured to meet the requirement, and the protrusion structure 111 occupies a part of the space at the lower part of the receiving cavity 110, so that the use of liquid can be reduced, the consumption of samples and reagents can be reduced on the premise of not changing a signal detection system, and the accuracy of signal detection is ensured. The sample and reagent consumption is reduced, so that the requirement on patient sampling can be reduced, the reagent consumption can be reduced, and the test cost can be reduced.

In one embodiment, referring to fig. 1 to 3, the reaction cup includes a first cup 130 and a second cup 140, and a reducing body 150 connecting the first cup 130 and the second cup 140, the first cup 130 being located at one side of the opening 120; the radial dimension of the first cup 130 is larger than the radial dimension of the second cup 140, the radial dimension of the variable diameter body 150 gradually decreases from the first cup 130 to the second cup 140, the second cup 140 is used for being irradiated by measuring light, and the whole reaction cup is approximately cylindrical.

Through the radial dimension of the first cup 130 being greater than the radial dimension of the second cup 140, the large-size first cup 130 is convenient for the insertion and the liquid separation of the liquid separating needle, the small-size second cup 140 is convenient for the rise of the liquid level in the cup, and the consumption of liquid amount can be reduced by applying the reaction cup of the embodiment under the condition of constant liquid level height.

The simplified calculation formula of the liquid amount in the reaction cup is set as V=pi×D×D×h, wherein V is the volume of the reaction liquid, pi is the circumference ratio, D is the inner diameter of the reaction cup, h is the liquid level height, as can be seen from the formula, the liquid level is inversely proportional to the square of the diameter for the same liquid level, so that the diameter is reduced, which results in a significant increase in the liquid level and thus a reduction in the liquid level consumption.

With continued reference to fig. 1 to 3, the diameter of the second cup 140 in the reaction cup is reduced by 15% compared with the diameter of the first cup 130, so that the liquid level of the reaction cup in this embodiment is about 1.4 times as high as that of the conventional solution, so that the liquid level is greatly increased, and the consumption of liquid is reduced.

Specifically, the cup body of the reaction cup is provided with a circular annular flange 160 for being matched and clamped with the gripper device 210, and the gripper device 210 is convenient to grasp and move the cup through the arrangement of the circular annular flange 160. The reaction cup is a structural member supported by transparent materials. Of course, in other embodiments, a rectangular annular flange may be provided on the cup body of the reaction cup to facilitate gripping and cup movement by the gripper 210.

In the present embodiment, the cross-section of the first cup 130, the cross-section of the second cup 140, and the cross-section of the variable diameter body 150 may be configured according to the need.

In an embodiment, referring to fig. 1 to 3, the cross section of the outer wall and the cross section of the inner wall of the first cup 130 are both circular, the cross section of the outer wall and the cross section of the inner wall of the second cup 140 are both circular, and the cross section of the outer wall and the cross section of the inner wall of the reducing body 150 are both circular.

In another embodiment, the cross section of the outer wall of the first cup 130 is square, the cross section of the inner wall of the first cup 130 is circular, the cross section of the outer wall of the second cup 140 and the cross section of the inner wall are circular, and the cross section of the outer wall and the cross section of the inner wall of the reducing body 150 are circular.

In yet another embodiment, the cross-section of the outer wall of the first cup 130 is square, the cross-section of the inner wall of the first cup 130 is circular, the cross-section of the outer wall of the second cup 140 and the cross-section of the inner wall are circular, and the cross-section of the outer wall and the cross-section of the inner wall of the reducing body 150 are square.

Referring to fig. 1 to 4, a sample analyzer of an embodiment can detect and analyze a sample (such as blood, urine, etc.), and provide reliable digital basis for clinical diagnosis of various diseases of a patient, and the sample analyzer needs to use a sample container such as a reaction cup and a magnetic bead cup for accommodating the sample and analyzing and detecting the sample during the detection process.

The sample analyzer of this embodiment includes a housing and a gripper 210, the gripper 210 is disposed inside the housing and is used for transferring the reaction cup, the gripper 210 includes a clamping jaw and a driving mechanism, the clamping jaw is used for clamping the reaction cup according to any of the embodiments, the clamping jaw is provided with a clamping position for clamping with the circular annular flange 160, and the driving mechanism is connected with the clamping jaw and is used for driving the clamping jaw to move so as to be capable of moving the reaction cup to a preset position.

Specifically, the driving mechanism comprises a first driving component, a second driving component and a third driving component, wherein the first driving component is connected with the clamping jaw and used for driving the clamping jaw to move along a first direction, the second driving component is connected with the first driving component and used for driving the first driving component to move along a second direction, the third driving component is connected with the second driving component and used for driving the second driving component to move along a third direction, and the first direction, the second direction and the third direction are mutually in included angle setting. The driving mechanism can realize the movement of the clamping jaw at any position in the working space, thereby completing the position transfer of the reaction cup or the magnetic bead cup.

Further, the driving mechanism is a triaxial linear module, namely, the first direction, the second direction and the third direction are perpendicular to each other, and the triaxial linear module can drive the clamping jaw to move in a three-dimensional space, so that the clamping jaw can move in the vertical direction and move in a plane perpendicular to the vertical direction.

In an embodiment, the sample analyzer further includes a liquid separating device disposed inside the housing and used for distributing the sample and the reagent to the reaction cup, and a detecting component disposed inside the housing and used for optically detecting the sample in the reaction cup transferred to the detection position by the gripper device 210, so as to detect and analyze the sample in the reaction cup by the detecting component, and output a detection analysis result.

Further, in this embodiment, the sample analyzer further includes a workbench, and the workbench is disposed inside the housing; the workbench is provided with a sample storage position 290 for storing a sample, a reagent storage position 280 for storing a reagent, a first storage position 230 for storing a reaction cup, a second storage position 250 for storing a magnetic bead cup, an incubation position 220 for incubating the sample in the reaction cup and/or the magnetic bead cup, a reagent adding position 260 for dripping the reagent into the reaction cup and/or the magnetic bead cup, and a cup throwing position 240 for throwing away the reaction cup and/or the magnetic bead cup. A cleaning tank 270 is also provided on the table.

Specifically, when the sample analyzer is a coagulation analyzer, the magnetic bead cup is a magnetic bead analysis cup for detecting a blood sample by a magnetic bead method, and the reaction cup is an optical analysis cup for detecting a blood sample by an optical method.

The sample storage position 290 is used for loading samples to be tested, and is usually in a sample rack form and a sample disk form, and can be provided with scanning equipment for scanning and identifying sample bar codes. The reagent storage location 280 can be used for loading reagents, and can have a low-temperature refrigeration function so as to ensure the stability of the reagents, and a single reagent card strip and a plurality of reagent bottles can be loaded in the area. The cup loading station, which typically provides for reaction cup loading, is of the cup tray type, auto loading type, cartridge type, etc., and includes a first placement station 230 for loading reaction cups and a second placement station 250 for loading magnetic bead cups.

The gripper 210 enables the dispatching of reaction cups, which can be transferred from a cup loading station to an incubation station 220, a reagent addition station 260, a detection station, a cup throwing station 240, etc. The liquid separation device can realize the suction and the separate injection of the sample and the reagent, and needs to have the functions of accurate quantification and preheating.

The sample analyzer also comprises a liquid path system and a hardware control system, wherein the liquid path system realizes the suction and the split injection of samples and reagents, the cleaning of split injection needles and pipelines and the like. The hardware control system realizes the functions of man-machine interaction, state monitoring, complete machine control, data acquisition and processing and the like.

Incubation site 220 enables heated incubation and detection of the reaction solution. And after the sample to be detected and the reagent are mixed uniformly, incubating for a designated time, and detecting. The device comprises an optical incubation test zone and a magnetic bead incubation test zone.

The reaction cup is made of a material with good light transmittance, and the reaction process is monitored by detecting the change of the light intensity transmitted through the reaction cup. The inside of the magnetic bead cup is provided with a groove which is convenient for the magnetic beads to roll, the magnetic beads roll in the detection position under the drive of the alternating coils, and the amplitude of the magnetic beads in the reaction liquid is smaller and smaller along with the solidification process. And a detection coil is arranged in a plane perpendicular to the driving coil, and the induction current generated by the cutting coil in the swing process of the magnetic beads is detected.

The optical method detection is influenced by substances such as chyle, jaundice, hemolysis and the like in the sample, so that the measurement result is biased, the magnetic bead method detection is not influenced by the interference substances, and the two methods are combined, so that the diversified requirements can be met.

In this embodiment, the sample analyzer includes 9 incubation sites 220, 6 scattering detection wells, 2 transmission detection wells in terms of optical detection. And 2 of the 6 scattering detection holes have transmission detection functions, such as 660nm of scattering detection wavelength and 575nm or 405nm of transmission detection wavelength; the 2 transmission detection holes may have a dual wavelength transmission detection function, such as 575nm and 405nm. The common method for detecting the coagulation method project (PT, APTT, TT, fib and the like) in the detection of the coagulation analyzer is a scattering turbidimetry method, and the detection wavelength is 660nm; a common method for detecting the immunological turbidimetry (D-Dimer, FDP, etc.) or the chromogenic substrate method (AT-III, etc.) is a transmission turbidimetry method, and the common detection wavelengths are 575nm and 405nm respectively.

The workflow steps of the sample analyzer applying the present embodiment specifically include:

s910, a user places a sample tube into the sample storage position 290, a reagent into the reagent storage position 280 and a reaction cup into the cup loading position, sets test items on an operation interface, and starts a test.

S920, the gripper device 210 transfers the reaction cup to a sample or reagent dispensing position to wait for dispensing.

S930, the dispensing needle sucks a specified amount of buffer solution or diluent (if dilution is required, if not, this operation is not required), sucks a specified amount of sample from the sample tube, dispenses the sample into the reaction cup, the gripper device 210 transfers the reaction cup to the incubation site 220 for incubation, and after the dispensing needle dispenses the sample, the dispensing needle is cleaned.

S940, after the specified time is reached, the dispensing needle sucks the specified amount of reagent and dispenses the reagent into the reaction cup, the gripper device 210 mixes the reaction liquid uniformly and transfers the reaction cup to the detection channel, after the specified time is reached, the detection system starts to collect signals, and then the indexes such as the solidification time or the concentration, the activity and the like of the target object are calculated, and the result is displayed on the operation interface.

S950, after the test is completed, the user takes out the tested sample, reagent, etc. from the device and performs necessary cleaning and maintenance operations.

It will be appreciated that for interference samples such as chyle, jaundice, haemolysis etc. the optical measurement is affected and the user may choose to use the magnetic bead method for sample analysis.

The foregoing disclosure is illustrative of the present utility model and is not to be construed as limiting the scope of the utility model, which is defined by the appended claims.

Claims

1. The reaction cup is provided with a containing cavity and an opening communicated with the containing cavity, and is characterized in that the bottom wall of the containing cavity is provided with a protruding structure.

2. The reaction cup of claim 1 wherein the reaction cup comprises a first cup and a second cup, and a reducing body connecting the first cup and the second cup, the first cup being located on the open side;

3. The reaction cup of claim 2 wherein the cross-section of the outer wall and the cross-section of the inner wall of the second cup are both circular.

4. A reaction cup as claimed in claim 3 wherein the inner wall of the first cup is circular in cross-section.

5. The reaction cup of claim 4 wherein the cross-section of the outer wall and the cross-section of the inner wall of the reducing body are both circular.

6. The reaction cup of claim 5 wherein the outer wall of the first cup has a circular cross-section.

7. A reaction cup as claimed in any one of claims 1 to 6 wherein the cup body of the reaction cup is provided with a circular annular flange for co-operation gripping with a gripping means.

8. A gripper apparatus, comprising:

a clamping jaw for clamping the reaction cup of claim 7, wherein the clamping jaw is provided with a clamping position for being matched and clamped with the circular annular flange; and

9. A sample analyzer, comprising:

a housing;

the gripper apparatus of claim 8, disposed inside the housing and configured to transfer the reaction cup;

10. The sample analyzer of claim 9, further comprising a table disposed inside the housing;