CN220276824U - A mixing device for pan-cancer species 50 gene detection detect reagent - Google Patents
A mixing device for pan-cancer species 50 gene detection detect reagent Download PDFInfo
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- CN220276824U CN220276824U CN202321811478.3U CN202321811478U CN220276824U CN 220276824 U CN220276824 U CN 220276824U CN 202321811478 U CN202321811478 U CN 202321811478U CN 220276824 U CN220276824 U CN 220276824U
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- 238000001514 detection method Methods 0.000 title claims abstract description 29
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 25
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 18
- 201000011510 cancer Diseases 0.000 title claims abstract description 16
- 101150052384 50 gene Proteins 0.000 title claims description 12
- 238000012360 testing method Methods 0.000 claims abstract description 35
- 230000007246 mechanism Effects 0.000 claims abstract description 14
- 230000005540 biological transmission Effects 0.000 claims abstract description 4
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- 108090000623 proteins and genes Proteins 0.000 abstract description 10
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 5
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- 206010069754 Acquired gene mutation Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
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- 230000003068 static effect Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
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Abstract
The utility model discloses a mixing device for detecting reagents for detecting 50 genes of a pan-cancer species, which relates to the field of gene detection and adopts the following technical scheme: the device comprises a base and a cylinder fixedly arranged at the top of the base, wherein a containing assembly is arranged in the cylinder, and a uniform mixing driving mechanism is arranged in the base; the mixing driving mechanism comprises a first gear and a second gear which are respectively positioned at the top and the bottom of the base, and a transmission shaft is fixedly connected between the first gear and the second gear, and the mixing driving mechanism has the beneficial effects that: the two reciprocating screw rods rotate in opposite directions through the mixing driving mechanism, so that the two sliding blocks move reversely to drive the second gears to rotate, so that the third gears synchronously rotate, the test tube racks drive the test tubes to rotate finally, and the sliding blocks reciprocate to drive the first gears to reciprocate, and finally the test tube racks drive the test tubes to frequently reciprocate.
Description
Technical Field
The utility model relates to the field of gene detection, in particular to a mixing device for a detection reagent for detecting a gene of a cancer cell 50.
Background
The detection of the pan-oncogene is a comprehensive NGSpanel (high-throughput sequencing gene detection set), and comprises the steps of detecting all exon regions of more than 500 genes closely related to tumors, and carrying out high-throughput sequencing on intron regions with frequent rearrangement and fusion, wherein the detection content comprises point mutation, small fragment deletion and insertion, copy number change and gene fusion. Analyzing tumor somatic mutation, germ line mutation, targeted drug, curative effect of immunotherapy and the like, and in the detection process, the detection reagent needs to be uniformly mixed so as to be more accurately detected.
In the existing detection process, the inspector manually shakes and mixes uniformly, the mixing degree of the detection reagent is not guaranteed, and some auxiliary equipment on the market only rotates unidirectionally, so that the detection reagent is easy to generate rotation inertia in the continuous unidirectional rotation process, and the mixing quality cannot achieve the optimal effect.
Therefore, it is necessary to invent a mixing device for detecting the detection reagent of the pan-cancerous species 50 gene.
Disclosure of Invention
Therefore, the utility model provides a mixing device for detecting the detection reagent of the pan-cancer species 50 genes, and solves the problems that some auxiliary devices on the market only rotate unidirectionally by arranging a mixing driving mechanism and a placement assembly, so that the detection reagent is easy to generate rotation inertia in the continuous unidirectional rotation process, and the mixing quality cannot reach the optimal effect.
In order to achieve the above object, the present utility model provides the following technical solutions: the mixing device for the detection reagent for detecting the pan cancer seed genes comprises a base and a cylinder fixedly arranged at the top of the base, wherein a containing assembly is arranged in the cylinder, and a mixing driving mechanism is arranged in the base;
the mixing driving mechanism comprises a first gear and a second gear which are respectively positioned at the top and the bottom of the base, a transmission shaft is fixedly connected between the first gear and the second gear, toothed plates meshed with the toothed plates are respectively arranged at the front side and the rear side of the second gear, sliding seats are respectively fixedly connected to the outer sides of the toothed plates, sliding blocks are respectively fixedly connected to the bottoms of the two sliding seats, a reciprocating screw and a limiting rod are sleeved in the sliding blocks, the sliding blocks are connected with the reciprocating screw through ball nut pairs, side plates are respectively fixedly connected to the two sides of the bottom of the base, the joints of the two ends of the reciprocating screw and the side plates are movably connected through bearings, two ends of the limiting rod are fixedly connected with the two side plates, a motor is fixedly installed in one side of the base, a driving gear is fixedly connected to an output shaft of the motor, a driven gear is fixedly connected to one end of the reciprocating screw positioned at the front side of the driven gear and is meshed with the driving gear, chain wheels are respectively fixedly connected to one ends of the output shaft of the motor and the reciprocating screw positioned at the rear side, and chain wheels are respectively sleeved on the outer sides of the driven gear and are connected with chain wheels through chains in a driving mode;
the holding assembly comprises a plurality of evenly distributed gears III positioned at the outer edge of the gear I, the gears III are meshed with the gear I, and test tube racks are fixedly connected to the tops of the gear I and the gear III.
Preferably, the third gear is rotatably mounted on the top of the base through a rotating shaft.
Preferably, the driven gear is rotatably mounted on a side plate close to one side of the motor through a rotating shaft.
Preferably, the inner wall of the top of the base is fixedly connected with two sliding rails which are symmetrically distributed around, the two sliding rails are respectively and correspondingly arranged at the tops of the two sliding seats, and the sliding seats are in sliding connection with the base through the sliding rails.
Preferably, the test tube rack is internally and fixedly provided with a rubber ring.
Preferably, the cylinder and the test tube rack are both made of transparent glass materials.
Preferably, the sliding block and the limiting rod are arranged in a sliding manner, and the limiting rod is positioned at the bottom of the reciprocating screw rod.
Preferably, the base is made of stainless steel material.
Preferably, anti-skid rubber pads are fixedly arranged at the bottoms of two sides of the base.
The beneficial effects of the utility model are as follows:
according to the utility model, by arranging the mixing driving mechanism and the placing component, a worker places the test tube filled with the detection reagent in the test tube rack, and the two reciprocating screw rods are rotated in opposite directions through the mixing driving mechanism, so that the two sliding blocks are reversely moved to drive the second gears to rotate, so that the third gears synchronously rotate, the test tube racks drive the test tube to rotate finally, and the sliding blocks are reciprocated to drive the first gears to reciprocate, so that the test tube rack drives the test tube to frequently reciprocate, the detection reagent in the test tube can be rapidly mixed uniformly through frequent bidirectional rotation, the mixing efficiency is improved, and the mixing quality is obviously improved.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It will be apparent to those skilled in the art from this disclosure that the drawings described below are merely exemplary and that other embodiments may be derived from the drawings provided without undue effort.
The structures, proportions, sizes, etc. shown in the present specification are shown only for the purposes of illustration and description, and are not intended to limit the scope of the utility model, which is defined by the claims, so that any structural modifications, proportional changes, or adjustments of size, which do not affect the efficacy of the utility model or the objects achieved, should fall within the scope of the utility model.
FIG. 1 is a schematic view of the overall structure provided by the present utility model;
FIG. 2 is a schematic view of the whole structure of the bottom view provided by the utility model;
FIG. 3 is an exploded view of the overall structure provided by the present utility model;
FIG. 4 is a schematic diagram of the movement of a slider according to the present utility model;
in the figure: 1 base, 2 gear one, 3 gear two, 4 pinion rack, 5 sliding seat, 6 sliding block, 7 reciprocating screw, 8 gag lever post, 9 curb plate, 10 motor, 11 driving gear, 12 driven gear, 13 sprocket, 14 gear three, 15 test-tube rack, 16 slide rail, 17 rubber ring, 18 drum, 19 antiskid rubber pad.
Detailed Description
The preferred embodiments of the present utility model will be described below with reference to the accompanying drawings, it being understood that the preferred embodiments described herein are for illustration and explanation of the present utility model only, and are not intended to limit the present utility model.
Referring to fig. 1-4, the utility model provides a mixing device for detecting a gene of a cancer flood 50, which comprises a base 1 and a cylinder 18 fixedly arranged at the top of the base 1, wherein a containing assembly is arranged in the cylinder 18, and a mixing driving mechanism is arranged in the base 1;
the mixing driving mechanism comprises a first gear 2 and a second gear 3 which are respectively positioned at the top and the bottom of a base 1, a transmission shaft is fixedly connected between the first gear 2 and the second gear 3, toothed plates 4 meshed with the first gear 2 and the second gear 3 are respectively arranged at the front side and the rear side of the second gear 3, sliding seats 5 are fixedly connected to the outer sides of the two toothed plates 4, sliding blocks 6 are fixedly connected to the bottoms of the two sliding seats 5, a reciprocating screw 7 and a limiting rod 8 are sleeved in the sliding blocks 6, the sliding blocks 6 are connected with the reciprocating screw 7 through ball nut pairs, side plates 9 are fixedly connected to the two sides of the bottom of the base 1, the joints of the two ends of the reciprocating screw 7 and the side plates 9 are movably connected through bearings, a motor 10 is fixedly arranged in one side of the base 1, a driving gear 11 is fixedly connected to an output shaft of the motor 10, one end of the reciprocating screw 7 positioned at the front side is fixedly connected with a driven gear 12, the driven gear 12 is positioned at one side of the driving gear 11 and is meshed with the driving gear 11, a sprocket 13 is fixedly connected to one end of the reciprocating 7 positioned at the rear side, and the two outer sides 13 are sleeved with a chain drive screw 13 through chains;
the holding assembly comprises a plurality of evenly distributed gears III 14 positioned at the outer edge of the gear I2, the gears III 14 are meshed with the gear I2, and the tops of the gear I2 and the gears III 14 are fixedly connected with a test tube rack 15;
in this embodiment, the staff places the test tube that is equipped with detect reagent in test-tube rack 15, makes two reciprocating screw rods 7 rotate in opposite directions through mixing actuating mechanism to make two sliding block 6 reverse movement, drive gear two 3 and rotate, thereby make a plurality of gears three 14 also synchronous rotation, finally make a plurality of test-tube racks 15 drive the test tube and rotate, and because sliding block 6 is reciprocating movement, thereby can drive gear one 2 reciprocating rotation, finally make test-tube rack 15 drive test tube frequent reciprocating rotation too.
In order to achieve the purpose of stable rotation of the gear III 14, the device is realized by adopting the following technical scheme: the third gear 14 is rotatably arranged at the top of the base 1 through a rotating shaft;
in order to achieve the purpose of stabilizing the rotation of the driven gear 12, the device is realized by adopting the following technical scheme: the driven gear 12 is rotatably arranged on the side plate 9 close to one side of the motor 10 through a rotating shaft;
in order to achieve the purpose of stable movement of the sliding seat 5, the device is realized by adopting the following technical scheme: the inner wall of the top of the base 1 is fixedly connected with two sliding rails 16 which are symmetrically distributed in the front-back direction, the two sliding rails 16 are respectively and correspondingly arranged at the tops of the two sliding seats 5, and the sliding seats 5 are in sliding connection with the base 1 through the sliding rails 16;
wherein, in order to realize the stable purpose of test tube placement, this device adopts following technical scheme to realize: the rubber ring 17 is fixedly arranged in the test tube rack 15, the rubber ring 17 has good elasticity, and the test tube can be clamped by the rubber ring 17 after being put in, so that a large static friction force exists between the test tube and the rubber ring 17, the test tube can be well clamped, and the test tube can be stably rotated when being driven to rotate;
in order to achieve the purpose of convenient observation, the device is realized by adopting the following technical scheme: the cylinder 18 and the test tube rack 15 are made of transparent glass materials, so that workers can observe the mixing condition of reagent solution in the test tube at any time;
in order to achieve the purpose of stabilizing the movement of the sliding block 6, the device is realized by adopting the following technical scheme: the sliding block 6 and the limiting rod 8 are arranged in a sliding way, the limiting rod 8 is positioned at the bottom of the reciprocating screw rod 7, the limiting rod 8 can limit the movement of the sliding block 6, and after the reciprocating screw rod 7 rotates, the movable block can stably move under the action of the limiting rod 8;
in order to achieve the purpose of durability, the device is achieved by adopting the following technical scheme: the base 1 is made of stainless steel materials, and the stainless steel materials have better corrosion resistance and longer service life;
in order to achieve the purpose of stable placement, the device is realized by adopting the following technical scheme: the bottoms of two sides of the base 1 are fixedly provided with anti-skid rubber pads 19.
The application process of the utility model is as follows: when the utility model is used, a worker places a test tube filled with a detection reagent in the test tube rack 15, the driving motor 10 can drive the driven gear 12 and the front reciprocating screw rod 7 to rotate through the driving gear 11, meanwhile, the rear reciprocating screw rod 7 can synchronously rotate through the cooperation of the chain and the chain wheel 13, but the two reciprocating screw rods 7 rotate in opposite directions, the two sliding blocks 6 respectively drive the two sliding seats 5 and the toothed plate 4 to reversely move, as shown in fig. 4, finally drive the gear II 3 and the gear I2 to rotate, so that the gears III 14 synchronously rotate, finally, the test tube racks 15 drive the test tube to rotate, and the sliding blocks 6 reciprocate, so that the gear I2 can be driven to reciprocate, and finally, the test tube rack 15 drives the test tube to frequently reciprocate.
The above description is of the preferred embodiments of the present utility model, and any person skilled in the art may modify the present utility model or make modifications to the present utility model with the technical solutions described above. Therefore, any simple modification or equivalent made according to the technical solution of the present utility model falls within the scope of the protection claimed by the present utility model.
Claims (9)
1. A mixing device for pan-cancer species 50 gene detection detect reagent, includes base (1) and fixed mounting at drum (18) at base (1) top, its characterized in that: a containing assembly is arranged in the cylinder (18), and a uniform mixing driving mechanism is arranged in the base (1);
the mixing driving mechanism comprises a first gear (2) and a second gear (3) which are respectively positioned at the top and the bottom of a base (1), a transmission shaft is fixedly connected between the first gear (2) and the second gear (3), toothed plates (4) meshed with the toothed plates are respectively arranged at the front side and the rear side of the second gear (3), sliding seats (5) are fixedly connected to the outer sides of the toothed plates (4), sliding blocks (6) are fixedly connected to the bottoms of the sliding seats (5), a reciprocating screw (7) and a limiting rod (8) are sleeved in the sliding blocks (6), the sliding blocks (6) are connected with the reciprocating screw (7) through ball nut pairs, side plates (9) are fixedly connected to the two sides of the bottom of the base (1), two ends of the reciprocating screw (7) are movably connected with the side plates (9) through bearings, a motor (10) is fixedly installed inside one side of the base (1), an output shaft of the motor (10) is fixedly connected with a driving gear (11), the driving gear (11) is fixedly connected with a driven gear (12) which is meshed with the driven gear (12) on one side of the driving gear (11), the output shaft of the motor (10) is fixedly connected with a chain wheel (13) at one end of the reciprocating screw rod (7) positioned at the rear side, and the outer sides of the two chain wheels (13) are sleeved with chains and are in driving connection through the chains;
the holding assembly comprises a plurality of evenly distributed gears III (14) positioned at the outer edge of the gear I (2), the gears III (14) are meshed with the gear I (2), and test tube racks (15) are fixedly connected to the tops of the gear I (2) and the gears III (14).
2. The mixing device for detecting the detection reagent of the pan-cancer species 50 gene according to claim 1, wherein: the gear III (14) is rotatably arranged at the top of the base (1) through a rotating shaft.
3. The mixing device for detecting the detection reagent of the pan-cancer species 50 gene according to claim 1, wherein: the driven gear (12) is rotatably arranged on a side plate (9) close to one side of the motor (10) through a rotating shaft.
4. The mixing device for detecting the detection reagent of the pan-cancer species 50 gene according to claim 1, wherein: the base (1) top inner wall fixedly connected with two slide rail (16) of fore-and-aft symmetric distribution, two slide rail (16) correspond respectively and set up at two sliding seat (5) tops, sliding seat (5) are through slide rail (16) and base (1) sliding connection.
5. The mixing device for detecting the detection reagent of the pan-cancer species 50 gene according to claim 2, wherein: the inside of the test tube rack (15) is fixedly provided with a rubber ring (17).
6. The mixing device for detecting the detection reagent of the pan-cancer species 50 gene according to claim 2, wherein: the cylinder (18) and the test tube rack (15) are both made of transparent glass materials.
7. The mixing device for detecting the detection reagent of the pan-cancer species 50 gene according to claim 1, wherein: the sliding block (6) and the limiting rod (8) are arranged in a sliding mode, and the limiting rod (8) is located at the bottom of the reciprocating screw rod (7).
8. The mixing device for detecting the detection reagent of the pan-cancer species 50 gene according to claim 1, wherein: the base (1) is made of stainless steel materials.
9. The mixing device for detecting the detection reagent of the pan-cancer species 50 gene according to claim 1, wherein: anti-slip rubber pads (19) are fixedly arranged at the bottoms of two sides of the base (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321811478.3U CN220276824U (en) | 2023-07-11 | 2023-07-11 | A mixing device for pan-cancer species 50 gene detection detect reagent |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321811478.3U CN220276824U (en) | 2023-07-11 | 2023-07-11 | A mixing device for pan-cancer species 50 gene detection detect reagent |
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| CN220276824U true CN220276824U (en) | 2024-01-02 |
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| CN202321811478.3U Active CN220276824U (en) | 2023-07-11 | 2023-07-11 | A mixing device for pan-cancer species 50 gene detection detect reagent |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117983102A (en) * | 2024-04-03 | 2024-05-07 | 山东诺瓦生物技术有限公司 | Nitrite detection device and application method thereof |
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2023
- 2023-07-11 CN CN202321811478.3U patent/CN220276824U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117983102A (en) * | 2024-04-03 | 2024-05-07 | 山东诺瓦生物技术有限公司 | Nitrite detection device and application method thereof |
| CN117983102B (en) * | 2024-04-03 | 2024-06-11 | 山东诺瓦生物技术有限公司 | Nitrite detection device and application method thereof |
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