CN220194887U - Centrifugal micro-fluidic chip - Google Patents
Centrifugal micro-fluidic chip Download PDFInfo
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- CN220194887U CN220194887U CN202321497200.3U CN202321497200U CN220194887U CN 220194887 U CN220194887 U CN 220194887U CN 202321497200 U CN202321497200 U CN 202321497200U CN 220194887 U CN220194887 U CN 220194887U
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- sample
- sample flow
- disc
- microfluidic chip
- centrifugal microfluidic
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- 238000001514 detection method Methods 0.000 claims abstract description 26
- 238000001914 filtration Methods 0.000 claims abstract description 19
- 239000012528 membrane Substances 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 description 18
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 206010063385 Intellectualisation Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- -1 electronics Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005459 micromachining Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The utility model relates to a centrifugal microfluidic chip, which comprises a disc, wherein a sample adding port for adding a sample to be detected is formed in the disc, a plurality of sample flow channels communicated with the sample adding port are also formed in the disc, filtering detection areas are formed in the ends, deviating from the sample adding port, of the sample flow channels, filter membranes are arranged between the filtering detection areas, a group of filtering detection areas are correspondingly arranged in each sample flow channel, even numbers of sample flow channels are arranged, the sample adding port is arranged at the center point of the disc, and the sample flow channels are symmetrically arranged with the sample adding port; a stopper is disposed in the sample flow channel.
Description
Technical Field
The utility model relates to a microfluidic chip, in particular to a centrifugal microfluidic chip.
Background
The microfluidic chip technology integrates basic operation units of sample preparation, reaction, separation, detection and the like in biological, chemical and medical analysis processes onto a micron-scale chip, and automatically completes the whole analysis process. Because of its great potential in biological, chemical, medical and other fields, it has been developed into a new research field where the disciplines of biology, chemistry, medicine, fluids, electronics, materials, machinery and the like are crossed. The micro-fluidic chip technology provides a plurality of realization platforms for single-molecule nucleic acid detection methods, and the analysis operation of biochemical samples is integrated on a micro-fluidic chip of several square centimeters through a micro-machining technology.
The centrifugal microfluidic chip with a tiny volume is used, and the centrifugal force generated by the motor rotating the disc-shaped chip is used for processing the fluid, so that the analysis cost is greatly reduced, the detection time is short, the sensitivity is high, the carrying is convenient, and the biochemical analysis instrument is led to develop to intellectualization and micromation. Centrifugal microfluidic chips often acquire different centrifugal forces by adjusting centrifugal speed, thereby controlling the movement of liquid on the chip; in the use process of the centrifugal microfluidic chip, the contents of components in the liquid to be detected are more, and in the centrifugation process, the mass of the substances of the micro components is different, the centrifugal force is different in the centrifugation process, and when the centrifugal microfluidic chip reaches a specified detection position, the contents of the components in the liquid to be detected are possibly different from the initial position.
Disclosure of Invention
The utility model aims to provide a centrifugal microfluidic chip.
The technical aim of the utility model is realized by the following technical scheme: the centrifugal microfluidic chip comprises a disc, wherein a sample adding port for adding a sample to be detected is formed in the disc, a plurality of sample flow channels communicated with the sample adding port are further formed in the disc, filtering detection areas are formed in the ends, deviating from the sample adding port, of the sample flow channels, filtering membranes are arranged between the filtering detection areas, a group of filtering detection areas are correspondingly arranged in each sample flow channel, an even number of sample flow channels are arranged, the sample adding port is formed in the center point of the disc, and the sample flow channels are symmetrically arranged in the center of the sample adding port; a stopper is disposed in the sample flow channel.
By adopting the technical scheme, the liquid to be detected is dripped from the sample adding port, the dripped liquid flows along the sample flow channel, then the liquid to be detected flows in the sample flow channel under the action of centrifugal force along with the rotation of the disc, and finally the effective sample components required by detection enter the filtering detection area through the filter membrane, and then the detection is completed; however, because the blood can generate layering trend under the centrifugal action, a stop block is arranged in the sample flow channel, and the setting of the stop block can improve the turbidity of the blood and other liquids to be detected, thereby effectively solving the technical problems in the background technology.
Preferably, the stop block array is provided with a plurality of stop blocks, and the cross section of each stop block is rectangular.
Preferably, the stopper is integrally formed with the sample flow channel.
By adopting the technical scheme, the situation that the liquid to be detected leaks at the joint and the like is avoided, so that the quantity of the liquid is damaged.
Preferably, the sample flow channel is recessed to form an arc groove at a position avoiding the stopper.
Preferably, the arc-shaped grooves are provided with a plurality of arc-shaped grooves.
Preferably, the arcuate slot and the stop are located at the same position in each of the sample flow channels.
By adopting the technical proposal, the structure and the quality of each sample flow channel are ensured to be uniform as far as possible, the risk of centrifugal disk production is avoided,
preferably, the sample injection device further comprises an abutting disc arranged at the sample injection port.
Preferably, the abutment disk is tapered upwardly at a position facing away from the disc.
By adopting the technical scheme, the added liquid drops at the conical sharp angle and then uniformly flows down along the conical arc.
In summary, the utility model has the following beneficial effects:
1. dripping liquid to be detected from a sample adding port, enabling the dripped liquid to flow along a sample flow channel, enabling the liquid to be detected to flow in the sample flow channel under the action of centrifugal force along with rotation of a disc, enabling effective sample components required by detection to enter a filtering detection area through a filter membrane, and then completing detection; however, because the blood can generate layering trend under the centrifugal action, a stop block is arranged in the sample flow channel, and the setting of the stop block can improve the turbidity of the blood and other liquids to be detected, thereby effectively solving the technical problems in the background technology.
Drawings
FIG. 1 is a schematic view of the overall structure in an embodiment;
FIG. 2 is a cross-sectional view of the overall structure in an embodiment;
fig. 3 is an enlarged schematic view of the part a of fig. 2.
In the figure, 1, a disc; 11. a sample adding port; 12. a sample flow channel; 121. a stop block; 122. an arc-shaped groove; 13. filtering the detection area; 14. abutting the disc.
Description of the embodiments
The present utility model will be described in further detail with reference to the accompanying drawings.
The present embodiment is only for explanation of the present utility model and is not to be construed as limiting the present utility model, and modifications to the present embodiment, which may not creatively contribute to the present utility model as required by those skilled in the art after reading the present specification, are all protected by patent laws within the scope of claims of the present utility model.
Examples
The centrifugal microfluidic chip comprises a disc 1, wherein a sample adding port 11 for adding a sample to be detected is formed in the disc 1, a plurality of sample flow channels 12 communicated with the sample adding port 11 are further formed in the disc 1, a filtering detection area 13 is formed in the end part, away from the sample adding port 11, of each sample flow channel 12, a filtering membrane is arranged between the filtering detection area 13 and the sample flow channel 12, a group of filtering detection areas 13 are correspondingly arranged in each sample flow channel 12, an even number of sample flow channels 12 are arranged, the sample adding port 11 is arranged at the center point of the disc 1, and the sample flow channels 12 are arranged in a central symmetry mode through the sample adding port 11; a stopper 121 is provided in the sample flow path 12.
As shown in fig. 2 and 3, a plurality of stoppers 121 are arranged in an array, and the cross section of each stopper 121 is rectangular.
As shown in fig. 2 and 3, the stopper 121 is integrally formed with the sample flow channel 12.
As shown in fig. 2 and 3, the sample flow channel 12 is recessed to form an arc groove 122 at a position avoiding the stopper 121.
As shown in fig. 2 and 3, the arc-shaped groove 122 is provided with a plurality of grooves.
As shown in fig. 2 and 3, the arcuate groove 122 and the stopper 121 are positioned identically in each of the sample flow channels 12.
As shown in fig. 2 and 3, the sample loading port 1 further includes an abutment plate 14.
As shown in fig. 2, the abutment disk 14 protrudes upward in a tapered shape at a position away from the disk 1.
Working principle:
dripping liquid to be detected from a sample adding port, enabling the dripped liquid to flow along a sample flow channel, enabling the liquid to be detected to flow in the sample flow channel under the action of centrifugal force along with rotation of a disc, enabling effective sample components required by detection to enter a filtering detection area through a filter membrane, and then completing detection; however, because the blood can generate layering trend under the centrifugal action, a stop block is arranged in the sample flow channel, and the setting of the stop block can improve the turbidity of the blood and other liquids to be detected, thereby effectively solving the technical problems in the background technology.
Claims (8)
1. A centrifugal microfluidic chip comprising a disc (1), characterized in that: the sample adding device comprises a disc (1), a plurality of sample adding ports (11) for adding samples to be detected are formed in the disc (1), a plurality of sample flow channels (12) communicated with the sample adding ports (11) are further formed in the disc (1), filtering detection areas (13) are formed in the ends, deviating from the sample adding ports (11), of the sample flow channels (12), filtering membranes are arranged between the filtering detection areas (13) and the sample flow channels (12), a group of filtering detection areas (13) are correspondingly arranged in each sample flow channel (12), an even number of sample flow channels (12) are arranged, the sample adding ports (11) are arranged at the center point of the disc (1), and the sample flow channels (12) are symmetrically arranged in the center of the sample adding ports (11); a stopper (121) is provided in the sample flow path (12).
2. The centrifugal microfluidic chip according to claim 1, wherein: the stop block (121) is arranged in an array, and the cross section of the stop block (121) is rectangular.
3. A centrifugal microfluidic chip according to claim 2, wherein: the block (121) and the sample flow channel (12) are integrally formed.
4. A centrifugal microfluidic chip according to claim 3, wherein: the sample flow channel (12) is recessed to form an arc groove (122) at a position avoiding the stop block (121).
5. The centrifugal microfluidic chip according to claim 4, wherein: the arc-shaped grooves (122) are arranged in a plurality of mode.
6. The centrifugal microfluidic chip according to claim 5, wherein: the arc-shaped groove (122) and the stop block (121) are positioned identically in each sample flow channel (12).
7. The centrifugal microfluidic chip according to claim 6, wherein: also comprises an abutting disc (14) arranged at the sample adding port (11).
8. The centrifugal microfluidic chip according to claim 7, wherein: the abutment disk (14) protrudes upwards in a conical shape at a position facing away from the disk (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321497200.3U CN220194887U (en) | 2023-06-13 | 2023-06-13 | Centrifugal micro-fluidic chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321497200.3U CN220194887U (en) | 2023-06-13 | 2023-06-13 | Centrifugal micro-fluidic chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220194887U true CN220194887U (en) | 2023-12-19 |
Family
ID=89140532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321497200.3U Active CN220194887U (en) | 2023-06-13 | 2023-06-13 | Centrifugal micro-fluidic chip |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220194887U (en) |
-
2023
- 2023-06-13 CN CN202321497200.3U patent/CN220194887U/en active Active
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