CN210510505U - Siphon valve device, microfluidic structure and analysis device - Google Patents
Siphon valve device, microfluidic structure and analysis device Download PDFInfo
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- CN210510505U CN210510505U CN201921254855.1U CN201921254855U CN210510505U CN 210510505 U CN210510505 U CN 210510505U CN 201921254855 U CN201921254855 U CN 201921254855U CN 210510505 U CN210510505 U CN 210510505U
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Abstract
The present application relates to a siphon valve apparatus, a microfluidic structure and an analysis apparatus, wherein the siphon valve apparatus comprises a hydrophobic inner wall portion; and a hydrophilic film layer is arranged on the hydrophobic inner wall part. The siphon valve device has the advantage of simple realization, and compared with the traditional siphon valve, the siphon valve device greatly reduces the complexity of the manufacturing process of the siphon valve, ensures that the process of the siphon valve is simpler to realize, and can better ensure the consistency of the siphon valve; compared with the traditional hydrophilic treatment method of the siphon valve, the method also has the advantages of strong reliability and high repeatability, ensures the long-term stability of the centrifugal microfluidic function, and also ensures the reliability of the function of the siphon valve in a microfluidic structure such as a centrifugal microfluidic chip and high repeatability in the quality control process in medical detection.
Description
Technical Field
The present application relates to the field of centrifugal microfluidics, and in particular to siphon valve devices, microfluidic structures and analytical devices.
Background
Microfluidics (Microfluidics) refers to the manipulation of liquids on a sub-millimeter scale. It integrates the basic operation units related to the biological and chemical fields, even the functions of the whole laboratory, including sampling, diluting, reacting, separating, detecting, etc. on a small Chip, so it is also called Lab-on-a-Chip. The chip generally comprises various liquid storage tanks and a micro-channel network which is connected with each other, can greatly shorten the sample processing time, and realizes the maximum utilization efficiency of reagent consumables by precisely controlling the liquid flow. The micro-fluidic provides a very wide prospect for the application in numerous fields such as biomedical research, drug synthesis screening, environmental monitoring and protection, health quarantine, judicial identification, biological reagent detection and the like. In particular, microfluidics is widely used in Point-of-care testing (POCT) because it can meet the demand of small-sized Point-of-care testing (POCT). In the industry, microfluidics is generally classified into the following types: pressure (pneumatic or hydraulic) driven microfluidics, centrifugal microfluidics, droplet microfluidics, digital microfluidics, paper microfluidics, and the like.
Microfluidic systems refer to devices that manipulate liquids on a sub-millimeter scale (typically a few microns to hundreds of microns). Centrifugal microfluidics belongs to a branch of microfluidics, and particularly relates to the use of centrifugal force to control the flow of liquid on a sub-millimeter scale by rotating a centrifugal microfluidic chip. It integrates the basic operation units involved in the fields of biology and chemistry on a small disc-shaped (disc-shaped) chip. In addition to the advantages specific to microfluidics, the overall device is more compact since only one motor is required for centrifugal microfluidics to provide the force required for liquid manipulation. And the ubiquitous centrifugal field on the disc chip can not only make liquid drive more effective and ensure that no liquid remains in the pipeline, but also can effectively realize sample separation based on density difference and make parallel processing simpler. Therefore, centrifugal microfluidics is also increasingly used in point-of-care diagnostics.
At present, the polymer materials are the commonly adopted microfluidic chip processing materials such as PC, PMMA and the like. The processing methods generally adopted by the microfluidic chip made of the polymeric material include hot pressing, laser processing and the like.
Siphon valves are passive valves commonly used in centrifugal microfluidics. Siphon valves are key functional structures on centrifugal microfluidic chips, mainly used for sequential dispensing loading of liquids in the chip and separation of samples. The principle behind siphon valves is based on the equilibrium of capillary and centrifugal forces. The loading process of the siphon valve comprises the following steps: firstly, when the centrifugal force is small, such as low-speed centrifugation, or when the centrifugal force is not available, such as the micro-fluidic chip stops rotating, liquid in the chamber is drawn by capillary force to submerge the highest position of the siphon pipeline, namely the position closest to the center of the centrifugal circle, until the siphon pipeline is filled with the liquid; then the centrifugal speed is increased, under the action of centrifugal force, siphon flow occurs in the siphon pipeline, and all liquid flows into the rear chamber, so that the sequential distribution of liquid or the separation of samples is completed. Capillary flow is therefore an essential prerequisite for liquid operation of a siphon valve. On the polymer microfluidic chip, due to the hydrophobicity of the surface of the polymer material, the capillary force in the siphon pipeline is smaller, and hydrophilic treatment is often needed to increase the capillary force of the pipeline, namely the pipeline of the siphon valve needs hydrophilic treatment. Common hydrophilic treatment methods mainly include ion beam irradiation, plasma treatment (plasma), and chemical treatment methods. However, the methods of ion radiation and plasma treatment make it difficult to maintain the hydrophilicity of the surface of the polymer material for a long time, and thus it is difficult to ensure the long-term effectiveness of the experimental chip; the chemical method for treating the surface of the polymer material needs high-temperature heating to cure the chemical coating, which increases the difficulties in the aspects of chip processing technology, surface treatment, long-term storage and the like and also increases the production cost of the chip; and the hydrophilic treated siphon valve is often difficult to ensure repeatability and reliability.
SUMMERY OF THE UTILITY MODEL
In view of the above, there is a need for a microfluidic structure and an analysis device.
A siphon valve apparatus comprising a hydrophobic inner wall portion; and a hydrophilic film layer is arranged on the hydrophobic inner wall part.
The siphon valve device has the advantage of simple realization, and compared with the traditional siphon valve, the siphon valve device greatly reduces the complexity of the manufacturing process of the siphon valve, ensures that the process of the siphon valve is simpler to realize, and can better ensure the consistency of the siphon valve; compared with the traditional hydrophilic treatment method of the siphon valve, the method also has the advantages of strong reliability and high repeatability, ensures the long-term stability of the centrifugal microfluidic function, and also ensures the reliability of the function of the siphon valve in a microfluidic structure such as a centrifugal microfluidic chip and high repeatability in the quality control process in medical detection.
In one embodiment, the hydrophilic film layer is arranged at the position of the hydrophobic inner wall part except the descending section.
In one embodiment, the hydrophilic film layer is disposed along an extending direction of the hydrophobic inner wall portion.
In one embodiment, a plurality of hydrophilic film layers are arranged at intervals.
In one embodiment, the hydrophobic inner wall portion has a groove along an extending direction thereof, and the hydrophilic film layer is disposed in the groove.
In one embodiment, the depth of the groove is equal to the thickness of the hydrophilic film layer; or the depth of the groove is equal to the sum of the thicknesses of the hydrophilic film layer and the adhesive thereof; or the hydrophilic film layer is flush with the top of the groove.
In one embodiment, the inner wall portion of the water-repellent wall is provided with the groove entirely or at a position other than the descending section.
In one embodiment, the hydrophilic film layer is disposed on the hydrophobic inner wall portion for being close to the ground.
In one embodiment, the hydrophilic film layer is disposed on the hydrophobic inner wall portion by hydraulic pressure, ultrasonic welding or gluing.
In one embodiment, the hydrophilic film layer is attached to the hydrophobic inner wall portion and is disposed in close contact with a position where the hydrophilic film layer contacts the hydrophobic inner wall portion.
A microfluidic structure comprising any of the siphon valve apparatus.
An assay device comprising any one of the microfluidic structures.
Drawings
Fig. 1 is a schematic structural diagram of an embodiment of a siphon valve apparatus according to the present application.
Fig. 2 is a schematic external view of the embodiment shown in fig. 1.
FIG. 3 is a schematic view of the hydrophilic film layer of the embodiment shown in FIG. 1.
Fig. 4 is a schematic view of an embodiment of a microfluidic structure according to the present application.
Fig. 5 is another schematic view of the embodiment shown in fig. 4.
Fig. 6 is a schematic view of another embodiment of a microfluidic structure according to the present application.
Fig. 7 is an enlarged schematic view of the embodiment shown in fig. 6 at a.
FIG. 8 is a schematic diagram of the embodiment of FIG. 7 with the hydrophilic film layer removed.
Fig. 9 is a schematic view of another embodiment of a microfluidic structure according to the present application.
Fig. 10 is an enlarged schematic view of the embodiment shown in fig. 9 at B.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present application more comprehensible, embodiments accompanying the present application are described in detail below with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application. This application is capable of embodiments in many different forms than those described herein and that modifications may be made by one skilled in the art without departing from the spirit and scope of the application and it is therefore not intended to be limited to the specific embodiments disclosed below.
It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only and do not represent the only embodiments.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the description of the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The present application replaces the hydrophilic treatment of traditional siphon tubing with a form of hydrophilic membrane sealing the bottom of the siphon tubing. The method has simple realization process, greatly reduces the complexity of the manufacturing process of the siphon valve compared with the existing method, and can better ensure the consistency of the siphon valve. The siphon valve device and the microfluidic structure obtained by the method have high reliability, and long-term stability of functions of the chip is ensured. The siphon valve device and the microfluidic structure obtained by the method have high repeatability, and the high repeatability of the chip in the quality control process is ensured. The concrete description is as follows. In one embodiment of the present application, a siphon valve apparatus includes a hydrophobic inner wall portion; and a hydrophilic film layer is arranged on the hydrophobic inner wall part. The siphon valve device has the advantage of simple realization, and compared with the traditional siphon valve, the siphon valve device greatly reduces the complexity of the manufacturing process of the siphon valve, ensures that the process of the siphon valve is simpler to realize, and can better ensure the consistency of the siphon valve; compared with the traditional hydrophilic treatment method of the siphon valve, the method also has the advantages of strong reliability and high repeatability, ensures the long-term stability of the centrifugal microfluidic function, and also ensures the reliability of the function of the siphon valve in a microfluidic structure such as a centrifugal microfluidic chip and high repeatability in the quality control process in medical detection.
In one embodiment, a siphon valve device comprises a part of or the whole structure of the following embodiments; that is, the siphon valve apparatus includes some or all of the following features.
In one embodiment, the hydrophilic film layer is arranged at the position of the hydrophobic inner wall part except the descending section. The siphon valve device is generally provided with a liquid inlet section, an ascending section, a transition section and a descending section; in one embodiment, the siphon valve device is provided with the hydrophilic membrane layer on the hydrophobic inner wall parts of the liquid inlet section, the ascending section and the transition section of the siphon valve device; that is, the siphon valve device is provided with the hydrophilic film layer at the positions of the liquid inlet section, the ascending section and the transition section of the hydrophobic inner wall part of the siphon valve device. Further, in one embodiment, the siphon valve device is provided with the hydrophilic membrane layer on the inner hydrophobic wall parts of the liquid inlet section and the rising section of the siphon valve device. The design is favorable for improving the siphon capacity of the siphon valve while realizing the siphon valve, ensures the realization of the siphon effect, reduces the complexity of the manufacturing process of the siphon valve compared with the traditional siphon valve, has the advantages of strong reliability and high repeatability, and ensures the long-term stability of the centrifugal microfluidic function.
In order to ensure that a siphon effect is achieved, in one embodiment the hydrophilic membrane layer is arranged along the extension of the hydrophobic inner wall portion. The design is beneficial to enabling the liquid reagent to flow along the siphon valve under the siphon action, so that the process of the siphon valve is simpler to realize, the consistency of the liquid reagent can be ensured, and the reliability of the function of the siphon valve in a microfluidic structure such as a centrifugal microfluidic chip in medical detection and the high repeatability in the quality control process are ensured.
In one embodiment, the hydrophilic membrane layer completely covers the hydrophobic inner wall portion. In one embodiment, the hydrophilic membrane layer partially covers the hydrophobic inner wall portion. In one embodiment, a plurality of hydrophilic film layers are arranged at intervals. That is, the hydrophilic rete is the bar and quantity is many, each hydrophilic rete interval sets up. Further, in one embodiment, each hydrophilic film layer is arranged at intervals along the extending direction of the hydrophobic inner wall part. In one embodiment, the hydrophilic film layer is disposed on the hydrophobic inner wall portion by hydraulic pressure, ultrasonic welding or gluing. By the design, the siphon suction force can be flexibly adjusted according to requirements to a certain extent, the moderation of the siphon action is ensured, and the over-strong siphon action is avoided.
In one embodiment, the hydrophobic inner wall portion has a groove along an extending direction thereof, and the hydrophilic film layer is disposed in the groove. Further, in one embodiment, the depth of the groove is equal to the thickness of the hydrophilic film layer. Alternatively, in one embodiment, the depth of the groove is equal to the sum of the thicknesses of the hydrophilic film layer and the adhesive thereof. Alternatively, in one embodiment, the hydrophilic film layer is flush with the top of the recess. Due to the design, the hydrophilic film layer is flush with the hydrophobic inner wall part, and the siphon effect is prevented from being influenced due to the fact that the shape of the bench part is generated.
In one embodiment, the inner wall portion of the water-repellent wall is provided with the groove entirely or at a position other than the descending section. In one embodiment, the hydrophilic film layer is disposed on the hydrophobic inner wall portion for being close to the ground. By adopting the design, the using amount of the hydrophilic film layer can be reduced to a certain extent. In one embodiment, the hydrophilic membrane layer is glued to the hydrophobic inner wall portion. In one embodiment, the hydrophilic film layer is attached to the hydrophobic inner wall portion. In one embodiment, the hydrophilic membrane layer is disposed in close contact with the hydrophobic inner wall portion at a location where it contacts. In one embodiment, the hydrophilic film layer is attached to the hydrophobic inner wall portion and is disposed in close contact with a position where the hydrophilic film layer contacts the hydrophobic inner wall portion.
In one embodiment, a siphon valve apparatus is shown in fig. 1 and 2, the siphon valve apparatus having a liquid inlet section 410, an ascending section 420, a transition section 430 and a descending section 440; the liquid inlet 450 is provided at one end of the liquid inlet section 410, the liquid outlet 460 is provided at one end of the liquid outlet section 440, the hydrophobic inner wall portion of the siphon valve device is provided with a groove 700 along the extending direction thereof, and the hydrophilic film 600 is disposed in the groove 700. In one embodiment, the hydrophilic membrane layer is arranged to fit into the recess or the hydrophobic inner wall portion. In one embodiment, the groove is adapted to the siphon valve means or the hydrophobic inner wall portion. In one embodiment, the hydrophilic film is as shown in fig. 3, the hydrophilic film 600 is adapted to the siphon valve device or groove 700, the hydrophilic film 600 is provided with a liquid inlet area 610, an ascending area 620, a transition area 630 and a descending area 640; wherein the inlet region 610 is adapted to the inlet section 410, the rising region 620 is adapted to the rising section 420, the transition region 630 is adapted to the transition section 430, and the falling region 640 is adapted to the falling section 440.
In one embodiment, a microfluidic structure comprises the siphon valve apparatus of any one of the embodiments. In one embodiment, an assay device comprises the microfluidic structure of any of the embodiments.
In one embodiment, the microfluidic structure is shown in fig. 4, and includes a body 999, the body 999 having a center of rotation 888; the body 999 has a liquid inlet 100, a first chamber 200, a second chamber 300, a siphon tube 400 and a third chamber 500 formed therein, and the siphon tube 400 forms a siphon valve, and is referred to as a siphon valve device 400. The liquid injection hole 100 is communicated with the first chamber 200, the liquid injection hole 100 is positioned at the position of the first chamber 200 close to the rotation center 888, the first chamber 200 is communicated with the second chamber 300 through the communication pipeline 210, and the second chamber 300 is communicated with the third chamber 500 through the siphon valve device 400; the second chamber 300 communicates with the inlet section 410 of the siphon valve apparatus 400 at the second communication port 320; the third chamber 500 communicates with the drop leg 440 of the siphon valve apparatus 400 at the fourth communication port 520. The second chamber 300 is provided with a second through hole 310 communicating with the external environment at a position close to the rotation center 888; the third chamber 500 is provided with a fourth through hole 510 at a position close to the rotation center 888 for communicating with the external environment. The second communication port 320 is provided to be enlarged toward one end of the second chamber 300, and the fourth communication port 520 is provided to be enlarged toward one end of the third chamber 500. As shown in fig. 5, the pour hole 100, the second through-hole 310, and the fourth through-hole 510 are provided through the main body 999. In this embodiment, the inner wall of the siphon valve apparatus 400, which is the corresponding position of the body 999, i.e. the inner wall of the siphon valve apparatus 400, which is the hydrophobic wall, is a part of the body 999; it is also understood that the siphon valve assembly 400 opens into the body 999, the body 999 being generally made of a polymeric material that is generally hydrophobic, the hydrophobic inner wall portion being a portion of the body 999; and a hydrophilic film layer is arranged on the hydrophobic inner wall part.
In one embodiment, the microfluidic structure is shown in fig. 6, and referring to fig. 7, a groove 700 is formed along the extending direction of the hydrophobic inner wall portion of the siphon valve apparatus 400, and the hydrophilic film 600 is disposed in the groove 700. Referring also to fig. 8, the siphon valve assembly 400 is thicker than the embodiment shown in fig. 4 due to the groove 700. In one embodiment, the liquid reagent is injected into the first chamber 200 through the liquid injection hole 100, the liquid in the first chamber 200 flows into the second chamber 300 under the condition of high-speed centrifugation, when the capillary force is greater than the centrifugal force, the liquid flows into the siphon valve device 400 under the action of capillary force traction, and when the liquid level in the siphon valve device 400, i.e. the siphon pipe, is kept at the same level as the liquid level in the second chamber 300, the capillary force and the centrifugal force in the siphon pipe are the same. However, on a microfluidic chip of polymeric material, the capillary forces within the channels are small due to the hydrophobic nature of the polymeric material surface. In order to increase the capillary force in the pipeline, the traditional technology generally treats the surface of the polymer material by a hydrophilic treatment method; the hydrophilic membrane layer is adopted in the embodiments of the application to replace the common hydrophilic treatment method. The hydrophilic film of the hydrophilic film layer can adopt MH 90368; the hydrophilic film may be cut to the shape shown in fig. 3 by methods including, but not limited to, laser cutting or die cutting. The siphon tube design is increased by the shape of the groove 700 shown in fig. 1, the width of the groove 700 is slightly larger than the width of the conventional siphon valve device, i.e. the width of the conventional siphon tube, in one embodiment, the depth of the groove 700 is just the thickness of the hydrophilic film, which ensures that the hydrophilic film can seal the siphon tube, and prevents the gap between the hydrophilic film and the siphon tube from causing liquid leakage. And finally, the cut hydrophilic membrane is sealed and clamped in the groove 700, so that the cut hydrophilic membrane is just sealed at the bottom of the siphon pipeline, then the centrifugal microfluidic pipeline is sealed in a hydraulic, ultrasonic welding or gluing mode, and the like, the hydrophilic membrane and the siphon pipeline are compacted, seamless adhesion between the hydrophilic membrane and the siphon pipeline is ensured, and the liquid leakage phenomenon is prevented. After the siphon pipe is sealed by the hydrophilic film, the bottom of the siphon pipe has hydrophilicity. When the centrifugal force is small, such as low-speed centrifugation, or when the centrifugal force is not small, such as the microfluidic chip stops rotating, the capillary force is larger than the centrifugal force; the liquid in the chamber is drawn by capillary force over the uppermost part of the siphon valve assembly 400 to fill the siphon channel with liquid; subsequently, the centrifugal speed is increased, siphon flow in the siphon pipeline occurs under the action of centrifugal force, and liquid completely flows into the third chamber 500, so that the reliability of the function of the siphon valve in the centrifugal micro-fluidic system is ensured.
In one embodiment, the microfluidic structure is shown in FIG. 9, and referring to FIG. 10, the transition section 430 of the siphon valve assembly 400, i.e. the top of the siphon valve assembly 400 near the center of rotation 888, is located a smaller distance from the center of rotation 888 than the first chamber 200 or the injection hole 100 thereof.
In one embodiment of particular application, the separation of plasma from whole blood is the first step in many assay protocols and is of great interest in medical diagnostics. The plasma separation process must be seamlessly interfaced with subsequent testing steps to avoid human contamination. The centrifugal microfluidic chip is highly integrated, is used in the separation process of whole blood and plasma, and does not need artificial participation, thereby avoiding artificial pollution in the operation process. The whole blood separates plasma and blood cells under the condition of high-speed centrifugation, the plasma accounts for about 50% of the whole blood, the plasma is supernatant and the blood cells are sediment in the whole blood separating process. In order to separate the plasma from the blood cells, the microfluidic structure of this embodiment is as shown in fig. 9 and 10, and the liquid inlet section 410 of the siphon valve device 400 is disposed at the position of the connecting communication channel 210, so as to ensure that the blood cells are not mixed in the plasma separation process, thereby ensuring the purity of the separated plasma.
In a specific implementation, the hydrophilic film is cut into the same shape as the groove 700 of the siphon valve apparatus 400, and then the cut hydrophilic film is attached to the groove 700 to form the hydrophilic film layer 600, so that the siphon valve apparatus 400 has hydrophilicity.
Then, the whole blood sample is added into the first chamber 200 through the injection hole 100 and flows into the second chamber 300, and is centrifuged at 3000rpm for 5min to separate plasma and blood cells in the whole blood. Wherein plasma is located in the upper half of the second chamber 300 and blood cells are located as sediment in the lower half of the second chamber 300. The volume of the whole blood sample is greater than the volume of the second chamber 300 and is designed as desired.
When the centrifugal rotation speed is reduced to 500rpm, the supernatant separated from the first chamber 200 and the second chamber 300 can submerge the highest point of the siphon pipeline formed by the supernatant along the siphon valve device 400 until the whole siphon pipeline is filled;
the centrifugal rotating speed is increased to 1500rpm, the plasma breaks through the siphon pipeline and enters the third chamber 500, the third chamber 500 is used as a collection chamber in the embodiment, the plasma is centrifuged at a high speed for 2min, and the separated plasma is enabled to completely flow into the third chamber 500, so that the separation process of the plasma from the whole blood is realized.
Other embodiments of the present application include a siphon valve device, a microfluidic structure, and an analysis device, which are formed by combining technical features of the above embodiments.
The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above examples only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the claims. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present application shall be subject to the appended claims.
Claims (10)
1. A siphon valve device, characterized in that it comprises a hydrophobic inner wall portion;
and a hydrophilic film layer is arranged on the hydrophobic inner wall part.
2. The siphon valve apparatus of claim 1, wherein the hydrophilic film layer is provided at a position of the hydrophobic inner wall portion other than the descender.
3. Siphon valve device according to claim 1, characterised in that the hydrophilic membrane layer is arranged along the extension of the hydrophobic inner wall portion.
4. A siphon valve device according to claim 3, characterised in that a plurality of said hydrophilic membrane layers are provided at intervals.
5. A siphon valve device according to claim 3, characterised in that the hydrophobic inner wall portion is provided with a groove along its extension, and the hydrophilic film layer is arranged in said groove.
6. A siphon valve device according to claim 5, characterised in that the depth of the groove is equal to the thickness of the hydrophilic membrane layer; or the depth of the groove is equal to the sum of the thicknesses of the hydrophilic film layer and the adhesive thereof; or the hydrophilic film layer is flush with the top of the groove; or the grooves are formed in all the inner wall part of the water drainage pipe, or the grooves are formed in other positions of the inner wall part of the water drainage pipe except the descending section.
7. The siphon valve apparatus of claim 1, wherein the hydrophilic film layer is disposed on the hydrophobic inner wall portion for being close to the ground, or the hydrophilic film layer is disposed on the hydrophobic inner wall portion by hydraulic pressure, ultrasonic welding or gluing.
8. The siphon valve apparatus of any of claims 1 to 7, wherein the hydrophilic film layer is attached to the hydrophobic inner wall portion and is disposed in close contact with the hydrophobic inner wall portion at a position where the hydrophilic film layer contacts the hydrophobic inner wall portion.
9. A microfluidic structure comprising a siphon valve apparatus according to any of claims 1 to 8.
10. An analytical device comprising the microfluidic structure of claim 9.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111644216A (en) * | 2020-08-06 | 2020-09-11 | 天津德祥生物技术有限公司 | Microfluidic structures for plasma separation and detection |
| CN113583839A (en) * | 2021-08-04 | 2021-11-02 | 苏州含光微纳科技有限公司 | Multi-axial micro-fluidic chip and processing method thereof |
| WO2022170930A1 (en) * | 2021-02-09 | 2022-08-18 | 深圳市亚辉龙生物科技股份有限公司 | Microfluidic chip |
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2019
- 2019-08-05 CN CN201921254855.1U patent/CN210510505U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111644216A (en) * | 2020-08-06 | 2020-09-11 | 天津德祥生物技术有限公司 | Microfluidic structures for plasma separation and detection |
| WO2022170930A1 (en) * | 2021-02-09 | 2022-08-18 | 深圳市亚辉龙生物科技股份有限公司 | Microfluidic chip |
| CN113583839A (en) * | 2021-08-04 | 2021-11-02 | 苏州含光微纳科技有限公司 | Multi-axial micro-fluidic chip and processing method thereof |
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Effective date of registration: 20220830 Address after: 518000 room 504, Block E, building 3, Yunzhi Science Park, south of Shuangming Avenue, Dongzhou community, Guangming Street, Guangming District, Shenzhen City, Guangdong Province Patentee after: Shenzhen Chenghui Medical Technology Co.,Ltd. Address before: 511-1, Shenzhen integrated circuit design and application Industrial Park, 1089 chaguang Road, Xili street, Nanshan District, Shenzhen, Guangdong 518051 Patentee before: SHENZHEN GANGZHU MEDICAL TECHNOLOGY Co.,Ltd. |