CN220158230U

CN220158230U - Intracranial pressure detection device and system

Info

Publication number: CN220158230U
Application number: CN202320725669.1U
Authority: CN
Inventors: 徐佳鸣; 陆海同
Original assignee: Hangzhou Sikang New Medical Technology Co ltd
Current assignee: Hangzhou Sikang New Medical Technology Co ltd
Priority date: 2023-03-30
Filing date: 2023-03-30
Publication date: 2023-12-12
Anticipated expiration: 2033-03-30

Abstract

The embodiment of the specification discloses an intracranial pressure detection device and system. The intracranial pressure detection device comprises an implantation probe and a signal relay, wherein the implantation probe is used for being implanted into the cranium of a target object to detect intracranial pressure; the implantation probe comprises at least two sensors which are sequentially arranged along the length extension direction of the implantation probe, wherein the sensors are used for detecting pressure data of different intracranial positions, and the pressure data comprise at least two of intra-ventricle pressure, intra-brain parenchyma pressure and subdural pressure; the signal relay is at least used for receiving the pressure data detected by the at least two sensors and forwarding the pressure data to processing equipment for processing.

Description

Intracranial pressure detection device and system

Technical Field

The present disclosure relates to the field of medical devices, and more particularly to an intracranial pressure detection device and system.

Background

Real-time monitoring of intracranial pressure is extremely important for understanding conditions within the brain, especially for unconscious patients. With the development of medical technology, intracranial pressure monitoring can be realized by placing an intracranial pressure probe, and the intracranial pressure probe is provided with a sensor, so that brain information can be obtained rapidly and acutely.

However, current pressure monitoring for different intracranial locations requires separate implementation using different modes of probe. When multiple positions are required to be monitored simultaneously, multiple probes are required to be placed, so that the operation is complex, and the brain injury of a human body is large.

Disclosure of Invention

One of the embodiments of the present specification provides an intracranial pressure detection device, comprising: an implantation probe for implantation within the cranium of a target subject to detect intracranial pressure; the implantation probe comprises at least two sensors which are sequentially arranged along the length extension direction of the implantation probe, wherein the sensors are used for detecting pressure data of different intracranial positions, and the pressure data comprise at least two of intra-ventricle pressure, intra-brain parenchyma pressure and subdural pressure; and the signal relay is at least used for receiving the pressure data detected by the at least two sensors and forwarding the pressure data to processing equipment for processing.

In some embodiments, the implantation probe is a tubular structure, at least two side openings are arranged on the wall of the tubular structure, and the at least two sensors are respectively and correspondingly arranged at the positions of the at least two side openings.

In some embodiments, at least a portion of the at least two side openings are helically arranged along a length extension of the implant probe.

In some embodiments, the at least two sensors include a first sensor, a second sensor, and a third sensor therein, and the at least two side openings include a first opening, a second opening, and a third opening therein; wherein the first sensor is used for detecting the intra-ventricular pressure, the second sensor is used for detecting the intra-brain parenchyma pressure, and the third sensor is used for detecting the subdural pressure; the first opening, the second opening and the third opening are sequentially distributed from the distal end of the implantation probe towards the proximal end of the implantation probe; the first sensor is arranged at the first opening, the second sensor is arranged at the second opening, the third sensor is arranged at the third opening, and the third sensor can extend out of the tubular structure through the third opening.

In some embodiments, the inner side of the third opening comprises a curved guiding structure for smoothly curving the third sensor relative to the tubular structure.

In some embodiments, the device further comprises a control structure connected to at least the third sensor of the at least two sensors for adjusting at least the position of the third sensor.

In some embodiments, the apparatus further comprises: at least one catheter for injecting a drug and/or draining cerebrospinal fluid; wherein the catheter comprises a control switch for controlling the on-off of the catheter, at least part of the catheter is accommodated in the tubular structure, and the catheter communicates the part to be tested with the injection inlet and/or the drainage outlet.

One of the embodiments of the present specification provides an intracranial pressure detection system, comprising: an intracranial pressure detection device, a processing device and a display device; the intracranial pressure detection device comprises: an implantation probe for implantation within the cranium of a target subject to detect intracranial pressure; the implantation probe comprises at least two sensors which are sequentially arranged along the length extension direction of the implantation probe, and the sensors are used for detecting pressure data of different intracranial positions; a signal relay for receiving at least the pressure data detected by the at least two sensors and forwarding the pressure data to a processing device; the processing equipment is at least used for receiving the pressure data and processing the pressure data to obtain target data; the display device is at least used for displaying the target data.

In some embodiments, the processing device is further to: when at least one of the pressure data is larger than a corresponding threshold parameter, generating a first reminding signal; and when at least one of the pressure data is smaller than the corresponding threshold parameter, generating a second reminding signal.

In some embodiments, the intracranial pressure detection device further comprises at least one catheter for injecting a drug and/or draining cerebrospinal fluid, the catheter comprising a control switch for controlling the on or off thereof; the processing device is also used for controlling the on or off of the control switch based on a preset threshold value and the pressure data forwarded by the signal repeater.

Additional features will be set forth in part in the description which follows, and in part will become apparent to those skilled in the art upon examination of the following and the accompanying drawings, or may be learned by the production or operation of the examples. The features of the present specification can be implemented and obtained by practicing or using the various aspects of the methods, tools, and combinations set forth in the detailed examples below.

Drawings

The present specification will be further elucidated by way of example embodiments, which will be described in detail by means of the accompanying drawings. The embodiments are not limiting, in which like numerals represent like structures, wherein:

FIG. 1 is a schematic illustration of an application scenario of an intracranial pressure detection system, according to some embodiments of the present description;

FIG. 2 is a schematic illustration of an exemplary configuration of an intracranial pressure detection device, as shown in accordance with some embodiments of the present disclosure;

FIG. 3 is a schematic illustration of an exemplary configuration of a tubular structure of an intracranial pressure detection device, according to some embodiments of the present disclosure;

FIG. 4 is a schematic view of an exemplary structure of a tubular structure of an intracranial pressure detection device, according to other embodiments of the present disclosure; and

FIG. 5 is a schematic view of an exemplary use scenario of an intracranial pressure detection device, according to some embodiments of the present description.

Detailed Description

In order to more clearly illustrate the technical solutions of the embodiments of the present specification, the drawings that are required to be used in the description of the embodiments will be briefly described below. It is apparent that the drawings in the following description are only some examples or embodiments of the present specification, and it is possible for those of ordinary skill in the art to apply the present specification to other similar situations according to the drawings without inventive effort. Unless otherwise apparent from the context of the language or otherwise specified, like reference numerals in the figures refer to like structures or operations.

It will be appreciated that "system," "apparatus," "unit" and/or "module" as used herein is one method for distinguishing between different components, elements, parts, portions or assemblies at different levels. However, if other words can achieve the same purpose, the words can be replaced by other expressions.

As used in this specification and the claims, the terms "a," "an," "the," and/or "the" are not specific to a singular, but may include a plurality, unless the context clearly dictates otherwise. In general, the terms "comprises" and "comprising" merely indicate that the steps and elements are explicitly identified, and they do not constitute an exclusive list, as other steps or elements may be included in a method or apparatus.

The intracranial space of human body is mainly divided into cranial cavity and the content of the cranial cavity. Wherein the cranial cavity is an invariable part, the content of the cranial cavity is a variable part, and the content of the cranial cavity mainly comprises: brain tissue (about 78%), blood (about 12%), cerebrospinal fluid (about 10%).

After the closing of the cranial suture of the adult, the volume of the cranial cavity is fixed and is about 1400ml-1500ml. The intracranial pressure in adults is generally 70-200mmH ₂ O, children are generally 50-100mmH ₂ O. The intracranial pressure is continuously 200mmH due to the increase of the content of the cranial cavity or the narrow cranial cavity ₂ O (15 mmHg) or more is called intracranial pressure increase (Increased Intracranial Pressure). Possible reasons for this include: (1) Increased cranial cavity contents, such as increased brain volume (cerebral edema), increased blood (vasodilation), increased cerebrospinal fluid (hydrocephalus); (2) Intracranial space occupying lesions such as brain tumor, intracranial hemorrhage, brain abscess, etc.

Real-time monitoring of intracranial pressure is extremely important for understanding conditions within the brain, especially for unconscious patients. In some embodiments, intracranial pressure monitoring can be achieved by placing an implanted probe. The sensor is arranged on the implantation probe, so that brain information can be obtained rapidly and sharply.

In some embodiments, specific procedures for intracranial pressure detection may include:

(1) A safe location for the entry of the implanted probe is marked in the brain of the patient. For example, a location to the right of the patient's brain and away from the brain centerline may be determined as a safe location to avoid controlling the brain function parts of the contralateral arms and legs, as well as avoiding damaging any major drainage veins of the brain.

(2) Making a small incision on the skin of the marked safety position, wherein the size of the small incision is close to that of a self-tapping bolt to be inserted;

(3) Drilling a small hole on the skull by using the skull drill to a proper depth to be used as a hole for screwing in a self-tapping bolt;

(4) The dura mater (a thick, membranous structure covering the surface of the brain) is pierced to implant the probe into the brain. The bolt is then screwed into the dura mater, and the implanted probe is pierced into the brain (typically about 20 mm deep);

(5) The implanted probe is fixed by using a locking nut (generally made of plastic) so as to avoid the implanted probe from sliding in and out. The probe wire can be sutured and fixed on the brain skin, so that the probe wire can be prevented from being pulled out. The other end of the implanted probe is connected to a monitor, and the pressure value is monitored and displayed in real time.

Currently, implanted probes for intracranial pressure detection generally include three modes of operation: 1. monitoring the intra-ventricular pressure; 2. monitoring pressure in brain parenchyma; 3. and monitoring the subdural pressure. In some embodiments, when simultaneous pressure monitoring of multiple locations is desired, multiple implanted probes may be placed simultaneously within the patient's cranium to simultaneously monitor pressure at different locations.

Since the manner of simultaneously placing a plurality of implanted probes in the cranium of a patient is considered to be complex in operation and has great damage to the brain of a human body, in some embodiments of the present specification, an array type intracranial pressure detecting device is provided, and pressure at different positions in the cranium is monitored simultaneously by arranging a plurality of sensors at different positions of the implanted probes, so as to make up for the defects.

The intracranial pressure detection device and system provided in the embodiments of the present specification are described in detail below with reference to the drawings.

FIG. 1 is a schematic illustration of an application scenario of an intracranial pressure detection system according to some embodiments of the present description.

Referring to fig. 1, an intracranial pressure detection system 100 can include an intracranial pressure detection device 110, a processing device 120, a display device 130, a network 140, and a terminal device 150. The various components of the intracranial pressure detection system 100 can be connected in a variety of ways. For example, the intracranial pressure detection device 110 may be connected to the processing apparatus 120 and/or the display device 130 via the network 140, or may be directly connected to the processing apparatus 120 and/or the display device 130. For another example, the display device 130 may be directly connected to the processing apparatus 120 or connected through the network 140. For another example, terminal device 150 may be coupled to processing device 120 and/or display device 130 via network 140, or may be coupled directly to intracranial pressure detection device 110 via network 140.

In the intracranial pressure detection system 100 provided in the present specification, the intracranial pressure detection device 110 can be used to detect intracranial pressure on a target object (e.g., a patient), such as for example, detection of intra-ventricular pressure, intra-brain parenchymal pressure, and subdural pressure. Referring to fig. 1, in some embodiments, an intracranial pressure detection device 110 can include an implanted probe 111 and a signal repeater 112. In some embodiments, the implant probe 111 may include one or more sensors (not shown in fig. 1). The one or more sensors may be used to implant into a cranial cavity of a patient to detect intracranial pressure therein, resulting in one or more intracranial pressure data such as intra-ventricular pressure, intra-brain parenchymal pressure, and subdural pressure. The signal relay 112 may be configured to receive pressure data detected by the one or more sensors and forward the pressure data to the processing device 120 and/or the display 130. In some embodiments, the intracranial pressure detection device 110 can have a separate power source, with the signal relay 112 sending data acquired by the implanted probe 111 to other components in the intracranial pressure detection system 100 (e.g., the processing device 120, the display device 130, the terminal device 150) via wired or wireless (e.g., bluetooth, wiFi, etc.).

In some embodiments, the processing device 120 may be used to process data acquired by the intracranial pressure detection apparatus 110, such as a/D conversion, noise reduction, and data evaluation, prediction, and the like. In some embodiments, the data processed by the processing device 120 may be sent to the display apparatus 130 for output, or sent to the terminal device 150 for feedback to the user. In some embodiments, the processing device 120 may generate corresponding alert signals or alarm information based on data collected by the intracranial pressure detection apparatus 110. In some embodiments, the processing device 120 may be implemented on a cloud platform. For example, the cloud platform may include a private cloud, a public cloud, a hybrid cloud, a community cloud, a distributed cloud, an inter-cloud, a multi-cloud, and the like, or any combination thereof.

In some embodiments, the intracranial pressure detection system 100 can further include a storage device (not shown in FIG. 1) that can be used to store data collected by the intracranial pressure detection device 110 and/or processed by the processing device 120. In some embodiments, the aforementioned storage device may include mass memory, removable memory, volatile read-write memory, read-only memory (ROM), and the like, or any combination thereof. Exemplary mass storage devices may include magnetic disks, optical disks, solid state disks, and the like. In some embodiments, the storage may be implemented on a cloud platform.

The display device 130 may output intracranial pressure data, such as intra-ventricular pressure, intra-brain parenchymal pressure, and subdural pressure, acquired by the intracranial pressure detection device 110. In some embodiments, the display device 130 may be integrated with the processing apparatus 120 described above. In some embodiments, the display device 130 may output a reminder or alarm message generated by the processing apparatus 120 based on the data acquired by the intracranial pressure detection device 110. In some embodiments, the display device 130 may include an audio output device, such as a speaker, etc., and the alert signal or alarm information may be output by any one of a signal, a light signal, or an image display, or a combination thereof.

The network 140 may facilitate the exchange of information and/or data. Network 140 may include any suitable network capable of facilitating the exchange of information and/or data by system 100. In some embodiments, at least one component of the intracranial pressure detection system 100 (e.g., the intracranial pressure detection device 110, the processing apparatus 120, the display device 130, the terminal device 150) can exchange information and/or data with at least one other component of the intracranial pressure detection system 100 via the network 140. For example, the processing device 120 may obtain data from the intracranial pressure detection apparatus 110 and/or a storage device via the network 140. As another example, processing device 120 may obtain user operational instructions from terminal device 150 over network 140, and exemplary operational instructions may include, but are not limited to, synchronizing patient information, setting parameter alarm thresholds, and the like.

In some embodiments, network 140 may be any form of wired or wireless network, or any combination thereof. By way of example only, the network 140 may include a cable network, a wired network, a fiber optic network, a telecommunications network, an intranet, the internet, a Local Area Network (LAN), a Wide Area Network (WAN), a Wireless Local Area Network (WLAN), a Metropolitan Area Network (MAN), a Public Switched Telephone Network (PSTN), a bluetooth network, a ZigBee network, a Near Field Communication (NFC) network, or the like, or any combination thereof. In some embodiments, network 140 may include at least one network access point. For example, the network 140 may include wired and/or wireless network access points, such as base stations and/or internet switching points, through which at least one component of the intracranial pressure detection system 100 may connect to the network 140 to exchange data and/or information.

Terminal device 150 may receive, transmit, and/or display data. The received data may include data collected by the intracranial pressure detection device 110, data stored by a storage device, data generated after processing by the processing device 120, and so forth. For example, the data received and/or displayed by terminal device 150 may include data collected by intracranial pressure detection device 110, data evaluation results determined by processing device 120 based on the collected data, and the like. The transmitted data may include input data and instructions of a user (e.g., patient family, nurse, attending physician, etc.), etc. For example, the terminal device 150 may send an operation instruction input by the user to the intracranial pressure detecting device 110 through the network 140, so as to control the intracranial pressure detecting device 110 to perform corresponding data acquisition. As another example, terminal device 150 may send user-entered evaluation instructions to processing device 120 over network 140.

In some embodiments, terminal device 150 may include a mobile device 151, a tablet computer 152, a laptop computer 153, etc., or any combination thereof. For example, the mobile device 151 may include a mobile phone, a Personal Digital Assistant (PDA), a medical grade mobile terminal, or the like, or any combination thereof. In some embodiments, terminal device 150 may include input devices (e.g., keyboard, touch screen), output devices (e.g., display, speaker), etc. In some embodiments, processing device 120 may be part of terminal device 150.

It should be noted that the above description of the intracranial pressure detection system 100 is for illustration and description only, and is not intended to limit the scope of applicability of the present description. Various modifications and variations of the intracranial pressure detection system 100 are possible to those skilled in the art under the guidance of the present specification. However, such modifications and variations are still within the scope of the present description. For example, the intracranial pressure detection device 110 can include more or fewer functional components.

FIG. 2 is a schematic diagram of an exemplary configuration of an intracranial pressure detection device, according to some embodiments of the present disclosure.

Referring to fig. 2, in some embodiments, an intracranial pressure detection device 110 can include an implanted probe 111 and a signal relay 112. Wherein the implantation probe 111 may be used to implant the intracranial space of a target object (e.g., a patient) for intracranial pressure detection thereof. In some embodiments, two or more sensors (not shown in fig. 2) may be included on the implant probe 111. The two or more sensors may be sequentially disposed along a length extension direction (e.g., Y direction in fig. 2) of the implantation probe 111 for detecting pressure data at different intracranial positions (different depths) of the target object. In some embodiments, the sensor may be a MEMS (Microelectro Mechanical Systems, microelectromechanical system) sensor, and exemplary sensor types may include any one or more of piezoresistive (e.g., silicon piezoresistive pressure sensor), electromagnetic, capacitive, piezoelectric, etc. sensors.

In some embodiments, the pressure data detected by the two or more sensors on the implanted probe 111 may include at least two of intra-ventricular pressure, intra-brain parenchymal pressure, and subdural pressure. Illustratively, the pressure data may include intra-ventricular pressure and subdural pressure; or the pressure data includes intra-ventricular pressure and intra-brain parenchymal pressure; or the pressure data includes both the aforementioned intra-ventricular pressure, intra-brain parenchymal pressure, and subdural pressure.

The signal relay 112 may be used to receive pressure data detected by two or more of the aforementioned sensors. In some embodiments, the signal repeater 112 may be connected to the two or more sensors via a signal transmission line (not shown in FIG. 2). Further, the signal relay 112 may forward the pressure data it receives to a processing device (e.g., processing device 120 in fig. 1), and then further data processing is performed by the processing device. In some embodiments, the signal relay 112 may forward the pressure data it receives to the processing device via wired and/or wireless means. In some embodiments, the signal repeater 112 may include a communication interface to connect with a processing device through the communication interface and a communication cable.

Referring to fig. 2, in some embodiments, a signal repeater 112 may be disposed at the proximal end of the implant probe 111. It should be noted that, in this specification, the proximal end of the implantation probe 111 may refer to an end thereof that does not need to enter the cranium of a patient during application, or an end thereof that is closer to an operator (e.g., doctor or nurse) during application, such as the upper end in fig. 2.

In some embodiments, the implant probe 111 may be a tubular structure including two or more side openings 113 in the wall of the tubular structure. In some embodiments, the two or more sensors may be disposed at positions corresponding to the two or more side openings 113, respectively.

In some embodiments, the tubular structure may be made of a flexible material in order to avoid unnecessary trauma to the patient during the implantation of the implant probe 111 within the cranium. Illustratively, the flexible material may include any one or combination of polyamide, polyethylene, polypropylene, polyvinyl chloride, polyurethane, silicone rubber, and the like. It should be noted that the above materials are only exemplary, and in the embodiments of the present disclosure, the tubular structure may be made of, but not limited to, the foregoing materials.

FIG. 3 is a schematic illustration of an exemplary configuration of a tubular structure of an intracranial pressure detection device, according to some embodiments of the present disclosure.

Referring to fig. 3, in some embodiments, the aforementioned two or more side openings 113 may include a first opening 1131, a second opening 1132, and a third opening 1133, and the first opening 1131, the second opening 1132, and the third opening 1133 may be sequentially arranged from the distal end of the implant probe 111 toward the proximal end of the implant probe 111. The distal end of the implant probe 111 may refer to the end that first enters the patient's cranium during application, or the end that is remote from the operator (e.g., doctor or nurse) during application, such as the left end in fig. 3, among others.

Accordingly, the aforementioned two or more sensors may include a first sensor, a second sensor, and a third sensor. Wherein a first sensor may be disposed at the first opening 1131 for detecting intra-ventricular pressure; a second sensor may be disposed at the second opening 1132 for detecting pressure within the brain parenchyma; a third sensor may be disposed at the third opening 1133 and may be extendable through the third opening 1133 relative to the tubular structure of the implant probe 111 for detecting subdural pressure.

It should be noted that, in some embodiments of the present disclosure, the first opening 1131, the second opening 1132, and the third opening 1133 may each include at least one opening. In other words, that is, in the present embodiment, each of the first, second and third openings 1131, 1132 and 1133 may include one or more openings, respectively. Similarly, each of the first sensor, the second sensor, and the third sensor may also include one or more sensors, wherein each sensor may correspond to one of the side openings 113.

In some embodiments, each sensor may have a corresponding identification, wherein each identification may correspond to a location on the implant probe 111. Thus, in some embodiments, the intracranial pressure corresponding to each location can be determined based on the data collected by the sensor and its corresponding identification. For example, the first sensor is located at the first opening 1131 and its corresponding identifier is Y001, the second sensor is located at the second opening 1132 and its corresponding identifier is Y002, and then the intracranial pressure corresponding to the first opening 1131 can be determined according to the data collected by the sensor identified as Y001, and similarly, the intracranial pressure corresponding to the second opening 1132 can be determined according to the data collected by the sensor identified as Y002.

Referring to fig. 3, in some embodiments, at least some of the two or more sensors may be arranged in a spiral along the length extension of the implant probe 111 (e.g., along the dashed line in fig. 3). In some embodiments, by this arrangement, the distance between two adjacent sensors may be increased within a limited length, thereby reducing the interference effect between the two adjacent sensors. In addition, through the arrangement mode, the weight distribution of the whole implantation probe 111 can be more uniform, so that the stability of the implantation probe 111 after being placed in the cranium of a patient is improved to a certain extent, and the influence on the detection result of the sensor after being extruded with the cranium brain tissue due to the unbalance of the gravity of the implantation probe 111 is avoided.

In some embodiments, two or more sensors may be uniformly or non-uniformly disposed on the implantation probe 111. Illustratively, in some embodiments, 3-5 sensors may be uniformly disposed on the implant probe 111, wherein the spacing between adjacent two sensors may be determined based on the length (or depth) of the implant probe 111 after it has been advanced intracranially. Taking the depth of penetration of the implantation probe 111 as 20 mm and the number of sensors as 3 as an example, two adjacent sensors may be spaced apart from each other by about 5 to 8 mm in the longitudinal direction of the implantation probe 111. In some embodiments, the distance between two adjacent sensors may be set according to the distance between the target locations to be detected. For example, the distance between the first sensor and the second sensor may be set according to the distance between the brain chamber and the brain parenchyma.

It will be appreciated that the above description with respect to fig. 2 and 3 is for purposes of illustration and description, and is not intended to limit the scope of applicability of the present description. Various modifications and changes may be made to fig. 2 and/or fig. 3 by those skilled in the art in light of the present description. For example, in fig. 3, two side openings, four side openings, or five side openings may be included on the wall of the tubular structure. For another example, two or more openings are arranged in a spiral manner, and the other openings are arranged in the same straight line or at equal intervals. However, such modifications and variations are still within the scope of the present description.

FIG. 4 is a schematic view of an exemplary structure of a tubular structure of an intracranial pressure detection device, according to other embodiments of the present disclosure.

Referring to fig. 4, in some embodiments, the inner side of the third opening 1133 may include a curved guide structure 115. The curved guide structure 115 may be used to constrain the path of movement of the third sensor during extension or retraction relative to the tubular structure of the implant probe 111. It should be noted that in some embodiments of the present disclosure, the curved guide structure 115 may include at least one arcuate stop disposed inwardly of the third opening 1133 that may inhibit movement of the third sensor toward the distal end of the implantation probe 111 beyond the third opening.

In some embodiments, the intracranial pressure detection device 110 can include an operating handle (not shown) that can include a control structure thereon. The control structure may be coupled to the third sensor (e.g., may be coupled by a connection wire or a connection shaft, or coupled to the curved guide structure 115, by controlling movement of the curved guide structure 115 to adjust the position of the third sensor) for adjusting the position of the third sensor. For example, the third sensor may be pushed out relative to the tubular structure of the implant probe 111 after the implant probe 111 is placed within the patient's cranium. For another example, the third sensor may be controlled to retract into the tubular structure prior to removal of the implant probe 111. In some embodiments, the control structure may be provided at other locations, for example, on a display device, on a hospital bed, or separately, etc. In some embodiments, the control structure may be, but is not limited to, a knob, a pull ring, or the like. In some embodiments, the control structure may include a remote control device that is wirelessly connected to the sensor on the implanted probe to control the position of the sensor. In some embodiments, the control structure may also be coupled to the second sensor and/or the third sensor for adjusting the position of the second sensor and/or the third sensor. It will be appreciated that in some embodiments, by adjusting the position of each sensor, intracranial pressure at different locations can be detected more flexibly, enabling pressure detection at different locations within the patient's cranium with a single implantation, thereby reducing the trauma to the patient to some extent.

In some embodiments, at least one camera may also be included on the implantation probe 111. The current position of the implant probe 111 can be confirmed through the images acquired by the at least one camera during the insertion or removal of the implant probe 111 into or from the patient's cranium. In some embodiments, the current position of the implant probe 111 may also be determined by X-ray and/or CT (Computer Tomography) images. Optionally, in some embodiments, a developing device, such as a developing ring, a developing coating, etc., may be provided on the implantation probe 111 in order to improve the imaging quality of the X-ray and/or CT images. Illustratively, in some embodiments, a developing ring may be provided at each sensor location, so that the location of each sensor is accurately located under the X-ray and/or CT images. Illustratively, in some embodiments, the material of the developer ring may include a platinum iridium alloy.

In some embodiments, a signal shielding layer may be disposed on the implanted probe 111 in order to avoid interference of electromagnetic waves in the external environment with signals detected by the sensor on the implanted probe 111. The signal shielding layer can be made of metal materials. For example, in some embodiments, a platinum iridium alloy may be used as a signal shielding layer for the implant probe 111 for the purpose of both developing and external signal shielding. In some embodiments, the signal shielding layer may be disposed on an inner wall of the tubular structure of the implant probe 111 and encase the plurality of sensors therein. In some embodiments, in order to avoid interference between the plurality of sensors, a signal shielding layer may be further disposed between two adjacent sensors.

Considering that the intra-brain temperature also has an important reference meaning for intracranial detection, the aforementioned first sensor may further comprise a temperature sensor in some embodiments in order to simultaneously achieve temperature detection within the brain. In particular, the first sensor may integrate a pressure sensor and a temperature sensor. Similarly, since brain partial pressure also has an important reference meaning for intracranial detection, based on this, in order to simultaneously achieve brain partial pressure detection, the aforementioned second sensor may also be used for brain partial pressure detection in some embodiments.

Referring to fig. 5, after the implant probe 111 is placed within the patient's cranium, the first, second, and third sensors 1171, 1172, 1173 may be positioned at different locations within the patient's cranium to enable simultaneous detection of pressure data at the different locations. The data collected by the first sensor 1171, the second sensor 1172 and the third sensor 1173 are forwarded to a processing device (for example, the processing device 120) through the signal relay 112 for processing, and then the data processed by the processing device is displayed through a display device (for example, the display device 130), so that pressure data of multiple intracranial positions of a patient can be obtained, and multi-position simultaneous monitoring is realized.

In some embodiments, the first sensor 1171 and the second sensor 1172 may have the same or different pressure sensing areas. For example, when the detection data is mainly intra-brain pressure data, in order to increase the accuracy of detecting intra-brain pressure, the pressure detection area of the second sensor 1172 may be made larger than the pressure detection area of the first sensor 1171. When the pressure in the brain parenchyma and the pressure in the ventricle are both required detection data, the pressure detection area of the second sensor 1172 may be made equal to the pressure detection area of the first sensor 1171. In some embodiments, when the pressure data in the brain parenchyma is the primary detection data, the pressure detection area of the second sensor 1172 may be more than 1.5 times the pressure detection area of the first sensor 1171. It will be appreciated that the pressure sensing area may be positively correlated to the number of sensors or the sensing area of a single sensor.

In some embodiments, to further monitor the patient for abnormalities in intracranial pressure data, the processing device may also generate a corresponding alert signal based on the preset threshold and the pressure data forwarded by the signal relay 112. In some embodiments, the alert signal may include a first alert signal and a second alert signal. Specifically, in some embodiments, the preset threshold may include at least two threshold parameters corresponding to pressure data at different locations, for example, a first sensor may collect intra-ventricular pressure corresponding to a first threshold range, a second sensor may collect intra-cerebral pressure corresponding to a second threshold range, and so on, other sensors may correspond to other threshold parameters. The processing device may generate a first alert signal when at least one of the two or more sets of pressure data acquired by the sensors on the implanted probe 111 is greater than its corresponding threshold parameter (e.g., greater than a first threshold); conversely, when at least one of the two or more sets of pressure data acquired by the sensors on the implanted probe 111 is less than its corresponding threshold parameter (e.g., less than a second threshold), the processing device may then generate a second alert signal. In some embodiments, the first alert signal and the second alert signal may be any one or a combination of an acoustic signal, an optical signal, and an image display.

In some embodiments, to ensure detection accuracy and consistency of the individual sensors, the individual sensors in the intracranial pressure detection device 110 can be calibrated prior to use of the intracranial pressure detection device 110. Illustratively, in some embodiments, calibration parameters corresponding to the sensors may be configured in a storage device, and the processing device 120 may read the pre-configured calibration parameters and perform corresponding processing, so as to improve detection accuracy and consistency of each sensor.

With continued reference to fig. 5, in some embodiments, the intracranial pressure detection device 110 can further include at least one catheter 116, which catheter 116 can be used to inject a drug and/or drain cerebrospinal fluid. Specifically, in some embodiments, the intracranial pressure detection device 110 can include only one catheter 116, and the catheter 116 can be used to drain cerebrospinal fluid when drainage of the cerebrospinal fluid is desired (e.g., when intracranial pressure is too high), and the catheter 116 can also be used to inject a drug when intracranial injection of the drug into a patient is desired (e.g., when intracranial pressure is too low). In some embodiments, the drug injected through the catheter 116 may include various antibiotics such as polymyxin, various chemotherapeutic agents such as temozolomide, and the like. In some embodiments, the intracranial pressure detection device 110 can also include two catheters 116, one of which can be used to drain cerebrospinal fluid and the other of which can be used to inject a drug.

The catheter 116 may include a control switch for controlling the on-off state thereof, at least a portion of the catheter 116 may be accommodated in the tubular structure of the implantation probe 111, and one end of the catheter 116 may be placed into a site to be measured (e.g., a brain chamber) through an end opening 114 (see fig. 2 to 4) of the implantation probe 111, and the other end may serve as an injection inlet and/or a drainage outlet. In some embodiments, the drainage outlet may be connected to a drainage bag that may be used to hold cerebrospinal fluid for drainage treatment from within the patient's cranium.

In some embodiments, the aforementioned first alert signal may be used to alert an associated person (e.g., a doctor, nurse, or patient family member) to turn on a control switch of the catheter 116 to drain to reduce intracranial pressure. Similarly, the second reminder signal may be used to remind the relevant person to inject a medication into the patient to compensate for the intracranial pressure in the patient.

In some embodiments, the control switch of the conduit 116 may be connected to a processing device (e.g., processing device 120) that may control the control switch of the conduit 116 to be turned on or off based on a preset threshold and pressure data forwarded by the signal repeater 112. Illustratively, in some embodiments, when pressure data collected by the first sensor is detected to be greater than a first preset threshold, the control switch of the catheter 116 for drainage may be controlled to conduct, thereby achieving automatic drainage; similarly, when pressure data acquired by the first sensor is detected to be smaller than a second preset threshold value, a control switch of the catheter 116 for injecting medicine can be controlled to be conducted, so that automatic medicine injection is realized. In some embodiments, the first preset threshold may be set to 120mmHg-180mmHg and the second preset threshold may be set to 90mmHg-150mmHg. It will be appreciated that the foregoing first and second predetermined thresholds are merely exemplary, and in some embodiments, the foregoing first and second predetermined thresholds may be adjusted as desired.

It should be noted that, in some embodiments of the present disclosure, for the aforementioned two or more sensors, only some of the sensors or all of the sensors may be used or activated as needed. For example, in some embodiments, when only intra-ventricular pressure data needs to be detected, only the first sensor 1171 located at the first opening 1131 may be activated, while the remaining sensors (e.g., the second sensor 1172, the third sensor 1173) may remain off. Conversely, when intracranial pressure at a plurality of positions needs to be monitored simultaneously, all sensors arranged at the corresponding positions can be controlled to be started.

Possible benefits of embodiments of the present description include, but are not limited to: (1) By arranging a plurality of sensors at different positions of the implantation probe, intracranial pressure detection at a plurality of positions can be realized under the condition of one implantation, and the damage to a patient is reduced; (2) By arranging the catheter in the implantation probe, drainage or medicine injection can be realized while intracranial pressure is monitored, and medical convenience and high efficiency are improved; (3) The sensors on the implanted probe are arranged in a spiral mode, the distance between two adjacent sensors can be increased within a limited length, the interference effect between the two adjacent sensors is reduced, and the weight distribution of the whole implanted probe is more uniform, so that the stability of the implanted probe after being placed into the cranium of a patient is improved, and the influence on the detection result of the sensors after being extruded with the cranium brain tissue due to unbalance of self gravity is avoided.

It should be noted that, the advantages that may be generated by different embodiments may be different, and in different embodiments, the advantages that may be generated may be any one or a combination of several of the above, or any other possible advantages that may be obtained.

While the basic concepts have been described above, it will be apparent to those skilled in the art that the foregoing detailed disclosure is by way of example only and is not intended to be limiting. Although not explicitly described herein, various modifications, improvements, and adaptations to the present disclosure may occur to one skilled in the art. Such modifications, improvements, and modifications are intended to be suggested within this specification, and therefore, such modifications, improvements, and modifications are intended to be included within the spirit and scope of the exemplary embodiments of the present invention.

Meanwhile, the specification uses specific words to describe the embodiments of the specification. Reference to "one embodiment," "an embodiment," and/or "some embodiments" means that a particular feature, structure, or characteristic is associated with at least one embodiment of the present description. Thus, it should be emphasized and should be appreciated that two or more references to "an embodiment" or "one embodiment" or "an alternative embodiment" in various positions in this specification are not necessarily referring to the same embodiment. Furthermore, certain features, structures, or characteristics of one or more embodiments of the present description may be combined as suitable.

Likewise, it should be noted that in order to simplify the presentation disclosed in this specification and thereby aid in understanding one or more inventive embodiments, various features are sometimes grouped together in a single embodiment, figure, or description thereof. This method of disclosure, however, is not intended to imply that more features than are presented in the claims are required for the present description. Indeed, less than all of the features of a single embodiment disclosed above.

In some embodiments, numbers describing the components, number of attributes are used, it being understood that such numbers used in the description of embodiments are modified in some examples by the modifier "about," left-right, "" approximately, "or" substantially. Unless otherwise indicated, "about," "approximately," or "substantially" indicate that the number allows for a 20% variation. Accordingly, in some embodiments, numerical parameters set forth in the specification and claims are approximations that may vary depending upon the desired properties sought to be obtained by the individual embodiments. In some embodiments, the numerical parameters should take into account the specified significant digits and employ a method for preserving the general number of digits. Although the numerical ranges and parameters set forth herein are approximations that may be employed in some embodiments to confirm the breadth of the range, in particular embodiments, the setting of such numerical values is as precise as possible.

Each patent, patent application publication, and other material, such as articles, books, specifications, publications, documents, etc., referred to in this specification is incorporated herein by reference in its entirety. Except for application history documents that are inconsistent or conflicting with the content of this specification, documents that are currently or later attached to this specification in which the broadest scope of the claims to this specification is limited are also. It is noted that, if the description, definition, and/or use of a term in an attached material in this specification does not conform to or conflict with what is described in this specification, the description, definition, and/or use of the term in this specification controls.

Finally, it should be understood that the embodiments described in this specification are merely illustrative of the principles of the embodiments of this specification. Other variations are possible within the scope of this description. Thus, by way of example, and not limitation, alternative configurations of embodiments of the present specification may be considered as consistent with the teachings of the present specification. Accordingly, the embodiments of the present specification are not limited to only the embodiments explicitly described and depicted in the present specification.

Claims

1. An intracranial pressure detection device, comprising:

An implantation probe for implantation within the cranium of a target subject to detect intracranial pressure; the implantation probe comprises at least two sensors which are sequentially arranged along the length extension direction of the implantation probe, wherein the sensors are used for detecting pressure data of at least two different intracranial positions, and the pressure data comprise at least two of intra-ventricle pressure, intra-brain parenchyma pressure and subdural pressure;

and the signal relay is used for receiving the pressure data detected by the at least two sensors and forwarding the pressure data to processing equipment for processing.

2. The device of claim 1, wherein the implantation probe is a tubular structure, at least two side openings are arranged on the wall of the tubular structure, and the at least two sensors are respectively and correspondingly arranged at the positions of the at least two side openings.

3. The device of claim 2, wherein at least a portion of the at least two side openings are helically arranged along a length extension of the implant probe.

4. The apparatus of claim 2, wherein the at least two sensors comprise a first sensor, a second sensor, and a third sensor, and the at least two side openings comprise a first opening, a second opening, and a third opening; wherein,

The first sensor is used for detecting the intra-ventricular pressure, the second sensor is used for detecting the intra-brain parenchyma pressure, and the third sensor is used for detecting the subdural pressure;

the first opening, the second opening and the third opening are sequentially distributed from the distal end of the implantation probe towards the proximal end of the implantation probe;

the first sensor is arranged at the first opening, the second sensor is arranged at the second opening, the third sensor is arranged at the third opening, and the third sensor can extend out of the tubular structure through the third opening.

5. The device of claim 4, wherein an inner side of the third opening includes a curved guide structure for smoothly curving the third sensor relative to the tubular structure.

6. The apparatus of claim 5, further comprising a control structure coupled to the third sensor for adjusting the position of the third sensor.

7. The apparatus of claim 2, wherein the apparatus further comprises:

at least one catheter for injecting a drug and/or draining cerebrospinal fluid;

Wherein the catheter comprises a control switch for controlling the on-off of the catheter, at least part of the catheter is accommodated in the tubular structure, and the catheter communicates the part to be tested with the injection inlet and/or the drainage outlet.

8. An intracranial pressure detection system, comprising:

an intracranial pressure detection device, comprising:

an implantation probe for implantation within the cranium of a target subject to detect intracranial pressure; the implantation probe comprises at least two sensors which are sequentially arranged along the length extension direction of the implantation probe, and the sensors are used for detecting pressure data of different intracranial positions;

a signal relay for receiving the pressure data detected by the at least two sensors and forwarding the pressure data to a processing device;

the processing equipment is used for receiving the pressure data and processing the pressure data to obtain target data;

and the display device is used for displaying the target data.

9. The system of claim 8, wherein the processing device is further to:

when at least one of the pressure data is larger than a corresponding threshold parameter, generating a first reminding signal; or (b)

And when at least one of the pressure data is smaller than the corresponding threshold parameter, generating a second reminding signal.

10. The system of claim 8, wherein the intracranial pressure detection device further comprises at least one catheter for injecting a drug and/or draining cerebrospinal fluid, the catheter comprising a control switch for controlling the conduction or closure thereof;

the processing device is also used for controlling the on or off of the control switch based on a preset threshold value and the pressure data forwarded by the signal repeater.