CN220137155U

CN220137155U - Immunoassay instrument

Info

Publication number: CN220137155U
Application number: CN202322916979.4U
Authority: CN
Inventors: 张雷; 李文泰; 张萌; 余占江
Original assignee: Suzhou Simeide Biotechnology Co ltd
Current assignee: Qianshen Technology (Suzhou) Co.,Ltd.
Priority date: 2023-10-30
Filing date: 2023-10-30
Publication date: 2023-12-05
Anticipated expiration: 2033-10-30

Abstract

The utility model provides an immunoassay analyzer, belonging to the technical field of medical appliances; the immunoassay analyzer comprises a reagent sample storage module, a centrifugation module, a transfer module, a magnetic separation module, an incubation reaction module, a detection module and a reaction cup loading module; a reagent sample storage module for storing a reagent and a sample; the reaction cup loading module is used for storing reaction cups; the transfer module comprises a transfer module disc, and the transfer module disc is provided with a plurality of transfer module cup placing holes which are annularly distributed; the magnetic separation module comprises a magnetic separation module disc, and the magnetic separation module disc is provided with a plurality of cup placing holes of the magnetic separation module which are annularly distributed; the detection module comprises a detection module disc and a detection unit; the detection module disc is connected with the detection unit; the detection module disc is provided with a plurality of detection module cup placing holes which are annularly distributed. The utility model can distinguish the whole blood sample from the plasma, and can pertinently carry out immunodiagnosis on the whole blood sample and the plasma, thereby realizing random detection and improving the timeliness of diagnosis.

Description

Immunoassay instrument

Technical Field

The utility model relates to the technical field of medical instruments, in particular to an immunoassay instrument.

Background

Immunoassay devices for analyzing a sample (plasma) are devices commonly used in clinical diagnosis, such as chemiluminescent immunoassay devices. The main operation flow of the immunoassay analyzer comprises sample loading, reagent loading, sample and reagent dispensing, reaction liquid mixing, reaction liquid incubation reaction, magnetic separation and detection. The gripper needs to grab the reaction cup from the reaction cup loading module, move the reaction cup to a set position to inject samples and reagents, then move the reaction cup to the mixing module, and move the reaction cup to the reaction liquid reaction module, the magnetic separation module and the detection module in sequence after the reaction cup is uniformly mixed.

In the immunoassay, blood plasma, serum and urine are generally used as samples, and the whole blood sample cannot be detected by an immunoassay instrument because red blood cells in the whole blood interfere with detection results. After a certain amount of whole blood samples are generally accumulated in hospitals, the whole blood samples are concentrated and centrifuged and then used for subsequent immune detection, so that the instantaneity of detection cannot be ensured.

For example, chinese patent No. CN215005445U discloses a chemiluminescent immunoassay analyzer. The plasma, serum and urine can be detected, and the plasma, serum and urine comprises a common module of a chemiluminescent instrument, but the analyzer adopts a test tube rack for loading samples, so that the expansibility of detection samples is poor, the random detection is difficult, and the instantaneity of detection cannot be ensured.

Chinese utility model patent application CN111257556a discloses an immunoassay instrument and a sample analysis method, the immunoassay instrument comprising: the sample injection device is used for accommodating an original sample and a reagent, transferring the original sample, the reagent and a sample to be tested according to a preset sequence, and the sample to be tested is prepared from the original sample and the reagent at least; the reaction control device is used for preparing a sample to be detected through preset operation, and the preset operation at least comprises cleaning and separating operation; the optical detection device is used for detecting the sample to be detected and outputting a detection result; wherein the reagent comprises at least one magnetic bead. Through the mode, the method and the device can carry out multi-item joint inspection on the original sample, and are high in detection efficiency. However, the immunity analyzer needs to pre-process the original sample outside the instrument, so that the follow-up detection is difficult to achieve, and the detection instantaneity cannot be ensured.

For example, chinese patent No. CN219694692U discloses a centrifugal mechanism for an immunoassay analyzer, which is capable of centrifuging 4 samples at a time, and cannot meet the requirement of a high-throughput immunoassay analyzer. In addition, the immunity analyzer has poor sample detection expansibility, needs to be provided with a balancing weight, and has the advantages of various instrument parts and high equipment cost.

For example, chinese patent application CN115055287a discloses a microfluidic test disc on which whole blood is centrifuged to obtain plasma for subsequent testing.

In the prior art, the immunity analyzer is faced with the problem that erythrocytes in whole blood can interfere with detection results, and the whole blood sample needs to be centralized and centrifuged outside the analyzer and then is used for subsequent immunity detection. The existing immunoassay detection sample has poor expansibility, is difficult to realize random detection, cannot guarantee the instantaneity of detection, and has high equipment cost and detection cost.

Disclosure of Invention

The utility model provides an immunoassay analyzer, which aims to solve the technical problems that the expansibility of a sample for the conventional immunoassay detection is poor, the random detection is difficult to achieve, the instantaneity of the detection cannot be ensured, and the equipment cost and the detection cost are high.

The technical scheme provided by the utility model is as follows:

an object of the present utility model is to provide an immunoassay analyzer comprising a reagent sample storage module, a centrifugation module, a transfer module, a magnetic separation module, an incubation reaction module, a detection module, and a cuvette loading module;

the reagent sample storage module is used for storing reagents and samples; the reaction cup loading module is used for storing reaction cups; the incubation reaction module is used for incubating the sample in the reaction cup;

the transfer module comprises a transfer module disc, wherein the transfer module disc is provided with a plurality of transfer module cup placing holes which are annularly distributed, and the transfer module cup placing holes are used for placing the reaction cups;

the magnetic separation module comprises a magnetic separation module disc, wherein the magnetic separation module disc is provided with a plurality of magnetic separation module cup placing holes which are annularly distributed, and the magnetic separation module cup placing holes are used for placing the reaction cups;

the detection module comprises a detection module disc and a detection unit; the detection module disc is connected with the detection unit;

the detection module disc is provided with a plurality of detection module cup placing holes which are annularly arranged, and the detection module cup placing holes are used for placing the reaction cups;

the centrifugal module comprises a centrifugal turntable and a plurality of hanging baskets;

the centrifugal turntable is configured to rotate in a first rotational direction; each of the baskets is mounted on the centrifugal turntable by means of a bearing and configured to oscillate in a second direction of rotation; wherein the first rotation direction and the second rotation direction are perpendicular;

each hanging basket is provided with at least one centrifugal module cup placing hole, and the centrifugal module cup placing holes are used for placing reaction cups;

wherein the gravity center of the hanging basket is lower than the axial height of the bearing for installing the hanging basket, so that the hanging basket is in a natural sagging state,

and when the reaction cup is placed in the cup placing hole of the centrifugal module, the gravity center height of the whole hanging basket and the reaction cup is lower than the axial height of the bearing for installing the hanging basket, so that the reaction cup is in a natural sagging state.

In a preferred embodiment, the basket is provided with a stop strip along the outside of the centrifugal module.

In a preferred embodiment, the cup placing holes of the centrifugal modules of the hanging baskets are distributed in an annular mode.

In a preferred embodiment, the centrifugal module further comprises a centrifugal motor and a coupling; the centrifugal motor is connected with the coupler, and the coupler is connected with the centrifugal turntable.

Compared with the prior art, the technical scheme of the utility model has at least the following beneficial effects:

the utility model provides an immunoassay analyzer, wherein a centrifugal module adopts ingenious gravity center height design, so that parts of the analyzer are effectively reduced, and the equipment cost is reduced.

The utility model provides an immunoassay analyzer, wherein a centrifugation module does not directly centrifuge an original sample tube adopted by conventional centrifugation, but sucks a certain amount of whole blood sample from the sample tube, and the whole blood sample is added into a reaction cup for centrifugation. The reaction cup used for centrifugation and the reaction cup used for detection are the same consumable, so that the centrifugation function is completed on the premise of not increasing the type of the consumable.

The utility model provides an immunoassay analyzer which can distinguish a whole blood sample from plasma and can pertinently perform immunodiagnosis on the whole blood sample and the plasma. Aiming at the plasma required by the immunity detection of the whole blood sample through the in-machine centrifugation, the sample type range is expanded, the out-of-instrument centrifugation is not needed, the random detection is realized, and the timeliness of diagnosis is improved.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings required for the description of the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present utility model, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram showing the arrangement of the individual modules of an immunoassay analyzer of the present utility model.

Fig. 2 is a schematic structural view of the centrifugal module of the present utility model.

Figure 3 is a schematic view of a basket according to the present utility model engaged with a bearing.

Fig. 4 is a top view of a plurality of centrifugal module cup placing holes of the hanging basket of the present utility model in an annular arrangement.

Fig. 5 is a block diagram of a control system of an immunoassay analyzer according to the present utility model.

Fig. 6 is a flowchart of a control method of an immunoassay analyzer of the present utility model.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present utility model more clear, the technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. It will be apparent that the described embodiments are some, but not all, embodiments of the utility model. All other embodiments, which can be made by a person skilled in the art without creative efforts, based on the described embodiments of the present utility model fall within the protection scope of the present utility model.

Unless defined otherwise, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this utility model belongs. The terms "first," "second," and the like, as used herein, do not denote any order, quantity, or importance, but rather are used to distinguish one element from another. Likewise, the terms "a," "an," or "the" and similar terms do not denote a limitation of quantity, but rather denote the presence of at least one. The word "comprising" or "comprises", and the like, means that elements or items preceding the word are included in the element or item listed after the word and equivalents thereof, but does not exclude other elements or items. The terms "connected" or "connected," and the like, are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect.

It should be noted that "upper", "lower", "left", "right", "front", "rear", and the like are used in the present utility model only to indicate a relative positional relationship, and when the absolute position of the object to be described is changed, the relative positional relationship may be changed accordingly.

Referring to fig. 1, according to an embodiment of the present utility model, there is provided an immunoassay analyzer including: the reagent sample storage module 1, the centrifugation module 2, the magnetic separation module 3, the transfer module 4, the needle washing module 5, the detection module 6, the incubation reaction module 7 and the reaction cup loading module 8.

A reagent sample storage module 1 for storing reagents and samples. The reagent sample storage module 1 includes a sample tray 101 and a reagent tray 103. A plurality of sample tubes 102 are arranged on a sample tray 101 in an annular arrangement, and a plurality of reagent boxes 104 are arranged on a reagent tray 103 in an annular arrangement. Sample is stored in the sample tube 102, and reagents are stored in the reagent cartridge 104.

The sample tray 101 is configured for rotational movement to cyclically align the sample tubes 102 in an annular arrangement with the reagent sample sampling sites 105 of the reagent sample storage module 1. The reagent disk 103 is configured for rotational movement to cyclically align the reagent sample sampling sites 105 of the reagent sample storage module 1 with the reagent cartridges 104 in an annular arrangement.

In one embodiment, the rotational movement of the sample disk 101 and the rotational movement of the reagent disk 103 are relative movements. In other embodiments, the sample disk 101 and the reagent disk 103 are in synchronous rotational motion. Preferably, the rotational movement of the sample disc 101 and the reagent disc 103 is driven by a motor.

Referring to fig. 1 to 4, the centrifugal module 2 includes a centrifugal motor 202, a coupling 203, a centrifugal turntable 204, and a plurality of baskets 206 according to an embodiment of the present utility model. The centrifugal turntable 204 is configured to rotate in a first rotational direction (as indicated by arrow a in fig. 2). Each basket 206 is mounted on the centrifugal turntable 204 by means of a bearing 205 and the baskets 206 are configured to oscillate in a second direction of rotation (as indicated by arrow b in fig. 2). The first rotational direction and the second rotational direction are perpendicular.

Specifically, the centrifugal motor 202 is connected to the coupling 203, the coupling 203 is connected to the centrifugal turntable 204, the coupling 203 is driven to rotate by the centrifugal motor 202, and the coupling 203 drives the centrifugal turntable 204 to rotate along a first rotation direction (shown by an arrow a in fig. 2).

Each basket 206 is provided with at least one centrifugation module cup-placing hole 208, and the centrifugation module cup-placing holes 208 are used for placing reaction cups 801. Preferably, in this embodiment, 3 centrifugal module cup holes 208 are configured for each basket 206, and in some specific embodiments, are configured appropriately according to actual needs.

According to the embodiment of the present utility model, the height of the center of gravity of the basket 206 is lower than the height of the axis Z of the bearing 205 on which the basket 206 is mounted, so that the basket 206 is in a natural sagging state, and when the reaction cup 801 is placed in the centrifugal module cup placing hole 208, the height of the center of gravity of the basket 206 and the reaction cup 801 as a whole is lower than the height of the axis Z of the bearing 205 on which the basket 206 is mounted, so that the reaction cup 801 is in a natural sagging state.

When the centrifugal turntable 204 rotates in a first rotational direction (as indicated by arrow a in fig. 2), the basket 206 swings in a second rotational direction (as indicated by arrow b in fig. 2) under the action of centrifugal force, tilting the reaction cup 801 and offsetting the bottom of the reaction cup 801 to the outside of the centrifugal module 2.

As shown in fig. 2 and 3, the basket 206 is provided with a stop 207 along the outside of the centrifugal module 2. When the centrifugal turntable 204 rotates along the first rotation direction, and the hanging basket 206 swings the reaction cup 801 along the second rotation direction to incline, the stop bar 207 is abutted with the centrifugal turntable 204, so that the phenomenon that the sample in the reaction cup 801 overflows due to overlarge inclination angle of the reaction cup 801 when the centrifugal force is large is avoided.

As shown in fig. 1 and 4, the centrifugal module cup holes 208 of the plurality of baskets 206 are arranged in a ring shape. When the centrifugal turntable 204 rotates in the first rotation direction, the centrifugal module cup placement holes 208 arranged in an annular shape are circularly aligned with the centrifugal module cup placement positions 201 of the centrifugal module 2, as shown in fig. 1.

As shown in fig. 1, the transfer module 4 is used for placing a cuvette 801 and mixing the reagent and the sample in the cuvette according to an embodiment of the utility model.

Specifically, the transfer module 4 includes a transfer module tray 403, and the transfer module tray 403 is configured with a plurality of transfer module cup placement holes 404 that are annularly arranged, and the transfer module cup placement holes 404 are used for placing reaction cups 801.

The transport module tray 403 is configured for rotational movement such that the transport module cup placement holes 404 in an annular arrangement are circularly aligned with the transport module cup placement locations 401 of the transport modules 4, and the transport module cup placement holes 404 in an annular arrangement are circularly aligned with the transport module mixing locations 402 of the transport modules 4. Preferably, the rotational movement of the transport module tray 403 is driven by a motor.

According to an embodiment of the present utility model, the incubation reaction module 7 is used for incubating the samples after being mixed in the reaction cup 801. Specifically, the incubation reaction module 7 is provided with an incubation reaction module cup hole for placing the reaction cup 801. After the reaction cup 801 is placed in the incubation reaction module 7, the incubation reaction module 7 performs an incubation reaction (reaction between the sample and the reagent) on the sample mixed uniformly in the reaction cup 801.

The magnetic separation module 3 is used for performing magnetic separation on the sample incubated by the incubation reaction module 7. Specifically, the magnetic separation module 3 includes a magnetic separation module disk 302, and the magnetic separation module disk 302 is provided with a plurality of magnetic separation module cup placement holes 303 arranged in an annular shape, and the magnetic separation module cup placement holes 303 are used for placing reaction cups 801.

The magnetic separation module disk 302 is configured for rotational movement to cyclically align the magnetic separation module cup placement holes 303 in an annular arrangement with the magnetic separation module cup placement locations 301 of the magnetic separation modules 3. Preferably, the rotational movement of the magnetic separation module disk 302 is driven by an electric motor.

And the detection module 6 is used for detecting the sample subjected to the magnetic separation by the magnetic separation module 3. Specifically, the detection module 6 includes a detection module tray 603 and a detection unit 602. The detection module plate 603 is engaged with the detection unit 602.

The detecting module tray 603 is provided with a plurality of detecting module cup placing holes 604 which are annularly arranged, and the detecting module cup placing holes 604 are used for placing the reaction cups 801. The detection module disc 603 is configured for rotational movement such that the detection module cup placement holes 604 in an annular arrangement are circularly aligned with the detection module cup placement positions 601 of the detection modules 6.

The reaction cup loading module 8 is used for storing the reaction cup 801. And the needle washing module 5 is used for washing the sample adding needle. The loading needle is not shown in the figures, and the movement area of the loading needle is driven by the loading needle module, as will be explained in detail below.

According to an embodiment of the present utility model, an immunoassay analyzer further includes: a cuvette jaw module (not shown) and a loading needle module (not shown). The reaction cup gripper module is configured to: the reaction cup clamping jaw is driven to move in a reaction cup clamping jaw movement area 10, so that the reaction cup 801 is transferred among the reaction cup loading module 8, the centrifugal module 2, the transfer module 4, the incubation reaction module 7, the magnetic separation module 3 and the detection module 6.

The loading needle module is configured to: the sample adding needle is driven to move in the sample adding needle moving area 9, so that the sample adding needle is transferred among the reagent sample storage module 1, the centrifugal module 2 and the transfer module 4.

In some embodiments, the reaction cup clamping jaw module preferably drives the reaction cup clamping jaw to move in the reaction cup clamping jaw movement area 10, and the sample adding needle module preferably drives the sample adding needle to move in the sample adding needle movement area 9 by a mechanical arm or a triaxial movement mechanism.

According to an embodiment of the utility model, the cuvette jaw movement zone 10 and the loading needle movement zone 9 at least partly overlap. Specifically, the reaction cup jaw movement area 10 covers the reaction cup loading module 8, the incubation reaction module 7, the transfer module 4, and the centrifugation module cup placement position 201 of the centrifugation module 2, the magnetic separation module cup placement position 301 of the magnetic separation module 3, and the detection module cup placement position 601 of the detection module 6.

The sample application needle movement area 9 covers the needle wash module 5, the reagent sample sampling station 105 of the reagent sample storage module 1, the centrifugation module cup placement station 201 of the centrifugation module 2 and the transport module cup placement station 401 of the transport module 4.

As shown in fig. 5, according to an embodiment of the present utility model, there is provided a control system of an immunoassay analyzer, including an upper computer bus 400 and a lower computer bus 600. The upper computer bus 400 and the lower computer bus 600 are connected to each other by a communication interface 500.

The host bus 400 is communicatively coupled to the processor 200 and the memory 300, and the processor 200 is communicatively coupled to the human interface 100.

The lower computer bus 600 is in communication connection with a reagent sample storage module 1, a centrifugation module 2, a transfer module 4, a magnetic separation module 3, a detection module 6, a sample adding needle module and a reaction cup clamping jaw module.

Referring to fig. 1 to 6, a control method of an immunoassay analyzer according to an embodiment of the present utility model includes the following steps:

step S1, sampling:

the sample type is obtained, and whether the sample is a blood sample is judged, if the sample is the blood sample, the step S2 is entered, otherwise, the step S12 is entered.

A sample is added to the sample tube 102 of the sample tray 101 and a reagent is added to the reagent cartridge 104 of the reagent tray 103. The human-computer interface 100 acquires the sample type of the sample in the sample tube 102, judges whether the sample is a blood sample, and if so, proceeds to step S2, otherwise, proceeds to step S12.

Step S2, a first cup placing:

the reaction cup clamping jaw module drives the reaction cup clamping jaw to clamp the reaction cup 801, and the reaction cup 801 is placed in the centrifugal module cup position 201 of the centrifugal module 2.

Specifically, rotation of the centrifugal turntable 204 in the first rotational direction rotates the basket 206 in the first rotational direction, such that a centrifugal module cup hole 208 aligns with the centrifugal module cup position 201 of the centrifugal module 2.

The cuvette jaw module drives the cuvette to move to the cuvette loading module 8 in the cuvette jaw movement area 10, and the cuvette jaw grabs the cuvette 801 (empty cuvette) stored in the cuvette loading module 8.

The reaction cup clamping jaw module drives the reaction cup to move to the centrifugal module cup position 201 of the centrifugal module 2 in the reaction cup clamping jaw movement area 10, and the reaction cup 801 is placed in the centrifugal module cup placing hole 208 aligned with the centrifugal module cup position 201 of the centrifugal module 2.

Rotation of the centrifugal turntable 204 in the first rotational direction causes the basket 206 to rotate in the first rotational direction, aligning the next centrifugal module cup hole 208 with the centrifugal module cup position 201 of the centrifugal module 2.

The above process is repeated and reaction cups 801 are placed in the centrifuge module cup holes 208 of all baskets 206 arranged in a ring. As shown in fig. 1 and 2, the reaction cups 801 are all placed in the cup placing holes 208 of 12 centrifugal modules in this embodiment.

The reaction cup clamping jaw module drives the reaction cup clamping jaw to clamp the reaction cup 801, and the reaction cup 801 is placed in the cup placing position 401 of the transfer module 4.

Specifically, the transport module tray 403 rotates such that one transport module cup placement hole 404 aligns with the transport module cup placement position 401 of the transport module 4.

The reaction cup clamping jaw module drives the reaction cup to move to a transfer module cup placing position 401 of the transfer module 4 in a reaction cup clamping jaw movement area 10, and the reaction cup 801 is placed in a transfer module cup placing hole 404 aligned with the transfer module cup placing position 401 of the transfer module 4.

The transfer module tray 403 rotates to align the next transfer module cup placement hole 404 with the transfer module cup placement position 401 of the transfer module 4.

The above process is repeated and reaction cups 801 are placed in all of the transfer module cup holes 404 in an annular arrangement. As shown in fig. 1 and 2, the reaction cups 801 are all placed in the cup placing holes 404 of 8 transfer modules in this embodiment.

Step S3, adding whole blood:

the sample application needle module drives the sample application needle to draw a blood sample from the reagent sample sampling site 105 of the reagent sample storage module 1 and to inject a whole blood sample into the reaction cup 801 of the centrifugation module 2.

Specifically, the sample plate 101 is rotated to align a sample tube 102 with the reagent sample sampling site 105 of the reagent sample storage module 1.

The loading needle module drives the loading needle to move to the reagent sample sampling position 105 of the reagent sample storage module 1 in the loading needle movement area 9, and the loading needle draws a blood sample from the sample tube 102 aligned with the reagent sample sampling position 105.

The sample adding needle module drives the sample adding needle to move to the centrifugal module cup position 201 of the centrifugal module 2 in the sample adding needle movement area 9, and the whole blood sample is injected into the reaction cup 801 in the centrifugal module cup placing hole 208 aligned with the centrifugal module cup position 201 of the centrifugal module 2.

The sample disk 101 is rotated to align the next sample tube 102 with the reagent sample sampling site 105 of the reagent sample storage module 1.

The above process is repeated and whole blood samples are injected into all reaction cups 801 placed in the cup holes 208 of the centrifugal modules of all baskets 206 arranged in a ring shape. As shown in fig. 1 and 2, the whole blood sample is injected into all of the 12 reaction cups 801 placed in the cup placing holes 208 of the 12 centrifugation modules in this embodiment.

Step S4, whole blood centrifugation:

the centrifugation module 2 centrifuges the whole blood sample in the cuvette 801 to obtain plasma. Specifically, the centrifugal motor 202 drives the coupling 203 to rotate, the coupling 203 drives the centrifugal turntable 204 to rotate along a first rotation direction (as shown by arrow a in fig. 2), and the basket 206 swings along a second rotation direction (as shown by arrow b in fig. 2) under the action of centrifugal force, so that the reaction cup 801 is inclined, the bottom of the reaction cup 801 is offset to the outside of the centrifugal module 2, and the centrifugation is performed for a preset time t1, so that the whole blood sample in the reaction cup 801 is centrifuged to obtain plasma.

Step S5, adding the first blood plasma:

the sample adding needle module drives the sample adding needle to extract the plasma from the cup placing position 201 of the centrifugal module 2, and injects the plasma into the reaction cup 801 of the transfer module 4.

Specifically, rotation of the centrifugal turntable 204 in the first rotational direction drives the basket 206 to rotate in the first rotational direction, so that the reaction cup 801 in the cup placing hole 208 of one centrifugal module is aligned with the cup position 201 of the centrifugal module 2.

The sample adding needle module drives the sample adding needle to move to the needle washing module 5 in the sample adding needle moving area 9 so as to wash the sample adding needle.

The sample adding needle module drives the sample adding needle to move to the centrifugal module cup position 201 of the centrifugal module 2 in the sample adding needle movement area 9, and the sample adding needle extracts plasma from the reaction cup 801 in the centrifugal module cup placing hole 208 aligned with the centrifugal module cup position 201.

The sample adding needle module drives the sample adding needle to move to the transferring module cup placing position 401 of the transferring module 4 in the sample adding needle moving area 9, and injects the plasma into the reaction cup 801 in the transferring module cup placing hole 404 aligned with the transferring module cup placing position 401 of the transferring module 4.

Step S6, adding a test agent:

the sample application needle module drives the sample application needle to extract the reagent from the reagent sample sampling position 105 of the reagent sample storage module 1, and injects the reagent into the reaction cup 801 of the transfer module 4.

Specifically, the reagent disk 103 rotates to align one of the reagent cartridges 104 with the reagent sample sampling site 105 of the reagent sample storage module 1.

The loading needle module drives the loading needle to move to the reagent sample sampling position 105 of the reagent sample storage module 1 in the loading needle movement area 9, and the loading needle extracts the reagent from the reagent box 104 aligned with the reagent sample sampling position 105.

The sample adding needle module drives the sample adding needle to move to the transferring module cup placing position 401 of the transferring module 4 in the sample adding needle moving area 9, and the reagent is injected into the reaction cup 801 in the transferring module cup placing hole 404 aligned with the transferring module cup placing position 401 of the transferring module 4.

Step S7, uniformly mixing:

the transfer module 4 drives the reaction cup 801 to rotate from the transfer module cup placing position 401 to the transfer module mixing position 402, and plasma and reagents in the reaction cup 801 of the transfer module 4 are mixed uniformly.

Specifically, the transferring module tray 403 rotates to drive the reaction cups 801 in the cup placing holes 404 of the transferring module to align with the transferring module mixing position 402 of the transferring module 4. The plasma and the reagent in the reaction cup 801 of the transfer module 4 are uniformly mixed at the transfer module uniformly mixing position 402 of the transfer module 4 for a preset time t2.

Step S8, incubation:

the reaction cup clamping jaw module drives the reaction cup clamping jaw to grab the reaction cup 801 of the mixing position 402 of the transfer module, and the reaction cup 801 (the reaction cup 801 is internally provided with uniformly mixed plasma and reagent) is placed in the incubation reaction module 7, and the incubation reaction module 7 incubates the sample in the reaction cup 801.

Specifically, the reaction cup clamping jaw module drives the reaction cup to move to the transfer module mixing position 402 of the transfer module 4 in the reaction cup clamping jaw movement area 10, and the reaction cup clamping jaw grabs the reaction cup 801 (the reaction cup 801 is internally provided with uniformly mixed plasma and reagent) in the transfer module cup placing hole 404 aligned with the transfer module mixing position 402 of the transfer module 4.

The reaction cup clamping jaw module drives the reaction cup to move to the incubation reaction module 7 in the reaction cup clamping jaw movement area 10, the reaction cup 801 is placed in the incubation reaction module 7, the incubation reaction module 7 incubates the sample in the reaction cup 801, and the incubation is performed for a preset time t3.

Step S9, magnetic separation:

the reaction cup clamping jaw module drives the reaction cup clamping jaw to clamp the reaction cup 801 of the incubation reaction module 7, the reaction cup 801 is arranged in the magnetic separation module 3, and the magnetic separation module 3 carries out magnetic separation on a sample incubated by the incubation reaction module 7.

Specifically, the magnetic separation module disk 302 is rotated to align one magnetic separation module cup placement hole 303 with the magnetic separation module cup placement position 301 of the magnetic separation module 3.

The reaction cup clamping jaw module drives the reaction cup to move to the incubation reaction module 7 in a reaction cup clamping jaw moving area 10, and the reaction cup clamping jaw clamps a reaction cup 801 (the reaction cup 801 is internally provided with incubated blood plasma) of the incubation reaction module 7.

The reaction cup clamping jaw module drives the reaction cup to move to a magnetic separation module cup placing position 301 of the magnetic separation module 3 in a reaction cup clamping jaw moving area 10 to align with a magnetic separation module cup placing hole 303, the reaction cup 801 is placed in the magnetic separation module cup placing hole 303 aligned with the magnetic separation module cup placing position 301 of the magnetic separation module 3, and the magnetic separation module 3 magnetically separates a sample incubated by the incubation reaction module 7.

Step S10, detection:

the cup clamping jaw module drives the reaction cup clamping jaw to clamp the reaction cup 801 of the magnetic separation module 3, and the reaction cup 801 is placed in the cup placing position 601 of the detection module 6; the detection module 6 drives the reaction cup 801 to rotate from the cup placing position 601 of the detection module to the detection unit 602, and the detection unit 602 detects a sample in the reaction cup 801.

Specifically, the detection module disc 603 rotates to align one detection module cup placement hole 604 with the detection module cup placement position 601 of the detection module 6.

The reaction cup clamping jaw module drives the reaction cup to move to a magnetic separation module cup placing position 301 of the magnetic separation module 3 in a reaction cup clamping jaw moving area 10, and the reaction cup clamping jaw grabs a reaction cup 801 (the reaction cup 801 is internally provided with magnetic separation finished plasma) in a magnetic separation module cup placing hole 303 aligned with the magnetic separation module cup placing position 301 of the magnetic separation module 3.

The reaction cup clamping jaw module drives the reaction cup to move to a detection module cup placing position 601 of the detection module 6 in a reaction cup clamping jaw movement area 10, and the reaction cup 801 is placed in a detection module cup placing hole 604 aligned with the detection module cup placing position 601 of the detection module 6.

The detection module disc 603 rotates to drive the reaction cup 801 to rotate from the cup placing position 601 of the detection module to the detection unit 602, and the detection unit 602 detects samples in the reaction cup 801.

Step S11, cup throwing:

the detection module 6 drives the reaction cup 801 to rotate from the detection unit 602 to the detection module cup placing position 601, and the cup clamping jaw module drives the reaction cup clamping jaw to clamp the reaction cup 801 after the detection of the detection module cup placing position 601 is completed, and the reaction cup 801 is discarded.

Specifically, the detection module disc 603 rotates to drive the reaction cup 801 to rotate from the detection unit 602 to the detection module cup placement position 601.

The reaction cup clamping jaw module drives the reaction cup to move to a detection module cup placing position 601 of the detection module 6 in a reaction cup clamping jaw moving area 10, the reaction cup clamping jaw grabs a reaction cup 801 (waste liquid after detection is arranged in the reaction cup 801) in a detection module cup placing hole 604 aligned with the detection module cup placing position 601 of the detection module 6, and the reaction cup 801 is discarded to a waste basket.

Step S12, placing the cup in the second way:

Step S13, adding second blood plasma:

the sample application needle module drives the sample application needle to extract plasma from the reagent sample sampling position 105 of the reagent sample storage module 1, and injects the plasma into the reaction cup 801 of the transfer module 4.

The loading needle module drives the loading needle to move to the reagent sample sampling position 105 of the reagent sample storage module 1 in the loading needle movement area 9, and the loading needle extracts plasma from the sample tube 102 aligned with the reagent sample sampling position 105.

The sample adding needle module drives the sample adding needle to move to the transferring module cup placing position 401 of the transferring module 4 in the sample adding needle moving area 9, plasma is injected into the reaction cup 801 in the transferring module cup placing hole 404 aligned with the transferring module cup placing position 401 of the transferring module 4, and the steps S6 to S11 are repeated to detect samples in the reaction cup 801.

The following points need to be described:

(1) The drawings of the embodiments of the present utility model relate only to the structures related to the embodiments of the present utility model, and other structures may refer to the general designs.

(2) In the drawings for describing embodiments of the present utility model, the thickness of layers or regions is exaggerated or reduced for clarity, i.e., the drawings are not drawn to actual scale. It will be understood that when an element such as a layer, film, region or substrate is referred to as being "on" or "under" another element, it can be "directly on" or "under" the other element or intervening elements may be present.

(3) The embodiments of the utility model and the features of the embodiments can be combined with each other to give new embodiments without conflict.

The present utility model is not limited to the above embodiments, but the scope of the utility model is defined by the claims.

Claims

1. An immunoassay analyzer is characterized by comprising a reagent sample storage module, a centrifugation module, a transfer module, a magnetic separation module, an incubation reaction module, a detection module and a reaction cup loading module;

2. The immunoassay analyzer of claim 1, wherein said basket is provided with a rail along an outer side of said centrifuge module.

3. The immunoassay analyzer of claim 1, wherein said centrifugation module cup-receiving holes of a plurality of said baskets are arranged in an annular pattern.

4. The immunoassay analyzer of claim 1, wherein said centrifugation module further comprises a centrifugation motor and a coupling; the centrifugal motor is connected with the coupler, and the coupler is connected with the centrifugal turntable.