CN220091009U - Disposable tangential flow system for liposome medicine - Google Patents
Disposable tangential flow system for liposome medicine Download PDFInfo
- Publication number
- CN220091009U CN220091009U CN202222119505.2U CN202222119505U CN220091009U CN 220091009 U CN220091009 U CN 220091009U CN 202222119505 U CN202222119505 U CN 202222119505U CN 220091009 U CN220091009 U CN 220091009U
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- China
- Prior art keywords
- filter
- end cover
- filtrate
- tangential flow
- flow system
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- 239000003814 drug Substances 0.000 title claims abstract description 22
- 239000002502 liposome Substances 0.000 title abstract description 20
- 239000000706 filtrate Substances 0.000 claims abstract description 41
- 230000002572 peristaltic effect Effects 0.000 claims abstract description 20
- 229940079593 drug Drugs 0.000 claims abstract description 17
- 239000012510 hollow fiber Substances 0.000 claims abstract description 16
- 238000005303 weighing Methods 0.000 claims description 19
- 239000007788 liquid Substances 0.000 claims description 17
- 230000001105 regulatory effect Effects 0.000 claims description 15
- 238000007789 sealing Methods 0.000 claims description 11
- 238000009434 installation Methods 0.000 claims description 5
- 239000011550 stock solution Substances 0.000 abstract description 18
- 238000002474 experimental method Methods 0.000 abstract description 5
- 238000001914 filtration Methods 0.000 description 13
- 239000012528 membrane Substances 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000000232 Lipid Bilayer Substances 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 239000003012 bilayer membrane Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 239000012065 filter cake Substances 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000013022 formulation composition Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The utility model discloses a disposable tangential flow system of liposome drugs, which comprises a buffer tank, wherein the buffer tank is connected with a storage container through a first peristaltic pump, the right side of the storage container is provided with a filter, the top end of the filter is connected with an upper end cover through a bolt, the bottom end of the filter is provided with a lower end cover, the upper end cover is connected with a filtrate collecting container through a filtrate outlet pipe, when the disposable tangential flow system is used, the first peristaltic pump and the second peristaltic pump are started, filtrate is filtered through a hollow fiber column and then enters the filtrate collecting container through the filtrate outlet pipe, unfiltered stock solution is returned to the storage container through a circulating pipe, the filtrate in the filtrate collecting container can be convenient for personnel to carry out experiments, when the interior of the filter is required to be cleaned, the upper end cover and the lower end cover are detached, then a mounting disc is taken out, the hollow fiber column is pulled out of the filter, and the interior of the filter is convenient for personnel to clean.
Description
Technical Field
The utility model relates to the technical field of liposome drug filtration, in particular to a disposable tangential flow system of a liposome drug.
Background
Since the discovery of phospholipid bilayer membranes in the 90 s of the 20 th century, the study of liposomes as drug delivery vehicles has been greatly advanced. Liposomes refer to the microvesicles formed by the encapsulation of drugs within a lipid bilayer. The phospholipid molecules have hydrophilic heads inserted into water and hydrophobic tails extending to air to form spherical liposome with lipid bilayer structure, and the particle size is usually 25-1000 nm. The bilayer membrane structure of the liposome is similar to a biological membrane, and has good biocompatibility; the liposome-encapsulated drug has the advantages of targeting, long-acting property, low toxicity and good encapsulation and protection. Liposomes are therefore used for the delivery of a variety of active agents to improve the blood circulation time after the agent enters the body, increasing accumulation at the target site. The function of the liposome can be altered by changing the particle size of the particles, the lipid formulation composition, and the surface characteristics of the lipid membrane. The different lipid materials can be used for preparing various functional liposomes such as long-circulating liposome, thermosensitive liposome, pH-sensitive liposome, immunoliposome and the like, so as to achieve the special treatment purpose.
Tangential flow refers to the ultrafiltration pattern in which the liquid flow direction is perpendicular to the filtration direction. The flow direction of the traditional vertical filtration liquid is consistent with the filtration direction, and along with the progress of filtration, the thickness of a filter cake layer or a gel layer formed on the surface of a filtration membrane is gradually increased, and the flow speed is gradually reduced, so that the capacity of treating the feed liquid for dead-end filtration is limited to a certain extent. The tangential flow ultrafiltration generates shearing force on the surface of the filter medium in the liquid flowing process, reduces the accumulation of filter cakes or gel layers, ensures stable filtration speed, and plays an extremely important role in the whole filtration process.
Existing disposable tangential flow systems for liposomal drugs generally include: the stock solution to be filtered is stored in the stock solution storage tank, is continuously pumped into the tangential membrane filter for filtration through the peristaltic pump, and can be collected from a purified water outlet of the tangential membrane filter to obtain the filtered stock solution for experiments. But it is inconvenient to clean the inside of the tangential membrane filter after the filtration process is finished, and for this reason we propose a liposome drug disposable tangential flow system.
Disclosure of Invention
The present utility model is directed to a disposable tangential flow system for liposomal drugs to solve the above-mentioned problems.
In order to achieve the above purpose, the present utility model provides the following technical solutions:
the utility model provides a disposable tangential flow system of liposome medicine, includes the buffer tank, the buffer tank is connected with storage vessel through first peristaltic pump, storage vessel's right side is provided with the filter, the top bolted connection of filter has the upper end cover, the bottom of filter is provided with the lower extreme cover, be provided with the mounting disc between lower extreme cover and the filter, the mounting disc passes through a plurality of support fixedly connected with installation annular plate, a plurality of hollow fiber posts are installed to the up end of installation annular plate, the inside top fixedly connected with annular plate of filter, a plurality of through-holes have been seted up to the up end on the annular plate, hollow fiber post wears to establish on the through-hole, be connected with the feed liquor pipe between lower extreme cover and the storage vessel, install the second peristaltic pump on the feed liquor pipe, the surface fixedly connected with drain pipe of filter, the drain pipe passes through fixed intercommunication with the storage vessel, the upper end cover is connected with the filtrate collection vessel through the filtrate exit tube, the below of storage vessel is provided with first weighing platform, the below of filtrate collection vessel is provided with the second weighing platform.
Preferably, the liquid inlet pipe is provided with a first regulating valve, the circulating pipe is provided with a second regulating valve, and the filtrate outlet pipe is provided with a third regulating valve.
Preferably, a sealing gasket is arranged in the through hole in the annular plate.
Preferably, a first sealing ring is arranged between the upper end cover and the filter.
Preferably, a second sealing ring is arranged between the lower end cover and the filter.
Preferably, a filter screen is fixedly arranged in the lower end cover.
Compared with the prior art, the utility model has the beneficial effects that: the disposable tangential flow system of the liposome medicine is convenient to use and simple in structure, stock solution in the buffer tank enters the storage container under the action of the first peristaltic pump, stock solution enters the filter under the action of the second peristaltic pump, filtrate is filtered by the hollow fiber column and enters the filtrate collecting container through the filtrate outlet pipe, unfiltered stock solution returns to the storage container through the circulating pipe, the filtrate in the filtrate collecting container can facilitate experiments by personnel, the first weighing table can facilitate weighing of the stock solution in the storage container, the second weighing table can facilitate weighing of the filtrate in the filtrate collecting container, when the interior of the filter is required to be cleaned, the upper end cover and the lower end cover are detached at the moment, the mounting disc is taken out, the hollow fiber column is pulled out of the filter, and the personnel can clean the interior of the filter conveniently; the filter screen that sets up can carry out prefiltering to the stoste, is favorable to improving the filter effect.
Drawings
FIG. 1 is a schematic diagram of the main structure of a disposable tangential flow system for liposomal drugs;
fig. 2 is a schematic diagram of a filter structure of a disposable tangential flow system for liposomal drug.
In the figure: the device comprises a 1-buffer tank, a 2-first peristaltic pump, a 3-storage container, a 4-circulating pipe, a 5-second regulating valve, a 6-filtrate outlet pipe, a 7-third regulating valve, an 8-filter, a 9-liquid inlet pipe, a 10-filtrate collecting container, an 11-second weighing platform, a 12-first regulating valve, a 13-second peristaltic pump, a 14-first weighing platform, a 15-lower end cover, a 16-filter screen, a 17-mounting disc, a 18-mounting annular plate, a 19-hollow fiber column, a 20-liquid outlet pipe, a 21-sealing gasket, a 22-upper end cover and a 23-annular plate.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Example 1: referring to fig. 1-2, a disposable tangential flow system of liposome medicine comprises a buffer tank 1, the buffer tank 1 is connected with a storage container 3 through a first peristaltic pump 2, the right side of the storage container 3 is provided with a filter 8, the top end of the filter 8 is connected with an upper end cover 22 through bolts, the bottom end of the filter 8 is provided with a lower end cover 15, a mounting disc 17 is arranged between the lower end cover 15 and the filter 8, the mounting disc 17 is fixedly connected with a mounting annular plate 18 through a plurality of brackets, a plurality of hollow fiber columns 19 are mounted on the upper end surface of the mounting annular plate 18, an annular plate 23 is fixedly connected with the inside upper part of the filter 8, a plurality of through holes are formed in the upper end surface of the annular plate 23, the hollow fiber columns 19 are arranged on the through holes in a penetrating mode, a liquid inlet pipe 9 is connected between the lower end cover 15 and the storage container 3, the outer surface of the filter 8 is fixedly connected with a liquid outlet pipe 20, the liquid outlet pipe 20 is fixedly communicated with the storage container 3 through 4, a filtrate collecting platform 10 is arranged below the second peristaltic pump 13 through the upper end cover 22, and a weighing platform 10 is arranged below the second storage container 10.
When the filter is used, the first peristaltic pump 2 and the second peristaltic pump 13 are started, stock solution in the buffer tank 1 enters the storage container 3, stock solution enters the filter 8 through the liquid inlet pipe 9 under the action of the second peristaltic pump 13, filtrate enters the filtrate collecting container 10 through the filtrate outlet pipe 6 after being filtered by the hollow fiber column 19, unfiltered stock solution returns to the storage container 3 through the circulating pipe 4, the filtrate in the filtrate collecting container 10 can be conveniently used for experiments by personnel, the first weighing table 14 can be conveniently used for weighing the stock solution in the storage container 3, the second weighing table 11 can be conveniently used for weighing the filtrate in the filtrate collecting container 10, when the interior of the filter 8 is required to be cleaned, the upper end cover 22 and the lower end cover 15 are detached, the mounting disc 17 is taken out, the hollow fiber column 19 is pulled out of the filter 8, and the personnel can conveniently clean the interior of the filter 8.
Wherein, install first governing valve 12 on the feed-in pipe 9, install second governing valve 5 on the circulating pipe 4, install third governing valve 7 on the filtrate outlet pipe 6.
The first regulating valve 12 can regulate the liquid inlet pressure on the liquid inlet pipe 9, the second regulating valve 5 can regulate the liquid outlet pressure on the circulating pipe 4, and the third regulating valve 7 can regulate the liquid outlet pressure on the filtrate outlet pipe 6.
Wherein, the inside of the through hole on the annular plate 23 is provided with a sealing gasket 21, and the sealing gasket 21 can be convenient for improving the tightness of the hollow fiber column 19 after installation.
Wherein a first sealing ring is arranged between the upper end cover 22 and the filter 8.
Wherein a second sealing ring is arranged between the lower end cover 15 and the filter 8.
Example 2: referring to fig. 1, a disposable tangential flow system of liposome drug is different from embodiment 1 in that a filter screen 16 is fixedly installed inside the lower end cap 15.
The filter screen 16 can be used for prefiltering the stock solution, which is beneficial to improving the filtering effect.
The working principle of the utility model is as follows: when the filter is used, the first peristaltic pump 2 and the second peristaltic pump 13 are started, the stock solution in the buffer tank 1 enters the storage container 3, the stock solution enters the filter 8 through the liquid inlet pipe 9 under the action of the second peristaltic pump 13, the filtrate is filtered through the hollow fiber column 19 and enters the filtrate collecting container 10 through the filtrate outlet pipe 6, the unfiltered stock solution returns to the storage container 3 through the circulating pipe 4, the filtrate in the filtrate collecting container 10 can facilitate the experiment of personnel, the first weighing table 14 can facilitate the weighing of the stock solution in the storage container 3, the second weighing table 11 can facilitate the weighing of the filtrate in the filtrate collecting container 10, when the interior of the filter 8 is required to be cleaned, the upper end cover 22 and the lower end cover 15 are dismounted, the mounting disc 17 is taken out, the hollow fiber column 19 is pulled out of the filter 8, and the personnel can clean the interior of the filter 8 conveniently; the first regulating valve 12 can regulate the inlet pressure on the inlet pipe 9, the second regulating valve 5 can regulate the outlet pressure on the circulating pipe 4, and the third regulating valve 7 can regulate the outlet pressure on the filtrate outlet pipe 6; the filter screen 16 can be used for prefiltering the stock solution, which is beneficial to improving the filtering effect.
In the present utility model, terms such as "upper", "lower", "left", "right", "front", "rear", "vertical", "horizontal", "side", "bottom", etc. refer to an orientation or a positional relationship based on that shown in the drawings, and are merely relational terms, which are used for convenience in describing structural relationships of various components or elements of the present utility model, and do not denote any one of the components or elements of the present utility model, and are not to be construed as limiting the present utility model.
Claims (6)
1. A disposable tangential flow system of a liposomal drug, comprising a buffer tank (1), characterized in that: the utility model discloses a filter, including buffer tank (1), filter, circulating pipe (4) and filter, buffer tank (1) is connected with reservoir (3) through first peristaltic pump (2), the right side of reservoir (3) is provided with filter (8), the top bolted connection of filter (8) has upper end cover (22), the bottom of filter (8) is provided with lower end cover (15), be provided with mounting disc (17) between lower end cover (15) and filter (8), mounting disc (17) are through a plurality of support fixedly connected with installation annular plate (18), a plurality of hollow fiber post (19) are installed to the up end of installation annular plate (18), a plurality of through holes have been seted up to the up end on annular plate (23), hollow fiber post (19) wear to establish on the through holes, be connected with feed liquor pipe (9) between lower end cover (15) and reservoir (3), install second peristaltic pump (13) on feed liquor pipe (9), the surface fixedly connected with drain pipe (20) of filter (8), circulating pipe (20) are through fixedly connected with annular plate (23) and reservoir (4) are connected with filtrate (10), a first weighing table (14) is arranged below the storage container (3), and a second weighing table (11) is arranged below the filtrate collecting container (10).
2. A liposomal drug disposable tangential flow system according to claim 1 wherein: the liquid inlet pipe (9) is provided with a first regulating valve (12), the circulating pipe (4) is provided with a second regulating valve (5), and the filtrate outlet pipe (6) is provided with a third regulating valve (7).
3. A liposomal drug disposable tangential flow system according to claim 2 wherein: a sealing gasket (21) is arranged in the through hole in the annular plate (23).
4. A liposomal drug disposable tangential flow system according to claim 3 wherein: a first sealing ring is arranged between the upper end cover (22) and the filter (8).
5. A liposomal drug disposable tangential flow system according to claim 4 wherein: a second sealing ring is arranged between the lower end cover (15) and the filter (8).
6. A liposomal drug disposable tangential flow system according to claim 5 wherein: a filter screen (16) is fixedly arranged in the lower end cover (15).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222119505.2U CN220091009U (en) | 2022-08-12 | 2022-08-12 | Disposable tangential flow system for liposome medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222119505.2U CN220091009U (en) | 2022-08-12 | 2022-08-12 | Disposable tangential flow system for liposome medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220091009U true CN220091009U (en) | 2023-11-28 |
Family
ID=88844080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202222119505.2U Active CN220091009U (en) | 2022-08-12 | 2022-08-12 | Disposable tangential flow system for liposome medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220091009U (en) |
-
2022
- 2022-08-12 CN CN202222119505.2U patent/CN220091009U/en active Active
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| GR01 | Patent grant |