CN220077210U - Substrate anti-pollution structure for chemiluminescence immunoassay - Google Patents
Substrate anti-pollution structure for chemiluminescence immunoassay Download PDFInfo
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- CN220077210U CN220077210U CN202321645633.9U CN202321645633U CN220077210U CN 220077210 U CN220077210 U CN 220077210U CN 202321645633 U CN202321645633 U CN 202321645633U CN 220077210 U CN220077210 U CN 220077210U
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- substrate
- tube
- hole
- substrate tube
- chemiluminescent immunoassay
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- 239000000758 substrate Substances 0.000 title claims abstract description 178
- 238000003018 immunoassay Methods 0.000 title claims abstract description 28
- 230000007246 mechanism Effects 0.000 claims abstract description 30
- 238000011109 contamination Methods 0.000 claims description 10
- 230000002265 prevention Effects 0.000 claims description 10
- 238000004891 communication Methods 0.000 claims description 5
- 239000000463 material Substances 0.000 abstract description 23
- 238000007789 sealing Methods 0.000 description 13
- 230000000694 effects Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 230000003373 anti-fouling effect Effects 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
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- Sampling And Sample Adjustment (AREA)
Abstract
The utility model discloses a substrate anti-pollution structure for chemiluminescent immunoassay, which comprises a containing bottle and a cover, wherein a first through hole and a second through hole are formed in the cover, the first through hole is penetrated by a substrate tube mechanism, one end of the substrate tube mechanism stretches into the containing bottle, the other end of the substrate tube mechanism is exposed out of the cover, two passages are respectively formed by the first through hole 3 and the second through hole 4 along the axial direction, and control valves are arranged on the passages of the first through hole and the passages of the second through hole. According to the utility model, through holes are formed in the cover, and two through hole passages are formed, so that not only is the tightness of the whole anti-pollution structure ensured, but also the purposes of avoiding the pollution of substrates in the accommodating body caused by the air entering during material taking and smoothly taking out the substrate are achieved.
Description
Technical Field
The utility model relates to the field of chemiluminescent immunity, in particular to a substrate anti-pollution structure for chemiluminescent immunoassay.
Background
Chemiluminescent immunoassay (chemiluminescence immunoassay, CLIA) combines a chemiluminescent assay technique with high sensitivity with a highly specific immune reaction, and is used for detection and analysis of various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins, drugs, etc. Is a latest immunoassay technology developed after the analysis of radioimmunoassay, enzyme immunoassay, fluorescence immunoassay and time-resolved fluorescence immunoassay. The principle of chemiluminescence is that molecules in an excited state in a substrate undergo chemical reactions of binding, photolysis and recombination, and energy is converted from the excited state to a ground state, thereby emitting light. Wherein the substrate is a key material on the chemiluminescent instrument, and the quality of the substrate determines the performance of the instrument to a certain extent. However, in the process of storing or taking out the substrate, the substrate can be polluted by air to deteriorate during air leakage, so that the measurement result of the instrument is affected, and it is important to reduce the pollution and deterioration of the substrate.
In order to solve the problem, in practical application, a containing device with better tightness is selected, but when the cover of the containing device is opened to take materials, air enters the containing chamber through the opening to contact with the substrate, and the substrate is certainly polluted at a high speed.
In view of this, the present utility model has been made.
Disclosure of Invention
The utility model aims to provide a substrate anti-pollution structure for chemiluminescent immunoassay, which solves the problem that a base material is polluted due to uncovering when taking materials by arranging through holes and two through hole passages on a cover.
The embodiment of the utility model is realized by the following technical scheme:
compared with the prior art, the embodiment of the utility model has the following advantages and beneficial effects: including holding bottle and lid, the lid closes on holding the bottle bottleneck, has seted up first through-hole and second through-hole on the lid, and first through-hole is run through by substrate pipe mechanism, and the one end of substrate pipe mechanism stretches into in holding the bottle and the other end exposes in the lid outside, and first through-hole and second through-hole form two passageways along axial direction respectively, all install the control valve on the passageway of first through-hole and the passageway of second through-hole.
Preferably, the substrate tube mechanism inside the cover is in communication with a substrate seal.
Preferably, the substrate tube mechanism is provided with a collar structure.
Preferably, the clip structure is adjustable.
Preferably, the substrate tube mechanism comprises a substrate tube and a substrate guide tube, the substrate tube penetrates through the first through hole, the substrate guide tube is sleeved on the substrate tube, the substrate tube is a hose, and the substrate guide tube is a hard tube.
Preferably, the substrate tube includes a first substrate tube and a second substrate tube communicating with each other, the second substrate tube being disposed at an end portion within the accommodating bottle, the second substrate tube having a radial diameter larger than that of the first substrate tube.
Preferably, the control valve on the second through hole passage is a one-way valve, and a filter is arranged on the one-way valve.
Preferably, the second through hole is connected with a bolt part, and a detachable connecting pipe is arranged between the bolt part and the one-way valve.
Preferably, the connection tube is a hose.
Preferably, the substrate seal is a rubber piston.
1. According to the utility model, through holes are formed in the cover, two through hole passages are formed, wherein the first through hole passage consists of the substrate tube mechanism, and the second through hole passage is matched with the first through hole passage to balance the pressure difference inside and outside the accommodating bottle so as to ensure that substrate materials can be easily taken out.
2. The clamp structure is arranged to be an adjustable structure, the substrate tube mechanism can be longitudinally adjusted to be extended to a sufficient position according to requirements so as to be convenient to take materials, and when the substrate tube is a hose, the clamp structure can control the switch of the first through hole passage.
3. The substrate tube is divided into a first substrate tube and a second substrate tube, and the radial diameter of the second substrate tube is set to be larger than that of the first substrate tube, so that liquid can be taken smoothly.
In general, the substrate anti-pollution structure for chemiluminescent immunoassay provided by the embodiment of the utility model achieves the purposes that the cover is not required to be opened during material taking, the material can be successfully taken successfully, and the substrate is not polluted by air by arranging two passages on the cover.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present utility model and therefore should not be considered as limiting the scope, and other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram showing the disassembly of a substrate anti-fouling structure useful in chemiluminescent immunoassay according to an embodiment of the present utility model;
FIG. 2 is a schematic top view of a cover for a substrate contamination prevention structure useful in chemiluminescent immunoassay according to an embodiment of the present utility model;
FIG. 3 is a schematic view of a substrate tube structure of a substrate anti-fouling structure useful in chemiluminescent immunoassay according to an embodiment of the present utility model;
FIG. 4 is a schematic diagram of a substrate anti-fouling structure useful in chemiluminescent immunoassay according to an embodiment of the present utility model after closure.
In the drawings, the reference numerals and corresponding part names:
1-accommodating bottle, 2-cover, 3-first through hole, 4-second through hole, 5-substrate sealing piece, 6-clamp structure, 7-substrate tube, 71-first substrate tube, 72-second substrate tube, 8-substrate guide tube, 9-check valve, 10-bolt component, 11-connecting tube.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present utility model more apparent, the technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model, and it is apparent that the described embodiments are some embodiments of the present utility model, but not all embodiments of the present utility model. The components of the embodiments of the present utility model generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the utility model, as presented in the figures, is not intended to limit the scope of the utility model, as claimed, but is merely representative of selected embodiments of the utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures.
In the description of the present utility model, it should be noted that the terms "first," "second," "third," and the like are used merely to distinguish between descriptions and are not to be construed as indicating or implying relative importance.
Examples
As shown in fig. 1-2 and fig. 4, the embodiment of the utility model provides a substrate anti-pollution structure for chemiluminescent immunoassay, which comprises a containing bottle 1 and a cover 2, wherein chemiluminescent immunoassay substrates are placed or stored in the containing bottle 1, the cover 2 is covered on the bottle mouth of the containing bottle 1, a first through hole 3 and a second through hole 4 are formed in the cover 2, the first through hole 3 is penetrated by a substrate tube mechanism for substrate taking, so that one end of the substrate tube mechanism stretches into the containing bottle 1 to be in contact with the substrates, the other end of the substrate tube mechanism is exposed to the outer side of the cover 2, during taking, the substrates enter the substrate tube mechanism from the containing bottle 1, the substrates are exposed to the outer side of the cover 2 through the substrate tube mechanism, control valves are respectively arranged on the paths of the first through hole 3 and the paths of the second through hole 4 exposed to the outer side of the substrate bottle, an operator can conveniently operate the control valves by respectively arranging the control valves on the outer sides of the covers 2 of the two paths, during taking, the substrates can be taken out from the first path through the control valve of the first through hole 3, and the substrates can be completely isolated from the containing bottle 1 by closing the control valve on the first path 3 when taking is not needed.
Meanwhile, in the process of taking materials, an operator can select and control a control valve on a passage of the second through hole 4, control the pressure difference between the inside and the outside of the accommodating bottle 1 during taking materials, ensure that the materials can be taken smoothly, control the opening time of the control valve on the passage of the second through hole 4 according to requirements, ensure that the materials can be taken smoothly under the condition of ensuring tightness as much as possible, and close the control valve on the passage of the second through hole 4 after the materials are taken to achieve the effect of sealing and preserving.
Further, the substrate tube mechanism inside the cover 2 is communicated with the substrate sealing member 5, and the substrate sealing member 5 has the function of enabling the sealing effect of the cover 2 and the accommodating bottle 1 to be better, and the substrate sealing member 5 can be of an O-shaped sealing ring, a piston sealing structure and the like, so long as the airtight sealing effect between the cover 2 and the accommodating bottle 1 can be achieved, and as the preferable embodiment, the rubber piston is selected as the substrate sealing member 5, and the sealing effect is good. It should be noted that the lid 2 and the container 1 may be hinged in a detachable manner, or may be hinged in a separate manner, so long as the functions of opening and sealing the bottle mouth are achieved.
Further, a clamp structure 6 is arranged on the substrate tube mechanism, the clamp structure 6 can fix the substrate tube mechanism on the cover 2 and isolate a gap between the first vent hole and the substrate tube mechanism, and as a preferable mode, the clamp structure 6 provided by the embodiment of the utility model is adjustable, the adjustable mode specifically means that the gap between the clamp structure 6 and the substrate tube mechanism is adjustable, so that an operator can control the movement of the substrate tube mechanism in the vertical direction by adjusting the gap between the clamp structure 6 and the substrate tube 7, namely, the length of the substrate tube mechanism in the accommodating bottle 1 is controlled, and through the structure, the length of the substrate tube mechanism in the accommodating bottle 1 can be adjusted according to the residual quantity of the substrate, and further the opening of the substrate tube mechanism in the accommodating bottle 1 can be fully contacted with the substrate, and the material taking efficiency is ensured.
Further, the substrate tube mechanism comprises a substrate tube 7 and a substrate guide tube 8, wherein the substrate tube 7 penetrates through the first through hole 3, the substrate guide tube 8 is sleeved on the substrate tube 7, the substrate tube 7 is a hose, and the substrate guide tube 8 is a hard tube. Specifically, the substrate tube 7 is set as a hose, an operator can squeeze the substrate tube 7 outside the cover 2 during material taking, squeeze part of air in the substrate tube 7, the pressure in the substrate tube 7 is smaller than the pressure in the accommodating bottle 1 when the squeezing is stopped, under the action of pressure difference, the substrate in the accommodating bottle 1 enters the substrate tube 7 through the opening of the substrate tube 7 in the accommodating bottle 1, and under the action of pressure difference, the substrate is conveyed to the outlet of the substrate tube 7 outside the accommodating bottle 1 until material taking is successful. In order to enable the substrate inlet of the substrate tube 7 in the accommodating bottle 1 to be conveniently adjusted, the substrate inlet of the substrate tube 7 in the accommodating bottle 1 can be smoothly adjusted to be fully contacted with the substrate, and a rigid substrate guide tube 8 is sleeved outside the substrate tube 7, so that the substrate guide tube 8 is arranged at the middle lower part of the substrate tube 7 in the accommodating bottle 1 and does not cover the substrate inlet, and the substrate inlet of the substrate tube 7 can be conveniently adjusted.
Of course, in other embodiments, the substrate guide tube 8 may be disposed so as to cover the substrate tube 7 in the accommodating bottle 1, or the substrate guide tube 8 may be disposed at a position at the middle upper portion of the substrate tube 7 in the accommodating bottle 1, as long as the substrate inlet position to the substrate tube 7 is reached. In other embodiments, the substrate tube 7 with moderate hardness may be directly selected or the substrate tube 7 may be a hard tube, and when the substrate tube 7 is a hard tube, the substrate tube 7 may be provided with an air extracting device, or an independent air extracting device may be used to implement the material taking, where the control valve on the first passage needs to be separately set and cannot be used with the clip structure 6.
Further, in order to make the material taking smoother, the substrate tube 7 is provided as a first substrate tube 71 and a second substrate tube 72 which are communicated with each other, the second substrate tube 72 is provided at the end portion inside the accommodating bottle 1, and the radial diameter of the second substrate tube 72 is larger than that of the first substrate tube 71. This structure is realized by increasing the material inlet portion of the substrate tube 7, and it should be noted that the second substrate tube 72 is disposed at the end portion of the substrate tube 7 in the accommodating bottle 1, and may include the substrate tube 7 in the entire accommodating bottle 1, or may include the substrate tube 7 in the portion accommodating bottle 1, or may include the substrate tube 7 in the entire accommodating bottle 1 and the substrate tube 7 outside the portion accommodating bottle 1, that is, the length between the first substrate tube 71 and the second substrate tube 72 may be selected according to the actual requirement, so long as the substrate inlet size of the substrate tube 7 in the accommodating bottle 1 can be increased. Meanwhile, the first substrate tube 71 and the second substrate tube 72 may be integrally provided, or may be spliced, as long as the mutual communication and sealing effect can be achieved.
Further, the control valve on the passageway of the second through hole 4 is the check valve 9, and the check valve 9 can control air and only get into in holding bottle 1 from the external world and control the internal and external atmospheric pressure of holding bottle 1, makes the gas in holding bottle 1 hardly flow out to holding bottle 1 outside through the second through hole 4, and the effectual gas exchange of holding bottle 1 inside and outside that has controlled is, and the in-process of getting the material, the check valve on the passageway of second through hole 4 opens under the effect of inside and outside differential pressure, and after getting the material, the check valve on the passageway of second through hole 4 self-closing. The check valve 9 is provided with a filter, and the filter can be a filter screen, an activated carbon bag pack and the like, and is arranged on the check valve 9 in a clamping, gluing and other modes. The device is used for filtering air impurities, can effectively control the limited material exchange with the air in the accommodating bottle 1, and reduces the possibility of polluting substrates by the impurities in the air.
Further, the second through hole 4 is connected with a bolt part 10, a detachable connecting pipe 11 is arranged between the bolt part 10 and the one-way valve 9, and the connecting pipe 11 can be detachably cleaned while the air tightness is ensured through the bolt and the detachable connecting pipe 11, so that the connecting pipe 11 is prevented from being blocked, and the effect of losing the balance air pressure of the passage of the second through hole 4 is prevented.
Further, the connection pipe 11 is a hose, and the hose is provided to more conveniently dredge the connection pipe 11 from impurities accumulated for a long period of time.
The above description is only of the preferred embodiments of the present utility model and is not intended to limit the present utility model, but various modifications and variations can be made to the present utility model by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present utility model should be included in the protection scope of the present utility model. It should be noted that the structures or components illustrated in the drawings are not necessarily drawn to scale, and that descriptions of well-known components and processing techniques and procedures are omitted so as not to unnecessarily limit the present utility model.
Claims (10)
1. The utility model provides a substrate anti-pollution structure that can be used to chemiluminescence immunoassay, includes holds bottle (1) and lid (2), and lid (2) lid closes on holding bottle (1) bottleneck, a serial communication port, first through-hole (3) and second through-hole (4) have been seted up on lid (2), first through-hole (3) are run through by substrate tube mechanism, the one end of substrate tube mechanism stretches into in holding bottle (1) and the other end exposes in lid (2) outside, first through-hole (3) and second through-hole (4) form two passageways along axial direction respectively, all install the control valve on the passageway of first through-hole (3) and on the passageway of second through-hole (4).
2. A substrate contamination prevention structure for use in a chemiluminescent immunoassay according to claim 1 wherein a substrate seal (5) is in communication with the substrate tube mechanism inside the lid (2).
3. A substrate contamination prevention structure for use in a chemiluminescent immunoassay according to claim 2 wherein the substrate tube mechanism is provided with a collar structure (6).
4. A substrate contamination prevention structure for use in a chemiluminescent immunoassay according to claim 3 wherein the collar structure (6) is adjustable.
5. A substrate contamination prevention structure for chemiluminescent immunoassay according to claim 3 wherein the substrate tube mechanism comprises a substrate tube (7) and a substrate guide tube (8), the substrate tube (7) extending through the first through hole (3), the substrate guide tube (8) is sleeved on the substrate tube (7), the substrate tube (7) is a flexible tube, and the substrate guide tube (8) is a rigid tube.
6. A substrate contamination prevention structure usable in chemiluminescent immunoassay according to claim 5 wherein the substrate tube (7) comprises a first substrate tube (71) and a second substrate tube (72) in communication with each other, the second substrate tube (72) being disposed at an end within the containment bottle (1), the second substrate tube (72) having a radial diameter greater than a radial diameter of the first substrate tube (71).
7. A substrate contamination prevention structure for chemiluminescent immunoassay according to claim 1 wherein the control valve on the second port (4) is a one-way valve (9), and a filter is provided on the one-way valve (9).
8. The substrate contamination prevention structure for chemiluminescent immunoassay according to claim 7, wherein a bolt member (10) is attached to the second through hole (4), and a detachable connection tube (11) is provided between the bolt member (10) and the check valve (9).
9. A substrate contamination prevention structure for use in a chemiluminescent immunoassay according to claim 8 wherein the connecting tube (11) is a hose.
10. A substrate contamination prevention structure for use in chemiluminescent immunoassay according to claim 2 wherein the substrate seal (5) is a rubber piston.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321645633.9U CN220077210U (en) | 2023-06-27 | 2023-06-27 | Substrate anti-pollution structure for chemiluminescence immunoassay |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321645633.9U CN220077210U (en) | 2023-06-27 | 2023-06-27 | Substrate anti-pollution structure for chemiluminescence immunoassay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220077210U true CN220077210U (en) | 2023-11-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321645633.9U Active CN220077210U (en) | 2023-06-27 | 2023-06-27 | Substrate anti-pollution structure for chemiluminescence immunoassay |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220077210U (en) |
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2023
- 2023-06-27 CN CN202321645633.9U patent/CN220077210U/en active Active
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