CN219951034U - Chip locking mechanism for molecular diagnosis equipment - Google Patents
Chip locking mechanism for molecular diagnosis equipment Download PDFInfo
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- CN219951034U CN219951034U CN202321098167.7U CN202321098167U CN219951034U CN 219951034 U CN219951034 U CN 219951034U CN 202321098167 U CN202321098167 U CN 202321098167U CN 219951034 U CN219951034 U CN 219951034U
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- connecting rod
- side frame
- movable side
- locking mechanism
- frame
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- 238000003745 diagnosis Methods 0.000 title abstract description 15
- 238000001514 detection method Methods 0.000 abstract description 9
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 238000005516 engineering process Methods 0.000 description 8
- 238000003752 polymerase chain reaction Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 5
- 150000007523 nucleic acids Chemical class 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 108020004707 nucleic acids Proteins 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 230000003321 amplification Effects 0.000 description 4
- 238000003199 nucleic acid amplification method Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000009007 Diagnostic Kit Methods 0.000 description 1
- 239000012807 PCR reagent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000001821 nucleic acid purification Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Abstract
The utility model provides a chip locking mechanism for molecular diagnostic equipment, which comprises a bottom plate frame, a movable side frame, a fixed side frame, a movable side connecting rod, a fixed side connecting rod and a transverse connecting rod, wherein the fixed side frame is fixed on the bottom plate frame, and the movable side frame is hinged on the bottom plate frame; a slot for accommodating the microfluidic chip is formed between the fixed side frame and the movable side frame; the movable side connecting rod is hinged with the movable side frame, the fixed side connecting rod is hinged with the fixed side frame, and the transverse connecting rod is hinged with the movable side connecting rod and the fixed side connecting rod; the transverse connecting rod drives the movable side connecting rod to pull or push the movable side frame to be close to or far away from the fixed side frame, so as to clamp or loosen the microfluidic chip inserted into the slot. When the PCR molecular diagnosis is carried out, the microfluidic chip is stably clamped on the molecular diagnosis equipment, so that the full-flow automatic detection is realized.
Description
Technical Field
The utility model relates to the technical field of medical instruments, in particular to a chip locking mechanism for molecular diagnosis equipment.
Background
Molecular diagnostics is an important branch of in vitro diagnostics. PCR (polymerase chain reaction) technology is one of the most widely used technologies in the molecular diagnostic technology center. The PCR technology comprises complex processing procedures including reagent preparation, nucleic acid extraction, nuclear amplification, result analysis and the like. Traditional PCR has the following pain points: (1) The laboratory site requirement is high, four links of sample preparation, reagent preparation, nucleic acid extraction and nucleic acid amplification are strictly partitioned, the air pressure in the four partitions is gradually reduced, and the laboratory flow and logistics routes are strictly adhered to; (2) The operation requirement of personnel is high, and molecular diagnosis detection personnel need to have certain professional skills to support the evidence on duty; (3) The cost is high, the molecular diagnosis process involves various special equipment, and the cost is high.
Microfluidic technology refers to the science and technology involved in systems that use microchannels to process or manipulate tiny fluids, and is an emerging interdisciplinary in relation to chemical, fluid physics, microelectronics, new materials, biology, and biomedical engineering. The microfluidic technology can concentrate the detection process on a chip with a centimeter-to-micrometer level, so that the whole detection is miniaturized and automated, thereby greatly reducing the requirements of the detection process on fields, personnel and equipment and realizing the one-step detection of 'sample in and sample out'. Microfluidic devices are known as microfluidic chips.
The PCR detection has high requirements on sites, personnel and equipment, and the microfluidic technology can effectively realize the integration and automation of detection, so that the microfluidic technology becomes a very promising technical route in the field of molecular diagnosis.
US8673238B2 discloses a GeneXpert molecular diagnostic kit from Cepheid and a test instrument for performing full-automatic analysis of the kit, which are typical molecular diagnostic microfluidic products, and discloses a piston which can move up and down in the middle of the kit and is arranged in a plurality of chambers in the kit. The middle piston chamber can be respectively communicated with the surrounding reagent chambers through a rotary valve at the bottom of the reagent box, so that the flow control of the reagent is realized. A reaction tube is designed at the rear part of the kit, and the mixed solution of the extracted nucleic acid and the PCR reagent is injected into the reaction tube to realize the nucleic acid amplification. However, the kit has a complex structure and a plurality of sealing links, especially rotary valves, and needs to realize motion sealing, thereby having high requirements on the production process.
U.S. patent No. 8940526B2 discloses a Filmarray microfluidic chip from Biofire, which detects 24 pathogens by performing one test on the same blood sample, and specifically discloses the separation of the chip into an upper reservoir portion and a lower reaction layer portion. The liquid storage pipe is partially pre-provided with freeze-drying reagent, and the chip is added with dissolving liquid for re-melting when in use, and the sample is required to be pretreated and then added with sample solution. The reaction layer part adopts a flexible bag to realize the partition design of a cell lysis region, a nucleic acid purification region and an amplification region, and the liquid flowing between different regions is realized by the extrusion of an air bag in the device. The microfluidic chip has low material cost, but has higher processing difficulty. In addition, the flexible membrane is difficult to realize accurate positioning, and dead angles exist in the extrusion of the air bags, so that reagents in the chip cannot be accurately controlled, dead angles exist, and the total dosage of the reagents is large.
Disclosure of Invention
The utility model provides a chip locking mechanism for molecular diagnosis equipment, which aims to solve the technical problem that the molecular diagnosis equipment in the prior art cannot stably clamp a microfluidic chip.
The technical scheme provided by the utility model is as follows:
an object of the present utility model is to provide a chip locking mechanism for a molecular diagnostic device, the chip locking mechanism comprising a base plate frame, a movable side frame and a fixed side frame, the fixed side frame being fixed to the base plate frame, the movable side frame being hinged to the base plate frame; a slot for accommodating the microfluidic chip is formed between the fixed side frame and the movable side frame,
the chip locking mechanism further comprises a movable side connecting rod, a fixed side connecting rod and a transverse connecting rod; the movable side connecting rod is hinged with the movable side frame, the fixed side connecting rod is hinged with the fixed side frame, and the transverse connecting rod is hinged with the movable side connecting rod and the fixed side connecting rod;
the transverse connecting rod moves downwards, and drives the movable side connecting rod to pull the movable side frame to be close to the fixed side frame, so as to clamp the microfluidic chip inserted into the slot;
the transverse connecting rod moves upwards, and drives the movable side connecting rod to push the movable side frame to be far away from the fixed side frame, so that the microfluidic chip inserted into the slot is loosened.
In a preferred embodiment, the chip locking mechanism further comprises a hinge shaft;
the movable side frame is provided with a hinge block, and is hinged to the bottom plate frame through a hinge shaft, so that the movable side frame can rotate and swing around the hinge shaft.
In a preferred embodiment, a driving connection block is arranged on the transverse connection rod, and the transverse connection rod is driven to move up and down through the driving connection block.
In a preferred embodiment, the chip locking mechanism further comprises a driving mechanism, and the driving connection block is connected with the driving mechanism;
the driving mechanism drives the driving connecting block to drive the transverse connecting rod to move up and down.
Compared with the prior art, the technical scheme of the utility model has at least the following beneficial effects:
the utility model provides a chip locking mechanism for molecular diagnosis equipment, a user only needs to insert a microfluidic chip into the chip locking mechanism, and clamps and releases the chip through up-and-down movement of a transverse connecting rod, so that the microfluidic chip is stably clamped on the molecular diagnosis equipment when PCR molecular diagnosis is carried out, and full-flow automatic detection is realized.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings required for the description of the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present utility model, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic view of a chip locking mechanism of the present utility model.
Fig. 2 is a schematic view of the driving side frame of the chip locking mechanism of the present utility model approaching the fixed side frame.
Fig. 3 is a schematic view of the chip locking mechanism of the present utility model driving the side frame away from the fixed side frame.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present utility model more clear, the technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. It will be apparent that the described embodiments are some, but not all, embodiments of the utility model. All other embodiments, which can be made by a person skilled in the art without creative efforts, based on the described embodiments of the present utility model fall within the protection scope of the present utility model.
Unless defined otherwise, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this utility model belongs. The terms "first," "second," and the like, as used herein, do not denote any order, quantity, or importance, but rather are used to distinguish one element from another. Likewise, the terms "a," "an," or "the" and similar terms do not denote a limitation of quantity, but rather denote the presence of at least one. The word "comprising" or "comprises", and the like, means that elements or items preceding the word are meant to encompass the elements or items listed thereafter and equivalents thereof without precluding other elements or items. The terms "connected" or "connected," and the like, are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect.
It should be noted that "upper", "lower", "left", "right", "front", "rear", and the like are used in the present utility model only to indicate a relative positional relationship, and when the absolute position of the object to be described is changed, the relative positional relationship may be changed accordingly.
As shown in a schematic view of the chip locking mechanism of the present utility model in fig. 1, according to an embodiment of the present utility model, there is provided a chip locking mechanism 1 for a molecular diagnostic device, comprising a base plate frame 101, a movable side frame 103, and a fixed side frame 102, the fixed side frame 102 being fixed to the base plate frame 101, the movable side frame 103 being hinged to the base plate frame 101.
The chip locking mechanism 1 further includes a moving-side link 104, a fixed-side link 105, a transverse link 106, a drive connection block 107, and a hinge shaft 108. The movable-side link 104 is hinged to the movable-side frame 103, the fixed-side link 105 is hinged to the fixed-side frame 102, and the horizontal link 106 is hinged to the movable-side link 104 and the fixed-side link 105, so that the movable-side frame 103, the movable-side link 104, the fixed-side link 105, and the fixed-side frame 102 constitute a four-bar linkage.
Further, the movable-side frame 103 is provided with a hinge block 109, and the movable-side frame 103 is hinged to the floor frame 101 via a hinge shaft 108, so that the movable-side frame 103 can be pivoted about the hinge shaft 108.
Further, a driving connection block 107 is disposed on the transverse connection rod 106, and the driving connection block 107 is connected to a driving mechanism (not shown in the driving mechanism diagram), and the driving mechanism drives the driving connection block 107 to drive the transverse connection rod 106 to move up and down.
Referring to fig. 2 to 3, a slot C accommodating a microfluidic chip is formed between the fixed side frame 102 and the movable side frame 103 according to an embodiment of the present utility model. The chip locking mechanism 1 drives the moving side frame 103 to reciprocate, and clamps or releases the microfluidic chip inserted into the slot C.
As shown in fig. 2, when the microfluidic chip is inserted into the slot C, the driving connection block 107 drives the transverse connection rod 106 to move downward, and the transverse connection rod 106 drives the moving side connection rod 104 to pull the moving side frame 103 to approach the fixed side frame 102, so as to clamp the microfluidic chip inserted into the slot C.
As shown in fig. 3, after the PCR diagnosis is completed, the driving connection block 107 drives the transverse connection rod 106 to move upward, the transverse connection rod 106 drives the moving side connection rod 104 to push the moving side frame 103 away from the fixed side frame 102, so as to relax the microfluidic chip inserted into the slot C, and take away the microfluidic chip after the PCR diagnosis as shown in fig. 3.
The following points need to be described:
(1) The drawings of the embodiments of the present utility model relate only to the structures related to the embodiments of the present utility model, and other structures may refer to the general designs.
(2) In the drawings for describing embodiments of the present utility model, the thickness of layers or regions is exaggerated or reduced for clarity, i.e., the drawings are not drawn to actual scale. It will be understood that when a device such as a layer, film, region, or substrate is referred to as being "on" or "under" another device, it can be "directly on" or "under" the other device or intervening devices may be present.
(3) The embodiments of the utility model and the features of the embodiments can be combined with each other to give new embodiments without conflict.
The present utility model is not limited to the above embodiments, but the scope of the utility model is defined by the claims.
Claims (4)
1. A chip locking mechanism for a molecular diagnostic device, characterized in that the chip locking mechanism comprises a base plate frame, a movable side frame and a fixed side frame, the fixed side frame is fixed on the base plate frame, and the movable side frame is hinged on the base plate frame; a slot for accommodating the microfluidic chip is formed between the fixed side frame and the movable side frame,
the chip locking mechanism further comprises a movable side connecting rod, a fixed side connecting rod and a transverse connecting rod; the movable side connecting rod is hinged with the movable side frame, the fixed side connecting rod is hinged with the fixed side frame, and the transverse connecting rod is hinged with the movable side connecting rod and the fixed side connecting rod;
the transverse connecting rod moves downwards, and drives the movable side connecting rod to pull the movable side frame to be close to the fixed side frame, so as to clamp the microfluidic chip inserted into the slot;
the transverse connecting rod moves upwards, and drives the movable side connecting rod to push the movable side frame to be far away from the fixed side frame, so that the microfluidic chip inserted into the slot is loosened.
2. The chip locking mechanism for a molecular diagnostic device according to claim 1, wherein the chip locking mechanism further comprises a hinge shaft;
the movable side frame is provided with a hinge block, and is hinged to the bottom plate frame through a hinge shaft, so that the movable side frame can rotate and swing around the hinge shaft.
3. The chip locking mechanism for molecular diagnostic device according to claim 1, wherein a driving connection block is provided on the transverse link, and the transverse link is driven to move up and down by the driving connection block.
4. The chip locking mechanism for a molecular diagnostic device according to claim 3, wherein the chip locking mechanism further comprises a driving mechanism to which the driving connection block is connected;
the driving mechanism drives the driving connecting block to drive the transverse connecting rod to move up and down.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321098167.7U CN219951034U (en) | 2023-05-09 | 2023-05-09 | Chip locking mechanism for molecular diagnosis equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321098167.7U CN219951034U (en) | 2023-05-09 | 2023-05-09 | Chip locking mechanism for molecular diagnosis equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219951034U true CN219951034U (en) | 2023-11-03 |
Family
ID=88539321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321098167.7U Active CN219951034U (en) | 2023-05-09 | 2023-05-09 | Chip locking mechanism for molecular diagnosis equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219951034U (en) |
-
2023
- 2023-05-09 CN CN202321098167.7U patent/CN219951034U/en active Active
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