CN219911964U - Micro-valve driving module for molecular diagnosis equipment - Google Patents
Micro-valve driving module for molecular diagnosis equipment Download PDFInfo
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- CN219911964U CN219911964U CN202321098163.9U CN202321098163U CN219911964U CN 219911964 U CN219911964 U CN 219911964U CN 202321098163 U CN202321098163 U CN 202321098163U CN 219911964 U CN219911964 U CN 219911964U
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- 238000003745 diagnosis Methods 0.000 title claims abstract description 14
- 238000012544 monitoring process Methods 0.000 claims description 2
- 238000001514 detection method Methods 0.000 abstract description 9
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 238000005516 engineering process Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 5
- 150000007523 nucleic acids Chemical class 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 108020004707 nucleic acids Proteins 0.000 description 5
- 238000003752 polymerase chain reaction Methods 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 230000003321 amplification Effects 0.000 description 4
- 238000003199 nucleic acid amplification method Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
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- 238000012545 processing Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000009007 Diagnostic Kit Methods 0.000 description 1
- 239000012807 PCR reagent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
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- 238000004377 microelectronic Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000001821 nucleic acid purification Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Abstract
The utility model provides a micro valve driving module for molecular diagnosis equipment, which comprises a frame, a plurality of large cams and a small cam, wherein the large cams and the small cams are arranged through a cam shaft which is arranged on the frame; a plurality of single-head micro valve ejector rods are arranged on the frame in a telescopic sliding mode, and the outer edges of the large cams are contacted with the plurality of single-head micro valve ejector rods; the cam shaft rotates to drive the large cams to squeeze the single-head micro valve ejector rods, so that the single-head micro valve ejector rods extend out of or retract into the frame. After the micro-fluidic chip is inserted into the molecular diagnosis equipment, the micro-valve of the micro-fluidic chip is driven by the micro-valve driving module, so that full-automatic detection is realized.
Description
Technical Field
The utility model relates to the technical field of medical equipment, in particular to a micro valve driving module for molecular diagnosis equipment.
Background
Molecular diagnostics is an important branch of in vitro diagnostics. PCR (polymerase chain reaction) technology is one of the most widely used technologies in the molecular diagnostic technology center. The PCR technology comprises complex processing procedures including reagent preparation, nucleic acid extraction, nuclear amplification, result analysis and the like. Traditional PCR has the following pain points: (1) The laboratory site requirement is high, four links of sample preparation, reagent preparation, nucleic acid extraction and nucleic acid amplification are strictly partitioned, the air pressure in the four partitions is gradually reduced, and the laboratory flow and logistics routes are strictly adhered to; (2) The operation requirement of personnel is high, and molecular diagnosis detection personnel need to have certain professional skills to support the evidence on duty; (3) The cost is high, the molecular diagnosis process involves various special equipment, and the cost is high.
Microfluidic technology refers to the science and technology involved in systems that use microchannels to process or manipulate tiny fluids, and is an emerging interdisciplinary in relation to chemical, fluid physics, microelectronics, new materials, biology, and biomedical engineering. The microfluidic technology can concentrate the detection process on a chip with a centimeter-to-micrometer level, so that the whole detection is miniaturized and automated, thereby greatly reducing the requirements of the detection process on fields, personnel and equipment and realizing the one-step detection of 'sample in and sample out'. Microfluidic devices are known as microfluidic chips.
The PCR detection has high requirements on sites, personnel and equipment, and the microfluidic technology can effectively realize the integration and automation of detection, so that the microfluidic technology becomes a very promising technical route in the field of molecular diagnosis.
US8673238B2 discloses a GeneXpert molecular diagnostic kit from Cepheid and a test instrument for performing full-automatic analysis of the kit, which are typical molecular diagnostic microfluidic products, and discloses a piston which can move up and down in the middle of the kit and is arranged in a plurality of chambers in the kit. The middle piston chamber can be respectively communicated with the surrounding reagent chambers through a rotary valve at the bottom of the reagent box, so that the flow control of the reagent is realized. A reaction tube is designed at the rear part of the kit, and the mixed solution of the extracted nucleic acid and the PCR reagent is injected into the reaction tube to realize the nucleic acid amplification. However, the kit has a complex structure and a plurality of sealing links, especially rotary valves, and needs to realize motion sealing, thereby having high requirements on the production process.
U.S. patent No. 8940526B2 discloses a Filmarray microfluidic chip from Biofire, which detects 24 pathogens by performing one test on the same blood sample, and specifically discloses the separation of the chip into an upper reservoir portion and a lower reaction layer portion. The liquid storage pipe is partially pre-provided with freeze-drying reagent, and the chip is added with dissolving liquid for re-melting when in use, and the sample is required to be pretreated and then added with sample solution. The reaction layer part adopts a flexible bag to realize the partition design of a cell lysis region, a nucleic acid purification region and an amplification region, and the liquid flowing between different regions is realized by the extrusion of an air bag in the device. The microfluidic chip has low material cost, but has higher processing difficulty. In addition, the flexible membrane is difficult to realize accurate positioning, and dead angles exist in the extrusion of the air bags, so that reagents in the chip cannot be accurately controlled, dead angles exist, and the total dosage of the reagents is large.
Disclosure of Invention
The utility model provides a micro valve driving module for molecular diagnosis equipment, which aims to solve the technical problem of micro valve driving of a micro-fluidic chip by the molecular diagnosis equipment in the prior art.
The technical scheme provided by the utility model is as follows:
an object of the present utility model is to provide a micro valve driving module for a molecular diagnostic device, which includes a frame, a plurality of large cams and a small cam,
a plurality of the large cams and the small cams mounted by a cam shaft mounted on the frame;
a plurality of single-head micro valve ejector rods are arranged on the frame in a telescopic sliding mode, and the outer side edges of the large cams are contacted with the single-head micro valve ejector rods;
and the cam shaft rotates to drive the large cams to squeeze the single-head micro valve ejector rods, so that the single-head micro valve ejector rods extend out of or retract into the frame.
In a preferred embodiment, the micro valve driving module further comprises a swing rod and a double-head micro valve ejector rod, wherein the double-head micro valve ejector rod is installed on the frame in a telescopic sliding manner;
one end of the swing rod is hinged with the frame, the other end of the swing rod is in contact with the double-head micro valve ejector rod, and the swing rod is in contact with the outer side edge of the small cam;
and the cam shaft rotates to drive the small cam to extrude the swinging rod, so as to drive the swinging rod to extrude the double-head micro valve ejector rod, and the double-head micro valve ejector rod extends out of or retracts into the frame.
In a preferred embodiment, the micro valve driving module further comprises a worm wheel, a worm and a motor;
the cam shaft is connected with an output shaft of the motor through the worm wheel and the worm, and the cam shaft is driven to rotate through the motor to drive the large cams and the small cams to rotate.
In a preferred embodiment, a return spring is provided between the frame and the plurality of single-head micro valve stems.
In a preferred embodiment, a return spring is disposed between the frame and the double-headed micro-valve plunger.
In a preferred embodiment, the micro valve drive module further comprises an encoder circuit board,
the encoder circuit board is arranged on one side of the cam shaft, is fixed with the frame and is used for monitoring the rotation angle of the cam shaft.
In a preferred embodiment, the camshaft is mounted on the frame by bearings.
Compared with the prior art, the technical scheme of the utility model has at least the following beneficial effects:
the utility model provides a micro-valve driving module for molecular diagnosis equipment, which is used for driving a micro-valve of a micro-fluidic chip through the micro-valve driving module after the micro-fluidic chip is inserted into the molecular diagnosis equipment, so as to realize full-automatic detection.
The utility model provides a micro valve driving module for molecular diagnosis equipment, which monitors the rotation angle of a cam shaft in real time through an encoder circuit board and realizes accurate feedback control of the angle of the cam shaft.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings required for the description of the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present utility model, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a microvalve drive module of the present utility model.
Fig. 2 is a schematic view of a microvalve drive module removal frame of the present utility model.
Fig. 3 is A-A view of fig. 1.
Fig. 4 is a B-B view of fig. 1.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present utility model more clear, the technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. It will be apparent that the described embodiments are some, but not all, embodiments of the utility model. All other embodiments, which can be made by a person skilled in the art without creative efforts, based on the described embodiments of the present utility model fall within the protection scope of the present utility model.
Unless defined otherwise, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this utility model belongs. The terms "first," "second," and the like, as used herein, do not denote any order, quantity, or importance, but rather are used to distinguish one element from another. Likewise, the terms "a," "an," or "the" and similar terms do not denote a limitation of quantity, but rather denote the presence of at least one. The word "comprising" or "comprises", and the like, means that elements or items preceding the word are meant to encompass the elements or items listed thereafter and equivalents thereof without precluding other elements or items. The terms "connected" or "connected," and the like, are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect.
It should be noted that "upper", "lower", "left", "right", "front", "rear", and the like are used in the present utility model only to indicate a relative positional relationship, and when the absolute position of the object to be described is changed, the relative positional relationship may be changed accordingly.
The micro valve driving module according to the present utility model is shown in a schematic view in fig. 1, the micro valve driving module according to the present utility model is shown in a schematic view in a removed frame in fig. 2, fig. 3 is A-A view in fig. 1, and fig. 4 is a B-B view in fig. 1. Referring to fig. 1 to 4, according to an embodiment of the present utility model, there is provided a micro valve driving module 1 for a molecular diagnostic device including a frame 101, a plurality of large cams 102, one small cam 102', a cam shaft 103, a worm wheel 104, a worm 105, a motor 106, a swing link 107, a double-headed micro valve plunger 109, a single-headed micro valve plunger 110, and an encoder circuit board 108.
A plurality of large cams 102 and small cams 102' are mounted by a cam shaft 103, and the cam shaft 103 is bearing-mounted on the frame 101. The cam shaft 103 is connected with an output shaft of a motor 106 through a worm wheel 104 and a worm 105, and the cam shaft 103 is driven to rotate through the motor 106 to drive a plurality of large cams 102 and small cams 102' to rotate.
According to an embodiment of the present utility model, a plurality of single-head micro valve lift pins 110 are installed on the frame 101 in a telescopic sliding manner, and outer side edges of the plurality of large cams 102 are in contact with the plurality of single-head micro valve lift pins 110. The number of the large cams 102 and the single-head micro-valve ejector rods 110 is 5.
When the motor 106 drives the worm 105 to rotate, the worm 105 drives the worm wheel 104 to rotate, and the worm wheel 104 drives the cam shaft 103 to rotate, the large cams 102 are driven to squeeze the single-head micro valve ejector rods 110, so that the single-head micro valve ejector rods 110 extend out of or retract into the frame 101, and the micro valves of the micro-fluidic chip are driven to be conducted or cut off.
Further, a return spring is arranged between the frame 101 and the plurality of single-head micro valve ejector rods 110, and when the large cam 102 does not press the single-head micro valve ejector rods 110, the single-head micro valve ejector rods 110 retract into the frame 101 under the action of the return spring.
According to an embodiment of the present utility model, the micro valve driving module 1 further comprises a swing link 107 and a double-headed micro valve lever 109. The double-headed micro valve lift pin 109 is installed in the frame 101 in a telescopic sliding manner, one end of the swing link 107 is hinged to the frame 101, the other end of the swing link 107 is in contact with the double-headed micro valve lift pin 109, and the swing link 107 is in contact with the outer side edge of the small cam 102'.
When the motor 106 drives the worm 105 to rotate, the worm 105 drives the worm wheel 104 to rotate, and the worm wheel 104 drives the cam shaft 103 to rotate, the small cam 102' is driven to squeeze the swing rod 107, the swing rod 107 is driven to squeeze the double-head micro valve ejector rod 109, the double-head micro valve ejector rod 109 is enabled to extend or retract into the frame 101, and two micro valves of the micro-fluidic chip are driven to be simultaneously conducted or cut off (simultaneously opened and closed).
Further, a return spring is arranged between the frame 101 and the double-head micro valve ejector 109, and when the small cam 102' does not press the swing rod 107 and the swing rod 107 does not press the double-head micro valve ejector 109, the double-head micro valve ejector 109 retracts into the frame 101 under the action of the return spring.
According to an embodiment of the present utility model, the encoder circuit board 108 is disposed at one side of the cam shaft 103, fixed to the frame 101. The encoder circuit board 108 monitors the rotation angle of the cam shaft 103 in real time, and as a feedback quantity controlled by the motor 106, controls the cam shaft 103 to rotate to a target angle. Precise feedback control of the angle of the camshaft 103 is achieved through the encoder circuit board 108.
The following points need to be described:
(1) The drawings of the embodiments of the present utility model relate only to the structures related to the embodiments of the present utility model, and other structures may refer to the general designs.
(2) In the drawings for describing embodiments of the present utility model, the thickness of layers or regions is exaggerated or reduced for clarity, i.e., the drawings are not drawn to actual scale. It will be understood that when a device such as a layer, film, region, or substrate is referred to as being "on" or "under" another device, it can be "directly on" or "under" the other device or intervening devices may be present.
(3) The embodiments of the utility model and the features of the embodiments can be combined with each other to give new embodiments without conflict.
The present utility model is not limited to the above embodiments, but the scope of the utility model is defined by the claims.
Claims (7)
1. A micro valve driving module for a molecular diagnosis apparatus, wherein the micro valve driving module comprises a frame, at least two large cams and a small cam,
at least two of the large cams and the small cams are mounted on the frame by a cam shaft;
at least two single-head micro valve ejector rods are arranged on the frame in a telescopic sliding mode, and the outer side edge of the large cam is contacted with the corresponding single-head micro valve ejector rods;
and the cam shaft rotates to drive the large cam to squeeze the corresponding single-head micro valve ejector rod, so that the single-head micro valve ejector rod extends out of or retracts into the frame.
2. The micro valve driving module for molecular diagnostic device according to claim 1, further comprising a swing link and a double-headed micro valve jack mounted on the frame in a telescopic sliding manner;
one end of the swing rod is hinged with the frame, the other end of the swing rod is in contact with the double-head micro valve ejector rod, and the swing rod is in contact with the outer side edge of the small cam;
and the cam shaft rotates to drive the small cam to extrude the swinging rod, so as to drive the swinging rod to extrude the double-head micro valve ejector rod, and the double-head micro valve ejector rod extends out of or retracts into the frame.
3. The micro valve driving module for a molecular diagnostic device according to claim 2, wherein the micro valve driving module further comprises a worm wheel, a worm and a motor;
the cam shaft is connected with an output shaft of the motor through the worm wheel and the worm, and the cam shaft is driven to rotate through the motor to drive the large cam and the small cam to rotate.
4. The micro valve driving module for a molecular diagnostic device according to claim 1, wherein a return spring is provided between the frame and the single-head micro valve jack.
5. The micro valve driving module for a molecular diagnostic device according to claim 2, wherein a return spring is provided between the frame and the double-headed micro valve plunger.
6. The micro valve driving module for a molecular diagnostic device according to claim 1 or 2, wherein the micro valve driving module further comprises an encoder circuit board,
the encoder circuit board is arranged on one side of the cam shaft, is fixed with the frame and is used for monitoring the rotation angle of the cam shaft.
7. The micro valve driving module for a molecular diagnostic device according to claim 1 or 2, wherein the camshaft is mounted on the frame through a bearing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321098163.9U CN219911964U (en) | 2023-05-09 | 2023-05-09 | Micro-valve driving module for molecular diagnosis equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321098163.9U CN219911964U (en) | 2023-05-09 | 2023-05-09 | Micro-valve driving module for molecular diagnosis equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219911964U true CN219911964U (en) | 2023-10-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321098163.9U Active CN219911964U (en) | 2023-05-09 | 2023-05-09 | Micro-valve driving module for molecular diagnosis equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219911964U (en) |
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2023
- 2023-05-09 CN CN202321098163.9U patent/CN219911964U/en active Active
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