CN219915054U - Slide for medical examination - Google Patents

Abstract

The utility model belongs to the technical field of medical examination, and particularly relates to a slide for medical examination. The slide for medical examination comprises a bearing substrate, wherein a detection area is configured on the bearing substrate, sample adding holes and vent holes are respectively formed in two sides of the detection area, the sample adding holes are communicated with the detection area through sample adding flow passages which are obliquely arranged, the sample adding holes are micro-channel holes, and waterproof and breathable films are arranged at the inner ends of the vent holes. Through the inclined sample adding flow channel, the sample liquid begins to be paved after being added, so that the uniformity of the sample liquid paved in the detection area is improved; the sample adding holes of the micro-channel hole structure are matched with the detection area, so that sample liquid is paved more uniformly, and meanwhile, the cross section of a sample adding flow channel is smaller through the micro-channel holes, so that sample liquid is prevented from being added from the sample Kong Fanliu, and the sample liquid can be effectively prevented from overflowing by matching the waterproof breathable film arranged at the end of the exhaust hole; the waterproof ventilated membrane that the exhaust hole end set up guarantees detection area air discharge when avoiding sample liquid excessive.

Description

Slide for medical examination

Technical Field

The utility model belongs to the technical field of medical examination, and particularly relates to a slide for medical examination.

Background

Vaginal diseases are common diseases in female diseases, are important risk factors for infertility, urinary tract infection, ectopic pregnancy, uterine cavity infection, salpingitis, endometritis and other diseases, are main causes of pregnancy complications such as amniotic fluid infection, neonatal infection, premature birth and the like in obstetrics, and generally relate to analysis of vaginal secretions in diagnosis of the vaginal diseases, wherein a secretion analysis slide is used for analysis of components of the secretions.

Conventional analytical slides are typically split and include two parts, a slide and a cover slip. Common slide making methods include a smear method, a tabletting method, a loading method and the like, wherein the smear method is a method of uniformly coating a material on a slide, the tabletting method is a method of applying a certain pressure between the slide and a cover plate to disperse tissue cells, and the loading method is a method of integrally sealing the biological material to prepare a slide specimen. The method has the advantages that the current slide is manufactured according to a plurality of operation rules, so that the process is complicated, the manufacturing process of the detection personnel consumes time, and the slide is easy to pollute in the manual touch process; the cover glass is easy to slide off and break during operation, so that the risk that the glass breaks the skin of an operator exists; in addition, the detection sample is easy to overflow, and the operation is relatively inconvenient. With the development of medical instrument detection and inspection technology, products such as a full-automatic gynecological secretion analysis system and the like are applied successively, and conventional slides are not suitable for being applied to a full-automatic gynecological secretion analysis platform and cannot meet the requirement of instant medical detection.

The Chinese patent publication No. CN204790174U and publication No. 2015, 11 and 18 discloses a slide glass which can be directly used for making a sheet without a cover glass. Analysis shows that the solution has the problem of uneven sample solution tiling after sample adding, and the problem of bubbles can be generated in the tiling process; in addition, after the sample is added, the sample needs to be sealed by paraffin, and the operation steps are added.

Disclosure of Invention

The utility model aims to provide a slide for medical examination, which solves the problems that the sample liquid is not uniformly paved after the sample is added and the sample is required to be sealed in an extra step after the sample is added.

In order to achieve the above object, a slide for medical examination according to the present utility model adopts the following technical scheme:

the utility model provides a slide for medical science inspection, includes bears the base member, bears and is provided with the detection zone on the base member, bears the base member and is provided with application of sample hole and exhaust hole respectively in the both sides of detection zone, application of sample hole and detection zone are through the application of sample runner intercommunication that the slope set up, the application of sample hole is the microchannel hole, the inner in exhaust hole is provided with waterproof ventilated membrane.

The beneficial effects of the technical scheme are that: according to the utility model, through improvement of the prior art and through the inclined sample adding flow channel, the sample liquid starts to be paved through the sample adding flow channel after being added, so that the uniformity of the sample liquid paved in the detection area is improved; the sample adding holes of the micro-channel hole structure are matched with the detection area, so that sample liquid is paved more uniformly, and meanwhile, the cross section of a sample adding flow channel is smaller through the micro-channel holes, so that sample liquid is prevented from being added from the sample Kong Fanliu, and the sample liquid can be effectively prevented from overflowing by matching the waterproof breathable film arranged at the end of the exhaust hole; the waterproof and breathable film arranged at the inner end of the exhaust hole can prevent the sample liquid from overflowing and ensure the air in the detection area to be discharged.

Further, the diameter of the sample adding hole is 0.05mm-0.15mm.

The beneficial effects of the technical scheme are that: by means of the arrangement, the cross section of the sample adding flow channel is smaller, the sample liquid is prevented from being added from the sample Kong Fanliu due to the existence of liquid tension, and meanwhile the sample liquid is evenly paved by matching with the detection area.

Further, the outer port of the sample adding hole is provided with a flaring structure.

The beneficial effects of the technical scheme are that: by the arrangement, the sample liquid can be conveniently added.

Further, the exhaust hole is communicated with the detection area through an exhaust channel, and a waterproof and breathable film is arranged at the joint of the detection area and the exhaust channel.

The beneficial effects of the technical scheme are that: the setting is that the air in the detection zone can be discharged through the exhaust hole through the exhaust channel after the sample liquid is added, the waterproof ventilated membrane is arranged at the joint of the detection zone and the exhaust channel, and the sample liquid can be prevented from overflowing while the exhaust in the detection zone is ensured.

Further, the detection area is provided with a groove formed by sinking relative to the surface of the bearing substrate, and the distance between the bottom surface of the groove and the surface of the bearing substrate in the vertical direction is 0.10-0.20mm.

The beneficial effects of the technical scheme are that: the arrangement is matched with the sample adding hole with the micro-channel structure, so that the sample liquid is more uniformly paved, and blockage and bubbles are not easy to occur; the thickness of the sample liquid space formed between the groove and the cover plate is proper, so that the layering phenomenon of the liquid sample can be reduced, namely, each cell or tissue exists in a pure flat focal plane, and a clearer observation effect can be obtained.

Further, the grooves are covered with the matched cover plates, and the cover plates and the bearing matrix are made of transparent materials.

The beneficial effects of the technical scheme are that: by means of the arrangement, the automatic genital secretion detection device is convenient for better observation and image acquisition, and is also convenient for realizing automatic genital secretion detection by using the automatic imaging and image intelligent interpretation technology when the automatic analysis platform is used.

Further, fluorescent dye for dyeing the sample is preset in the groove.

The beneficial effects of the technical scheme are that: by the arrangement, fluorescent dye is preset in the groove of the detection area, so that the sample is dyed after being added into the sample through the sample adding holes communicated with the detection area, and compared with the prior art, the operation steps of independent dyeing are reduced, and the detection efficiency is improved.

Further, the cross section of the sample adding flow channel along the direction from the sample adding hole to the detection area is gradually increased.

The beneficial effects of the technical scheme are that: the sample liquid is added, then the sample liquid starts to be paved, and the cross section of the sample adding flow channel gradually increases along the direction from the sample adding hole to the detection area, so that the sample liquid is paved more uniformly.

Further, the sample adding hole and the exhaust hole are respectively provided with a detachable dustproof film, and the dustproof films are connected with the sample adding hole and the exhaust hole in an electrostatic attraction prevention mode.

The beneficial effects of the technical scheme are that: by the arrangement, the slide can be prevented from being polluted in the storage process, so that the accuracy of a test result is ensured; when in use, the dustproof film can be conveniently torn off for loading and exhausting; the dustproof film is convenient to take down through electrostatic adsorption's trial work connection, and this integral type slide is as disposable consumptive material, and the setting of dustproof film also enables the user to distinguish whether the slide of this utility model has been used, ensures the accuracy of test result.

Further, the bearing substrate is further provided with a handheld area, and the handheld area is made of frosted materials.

The beneficial effects of the technical scheme are that: by the arrangement, the detection area is prevented from being polluted when the slide is held by the hand, the detection result is prevented from being interfered, and the risk of sliding off when the slide is held by the hand is avoided.

Drawings

FIG. 1 is a top view of a medical test slide of the present utility model;

fig. 2 is a view in the A-A direction of fig. 1.

In the figure: 1. a carrier substrate; 2. a sample adding hole; 3. a detection zone; 4. an exhaust hole; 5. a hand-held region; 6. a waterproof breathable film; 21. a sample adding flow channel; 41. an exhaust passage.

Detailed Description

The present utility model will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present utility model more apparent. It should be understood that the particular embodiments described herein are illustrative only and are not intended to limit the utility model, i.e., the embodiments described are merely some, but not all, of the embodiments of the utility model. The components of the embodiments of the present utility model generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the utility model, as presented in the figures, is not intended to limit the scope of the utility model, as claimed, but is merely representative of selected embodiments of the utility model. All other embodiments, which can be made by a person skilled in the art without making any inventive effort, are intended to be within the scope of the present utility model.

It is noted that relational terms such as "first" and "second", and the like, may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, terms such as "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" or the like does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.

The features and capabilities of the present utility model are described in further detail below in connection with the examples.

Example 1 of a slide for medical examination of the present utility model:

as shown in fig. 1 and 2, a slide for medical examination according to the present utility model includes a carrier substrate 1, a detection area 3 is disposed on the carrier substrate 1, sample loading holes 2 and air exhaust holes 4 are respectively disposed on two sides of the detection area 3 on the carrier substrate 1, the sample loading holes 2 are communicated with the detection area 3 through a sample loading flow channel 21, and the air exhaust holes 4 are communicated with the detection area 3 through an air exhaust channel 41.

In this embodiment, the sample addition well 2 is a micro channel well, specifically, the diameter of the sample addition well 2 is 0.05mm-0.15mm; like this for loading runner 21 cross section size is less, because the existence of liquid tension, has avoided the sample liquid to return from loading hole 2, and it is more even to make the sample liquid tiling with the cooperation of detection zone simultaneously, also further avoids detecting the working face by the overflow of sample liquid and pollute. Because the sample adding hole 2 is of a micro-channel structure, in order to facilitate the addition of the sample liquid, the outer port of the sample adding hole 2 is provided with a flaring structure.

The sample loading channel 21 is a circular channel with a through diameter, and has an injection port (not labeled in the figure) for adding a sample liquid and a discharge port (not labeled in the figure) for discharging the sample liquid, in this embodiment, the injection port is integrally disposed with the sample loading hole 2, the position of the injection port is higher than that of the discharge port, the injection port and the discharge port are disposed offset from each other, specifically, the injection port is disposed on the upper surface of the carrier substrate 1, and the discharge port is disposed at the junction between the sample loading channel 21 and the detection area 3. In this way, the sample adding flow channel 21 has a certain distance from the injection port to the discharge port, and after the sample liquid is added, the sample liquid starts to be spread through the sample adding flow channel 21, so that the spreading uniformity of the sample liquid in the detection area 3 is improved; meanwhile, the position of the injection opening is higher than that of the discharge opening, so that the tiling speed is improved through the height difference between the injection opening and the discharge opening after the sample liquid is added; because the sample adding hole 2 is of a micro-channel structure, the cross section of the sample adding flow channel 21 is small, so that the reflux of sample liquid from the sample adding hole 2 is avoided, the sample liquid can be effectively prevented from overflowing by matching with the waterproof breathable film 6 arranged at the end of the exhaust hole 4, and additional operation on a slide after sample adding is completed is not needed.

A waterproof and breathable membrane 6 is arranged between the exhaust hole 4 and the detection area 3, and specifically, the waterproof and breathable membrane 6 is arranged at the joint of the detection area 3 and the exhaust channel 41. Like this, the air in the detection zone 3 can be discharged through exhaust hole 4 through exhaust channel 41 after the sample liquid is added, sets up in the waterproof ventilated membrane 6 that detection zone 3 and exhaust channel 41 junction set up, can avoid the sample liquid excessive when guaranteeing the interior air discharge of detection zone 3.

The detection area 3 has a depth sinking relative to the surface of the bearing substrate 1 to form a groove, a cover plate (not labeled in the figure) matched with the groove is covered on the groove, in this embodiment, a step sinking relative to the surface of the bearing substrate 1 is arranged at the periphery of the groove and is used for supporting the cover plate, the depth of the step is equal to the thickness of the cover plate, so that after the cover plate is fixed with the bearing substrate 1 in a sticking manner, the upper surface of the cover plate is flush with the upper surface of the bearing substrate 1, thereby the cover plate and the bearing substrate 1 form an integrated slide, the need of separately processing the cover plate during traditional microscopic inspection is avoided, the risks of liquid drop splashing and aerosol generation are effectively reduced, and the method is more convenient for a full-automatic analysis instrument; in addition, compared with the existing separated slide, the cover plate and the bearing substrate are fixed in advance, so that the cover plate is not required to be installed when a sample is manufactured, the sample to be detected is simpler to manufacture, the time consumption is effectively reduced, the problems that the cover plate is easy to slide and break during operation and the detection sample liquid is easy to overflow are fundamentally solved, and meanwhile, the management cost in the aspects of separately purchasing and storing the cover plate and the bearing substrate is effectively reduced. In other embodiments, the cover plate may be connected and fixed to the bearing substrate by bolting or bolting.

The distance between the bottom surface of the groove of the detection area 3 and the surface of the bearing substrate 1 in the vertical direction is 0.10-0.20mm, and the depth of the detection area 3 is proper and matched with the sample adding hole 2 with the micro-channel structure, so that the sample liquid is more uniformly paved, and blockage and bubbles are not easy to occur; meanwhile, layering phenomenon of the liquid sample can be reduced, namely, each cell or tissue exists in a pure flat focal plane, and a clearer observation effect can be obtained; meanwhile, the cell fixing effect is improved, and the overflow of the cell suspension is avoided, so that the loss of cells is reduced.

The sample adding hole 2 and the vent hole 4 are respectively provided with a detachable dustproof film (not marked in the figure), so that the glass slide can be prevented from being polluted before use, and the dustproof films can be conveniently torn off for sample adding and venting before sample adding, thereby ensuring the sample liquid tiling effect and the accuracy of test results; meanwhile, as the glass slide is a disposable product, the dustproof film can also enable a user to distinguish whether the glass slide is used or not, so that the accuracy of a test result is further ensured. In this embodiment, the dustproof membrane adopts electrostatic adsorption's mode to be connected with application of sample hole 2 and exhaust hole 4, compares in the sticky structure, and electrostatic adsorption makes the dustproof membrane comparatively convenient when taking off.

In this embodiment, the carrier substrate 1 and the cover sheet are made of transparent materials, specifically, glass may be used, and since the glass has high light transmittance, it is convenient to better observe the sample and acquire the image.

In this embodiment, a hand-held area 5 is provided on one side of the carrying substrate 1 far away from the sample loading hole 2, and the hand-held area 5 is made of frosted materials, so that the risk of sliding down during movement of the hand-held slide can be prevented.

When the slide for medical examination is used, the dustproof films of the sample adding hole 2 and the vent hole 4 are torn off, a sample is injected into the detection area 3 from the sample adding hole 2 through the sample adding flow channel 21 so as to finish the 'filling pool' of the secretion sample, the sample enters the detection area 3, the gas in the detection area 3 is discharged through the vent channel 41 and the vent hole 4, and the sample can be subjected to microscopic examination and observation after entering the detection area 3. In this embodiment, the injection loading method is adopted for loading, so that an initial flow rate can be provided after the sample liquid is added, and the tiling efficiency is accelerated.

The slide integrated sealing design for medical examination avoids the cover plate treatment process of the conventional slide, can effectively avoid the overflow of sample liquid, and is more suitable for a full-automatic gynecological secretion analysis instrument. When the slide for medical examination is applied to a full-automatic gynecological secretion analysis platform, the sample adding hole 2 and the exhaust hole 4 can be further plugged by adopting an adsorption type dustproof film, so that pollution caused by overflow of sample liquid is avoided.

Example 2 of a slide for medical examination of the present utility model:

compared with the embodiment 1, in this embodiment, a fluorescent dye for dyeing the sample is preset in the groove of the detection area 3, and the fluorescent dye is a processed freeze-dried powder; in other embodiments, the fluorescent dye may be other fluorescent dyes in a lyophilized state. The lyophilized powder or other lyophilized state of the fluorescent dye is a prior art or product in the art and will not be described in detail herein. Thus, the freeze-dried fluorescent dye has long-term storage condition and is easy to be manufactured into a shape which is matched with the appearance of the detection area; the freeze-dried powder fluorescent dye is easy to quickly redissolve by means of dripped sample liquid, so that the sample is quickly dyed, the operation steps are effectively reduced, and the detection efficiency is further improved.

When the medical detection slide is used, the dustproof film is torn off, a sample is injected into the detection area from the sample-adding Kong Jingjia sample flow channel, so that 'pond filling' of secretion samples is completed, the samples are not mixed with fluorescent dye powder preset in the detection area 3, the samples are dyed after the dye powder is not redissolved, and microscopic examination and observation can be carried out after the dyeing is completed. From the above use process, it can be found that the medical detection slide provided by the utility model simplifies the operation steps compared with the conventional slide for manual operation; for the full-automatic gynecological secretion detection system, the storage bin space of the staining solution and the staining module can be reduced, so that the structure of the detection instrument is effectively simplified.

Example 3 of a slide for medical examination of the present utility model:

in example 1 of a medical test slide, both the carrier substrate and the coverslip are made of glass. In this embodiment, the carrier substrate and cover sheet are made of a transparent plastic material, such as PMMA, PC, PS.

Example 4 of a slide for medical examination of the present utility model:

in example 1 of a slide for medical examination, the loading channel is a circular channel having an aperture. In this embodiment, the sample loading flow channel is set to gradually increase the cross section along the direction from the injection port to the discharge port, so that the sample liquid can be spread more uniformly. In other embodiments, the loading channel may be configured as a conical structure, and the cross section of the outlet and the cross section of the injection port are square.

Example 5 of a slide for medical examination of the present utility model:

in example 1 of a slide for medical examination, the well has a hole-enlarging structure to facilitate the addition of the sample liquid. In this embodiment, the protrusion may be disposed above the sample application hole, so as to be convenient to cooperate with a sample liquid filling device, which may be a dropper or a syringe.

Example 6 of a slide for medical examination of the present utility model:

in example 1 of a slide for medical examination, the injection port of the sample addition channel is located higher than the discharge port. In this embodiment, the injection port and the discharge port of the sample addition channel are at the same height.

Example 7 of a slide for medical examination of the present utility model:

in example 1 of a slide for medical examination, the loading well is a microchannel well. In this embodiment, the sample loading hole is a hole with a conventional opening, and is conveniently loaded by instillation.

Example 8 of a slide for medical examination of the present utility model:

in example 2 of a slide for medical examination, the fluorescent dye preset in the detection zone is lyophilized powder. In this embodiment, a certain amount of liquid fluorescent dye is preset in the detection area, and accordingly, in order to ensure that the preset fluorescent dye does not leak, paraffin or other reliable materials are used to seal the sample adding hole and the exhaust hole.

The above description is only a preferred embodiment of the present utility model, and the patent protection scope of the present utility model is defined by the claims, and all equivalent structural changes made by the specification and the drawings of the present utility model should be included in the protection scope of the present utility model.

Claims (10)

1. The utility model provides a slide for medical science inspection, includes bears the base member, bears and is furnished with the detection area on the base member, bears the base member and is provided with application of sample hole and exhaust hole in the both sides of detection area respectively, its characterized in that: the sample adding hole is communicated with the sample adding flow passage which is obliquely arranged in the detection area, the sample adding hole is a micro-channel hole, and a waterproof and breathable film is arranged at the inner end of the exhaust hole.

2. The medical test slide according to claim 1, wherein: the diameter of the sample adding hole is 0.05mm-0.15mm.

3. The medical test slide according to claim 1 or 2, wherein: the outer port of the sample adding hole is provided with a flaring structure.

4. The medical test slide according to claim 1 or 2, wherein: the exhaust hole is communicated with the detection area through an exhaust channel, and a waterproof and breathable film is arranged at the joint of the detection area and the exhaust channel.

5. The medical test slide according to claim 4, wherein: the detection area is provided with a groove formed by sinking relative to the surface of the bearing substrate, and the distance between the bottom surface of the groove and the surface of the bearing substrate in the vertical direction is 0.10-0.20mm.

6. The medical test slide according to claim 5, wherein: the grooves are covered with adaptive cover plates, and the cover plates and the bearing matrix are made of transparent materials.

7. The medical test slide according to claim 5 or 6, wherein: fluorescent dye for dyeing the sample is preset in the groove.

8. The medical test slide according to claim 1 or 2, wherein: the cross section of the sample adding flow channel along the direction from the sample adding hole to the detection area is gradually increased.

9. The medical test slide according to claim 8, wherein: the sample adding hole and the exhaust hole are respectively provided with a detachable dustproof film, and the dustproof films are connected with the sample adding hole and the exhaust hole in an electrostatic suction prevention mode.

10. The medical test slide according to claim 9, wherein: the bearing substrate is also provided with a hand-held area, and the hand-held area is made of frosted materials.