CN219878196U - Lesion cell collector - Google Patents
Lesion cell collector Download PDFInfo
- Publication number
- CN219878196U CN219878196U CN202321017438.1U CN202321017438U CN219878196U CN 219878196 U CN219878196 U CN 219878196U CN 202321017438 U CN202321017438 U CN 202321017438U CN 219878196 U CN219878196 U CN 219878196U
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- China
- Prior art keywords
- connecting rod
- rod
- insertion hole
- jack
- antibody layer
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- 230000003902 lesion Effects 0.000 title abstract description 9
- 238000012360 testing method Methods 0.000 claims abstract description 24
- 238000007789 sealing Methods 0.000 claims abstract description 16
- 230000036285 pathological change Effects 0.000 claims abstract description 8
- 231100000915 pathological change Toxicity 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 7
- 238000003780 insertion Methods 0.000 claims description 11
- 230000037431 insertion Effects 0.000 claims description 11
- 239000002184 metal Substances 0.000 claims description 10
- 229910052751 metal Inorganic materials 0.000 claims description 10
- 239000011248 coating agent Substances 0.000 claims description 9
- 238000000576 coating method Methods 0.000 claims description 9
- 239000003365 glass fiber Substances 0.000 claims description 8
- 229910001220 stainless steel Inorganic materials 0.000 claims description 8
- 239000010935 stainless steel Substances 0.000 claims description 8
- 229920000249 biocompatible polymer Polymers 0.000 claims description 4
- 239000008280 blood Substances 0.000 abstract description 18
- 210000004369 blood Anatomy 0.000 abstract description 18
- 230000001575 pathological effect Effects 0.000 abstract description 17
- 238000000034 method Methods 0.000 abstract description 11
- 238000001514 detection method Methods 0.000 abstract description 10
- 230000008569 process Effects 0.000 abstract description 10
- 238000003556 assay Methods 0.000 abstract description 5
- 239000010410 layer Substances 0.000 description 23
- 230000017531 blood circulation Effects 0.000 description 3
- 238000010241 blood sampling Methods 0.000 description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 3
- 239000010931 gold Substances 0.000 description 3
- 229910052737 gold Inorganic materials 0.000 description 3
- 238000005192 partition Methods 0.000 description 3
- 238000007747 plating Methods 0.000 description 3
- 239000004576 sand Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002344 surface layer Substances 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model relates to the field of cell collectors, and provides a lesion cell collector. Including the test tube, the centre of test tube is equipped with U type logical groove, the centre of U type logical groove is equipped with the wall, the centre of wall is equipped with the ladder jack, peg graft in the jack has the connecting rod, the bottom of connecting rod is connected with the collection pole, the surface of collection pole covers has the antibody layer, through the target pathological change cell is caught on the antibody layer, two ports of U type logical groove are filled with the sealing plug. The collector of the embodiment can be used for containing collected blood or processed collection liquid, and also has an antibody layer which can capture pathological cells and can extract the pathological cells in advance, so that the concentration of target pathological cells in the assay process can be improved, and the assay detection accuracy is improved.
Description
Technical Field
The utility model relates to the field of cell collectors, in particular to a lesion cell collector.
Background
In disease diagnosis, in order to accurately judge the cause of disease and to perform pathological culture, it is necessary to collect cells in human blood so as to perform corresponding detection processing. At present, most of the cell collection methods are to sample blood from human body and then collect cells from the blood sample for detection.
The primary blood sampling amount is generally 5-15 ml, only part of pathological cells are contained in the primary blood sampling amount, the test detection equipment generally does not test the blood in the whole test tube, only part of the blood in the primary blood sampling amount is taken for testing, so that the content of the target pathological cells of the unrefined blood is low, and the reliability of the detection result is low. The existing test tubes have no function of purifying or extracting pathological cells, and can only be purified by inspection equipment.
Disclosure of Invention
The utility model aims to provide a lesion cell collector which is mainly used for solving the technical problems in the background technology.
In order to achieve the above purpose, the present utility model provides the following technical solutions:
including the test tube, the centre of test tube is equipped with U type logical groove, the centre of U type logical groove is equipped with the wall, the centre of wall is equipped with the ladder jack, peg graft in the jack has the connecting rod, the bottom of connecting rod is connected with the collection pole, the surface of collection pole covers has the antibody layer, through the target pathological change cell is caught on the antibody layer, two ports of U type logical groove are filled with the sealing plug.
Through the technical scheme, the test tube with the U-shaped through groove is provided, when the extracted blood is filled into the U-shaped through groove, the blood flows in the U-shaped through groove in the process of shaking the test tube, the blood flows in the process of repeatedly contacting with the collecting rod, and the antibody layer on the collecting rod can capture target lesion cells. Therefore, in the process of collecting blood by using the test tube, the collector can be directly used for extracting the pathological cells, and when the pathological cells are tested, the pathological cells collected on the surface layer of the collecting rod are only required to be stripped to test equipment for test detection.
Preferably, the collecting rod is rotatably connected with the bottom of the connecting rod, and the detecting liquid in the U-shaped through groove can be rocked to enable the collecting rod to rotate.
Through the technical scheme, the collecting rod can rotate along with the rocked blood, and the efficiency of collecting and extracting pathological cells by the collecting rod can be improved.
Preferably, the collecting rod is a diamond cylinder.
Preferably, the connecting rod is made of glass fiber, the collecting rod is made of stainless steel, a metal coating is coated on the surface of the collecting rod, the antibody layer is coated on the outer side of the metal coating, and the antibody layer is a hydrogel-like biocompatible polymer layer.
Through the technical scheme, the connecting rod can be made of glass fiber and plastic, and the collector is made of glass fiber. The collecting rod is made of stainless steel, and can be made of glass fiber together with the connecting rod, and then the stainless steel layer is coated on the outer side of the collecting rod. The metal coating coated on the surface of the acquisition rod can be a gold plating layer,
preferably, an internal thread is arranged at the top end of the jack, a screw cap is rotatably connected to the top end of the connecting rod, an external thread matched with the internal thread screw is arranged at the bottom of the screw cap, and the connecting rod is fixed in the jack through the screw cap.
Through the technical scheme, after the connecting rod is inserted into the jack, the connecting rod can be fixed in the jack through rotating the cap, and in the process of fixing the connecting rod, the bottom of the connecting rod is in contact with the sealing gasket, so that the sealing gasket plays a role to form a seal, and liquid is prevented from flowing out of the jack.
Preferably, a sealing gasket is arranged at the bottom of the jack, and when the connecting rod is fixed in the jack, the bottom of the connecting rod is in extrusion contact with the sealing gasket.
Preferably, the insertion hole is provided with a chute, a convex strip is arranged on the side surface of the connecting rod, and when the connecting rod is inserted into the insertion hole, the convex strip slides in the chute.
Through above-mentioned technical scheme, under the cooperation effect of sand grip and spout, can avoid gathering the inner wall contact of pole and jack, avoid gathering the pathological change cell of gathering on the pole and be scraped to scratch on the jack inner wall.
Compared with the prior art, the utility model has the beneficial effects that: the utility model has reasonable structure and strong functionality and has the following advantages:
1. the collector can be used for containing collected blood or processed collection liquid, and also has an antibody layer capable of capturing pathological cells, so that the pathological cells can be extracted in advance, the concentration of target pathological cells in the assay process can be improved, and the assay detection accuracy is improved.
2. The collector is designed with a U-shaped through groove, and the connecting rod connected with the collecting rod can be placed in the U-shaped through groove to be in contact with blood, so that the extraction of target lesion cells can be completed only by shaking the collector.
3. The collecting rod is directly made of stainless steel, and meanwhile, a gold-plated layer and an antibody layer are coated on the surface layer of the collecting rod from inside to outside, and the antibody layer is made of a hydrogel-like biocompatible polymer layer, so that pathological cells can be conveniently scraped from the collecting rod for detection.
Drawings
FIG. 1 is a schematic cross-sectional view of the present utility model.
FIG. 2 is a cross-sectional view of a component tube of the present utility model.
FIG. 3 is a top view of a component tube of the present utility model.
FIG. 4 is a partial cross-sectional view of a component link and acquisition rod of the present utility model.
Fig. 5 is a cross-sectional view of a component collection rod of the present utility model.
Fig. 6 is a cross-sectional view of a component link of the present utility model.
The figure indicates:
1. a test tube; 2. partition; 3. u-shaped through grooves; 4. a connecting rod; 5. a cap is screwed; 6. a collection rod; 7. a sealing gasket; 8. a sealing plug; 9. an external thread; 10. an internal thread; 11. a metal coating; 12. an antibody layer; 13. a convex strip; 14. a chute; 15. and a jack.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Referring to fig. 1-3, the present utility model provides a technical solution for a diseased cell collector:
the test tube comprises a test tube 1, a U-shaped through groove 3 is arranged in the middle of the test tube 1, and sealing plugs 8 are plugged at two ports of the U-shaped through groove 3. The middle of the U-shaped through groove 3 is provided with a partition 2, and the middle of the partition 2 is provided with a step jack 15.
The jack 15 is internally inserted with the connecting rod 4, the bottom of the connecting rod 4 is rotationally connected with the diamond-shaped cylinder acquisition rod 6, and the acquisition rod 6 can be rotated by shaking the detection liquid in the U-shaped through groove 3. The collection rod 6 can rotate along with the swaying blood, so that the efficiency of collecting and extracting pathological cells by the collection rod 6 can be improved.
Wherein, the top of jack 15 is equipped with internal thread 10, and the top rotation of connecting rod 4 is connected with and revolves cap 5, and the bottom of revolvecap 5 is equipped with in the supporting external screw thread 9 of internal thread 10 spiral, is fixed in jack 15 with connecting rod 4 through revolvecap 5. The sealing gasket 7 is placed at the bottom of the jack 15, and when the connecting rod 4 is fixed in the jack 15, the bottom of the connecting rod 4 is in extrusion contact with the sealing gasket 7.
After the connecting rod 4 is inserted into the insertion hole 15, the connecting rod 4 is fixed in the insertion hole 15 by rotating the screw cap 5, and in the process of fixing the connecting rod 4, the bottom of the connecting rod 4 is contacted with the sealing gasket 7, so that the sealing gasket 7 plays a role to form a seal, and liquid is prevented from flowing out of the insertion hole 15.
Wherein, jack 15 is equipped with spout 14, and the side of connecting rod 4 is equipped with sand grip 13, and when connecting rod 4 inserted jack 15, sand grip 13 slides in spout 14.
Under the cooperation of the convex strips 13 and the sliding grooves 14, the contact between the collecting rod 6 and the inner wall of the jack 15 can be avoided, and the pathological cells collected on the collecting rod 6 are prevented from being scraped and rubbed on the inner wall of the jack 15.
The surface of the collection stick 6 is covered with an antibody layer 12, and target lesion cells are captured by the antibody layer 12.
Wherein, the connecting rod 4 is glass fiber material, the collection rod 6 is stainless steel material, the surface of the collection rod 6 is covered with a metal coating 11, the outer side of the metal coating 11 is covered with an antibody layer 12, and the antibody layer 12 is a hydrogel-like biocompatible polymer layer.
In this embodiment, the connecting rod 4 is made of glass fiber, or may be made of plastic. The collecting rod 6 is made of stainless steel, and can be made of glass fiber together with the connecting rod 4. The head of the collection rod 6 is provided with a T-shaped structure, and the bottom of the connecting rod 4 is provided with a T-shaped groove, so that the collection rod 6 can rotate at the bottom of the connecting rod 4.
During manufacturing, the outer side of the collection rod 6 is coated with a stainless steel layer. The metal coating 11 coated on the surface of the collecting rod 6 can be a gold plating layer, and specific gold plating metals can be copper and silver.
When in use, the disposable blood suction tube is connected, and blood is directly filled into the U-shaped through groove 3. In the assay detection, the test tube 1 is first shaken a plurality of times. Blood flows in the U-shaped through groove 3, and repeatedly contacts with the collecting rod 6 in the blood flowing process, and the antibody layer 12 on the collecting rod 6 captures target lesion cells in the blood.
And then the screw cap 5 is rotated, the connecting rod 4 and the collecting rod 6 are lifted, and in the process of lifting the connecting rod 4, a boss of the connecting rod 4 slides in the sliding groove 14, so that the collecting rod 6 is prevented from being contacted with the jack 15 due to inclination in the process of lifting the connecting rod 4. The outermost antibody layer 12 of the collection stick 6 is then scraped off the test device and, in order to maintain the cell activity, an appropriate amount of blood is also withdrawn from the test tube 1 to participate in the test.
Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. The utility model provides a pathological change cell collector, includes test tube (1), the centre of test tube (1) is equipped with U type logical groove (3), its characterized in that, the centre of U type logical groove (3) is equipped with cuts off (2), the centre of cutting off (2) is equipped with ladder jack (15), peg graft in jack (15) has connecting rod (4), the bottom of connecting rod (4) is connected with collection pole (6), the surface of collection pole (6) covers has antibody layer (12), through antibody layer (12) catches target pathological change cell, two ports of U type logical groove (3) are filled with sealing plug (8).
2. The pathological change cell collector according to claim 1, wherein the collecting rod (6) is rotatably connected with the bottom of the connecting rod (4), and the detecting liquid in the U-shaped through groove (3) can be shaken to rotate the collecting rod (6).
3. The diseased cell collector according to claim 1, characterized in that the collection rod (6) is a diamond-shaped cylinder.
4. The pathological change cell harvester according to claim 1, wherein the connecting rod (4) is made of glass fiber, the collecting rod (6) is made of stainless steel, a metal coating (11) is coated on the surface of the collecting rod (6), the antibody layer (12) is coated on the outer side of the metal coating (11), and the antibody layer (12) is a hydrogel-like biocompatible polymer layer.
5. The pathological change cell collector according to claim 1, wherein the top end of the insertion hole (15) is provided with an internal thread (10), the top end of the connecting rod (4) is rotationally connected with a screw cap (5), the bottom of the screw cap (5) is provided with an external thread (9) which is in screw fit with the internal thread (10), and the connecting rod (4) is fixed in the insertion hole (15) through the screw cap (5).
6. The diseased cell collector according to claim 1, characterized in that a sealing gasket (7) is placed at the bottom of the insertion hole (15), and when the connecting rod (4) is fixed in the insertion hole (15), the bottom of the connecting rod (4) is in pressing contact with the sealing gasket (7).
7. The diseased cell collector according to claim 1, characterized in that the insertion hole (15) is provided with a chute (14), the side surface of the connecting rod (4) is provided with a convex strip (13), and when the connecting rod (4) is inserted into the insertion hole (15), the convex strip (13) slides in the chute (14).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321017438.1U CN219878196U (en) | 2023-04-28 | 2023-04-28 | Lesion cell collector |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321017438.1U CN219878196U (en) | 2023-04-28 | 2023-04-28 | Lesion cell collector |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219878196U true CN219878196U (en) | 2023-10-24 |
Family
ID=88395076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321017438.1U Active CN219878196U (en) | 2023-04-28 | 2023-04-28 | Lesion cell collector |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219878196U (en) |
-
2023
- 2023-04-28 CN CN202321017438.1U patent/CN219878196U/en active Active
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