CN219872645U - Bionic fluid model for dynamic in-vitro imaging of ultrasonic contrast agent - Google Patents
Bionic fluid model for dynamic in-vitro imaging of ultrasonic contrast agent Download PDFInfo
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- CN219872645U CN219872645U CN202223222760.6U CN202223222760U CN219872645U CN 219872645 U CN219872645 U CN 219872645U CN 202223222760 U CN202223222760 U CN 202223222760U CN 219872645 U CN219872645 U CN 219872645U
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- 238000003384 imaging method Methods 0.000 title claims abstract description 28
- 239000012530 fluid Substances 0.000 title claims abstract description 20
- 239000002961 echo contrast media Substances 0.000 title claims abstract description 19
- 239000011664 nicotinic acid Substances 0.000 title claims abstract description 18
- 238000000338 in vitro Methods 0.000 title claims abstract description 10
- 239000000499 gel Substances 0.000 claims abstract description 19
- 230000002572 peristaltic effect Effects 0.000 claims abstract description 17
- 239000011543 agarose gel Substances 0.000 claims abstract description 9
- 239000004973 liquid crystal related substance Substances 0.000 claims description 6
- 230000003592 biomimetic effect Effects 0.000 claims description 2
- 239000002872 contrast media Substances 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 7
- 238000002604 ultrasonography Methods 0.000 description 5
- 210000004204 blood vessel Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000010874 in vitro model Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000012285 ultrasound imaging Methods 0.000 description 1
Abstract
The utility model relates to a bionic fluid model for dynamic in-vitro imaging of an ultrasonic contrast agent, which comprises the following components: the peristaltic pump comprises a placement box, a gel block arranged in the placement box, a plurality of main pipes buried in the gel block, connecting pipes with pipelines connected to two ends of the main pipes and peristaltic pumps with pipelines connected between the connecting pipes; wherein, the main pipes are vertically arranged in the gel block in a U shape, and the inner diameters of the main pipes are different; by embedding a plurality of main pipes made of transparent hose in the agarose gel model, air interference during ultrasonic imaging is eliminated, ultrasonic contrast agent is injected into the main pipe from the opening of the three-way interface to one end of the main pipe, and interference-free imaging can be realized; by the peristaltic pump, the peristaltic pump provides power to enable the contrast agent in the main tube to further circulate, and the dynamic imaging effect can be achieved.
Description
Technical Field
The utility model relates to the technical field of medical instruments, in particular to a bionic fluid model for dynamic in-vitro imaging of an ultrasonic contrast agent.
Background
Ultrasound contrast is a technology for dynamically observing microvascular perfusion information of tissues in real time by using intravenous injection of an ultrasound contrast agent on the basis of conventional two-dimensional ultrasound examination, and real-time dynamic imaging is a main advantage of distinguishing the device from other imaging means. Microbubbles of an ultrasound contrast agent vibrate under the action of ultrasound, thereby enhancing the backscatter signal. Ultrasound contrast agents are generally injected into human blood vessels in clinic to enhance ultrasound Doppler signals of blood flow and improve definition and resolution of ultrasound images, and blood perfusion conditions of tissues are evaluated in a contrast process to achieve the purpose of assisting diagnosis.
With the application and development of nanotechnology, nanoultrasonic contrast agents have been developed. Since nano-ultrasound contrast agents are still in the preclinical research stage, many properties remain to be examined, the most important of which is their imaging capabilities for ultrasound imaging.
At present, based on the consideration of factors such as cost, safety and the like, the imaging capability verification of most nanometer ultrasonic contrast agents is carried out in vitro, so that the preparation of an in vitro model capable of verifying the ultrasonic contrast imaging effect is particularly important. A number of simple models prepared using latex gloves have been used in related studies, and there is a need for improvement in both practicality and aesthetics. In addition, because blood in a human body always flows circularly, the simple static model cannot truly simulate the internal environment state of blood vessels in the human body, and the imaging performance verification of the self-made ultrasonic contrast agent is insufficient. Therefore, aiming at the problems, the bionic fluid model based on self-made ultrasonic contrast agent dynamic in-vitro imaging is urgently designed, the extracorporeal circulation dynamic contrast can be realized to a large extent, and air between an ultrasonic probe and the model can be eliminated, so that the actual use requirement is met.
Therefore, the utility model provides a bionic fluid model for dynamic in-vitro imaging of an ultrasonic contrast agent, which eliminates air interference during ultrasonic imaging by embedding a plastic hose in an agarose gel model, and the ultrasonic contrast agent is injected into a tube from one end of the hose, so that interference-free imaging can be realized; in addition, the tee joints are connected with peristaltic pumps externally at the two ends of the hose, and the peristaltic pumps provide power to enable the contrast agent in the hose to further circulate, so that the effect of dynamic imaging is achieved.
Disclosure of Invention
The utility model aims at overcoming the defects in the prior art and provides a bionic fluid model for dynamic in-vitro imaging of an ultrasonic contrast agent.
In order to achieve the above purpose, the technical scheme adopted by the utility model is as follows:
a biomimetic fluid model for dynamic in vitro imaging of ultrasound contrast agents, comprising: the peristaltic pump comprises a placement box, a gel block arranged in the placement box, a plurality of main pipes buried in the gel block, connecting pipes with pipelines connected to two ends of the main pipes and peristaltic pumps with pipelines connected between the connecting pipes; wherein, the liquid crystal display device comprises a liquid crystal display device,
the main pipes are vertically arranged in the gel block in a U shape, and the inner diameters of the main pipes are different.
Further, two groups of three-way interfaces are arranged at the joints of the two ends of the main pipes and the connecting pipes.
Further, the opening directions of the plurality of main pipes are all vertically upward.
Further, the gel block is made of agarose gel.
Further, the inner walls of the front side and the rear side of the placement box are respectively provided with a plurality of clamping blocks, the clamping blocks are matched with the main pipe, and the main pipe is fixed on the inner wall of the placement box through the clamping blocks.
Further, the fixture block is of a detachable split structure, and a clamping strip is arranged at the joint of the fixture block.
Further, the connecting pipes and the plurality of main pipes are transparent hoses, and the placing box is a transparent box without a cover.
Compared with the prior art, the utility model has the following technical effects:
according to the bionic fluid model, the plurality of main pipes made of the transparent hose are buried in the agarose gel model, so that air interference during ultrasonic imaging is eliminated, and ultrasonic contrast agent is injected into the main pipe from the opening of the three-way interface to one end of the main pipe, so that interference-free imaging can be realized; by the peristaltic pump, the peristaltic pump provides power to enable the contrast agent in the main tube to further circulate, and the dynamic imaging effect can be achieved.
Drawings
FIG. 1 is a schematic diagram of a bionic fluid model according to the present utility model;
FIG. 2 is a schematic diagram of the internal structure of a bionic fluid model according to the present utility model;
wherein, the reference numerals include:
a placement box 1; gel block 2; a connecting pipe 3; a peristaltic pump 4; a clamping block 5; a main pipe 6; a three-way interface 7; and a clamping strip 8.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
It should be noted that, without conflict, the embodiments of the present utility model and features of the embodiments may be combined with each other.
The utility model is further described below with reference to the drawings and specific examples, which are not intended to be limiting.
Example 1
Referring to fig. 1, the bionic fluid model of the present embodiment includes: the gel box comprises a placement box 1, a gel block 2 arranged in the placement box 1, a plurality of main pipes 6 buried in the gel block 2, connecting pipes 3 connected to two ends of the main pipes 6 through pipelines and peristaltic pumps 4 connected between the connecting pipes 3 through pipelines; wherein, the liquid crystal display device comprises a liquid crystal display device,
the main pipes 6 are vertically arranged in the gel block 2 in a U shape, and the inner diameters of the main pipes 6 are different.
Referring to fig. 2, two sets of three-way connectors 7 are provided at the connection points between the two ends of the main pipe 6 and the connecting pipe 3; the opening directions of the plurality of main pipes 6 are all vertically upward; the gel block 2 is prepared from agarose gel; the inner walls of the front side and the rear side of the placement box 1 are respectively provided with a plurality of clamping blocks 5, the clamping blocks 5 are matched with the main pipe 6, and the main pipe 6 is fixed on the inner wall of the placement box 1 through the clamping blocks 5; the clamping block 5 is of a detachable split structure, and a clamping strip 8 is arranged at the joint of the clamping block 5; the connecting pipes 3 and the plurality of main pipes 6 are transparent hoses, and the placing box 1 is a transparent box without a cover.
When the main pipe fixing device is used, a plurality of main pipe 6 ports with different inner diameters are upwards and vertically placed at the bottom of the placement box 1 in a U shape, clamping blocks 5 are separated, the main pipe 6 is placed in the clamping blocks 5, the clamping blocks 5 are clamped together through clamping strips 8, the main pipe 6 is fixed, agarose gel is injected into the placement box 1, and after the agarose gel is cooled and solidified, a gel block 2 is formed, and the main pipe 6 is fixed; at the moment, the input end and the output end of one group of main pipes 6 are respectively connected with the peristaltic pump 4 through the connecting pipes 3, then contrast agent is injected into the main pipes 6 along the openings of one group of three-way interfaces 7, after the contrast agent is injected, the openings of the two groups of three-way interfaces 7 are sealed, and the peristaltic pump 4 provides power to enable the contrast agent in the main pipes 6 to circularly flow, so that the effect of dynamic imaging is achieved; the flow state of blood in different blood vessels can be simulated by the main pipes 6 with different inner diameters.
In summary, according to the bionic fluid model disclosed by the utility model, the air interference during ultrasonic imaging is eliminated by embedding the plurality of main pipes 6 made of the transparent hose in the agarose gel model, and the ultrasonic contrast agent is injected into one end of the main pipe 6 from the opening of the three-way interface 7 to enter the pipe, so that interference-free imaging can be realized; by providing peristaltic pump 4, the peristaltic pump 4 provides power to further circulate the contrast agent in main tube 6, and dynamic imaging effect can be achieved.
The foregoing description is only illustrative of the preferred embodiments of the present utility model and is not to be construed as limiting the scope of the utility model, and it will be appreciated by those skilled in the art that equivalent substitutions and obvious variations may be made using the description and illustrations of the present utility model, and are intended to be included within the scope of the present utility model.
Claims (7)
1. A biomimetic fluid model for dynamic in vitro imaging of an ultrasound contrast agent, comprising: the gel box comprises a placement box (1), a gel block (2) arranged in the placement box (1), a plurality of main pipes (6) buried in the gel block (2), connecting pipes (3) connected with two ends of the main pipes (6) through pipelines and peristaltic pumps (4) connected between the connecting pipes (3) through pipelines; wherein, the liquid crystal display device comprises a liquid crystal display device,
the main pipes (6) are vertically arranged in the gel block (2) in a U shape, and the inner diameters of the main pipes (6) are different.
2. Bionic fluid model according to claim 1, characterized in that two sets of three-way interfaces (7) are arranged at the connection of the two ends of the main pipe (6) and the connecting pipe (3).
3. Bionic fluid model according to claim 1, characterized in that the opening direction of several main tubes (6) is all vertically upwards.
4. Bionic fluid model according to claim 1, characterized in that the gel block (2) is made of agarose gel.
5. The bionic fluid model according to claim 1, wherein a plurality of clamping blocks (5) are arranged on the inner walls of the front side and the rear side of the placement box (1), the clamping blocks (5) are matched with the main pipe (6), and the main pipe (6) is fixed on the inner wall of the placement box (1) through the clamping blocks (5).
6. The bionic fluid model according to claim 5, wherein the clamping block (5) is of a detachable split type structure, and a clamping strip (8) is arranged at the joint of the clamping block (5).
7. Bionic fluid model according to claim 1, characterized in that the connecting tube (3) and the number of main tubes (6) are transparent hoses, and the placement box (1) is a transparent, cover-free box.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223222760.6U CN219872645U (en) | 2022-12-02 | 2022-12-02 | Bionic fluid model for dynamic in-vitro imaging of ultrasonic contrast agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223222760.6U CN219872645U (en) | 2022-12-02 | 2022-12-02 | Bionic fluid model for dynamic in-vitro imaging of ultrasonic contrast agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219872645U true CN219872645U (en) | 2023-10-20 |
Family
ID=88331718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202223222760.6U Active CN219872645U (en) | 2022-12-02 | 2022-12-02 | Bionic fluid model for dynamic in-vitro imaging of ultrasonic contrast agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219872645U (en) |
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2022
- 2022-12-02 CN CN202223222760.6U patent/CN219872645U/en active Active
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